Femtomolar transition state analogue inhibitors of 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 18265-18273

  Singh, Vipender ^a   Evans, Gary B ^b   Lenz, Dirk H ^b   Mason, Jennifer M ^b   Clinch, Keith ^b   Mee, Simon ^b   Painter, Gavin F ^b   Tyler, Peter C ^b   Furneaux, Richard H ^b   Lee, Jeffrey E ^c,d   Howell, P Lynne ^c,d   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BYPRODUCTS; DISSOCIATION; HYDROLYSIS; IONS; SUBSTITUTION REACTIONS; SUBSTRATES;

ANALOGUE; CYSTEINE; METHYL GROUP; TRANSITION STATE;

ENZYMES;

5' METHYLTHIOADENOSINE; ADENINE PHOSPHORIBOSYLTRANSFERASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; IMMUCILLIN H; 5'-METHYLTHIOADENOSINE; ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; GLYCOSIDASE; NUCLEOSIDE;

AMINO ACID SUBSTITUTION; ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; HYDROPHOBICITY; METHYLATION; NONHUMAN; PHASE TRANSITION; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; KINETICS; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

DEOXYADENOSINES; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HYDROLYSIS; KINETICS; N-GLYCOSYL HYDROLASES; SUBSTRATE SPECIFICITY; THIONUCLEOSIDES;

EID: 20244369305     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414472200     Document Type: Article

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