Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

Journal of Antimicrobial Chemotherapy

Volumn 53, Issue 6, 2004, Pages 1054-1061

  Wu, Hong ^a   Song, Z ^a   Hentzer, M ^b   Andersen, J B ^b   Molin, S ^b   Givskov, M ^b   Hoiby N ^a  

^a Mental Health Services CPH   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Acyl homoserine lactones; Antibiotic resistance; GFP; Green flourescent protein; Mouse models

Indexed keywords

ANTIBIOTIC AGENT; FURANONE DERIVATIVE; GREEN FLUORESCENT PROTEIN; LACTONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BIOFILM; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; GROWTH INHIBITION; LUNG CLEARANCE; LUNG INFECTION; MICROBIAL ATTENUATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; SURVIVAL;

ALGAE; ALGINATES; ANIMALS; ANTI-INFECTIVE AGENTS; FURANS; LUNG; LUNG DISEASES; MICE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SURVIVAL ANALYSIS;

EID: 3042597309     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh223     Document Type: Article

References (34)

1. Hoiby, N. & Frederiksen, B. (2000). Microbiology of cystic fibrosis. In Cystic fibrosis. (Hodson, M. E. & Geddes, D. M., Eds), pp. 83-107. Chapman & Hall, London, UK.
2. Frederiksen, B., Lanng, S. & Koch, C. et al. (1996). Improved survival in the Danish center-treated cystic fibrosis patients: results of aggressive treatment. Pediatric Pulmonology 21, 153-8.
3. Fuqua, C. & Greenberg, E. P. (2002). Listening in on bacteria: acyl-homoserine lactone signaling. Nature Reviews Molecular Cell Biology 3, 685-95.
4. de Kievit, T. R. & Iglewski, B. H. (2000). Bacterial quorum sensing in pathogenic relationships. Infection and Immunity 68, 4839-49.
5. Eberl, L. (1999). N-acyl homoserine lactone-mediated gene regulation in gram-negative bacteria. Systematic and Applied Microbiology 22, 493-506.
6. Pearson, J. P., Feldman, M., Iglewski, B. H. et al. (2000). Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infection and Immunity 68, 4331-4.
7. Pirhonen, M., Flego, D., Heikinheimo, R. et al. (1993). A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora. EMBO Journal 12, 2467-76.
8. Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H. et al. (1999). Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infection and Immunity 67, 5854-62.
9. Wu, H., Song, Z., Givskov, M. et al. (2001). Pseudomonas aeruginosa mutations in lasI and rhII quorum sensing systems result in milder chronic lung infection. Microbiology 147, 1105-13.
10. Costerton, J. W., Stewart, P. S. & Greenberg, E. P. (1999). Bacterial biofilms: a common cause of persistent infections. Science 284, 1318-22.
11. Davies, D. G., Parsek, M. R., Pearson, J. P. et al. (1998). The involvement of cell-to-cell signals in the development of a bacterial biofilm [see comments]. Science 280, 295-8.
12. Eberl, L., Winson, M. K., Sternberg, C. et al. (1996). Involvement of N-acyl-L-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens. Molecular Microbiology 20, 127-36.
13. Hoiby, N. (2002). Understanding bacterial biofilms in patients with cystic fibrosis: current and innovative approaches to potential therapies. Journal of Cystic Fibrosis 1, 249-54.
14. Singh, P. K., Schaefer, A. L., Parsek, M. R. et al. (2000). Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407, 762-4.
15. Kjelleberg, S., Steinberg, P. D., Givskov, M. et al. (1997). Do marine products interfere with prokaryotic AHL regulatory systems? Aquatic Microbial Ecology 13, 85-93.
16. Manny, A., Kjelleberg, S., Kumar, N. et al. (1997). Reinvestigation of the sulfuric acid-catalysed cyclisation of brominated 2-alkyllevulinic acids to 3-alkyl-5-methylene-2(5H)-furanones. Tetrahedron 53, 15813-26.
17. Pearson, J. P., Pesci, E. C. & Iglewski, B. H. (1997). Roles of Pseudomonas aeruginosa las and rhI quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. Journal of Bacteriology 179, 5756-67.
18. Andersen, J. B., Heydorn, A., Hentzer, M. et al. (2001). gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication. Applied and Environmental Microbiology 67, 575-85.
19. Hentzer, M., Riedel, K., Rasmussen, T. B. et al. (2002). Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148, 87-102.
20. Pedersen, S. S., Shand, G. H., Hansen, B. L. et al. (1990). Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres. APMIS 98, 203-11.
21. Johansen, H. K. & Hoiby, N. (1999). Rat model of chronic Pseudomonas aeruginosa lung infection. In Handbook of Animal Models of Infection (Zak, O. & Sande, M. A., Eds), pp. 517-26. Academic Press, London, UK.
22. Moser, C., Johansen, H. K., Song, Z. et al. (1997). Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. APMIS 105, 838-42.
23. Wu, H., Song, Z., Hentzer, M. et al. (2000). Detection of N-acyl homoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology 146, 2481-93.
24. Song, Z., Kharazmi, A., Wu, H. et al. (1998). Effects of ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia. Clinical and Diagnostic Laboratory Immunology 5, 882-7.
25. Johansen, H. K., Hougen, H. P., Cryz, S. J., Jr et al. (1995). Vaccination promotes TH1-like inflammation and survival in chronic Pseudomonas aeruginosa pneumonia in rats. American Journal of Respiratory and Critical Care Medicine 152, 1337-46.
26. Manefield, M., de Nys, R., Kumar, N. et al. (1999). Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 145, 283-91.
27. Manefield, M., Harris, L., Rice, S. A. et al. (2000). Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists. Applied and Environmental Microbiology 66, 2079-84.
28. Manefield, M., Rasmussen, T. B., Henzter, M. et al. (2002). Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 148, 1119-27.
29. Rasmussen, T. B., Manefield, M., Andersen, J. B. et al. (2000). How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146, 3237-44.
30. Pearson, J. P., Van Delden, C. & Iglewski, B. H. (1999). Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. Journal of Bacteriology 181, 1203-10.
31. Smith, R. S., Harris, S. G., Phipps, R. et al. (2002). The Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl) homoserine lactone contributes to virulence and induces inflammation in vivo. Journal of Bacteriology 184, 1132-9.
32. Telford, G., Wheeler, D., Williams, P. et al. (1998). The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infection and Immunity 66, 36-42.
33. Finch, R. G., Pritchard, D. I., Bycroft, B. W. et al. (1998). Quorum sensing: a novel target for anti-infective therapy. Journal of Antimicrobial Chemotherapy 42, 569-71.
34. Hartman, G. & Wise, R. (1998). Quorum sensing: potential means of treating gram-negative infections? Lancet 351, 848-9.