Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 18, 2007, Pages 7612-7616

  Wang, Jun ^a   Kodali, Srinivas ^a   Sang, Ho Lee ^a   Galgoci, Andrew ^a   Painter, Ronald ^a   Dorso, Karen ^a   Racine, Fred ^a   Motyl, Mary ^a   Hernandez, Lorraine ^a   Tinney, Elizabeth ^a   Colletti, Steven L ^a   Herath, Kithsiri ^a   Cummings, Richard ^a   Salazar, Oscar ^b   González, Ignacio ^b   Basilio, Angela ^b   Vicente, Francisca ^b   Genilloud, Olga ^b   Pelaez, Fernando ^b   Jayasuriya, Hiranthi ^a   Young, Katherine ^a   Cully, Doris F ^a   Singh, Sheo B ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

Antisense; Fatty acid synthesis; Natural product; Platensimycin; Thiolactomycin

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; LINEZOLID; METICILLIN; NATURAL PRODUCT; PLATENCIN; PLATENSIMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; AMINOPHENOL DERIVATIVE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; POLYCYCLIC HYDROCARBON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL INFECTION; BIOSYNTHESIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENTEROCOCCUS; FATTY ACID SYNTHESIS; GRAM POSITIVE BACTERIUM; HELA CELL; HEMOLYSIS; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MICROBIAL VIABILITY;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; AMINOPHENOLS; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; MICROBIAL VIABILITY; MOLECULAR STRUCTURE; POLYCYCLIC COMPOUNDS;

EID: 34250649348     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700746104     Document Type: Article

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