Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis

Science

Volumn 311, Issue 5766, 2006, Pages 1464-1467

  Li, Bo ^a   Yu, John Paul J ^a   Brunzelle, Joseph S ^b   Moll, Gert N ^c   Van Der Donk, Wilfred A ^a   Nair, Satish K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; FOOD PRESERVATIVES; X RAYS;

CYCLIC THIOETHERS; HUMAN HOMOLOGS; SUBSTRATE ACTIVATION;

BIOSYNTHESIS;

CYSTEINE; ENZYME; FARNESYL TRANS TRANSFERASE; FOOD PRESERVATIVE; LANTIBIOTIC CYCLASE; NISIN; SULFIDE; UNCLASSIFIED DRUG;

PEPTIDE;

ARTICLE; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MAMMAL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROCESSING; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CARBON-SULFUR LYASES; CRYSTALLOGRAPHY, X-RAY; FARNESYLTRANSTRANSFERASE; HUMANS; LACTOCOCCUS LACTIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NISIN; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 33644854595     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1121422     Document Type: Article

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36. The structures have been deposited in the Protein Data Bank with the following accession codes: 2G02 (native NisC) and 2G0D (NisC with lead). This work was supported by the NIH (grant GM58822 to WAV.) and by the University of Illinois. J.J.Y. was supported by the Molecular Biophysics Training Grant (NIH) and by a National Research Service Award from the National Institute on Drug Abuse. We thank E. de Boef (BiOMaDe) for technical assistance and R. Matthews for helpful discussions.