메뉴 건너뛰기




Volumn 2, Issue 3, 2009, Pages 315-334

Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis

Author keywords

Animal model; GATA1; Hematopoietic stem cell; Megakaryocyte; Primary myelofibrosis; Transcription factor

Indexed keywords

THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; TRANSCRIPTION FACTOR GATA 1;

EID: 77952906589     PISSN: 17474086     EISSN: None     Source Type: Journal    
DOI: 10.1586/ehm.09.17     Document Type: Review
Times cited : (27)

References (199)
  • 1
    • 33746740093 scopus 로고    scopus 로고
    • Chronic idiopathic myelofibrosis: Clinicopathologic features, pathogenesis, and prognosis
    • Ahmed A, Chang CC. Chronic idiopathic myelofibrosis: clinicopathologic features, pathogenesis, and prognosis. Arch. Pathol. Lab. Med. 130(8), 1133-1143 (2006).
    • (2006) Arch. Pathol. Lab. Med. , vol.130 , Issue.8 , pp. 1133-1143
    • Ahmed, A.1    Chang, C.C.2
  • 2
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 6(4), 372-375 (1951).
    • (1951) Blood , vol.6 , Issue.4 , pp. 372-375
    • Dameshek, W.1
  • 3
    • 38349101871 scopus 로고    scopus 로고
    • Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
    • Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 22(1), 14-22 (2008).
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 14-22
    • Tefferi, A.1    Vardiman, J.W.2
  • 4
    • 47549083663 scopus 로고    scopus 로고
    • The myelodysplastic/ myeloproliferative neoplasms: Myeloproliferative diseases with dysplastic features
    • Orazi A, Germing U. The myelodysplastic/ myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features. Leukemia 22(7), 1308-1319 (2008).
    • (2008) Leukemia , vol.22 , Issue.7 , pp. 1308-1319
    • Orazi, A.1    Germing, U.2
  • 5
    • 72849159485 scopus 로고
    • Chromosome studies on normal and leukemic human leukocytes
    • Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J. Natl Cancer Inst. 25, 85-109 (1960).
    • (1960) J. Natl Cancer Inst. , vol.25 , pp. 85-109
    • Nowell, P.C.1    Hungerford, D.A.2
  • 6
    • 0021346853 scopus 로고
    • Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
    • Groffen J, Stephenson JR, Heisterkamp N et al. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 36(1), 93-99 (1984).
    • (1984) Cell , vol.36 , Issue.1 , pp. 93-99
    • Groffen, J.1    Stephenson, J.R.2    Heisterkamp, N.3
  • 7
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
    • Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315(6020), 550-554 (1985).
    • (1985) Nature , vol.315 , Issue.6020 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3    Canaani, E.4
  • 8
    • 8944262829 scopus 로고    scopus 로고
    • Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells
    • Hallek M, Danhauser-Riedl S, Herbst R et al. Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr/abl kinase in myeloid cells. Br. J. Haematol. 94(1), 5-16 (1996).
    • (1996) Br. J. Haematol. , vol.94 , Issue.1 , pp. 5-16
    • Hallek, M.1    Danhauser-Riedl, S.2    Herbst, R.3
  • 9
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat. Med. 2(5), 561-566 (1996).
    • (1996) Nat. Med. , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 10
    • 34548042964 scopus 로고    scopus 로고
    • Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
    • Tefferi A, Thiele J, Orazi A et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood 110(4), 1092-1097 (2007).
    • (2007) Blood , vol.110 , Issue.4 , pp. 1092-1097
    • Tefferi, A.1    Thiele, J.2    Orazi, A.3
  • 11
    • 77953452821 scopus 로고    scopus 로고
    • Primary myelofibrosis: Update on definition, pathogenesis, and treatment
    • Abdel-Wahab OI, Levine RL. Primary myelofibrosis: update on definition, pathogenesis, and treatment. Annu. Rev. Med. (2008).
    • (2008) Annu. Rev. Med.
    • Abdel-Wahab, O.I.1    Levine, R.L.2
  • 12
    • 25844476814 scopus 로고    scopus 로고
    • Idiopathic myelofibrosis
    • Barosi G, Hoffman R. Idiopathic myelofibrosis. Semin. Hematol. 42(4), 248-258 (2005).
    • (2005) Semin. Hematol. , vol.42 , Issue.4 , pp. 248-258
    • Barosi, G.1    Hoffman, R.2
  • 13
    • 33745776045 scopus 로고    scopus 로고
    • Idiopathic myelofibrosis: Pathogenesis to treatment
    • Reilly JT. Idiopathic myelofibrosis: pathogenesis to treatment. Hematol. Oncol. 24(2), 56-63 (2006).
    • (2006) Hematol. Oncol. , vol.24 , Issue.2 , pp. 56-63
    • Reilly, J.T.1
  • 14
    • 33750342529 scopus 로고    scopus 로고
    • Myelofibrosis in chronic myeloproliferative disorders - Dynamics and clinical impact
    • Thiele J, Kvasnicka HM. Myelofibrosis in chronic myeloproliferative disorders - dynamics and clinical impact. Histol. Histopathol. 21(12), 1367-1378 (2006).
