Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

Science

Volumn 310, Issue 5748, 2005, Pages 670-674

  Hung, Deborah T ^a   Shakhnovich, Elizabeth A ^a   Pierson, Emily ^a   Mekalanos, John J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; VIRUSES;

ANTIBIOTIC DISCOVERY; ANTIBIOTIC RESISTANCE; CHOLERAE VIRULENCE; COLONIZATION; TRANSCRIPTIONAL REGULATOR; VIRULENCE GENE; VIRULENCE REGULATION;

ANTIBIOTICS;

AMPICILLIN; ANTIBIOTIC AGENT; ARABINOSE; BACTERICIDE; CHOLERA TOXIN; KANAMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; VIRSTATIN; VIRULENCE FACTOR;

ANTIBIOTICS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIUM PILUS; CHOLERA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL INFECTION; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXIN ANALYSIS; VIBRIO; VIBRIO CHOLERAE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BUTYRIC ACIDS; CELL LINE; CHOLERA; CHOLERA TOXIN; FIMBRIAE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; INTESTINE, SMALL; MICE; MICROBIAL SENSITIVITY TESTS; NAPHTHALENES; NAPHTHALIMIDES; TRANSCRIPTION FACTORS; VIBRIO CHOLERAE; VIRULENCE; VIRULENCE FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS); VIBRIO; VIBRIO CHOLERAE;

EID: 27344443267     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116739     Document Type: Article

References (24)

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24. We thank the National Cancer Institute's Initiative for Chemical Genetics (S. L. Schreiber, P.I.) and the Harvard Institute of Chemistry and Cett Biology for their support of and assistance with the high-throughput small molecule screen; the New England Regional Center of Excellence in Biodefense and Infectious Disease Research for its continued support of research activities involving the identification of small molecule inhibitors of bacterial virulence; and S. Chiang, J. Mougous, and J. Zhu for review of the manuscript. Supported by NIH grant nos. K08 AI060708-01 (D.T.H.) and AI26289 (J.J.M.) and by an NSF predoctoral fellowship (E.A.S.).