The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus

Journal of Industrial Microbiology and Biotechnology

Volumn 27, Issue 3, 2001, Pages 177-182

  Horinouchi, S ^a   Ohnishi, Y ^a   Kang, D K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

A factor receptor protein; Aerial hyphae formation; Protein tyrosine phosphorylation; Signal transduction; Streptomycin biosynthesis; Stringent response factor ppGpp

Indexed keywords

A FACTOR RECEPTOR PROTEIN; ADENYLATE CYCLASE; CYCLIC AMP; DNA; DNA BINDING PROTEIN; FACTOR A; GUANOSINE TRIPHOSPHATE PYROPHOSPHOKINASE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIUM MUTANT; CONFERENCE PAPER; GENE REPRESSION; MOLECULAR CLONING; MORPHOLOGY; MYCELIUM; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STREPTOMYCES GRISEUS;

4-BUTYROLACTONE; BACTERIAL PROTEINS; CYCLIC AMP; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; REPRESSOR PROTEINS; STREPTOMYCES GRISEUS; STREPTOMYCIN;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); EUKARYOTA; STREPTOMYCES; STREPTOMYCES GRISEUS; UNCULTURED ACTINOMYCETE;

EID: 0035734689     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.7000068     Document Type: Conference Paper

References (34)

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2. Involvement of AfsA in A-factor biosynthesis as a key enzyme
3. A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and a high concentration of A-factor during early growth
4. Regulators of the development of Streptomyces coelicolor A3(2)
5. The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation
6. The adenylate cyclase domain of Streptomyces coelicolor is carboxy-terminal
7. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2)
8. Cyclic AMP stimulates the protein tyrosine kinase activity of Acinetobacter calcoaceticus
9. Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus
10. Streptomyces genes involved in aerial mycelium formation
11. γ-butyrolactones that control secondary metabolism and cell differentiation in Streptomyces
12. Autoregulatory factors and communication in actinomycetes
13. A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus
14. Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis
15. Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus
16. Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae
17. Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase
18. Decision phase regulation of streptomycin production in Streptomyces griseus
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22. Cloning and characterization of the A-factor receptor gene from Streptomyces griseus
23. DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences
24. Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis
25. Intracellular cyclic adenosine 3′,5′-monophosphate levels and streptomycin production in cultures of Streptomyces griseus
26. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites
27. Pleiotropic effects of cAMP on germination, antibiotic biosynthesis and morphological development in Streptomyces coelicolor
28. Cyclic AMP regulation of tylosin biosynthesis and secondary metabolism in Streptomyces fradiae
29. Characterization of an A-factor-responsive repressor for amfR essential for onset of aerial mycelium formation in Streptomyces griseus
30. An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus
31. Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)
32. Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus
33. Protein tyrosine phosphorylation in streptomycetes
34. AdsA) that is essential for morphological development in Streptomyces griseus