Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Science

Volumn 288, Issue 5468, 2000, Pages 1053-1058

  Oda, Eri ^a   Ohki, Rieko ^a   Murasawa, Hideki ^a   Nemoto, Jiro ^a   Shibue, Tsukasa ^a   Yamashita, Toshiharu ^a   Tokino, Takashi ^a   Taniguchi, Tadatsugu ^a   Tanaka, Nobuyuki ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENE ISOLATION; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; X IRRADIATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 9; CASPASES; CELL LINE; CELLS, CULTURED; DNA DAMAGE; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034640281     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5468.1053     Document Type: Article

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47. We thank M. Libonati, E. Barsoumian, G. Harris, H. Nozawa, H. Harada, Y. Saga, J. Inazawa, M. Emi, S. Taki, K. Ogasawara, M. Sato, A. Takaoka, H. Otsuka, K. Ishiodori, S. Hida, and T. Yokochi for invaluable advice and helpful discussions and N. Motoyama for human Bcl-XL cDNA. The mouse Noxa cDNA and its promoter sequences were deposited with GenBank (accession numbers AB041230 and AB04231, respectively). This work was supported in part by a special grant for advanced research on cancer from the Ministry of Education, Science, and Culture of Japan and by a research grant of the Princess Takamatsu Cancer Research Fund. E.O. and R.O. are research fellows of the Japan Society for the Promotion of Science.