Synthetic studies on thiostrepton: Construction of thiostrepton analogues with the thiazoline-containing macrocycle

Angewandte Chemie - International Edition

Volumn 42, Issue 29, 2003, Pages 3418-3424

  Nicolaou, K C ^a,b   Nevalainen, Marta ^a,b   Zak, Mark ^a,b   Bulat, Stephan ^a,b   Bella, Marco ^a,b   Safina, Brian S ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amino acids; Antibiotics; Macrocycles; Natural products; Thiazolines

Indexed keywords

ISOMERS; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

DIASTEREOMERS;

ORGANIC COMPOUNDS;

MACROCYCLIC COMPOUND; THIAZOLE DERIVATIVE; THIOSTREPTON; THIOSTREPTON DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DIASTEREOISOMER; DIELS ALDER REACTION; DIMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; MACROLACTAMIZATION; REACTION ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; THIAZOLES; THIOSTREPTON;

EID: 0043031383     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351745     Document Type: Article

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27. Minimum inhibitory concentration (MIC) assays were performed with the following bacteria: methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 33591), vancomycin-resistant Enterococcus faecium (VRE) (ATCC 700221), Pseudomonas aeruginosa (PA) (27853), Escherichia coli (EC1) (ATCC 700336), Escherichia coli (EC2) (ATCC 29425). We thank Dr. J. Fletcher and Dr. R. Ghadiri for these experiments.