CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

Immunity

Volumn 5, Issue 3, 1996, Pages 285-293

  Lenschow, Deborah J ^a   Herold, Kevan C ^b   Rhee, Lesley ^a   Patel, Bina ^a   Koons, Ann ^a   Qin, Hui Yu ^c   Fuchs, Elaine ^b   Singh, Bhagarith ^c   Thompson, Craig B ^b   Bluestone, Jeffrey A ^a  

^a Cancer Biology and Developmental Biology   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B7 ANTIGEN; CD28 ANTIGEN; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; ETIOLOGY; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 16044371193     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80323-4     Document Type: Article

References (42)

1. Abe, R., Vandenberghe, P., Craighead, N., Smoot, D.S., Lee, K.P., and June, C.H. (1995). Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J. Immunol. 154, 985-997.
2. Corry, D.B., Reiner, S.L., Linsley, P.S., and Locksley, R.M. (1994). Differential effects of blockade of CD28-B7 on the development of Th1 orTh2 effector cells in experimental leishmaniasis. J. Immunol. 153, 4142-4148.
3. Cross, A.H., Girard, T.J., Giacoletto, K.S., Evans, R.J., Keeling, R.M., Lin, R.F., Trotter, J.L., and Karr, R.W. (1995). Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95, 2783-2789.
4. Debray-Sachs, M., Carnaud, C., Boitard, C., Cohen, H., Gresser, I., Bedossa, P., and Bach, J.F. (1991). Prevention of diabetes in NOD mice treated with antibody to murine IFNγ. J. Autoimmun. 4, 237-248.
5. 67) prevents autoimmune diabetes in NOD mice. Diabetes 43, 1494-1499.
6. Finck, B.K., Linsley, P.S., and Wofsy, D. (1994). Treatment of murine lupus with CTLA-4lg. Science 265, 1225-1227.
7. Green, J.M., Noel, P.J., Spelling, A.I., Walunas, T.L., Gray, G.S., Bluestone, J.A., and Thompson, C.B. (1994). Absence of B7-dependent responses in CD28-deficient mice. Immunity 1, 501-508.
8. Harding, F.A., McArthur, J.G., Gross, J.A., Raulet, D.H., and Allison, J.P. (1992). CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356, 607-610.
9. June, C.H., Bluestone, J.A., Nadler, L.M., and Thompson, C.B. (1994). The B7 and CD28 receptor families. Immunol. Today 15, 321-331.
10. Katz, J.D., Wang, B., Haskins, K., Benoist, C., and Mathis, D. (1993). Following a diabetogenic T cell from genesis through pathogenesis. Cell 74, 1089-1100.
11. Katz, J.D., Benoist, C., and Mathis, D. (1995). T helper cell subsets in insulin-dependent diabetes. Science 268, 1185-1188.
12. Kaufman, D.L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G.S.P., Robinson, P., Atkinson, M.A., Sercarz, E.E., Tobin, A.J., and Lehmann, P.V. (1993). Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366, 69-72.
13. Kawai, K., Shahinian, A., Mak, T.W., and Ohashi, P.S. (1996). Skin allograft rejection in CD28-deficient mice. Transplantation 61, 352-355.
14. Kearney, E.R., Walunas, T.L., Karr, R.W., Morton, P.A., Loh, D.Y., Bluestone, J.A., and Jenkins, M.K. (1995). Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155, 1032-1036.
15. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N., and Glimcher, L.H. (1995). B7-1 and B7-2 costimulatory molecules activate differentially the Th1/ Th2 developmental pathways: application to autoimmune disease therapy. Cell 80, 707-718.
16. Kummel, M.F., and Allison, J.P. (1995). CD28 and CTLA-4 deliver opposing signals which regulate the response of T cells to stimulation. J. Exp. Med. 182, 459-466.
17. Lane, P., Burdet, C., Hubele, S., Scheidegger, D., Muller, U., McConnell, F., and Kosco-Vilbois, M. (1994). B cell function in mice transgenic for mCTLA-4-Hγ1 : lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells. J. Exp. Med. 179, 819-830.
18. Lenschow, D.J., Ho, S.C., Sattar, H., Rhee, L., Gray, G., Nabavi, N., Herold, K.C., and Bluestone, J.A. (1995). Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181, 1145-1155.
19. Lenschow, D.J., Walunas, T.L., and Bluestone, J.A. (1996). CD28/ B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258.
