Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 11, 2006, Pages 3674-3679

  Müh, Ute ^a   Schuster, Martin ^b   Heim, Roger ^a   Singh, Ashvani ^a   Olson, Eric R ^a   Greenberg, E Peter ^b  

^a VERTEX PHARMACEUTICALS   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL HOMOSERINE LACTONE; ELASTASE; LACTONE; LASI PROTEIN; LASR PROTEIN; N 3 OXODODECANOYL HOMOSERINE LACTONE; PD 12; PYOCYANINE; RHII PROTEIN; RHIR PROTEIN; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; V 06018; VIRULENCE FACTOR;

ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; DRUG STRUCTURE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; IC 50; MICROARRAY ANALYSIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BLOTTING, WESTERN; CULTURE MEDIA; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE LIBRARY; GENES, BACTERIAL; MICROBIAL SENSITIVITY TESTS; PLASMIDS; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; VIRULENCE FACTORS;

EID: 33750582503     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00665-06     Document Type: Article

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