Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6699-6706

  Wnuk, Stanislaw F ^a   Robert, Jenay ^a   Sobczak, Adam J ^a   Meyers, Brandon P ^a   Malladi, Venkata L A ^a   Zhu, Jinge ^b   Gopishetty, Bhaskar ^b   Pei, Dehua ^b  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Enzyme inhibition; Fluoro sugars; LuxS enzyme; S Ribosylhomocysteine

Indexed keywords

(3,5 DIDEOXY 1,2 O ISOPROPYLIDENE ALPHA DEXTRO ERYTHROPENTOFURANOS 5 YL)HOMOCYSTEINE; (3,5 DIDEOXY 3 FLUORO 1 O METHYL DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE; (3,5 DIDEOXY 3 FLUORO 1,2 O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE; (3,5 DIDEOXY 3 FLUORO DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE; (3,5 DIDEOXY DEXTRO ERYTHROPENTOFURANOS 5 YL)HOMOCYSTEINE; (5 DEOXY 1,2 O ISOPROPYLIDENE 3 O METHYL ALPHA DEXTRO ERYTHROPENTOFURANOS 5 YL)HOMOCYSTEINE; (5 DEOXY 1,2 O ISOPROPYLIDENE 3 O METHYL ALPHA DEXTRO RIBOFURANOS 5 YL)HOMOCYSTEINE; (5 DEOXY 3 O METHYL DEXTRO RIBOFURANOS 5 YL)HOMOCYSTEINE; (5 DEOXY 3 O METHYL DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE; (5 DEOXY DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE; 1,2 O ISOPROPYLIDENE 3 O METHYL 5 O 4 TOLUENESULFONYL ALPHA DEXTRO RIBOFURANOSE; 1,2 O ISOPROPYLIDENE 3 O METHYL 5 O METHYLSULFONYL ALPHA DEXTRO XYLOFURANOSE; 1,2 O ISOPROPYLIDENE 3,5 O SULFONYL ALPHA DEXTRO XYLOFURANOSE; 3 DEOXY 1,2 O ISOPROPYLIDENE 5 O METHYLSULFONYL ALPHA DEXTRO ERYHTHROPENTOFURANOSE; 3 DEOXY 1,2 O ISOPROPYLIDENE ALPHA DEXTRO ERYHTHROPENTOFURANOSE; 3 DEOXY 3 FLUORO 1,2 O ISOPROPYLIDENE 5 O 4 TOLUENESULFONYL ALPHA DEXTRO XYLOFURANOSE; 3 DEOXY 3 FLUORO 1,2 O ISOPROPYLIDENE 5 O METHANESULFONYL ALPHA DEXTRO XYLOFURANOSE; 3 DEOXY 3 FLUORO 1,2 O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOSE; CARBON; ENZYME INHIBITOR; FLUORINE; N (TERT BUTOXYCARBONYL)(3,5 DIDEOXY 3 FLUORO 1,2 O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE TERT BUTYL ESTER; N TERT BUTOXYCARBONYL (5 DEOXY 1,2 O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOS 5 YL)HOMOCYSTEINE TERT BUTYL ESTER; S RIBOSYLHOMOCYSTEINASE; S RIBOSYLHOMOCYSTEINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CONCENTRATION RESPONSE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE; METHYLATION; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; CARBON-SULFUR LYASES; HOMOCYSTEINE; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 69249084980     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.057     Document Type: Article

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