20. Leo, O., Foo, M., Sachs, D.H., Samelson, L.E., and Bluestone, J.A. (1987). Identification of a monoclonal antibody specific for murine T3. Proc. Natl. Acad. Sci. USA 84, 1374-1378.
21. Lucas, P.J., Negishi, I., Nakayama, K., Fields, L.E., and Loh, D.Y. (1995). Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154, 5757-5768.
22. McKnight, A.J., Perez, V.L., Shea, C.M., Gray, G.S., and Abbas, A.K. (1994). Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. J. Immunol. 152, 5220-5225.
23. Nakajima, A., Azuma, M., Kodera, S., Nuriya, S., Terashi, A., Abe, M., Hirose, S., Shirai, T., Yagita, H., Okumura, K. (1995). Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur. J. Immunol. 25, 3060-3067.
24. Nishikawa, K, Linsley, P.S, Collins, A.B., Stamenkovic, I., McCluskey, R.T., and Andres, G. (1994). Effect of CTLA-4 chimeric protein on rat autoimmune anti-glomerular basement membrane glomerulonephritis. Eur. J. Immunol. 24, 1249-1254.
25. Perrin, P.J., Scott, D., Quigley, L., Albert, P.S., Feder, O., Gray, G.S., Abe, R., June, C.H., and Racke, M.K. (1995). Role of B7:CD28/ CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154, 1481-1490.
26. Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H., Cyopick, P., Danska, J.S., and Delovitch, T.L. (1993). Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178, 87-99.
27. Reiner, S.L., Zheng, S., Corry, D.B., and Locksley, R.M. (1993). Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Meth. 165, 37-46.
28. Ronchese, F., Hausmann, B., Hubele, S., and Lane, P. (1994). Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 179, 809-817.
29. Seder, R.A., Germain, R.N., Linsley, P.S., and Paul, W.E. (1994). CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 179, 299-304.
30. Shahinian, A., Pfeffer, K., Lee, K.P., Kundig, T.M., Kishihara, K., Wakeham A., Kawai, K., Ohashi, P.S., Thompson, C.B., and Mak, T.W. (1993). Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612.
31. Shehadeh, N.N., LaRosa, F., and Lafferty, K.J. (1993). Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6, 291-300.
32. Smith, D.K., Kassam, T., Singh, B., and Elliott, J.F. (1992). Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci. J. Bacteriol. 174, 5820-5826.
33. Sperling, A.I., Green, J.M., Mosley, R.L., Smith, P.L., Klein, J.R., Bluestone, J.A., and Thompson, C.B. (1995). CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182, 139-146.
34. Tisch, R., Yang, X.-D., Singer, S.M., Liblau, R.S., Fugger, L., and McDevitt, H.O. (1993). Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75.
35. Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A., and Sharpe, A.H. (1995). Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547.
36. Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M.K., and Adorini, L. (1995). Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181, 817-821.
37. van der Pouw-Kraan, T., De Jong, R., and Aarden, L. (1993). Development of human Th1 and Th2 cytokine responses: the cytokine production profile of T cells is dictated by the primary in vitro stimulus. Eur. J. Immunol. 23, 1-5.
38. Vassar, R., and Fuchs, E. (1991). Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation. Genes Dev. 5, 714-727.
39. Walunas, T.L., Lenschow, D.J., Bakker, C.Y., Linsley P.S., Freeman, G.J, Green, J.M., Thompson, C.B., and Bluestone, J.A. (1994). CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413.
40. Waterhouse, P., Penninger, J.M., Timms, E., Wakeham, A., Shahinian, A., Lee, K.P., Thompson, C.B., Griesser, H., and Mak, T.W. (1995). Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988.
41. Webb, L., and Feldmann, M. (1995). Critical role of CD28/B7 costimulation in the development of human Th2 cells. Blood 86, 3479-3486.
42. Wicker, L.S., Todd, J.A., and Peterson, L.B. (1995). Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13, 179-200.