Probing the catalytic mechanism of s-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues

Journal of the American Chemical Society

Volumn 131, Issue 3, 2009, Pages 1243-1250

  Gopishetty, Bhaskar ^a   Zhu, Jinge ^a   Rajan, Rakhi ^a   Sobczak, Adam J ^b   Wnuk, Stanislaw F ^b   Bell, Charles E ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; CATALYTIC INTERMEDIATES; CATALYTIC MECHANISMS; CATALYTIC PATHWAYS; ELIMINATION REACTION; GENERAL BASE; HALIDE IONS; HOMOCYSTEINE; PROTON ABSTRACTION; QUORUM-SENSING; REACTION STEPS; S-RIBOSYLHOMOCYSTEINE; SUBSTRATE BINDING; THIOETHER BONDS; THREE REACTION STEPS; TIME DEPENDENCE; TIME-DEPENDENT; TYPE II; WILD TYPES;

ENZYMES; PROTON TRANSFER; PROTONS; QUANTUM CHEMISTRY; REACTION KINETICS; SUBSTRATES;

KETONES;

4,5 DIHYDROXY 2,3 PENTANEDIONE; CARBONYL DERIVATIVE; CYSTEINE; GLUTAMIC ACID; HALIDE; HOMOCYSTEINE; KETONE DERIVATIVE; PENTANE; RIBOSE; S (3 BROMO 3,5 DIDEOXY DEXTRO RIBOFURANOS 5 YL)HOMOCYSTEINE; S (3 FLUORO 3,5 DIDEOXY DEXTRO RIBOFURANOS 5 YL)HOMOCYSTEINE; S RIBOSYLHOMOCYSTEINASE; S RIBOSYLHOMOCYSTEINE; SULFIDE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; KETONE; LUXS PROTEIN, BACTERIA; LYASE;

ARTICLE; CATALYSIS; ENZYME KINETICS; PROTON TRANSPORT; QUORUM SENSING; SYNTHESIS; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TIME;

BACTERIAL PROTEINS; BIOCATALYSIS; CARBON-SULFUR LYASES; CATALYTIC DOMAIN; HOMOCYSTEINE; KETONES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 61749084462     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja808206w     Document Type: Article

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