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Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 47, 2007, Pages 18433-18438

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

(4) Barb, Adam W a Jiang, Ling a,b Raetz, Christian R H a Zhou, Pei a

a DUKE UNIVERSITY MEDICAL CENTER (United States)

b Wuhan National Laboratory for Optoelectronics (China)

Author keywords

Aquifex aeolicus; Lipid A; Lipopolysaccharide; NMR

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; CHIR 090; CIPROFLOXACIN; ENZYME INHIBITOR; L 161 240; LIPID A; LIPOPOLYSACCHARIDE; LPXC ENZYME; TOBRAMYCIN; UNCLASSIFIED DRUG;

AQUIFEX AEOLICUS; ARTICLE; COMPLEX FORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; GRAM NEGATIVE BACTERIUM; LIGAND BINDING; LIPOGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ACETYLENE; ACETYLESTERASE; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIPHENYL COMPOUNDS; CATALYSIS; CONSERVED SEQUENCE; ENZYME INHIBITORS; HYDROXAMIC ACIDS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MORPHOLINES; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; THREONINE; TIME FACTORS;

AQUIFEX AEOLICUS; NEGIBACTERIA;

EID: 36749037830 PISSN: 00278424 EISSN: 10916490 Source Type: Journal
DOI: 10.1073/pnas.0709412104 Document Type: Article

Times cited : (93)

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