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Volumn 127, Issue 37, 2005, Pages 12762-12763

Small molecule inhibitors of bacterial quorum sensing and biofilm formation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BROMOPHENYL N ACYL HOMOSERINE LACTONE; INDOLE N ACYL HOMOSERINE LACTONE; UNCLASSIFIED DRUG;

EID: 25144448174     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0530321     Document Type: Article
Times cited : (288)

References (22)
  • 14
    • 25144452171 scopus 로고    scopus 로고
    • note
    • All MW-assisted reactions were performed in a commercial MW reactor.
  • 15
    • 0007515394 scopus 로고
    • Protected β-keto acids were synthesized using established procedures: Rathke, M. W.; Nowak, M. A. Synth. Commun. 1985, 15, 1039-1049.
    • (1985) Synth. Commun. , vol.15 , pp. 1039-1049
    • Rathke, M.W.1    Nowak, M.A.2
  • 17
  • 18
    • 25144516997 scopus 로고    scopus 로고
    • note
    • AHLs generated via Scheme 1 were isolated in high enantiopurity (ca. >95%); see Supporting Information.
  • 21
    • 25144485836 scopus 로고    scopus 로고
    • note
    • The non-native AHLs failed to activate LasR or TraR at levels similar to or greater than the native ligand (8b or 8d); see Supporting Information (Figures S-3 and S-4). No ligand had an appreciable effect on bacterial growth over an 18-48 h period.
  • 22
    • 25144444667 scopus 로고    scopus 로고
    • note
    • See Supporting Information for full dose response data and IC50 values at 100 nM 8b in A. tumefaciens and 1 μM 8d in P. aeruginosa.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.