A topoisomerase IIβ-mediated dsDNA break required for regulated transcription

Science

Volumn 312, Issue 5781, 2006, Pages 1798-1802

  Ju, Bong Gun ^a   Lunyak, Victoria V ^a   Perissi, Valentina ^a   Garcia Bassets, Ivan ^a   Rose, David W ^a   Glass, Christopher K ^b   Rosenfeld, Michael G ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOTECHNOLOGY; DNA; GENES; PROTEINS;

DNA TOPOISOMERASE; DOUBLE-STRANDED DNA; ENZYMATIC ACTIVITIES; GENE PROMOTER REGIONS;

ENZYME KINETICS;

CELL NUCLEUS RECEPTOR; DNA TOPOISOMERASE (ATP HYDROLYSING) B; DOUBLE STRANDED DNA; HISTONE H1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; DNA; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II BETA; ENZYME INHIBITOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HISTONE; MEMBRANE PROTEIN; MERBARONE; PARP1 PROTEIN, HUMAN; PRESENILIN 2; PSEN2 PROTEIN, HUMAN; THIOBARBITURIC ACID DERIVATIVE;

DNA FINGERPRINTING; ENZYME ACTIVITY; GENE EXPRESSION; PROTEIN;

ARTICLE; CHROMATIN STRUCTURE; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENE ACTIVATION; GENETIC TRANSCRIPTION; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DNA RESPONSIVE ELEMENT; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; TRANSACTIVATION; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HISTONES; HUMANS; MEMBRANE PROTEINS; NUCLEOSOMES; POLY(ADP-RIBOSE) POLYMERASES; PRESENILIN-2; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; THIOBARBITURATES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33745255099     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1127196     Document Type: Article

References (35)

1. C. K. Glass, M. G. Rosenfeld, Genes Dev. 14, 121 (2000).
2. B. M. Spiegelman, R. Heinrich, Cell 119, 157 (2004).
3. V. Perissi, M. G. Rosenfeld, Nat. Rev. Mol. Cell Biol. 6, 542 (2005).
4. A. Tulin, D. Stewart, A. C. Spradling, Genes Dev. 16, 2108 (2002).
5. R. Pavri et al., Mol. Cell 18, 83 (2005).
6. M. Y. Kim, S. Mauro, N. Gevry, J. T. Lis, W. L. Kraus, Cell 119, 803 (2004).
7. B. G. Ju et al., Cell 119, 815 (2004).
8. M. Malanga, F. R. Althaus, Biochem. Cell Biol. 83, 354 (2005).
9. S. Burma, D. J. Chen, DNA Repair 3, 909 (2004).
10. J. M. Jeltsch et al., Nucleic Acids Res. 15, 1401 (1987).
11. J. C. Wang, Nat. Rev. Mol. Cell Biol. 3, 430 (2002).
12. A. Dvir, S. R. Peterson, M. W. Knuth, H. Lu, W. S. Dynan, Proc. Natl. Acad. Sci. U.S.A. 89, 11920 (1992).
13. T. Chibazakura et al., Eur. J. Biochem. 247, 1166 (1997).
14. C. A. Sartorius, G. S. Takimoto, J. K. Richer, L. Tung, K. B. Horwitz, J. Mol. Endocrinol. 24, 165 (2000).
15. G. L. Mayeur et al., J. Biol. Chem. 280, 10827 (2005).
16. C. Leontiou, J. H. Lakey, R. Lightowlers, R. M. Turnbull, C. A. Austin, Mol. Pharmacol. 69, 130 (2006).
17. R. Metivier et al., Cell 115, 751 (2003).
18. L. Ko, G. R. Cardona, W. W. Chin, Proc. Natl. Acad. Sci. U.S.A. 97, 6212 (2000).
19. S. K. Lee et al., Mol. Endocrinol. 14, 915 (2000).
20. J. Torchia et al., Nature 387, 677 (1997).
21. M. Binaschi, R. Farinosi, M. E. Borgnetto, G. Capranico, Cancer Res. 60, 3770 (2000).
22. M. N. Cervellera, A. Sala, J. Biol. Chem. 275, 10692 (2000).
23. P. O. Hassa, M. Covic, S. Hasan, R. Imhof, M. O. Hottiger, J. Biol. Chem. 276, 45588 (2001).
24. C. Le Page, J. Sanceau, J. C. Drapier, J. Wietzerbin, Biochem. Biophys. Res. Commun. 243, 4S1 (1998).
25. A. J. Butler, C. P. Ordahl, Mol. Cell. Biol. 19, 296 (1999).
26. M. Ku, S. Stewart, A. Hata, Biochem. Biophys. Res. Commun. 311, 702 (2003).
27. F. R. Althaus et al., Mol. Cell. Biochem. 138, 53 (1994).
28. D. T. Brown, Biochem. Cell Biol. 81, 221 (2003).
29. J. O. Thomas, Biochem. Soc. Trans. 29, 395 (2001).
30. M. F. Ruh, J. C. Chrivia, L. K. Cox, T. S. Ruh, Mol. Cell. Endocrinol. 214, 71 (2004).
31. D. Das, R. C. Peterson, W. M. Scovell, Mol. Endocrinol. 18, 2616 (2004).
32. A. M. Nunez, M. Berry, J. L. Imler, P. Chambon, EMBO J. 8, 823 (1989).
33. T. Barkhem, L. A. Haldosen, J. A. Gustafsson, S. Nilsson, Mol. Pharmacol. 61, 1273 (2002).
34. I. Collins, A. Weber, D. Levens, Mol. Cell. Biol. 21, 8437 (2001).
35. We thank C. Nelson and K. Ohgi for their assistance; S. Ogawa and J. Puc for reagents; and X. Zhu and T. Wang for discussions and advice. We also thank J. Hightower and M. Fisher for assistance in figure and manuscript preparation and M. Gonzalez (Santa Cruz Biotechnology) for advice on reagents. M.G.R. is an investigator with the Howard Hughes Medical Institute and B.J. is supported by the U.S. Army Medical Research and Materiel Command (grant DAMD17-01-1-0184). These studies are supported by NIH and National Cancer Institute grants to M.G.R. and C.K.G.