Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target

Journal of Clinical Investigation

Volumn 112, Issue 10, 2003, Pages 1460-1465

  Smith, Roger S ^a   Iglewski, Barbara H ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PROTEIN LAS; PROTEIN RHE; REGULATOR PROTEIN; SYNTHETASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BIOSENSOR; DRUG TARGETING; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING SYSTEM; REVIEW;

ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; CELL COMMUNICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TRANS-ACTIVATORS; VIRULENCE FACTORS;

EID: 0346969987     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200320364     Document Type: Review

References (39)

1. Van Delden, C., and Iglewski, B.H. 1998. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg. Infect. Dis. 4:551-560.
2. Gambello, M.J., and Iglewski, B.H. 1991. Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J. Bacteriol. 173:3000-3009.
3. Pearson, J.P., et al. 1994. Structure of the auroinducer required for expression of Pseudomonas aerugmosa virulence genes. Proc. Natl. Acad. Sci. U. S. A. 91:197-201.
4. Kiratisin, P., Tucker, K.D., and Passador, L. 2002. LasR, a transcriptional activator of Pseudomonas aeruginosa virulence genes, functions as a multimer. J. Bacteriol. 184:4912-4919.
5. Ochsner, U.A., Koch, A.K., Fiechter, A., and Reiser, J. 1994. Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aerugmosa. J. Bacteriol. 176:2044-2054.
6. Pearson, J.P., Passador, L., Iglewski, B.H., and Greenberg, E.P. 1995. A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 92:1490-1494.
7. Pearson, J.P., Van Delden, C., and Iglewski, B.H. 1999. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J. Bacteriol. 181:1203-1210.
8. Chugani S.A., et al. 2001. QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 98:2752-2757.
9. de Kievit, T.R., and Iglewski, B.H. 2000. Bacterial quorum sensing in pathogenic relationships. Infect. Immun. 68:4839-4849.
10. Whiteley, M., Lee, K.M., and Greenberg, E.P. 1999. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 96:13904-13909.
11. Wagner, V.E., Bushnell, D., Passador, L., Brooks, A., and Iglewski, B. 2003. Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol. 185:2080-2095.
12. Schuster, M., Lostroh, P., Ogi, T., and Greenberg, E.P. 2003. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185:2066-2079.
13. Hentzer, M., et al. 2003. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22:3803-3815.
14. Rumbaugh, K.P., Griswold, J.A., Iglewski, B.H., and Hamood, A.N. 1999. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect. Immun. 67:5854-5862.
15. Smith, R.S., Harris, S.G., Phipps, R., and Iglewski, B.H., 2002. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J. Bacteriol. 184:1132-1139.
16. Pearson, J.P., Feldman, M., Iglewski, B.H., and Prince, A. 2000. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68:4331-4334.
17. Wu, H., et al. 2001. Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. Microbiology. 147:1105-1113.
18. Storey, D.G., Ujack, E.E., Rabin, H.R., and Mitchell, I. 1998. Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis. Infect. Immun. 66:2521-2528.
19. Erickson, D.L., et al. 2002. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect Immun. 70:1783-1790.
20. DiMango, E., Zar, H.J., Bryan, R., and Prince, A. 1995. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 96:2204-2210.
21. Smith, R.S., et al. 2001. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappaB and activator protein-2. J. Immunol. 167:366-374.
22. Telford, G., et al. 1998. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect. Immun. 66:36-42.
23. Chhabra, S.R., et al. 2003. Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-1-homoserine lacrone as immune modulators. J. Med. Chem. 46:97-104.
24. Passador, L., Tucker, K., Guertin, K., Kende, A., and Iglewski, B. 1996. Functional analysis of the Pseudomonas aeruginosa autoinducer PAI. J. Bacteriol. 178:5595-6000.
25. Smith, K.M., Bu, Y., and Suga, H. 2003. Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer. Chem. Biol. 10:563-571.
26. Zhang, R.G., et al. 2002. Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA. Nature. 417:971-974.
27. Vannini, A., et al. 2002. The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA. EMBO J. 21:4393-4401.
28. Dong, Y.-H., Gusti, A.R., Zhang, Q.-L., Xu, J. and Zhang, L.-H. 2002. Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species. Appl. Environ. Microbiol. 68:1754-1759.
29. Leadbetter, J.R., and Greenberg E.P. 2000. Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. J. Bacteriol. 182:6921-6926.
30. Park, S.Y., et al. 2003. AhID, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria. Microbiology. 149:1541-1550.
31. Carlier, A., et al. 2003. The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activity. Appl. Environ. Microbiol. 69:4989-4993.
32. Reimmann, C., et al. 2002. Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Microbiology. 148:923-932.
33. Parsek, M.R., Val, D.L., Hanzelka, B.L., Cronan, J.E., and Greenberg, E.P. 1999. Acyl homoserine-lactone quorum-sensing signal generation. Proc. Natl. Acad. Sci. U. S. A. 98:4360-4365.
34. Hoang, T.T., and Schweizer, H.P. 1999. Characterization of the Pseudomonas aeruginosa enoyl-acyl carrier protein reductase: a target for triclosan and its role in acylated homoserine lactone synthesis. J. Bacteriol. 181:5489-5497.
35. Hoang, T.T., Sullivan, S.A., Cusick, J.K., and Schweizer, H.P. 2002. β-Keroacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths. Microbiology. 148:3849-3856.
36. Kurreck, J. 2003. Antisense technologies. Improvement through novel chemical modifications. Eur. J. Biochem. 270:1628-1644.
37. Harth, G., Zamecnik, P.C., Tang, J.-Y., Tabatadze, D., and Horwitz, M. 2000. Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication. Proc. Natl. Acad. Sci. U. S. A. 97:418-423.
38. Good, L., Awasthi, S.K., Dryselius, R., Larsson, O., and Nielsen, P. 2001. Bactericidal antisense effects of peptide-PNA conjugates. Nat. Biotechnol. 19:360-364.
39. Ji, Y., Zhang, et al. 2001. Identification of critical Stapbylococcal genes using conditional phenotypes generated by antisense RNA. Science. 293:2266-2269.