Polyvalent inhibitors of anthrax toxin that target host receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 36, 2006, Pages 13509-13513

  Basha, Saleem ^a   Rai, Prakash ^a   Poon, Vincent ^b   Saraph, Arundhati ^a   Gujraty, Kunal ^a   Go, Mandy Y ^b   Sadacharan, Skanda ^b   Frost, Mia ^b   Mogridge, Jeremy ^b   Kane, Ravi S ^a  

^a Rensselaer Polytechnic Institute   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antimicrobial resistance; Phage display; Therapeutics

Indexed keywords

ALANYLTHREONYLTRYPTOPHYLGLYCYLHISTIDYLPROLYLARGINYLSERYLSERYLGLUTAMINYLGLYC YLMETHIONINE; ALANYLTRYPTOPHYLPROLYLLEUCYLSERYLGLUTAMINYLLEUCYLASPARTYLHISTIDYLSERYLTYROS YLASPARAGINE; ANTHRAX TOXIN; ANTHRAX TOXIN POLYVALENT INHIBITOR; ANTITOXIN; CELL RECEPTOR; CYSTEINYLPROLYLSERYLSERYLTHREONYLLEUCYLPHENYLALANYLALANYLCYSTEINE; TYROSYLHISTIDYLLEUCYLSERYLSERYLGLUTAMINYLGLUTAMINYLLEUCYLASPARTYLHISTIDYLSE RYLLEUCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTHRAX; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS ANTHRACIS; BIOLOGICAL WARFARE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENETIC ENGINEERING; HOST; MOUSE; NONHUMAN; PATHOGENESIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR BLOCKING;

ACETYLATION; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; CELL LINE; CHO CELLS; CRICETINAE; FLUORESCEIN; FLUORESCENT DYES; INHIBITORY CONCENTRATION 50; LIPOSOMES; MACROPHAGES; MICE; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; RATS; RATS, INBRED F344; RECEPTORS, PEPTIDE;

BACTERIA (MICROORGANISMS);

EID: 33748601221     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509870103     Document Type: Article

References (34)

1. Levy, S. B. & Marshall, B. (2004) Nat. Med. 10, S122-S129.
2. Hogan, D. & Kolter, R. (2002) Curr. Opin. Microbiol. 5, 472-477.
3. Mammen, M., Choi, S. K. & Whitesides, G. M. (1998) Angew. Chem. Int. Ed. 37, 2754-2794.
4. Mammen, M., Dahmann, G. & Whitesides, G. M. (1995) J. Med. Chem. 38, 4179-4190.
5. Mochalova, L. V., Tuzikov, A. B., Marinina, V. P., Gambaryan, A. S., Byramova, N. E., Bovin, N. V. & Matrosovich, M. N. (1994) Antiviral Res. 23, 179-190.
6. Yarema, K. J. & Bertozzi, C. R. (1998) Curr. Opin. Chem. Biol. 2, 49-61.
7. Kamitakahara, H., Suzuki, T., Nishigori, N., Suzuki, Y., Kanie, O. & CH, W. (1998) Angew. Chem. Int. Ed. 37, 1524-1528.
8. Mourez, M., Kane, R. S., Mogridge, J., Metallo, S., Deschatelets, P., Sellman, B. R., Whitesides, G. M. & Collier, R. J. (2001) Nat. Biotechnol. 19, 958-961.
9. Kitov, P. I., Sadowska, J. M., Mulvey, G., Armstrong, G. D., Ling, H., Pannu, N. S., Read, R. R. & Bundle, D. R. (2000) Nature 403, 669-672.
10. Fan, E., Zhang, Z., Minke, W. E., Hou, Z., Verlinde, C. L. M. J. & Hol, W. G. J. (2000) J. Am. Chem. Soc. 122, 2663-2664.
11. Bradley, K. A., Mogridge, J., Mourez, M., Collier, R. J. & Young, J. A. T. (2001) Nature 414, 225-229.
12. Scobie, H. M., Rainey, G. J. A., Bradley, K. A. & Young, J. A. T. (2003) Proc. Natl. Acad. Sci. USA 100, 5170-5174.
13. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A. & Davis, G. E. (2001) J. Cell Sci. 114, 2755-2773.
14. Santelli, E., Bankston, L. A., Leppla, S. H. & Liddington, R. C. (2004) Nature 430, 905-908.
15. Lacy, D. B., Wigelsworth, D. J., Scobie, H. M., Young, J. A. T. & Collier, R. J. (2004) Proc. Natl. Acad. Sci. USA 101, 6367-6372.
16. Collier, R. J. & Young, J. A. T. (2003) Annu. Rev. Cell Dev. Biol. 19, 45-70.
17. Wei, W., Lu, Q., Chaudry, G. J., Leppla, S. H. & Cohen, S. N. (2006) Cell 124, 1141-1154.
18. Rainey, G. J. A., Wigelsworth, D. J., Ryan, P. L., Scobie, H. M., Collier, R. J. & Young, J. A. T. (2005) Proc. Natl. Acad. Sci. USA 102, 13278-13283.
19. Krantz, B. A., Melnyk, R. A., Zhang, S., Juris, S. J., Lacy, D. B., Wu, Z., Finkelstein, A. & Collier, R. J. (2005) Science 309, 777-781.
20. Rainey, G. J. A. & Young, J. A. T. (2004) Nat. Rev. Microbiol. 2, 721-726.
21. Karginov, V. A., Nestorovich, E. M., Moayeri, M., Leppla, S. H. & Bezrukov, S. M. (2005) Proc. Natl. Acad. Sci. USA 102, 15075-15080.
22. Sellman, B. R., Mourez, M. & Collier, R. J. (2001) Science 292, 695-697.
23. Maynard, J. A., Maassen, C. B. M., Leppla, S. H., Brasky, K., Patterson, J. L., Iverson, B. L. & Georgiou, G. (2002) Nat. Biotechnol. 20:597-601.
24. Numa, M. M. D., Lee, L. V. Hsu, C. C., Bower, K. E. & Wong, C. H. (2005) ChemBioChem 6, 1002-1006.
25. Panchal, R., Hermone, A. R., Nguyen, T. L., Wong, T. Y., Schwarzenbacher, R., Schmidt, J., Lane, D., McGrath, C., Turk, B., Burnett, J., et al. (2004) Nat. Struct. Mol. Biol. 11, 67-72.
26. Rai, P., Padala, C., Poon, V., Saraph, A., Basha, S., Kate, S., Tao, K., Mogridge, J. & Kane, R. S. (2006) Nat. Biotechnol. 24, 582-586.
27. Zwick, M. B., Shen, J. Q. & Scott, J. (1998) Curr. Opin. Biotechnol. 9,427-436.
28. Banks, D. J., Barnajian, M., Maldonado-Arocho, F. J., Sanchez, A. M. & Bradley, K. A. (2005) Cell. Microbiol. 7, 1173-1185.
29. Peer, D. & Margalit, R. (2004) Int. J. Cancer 108, 780-789.
30. Dhiman, N., Jacobson, R. M. & Poland, G. A. (2004) Rev. Med. Virol. 14, 217-229.
31. Cywes, C., Stamenkovic, I. & Weiss, M. (2000) J. Clin. Invest. 106, 995-1002.
32. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454.
33. Berger, E. A., Murphy, P. M. & Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700.
34. Bradley, K. A., Mogridge, J., Rainey, G. J. A., Batty, S. & Young, J. A. T. (2003) J. Biol. Chem. 278, 49342-49347.