    • (2006) Histol. Histopathol. , vol.21 , Issue.12 , pp. 1367-1378
    • Thiele, J.1    Kvasnicka, H.M.2
  • 15
    • 34548262256 scopus 로고    scopus 로고
    • Myelofibrosis: Biology and treatment options
    • Cervantes F. Myelofibrosis: biology and treatment options. Eur. J. Haematol. Suppl. 68, 13-17 (2007).
    • (2007) Eur. J. Haematol. Suppl. , vol.68 , pp. 13-17
    • Cervantes, F.1
  • 16
    • 40549123059 scopus 로고    scopus 로고
    • Primary myelofibrosis
    • Tefferi A. Primary myelofibrosis. Cancer Treat. Res. 142, 29-49 (2008).
    • (2008) Cancer Treat. Res. , vol.142 , pp. 29-49
    • Tefferi, A.1
  • 17
    • 0033898269 scopus 로고    scopus 로고
    • Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity
    • Lundberg LG, Lerner R, Sundelin P et al. Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity. Am. J. Pathol. 157(1), 15-19 (2000).
    • (2000) Am. J. Pathol. , vol.157 , Issue.1 , pp. 15-19
    • Lundberg, L.G.1    Lerner, R.2    Sundelin, P.3
  • 18
    • 0025237668 scopus 로고
    • Myelofibrosis with myeloid metaplasia: Clinical and haematological parameters predicting survival in a series of 133 patients
    • Visani G, Finelli C, Castelli U et al. Myelofibrosis with myeloid metaplasia: clinical and haematological parameters predicting survival in a series of 133 patients. Br. J. Haematol. 75(1), 4-9 (1990).
    • (1990) Br. J. Haematol. , vol.75 , Issue.1 , pp. 4-9
    • Visani, G.1    Finelli, C.2    Castelli, U.3
  • 19
    • 0032916213 scopus 로고    scopus 로고
    • Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: An Olmsted County Study 1976-1995
    • Mesa RA, Silverstein MN, Jacobsen SJ, Wollan PC, Tefferi A. Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County Study, 1976-1995. Am. J. Hematol. 61(1), 10-15 (1999).
    • (1999) Am. J. Hematol. , vol.61 , Issue.1 , pp. 10-15
    • Mesa, R.A.1    Silverstein, M.N.2    Jacobsen, S.J.3    Wollan, P.C.4    Tefferi, A.5
  • 20
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • Zhao R, Xing S, Li Z et al. Identification of an acquired JAK2 mutation in polycythemia vera. J. Biol. Chem. 280(24), 22788-22792 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.24 , pp. 22788-22792
    • Zhao, R.1    Xing, S.2    Li, Z.3
  • 22
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7(4), 387-397 (2005).
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 24
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365(9464), 1054-1061 (2005).
    • (2005) Lancet , vol.365 , Issue.9464 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 25
    • 54149085320 scopus 로고    scopus 로고
    • JAK2 and MPL mutations in myeloproliferative neoplasms: Discovery and science
    • Kilpivaara O, Levine RL. JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science. Leukemia 22(10), 1813-1817 (2008).
    • (2008) Leukemia , vol.22 , Issue.10 , pp. 1813-1817
    • Kilpivaara, O.1    Levine, R.L.2
  • 26
    • 33750627651 scopus 로고    scopus 로고
    • JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
    • Mercher T, Wernig G, Moore SA et al. JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood 108(8), 2770-2779 (2006).
    • (2006) Blood , vol.108 , Issue.8 , pp. 2770-2779
    • Mercher, T.1    Wernig, G.2    Moore, S.A.3
  • 27
    • 48749084130 scopus 로고    scopus 로고
    • Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
    • Bersenev A, Wu C, Balcerek J, Tong W. Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J. Clin. Invest. 118(8), 2832-2844 (2008).
    • (2008) J. Clin. Invest. , vol.118 , Issue.8 , pp. 2832-2844
    • Bersenev, A.1    Wu, C.2    Balcerek, J.3    Tong, W.4
  • 28
    • 22844438893 scopus 로고    scopus 로고
    • Janus kinases affect thrombopoietin receptor cell surface localization and stability
    • Royer Y, Staerk J, Costuleanu M, Courtoy PJ, Constantinescu SN. Janus kinases affect thrombopoietin receptor cell surface localization and stability. J. Biol. Chem. 280(29), 27251-27261 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.29 , pp. 27251-27261
    • Royer, Y.1    Staerk, J.2    Costuleanu, M.3    Courtoy, P.J.4    Constantinescu, S.N.5
  • 29
    • 47149112573 scopus 로고    scopus 로고
    • Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2
    • Grebien F, Kerenyi MA, Kovacic B et al. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111(9), 4511-4522 (2008).
    • (2008) Blood , vol.111 , Issue.9 , pp. 4511-4522
    • Grebien, F.1    Kerenyi, M.A.2    Kovacic, B.3
  • 30
    • 40749093314 scopus 로고    scopus 로고
    • Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
    • Funakoshi-Tago M, Pelletier S, Moritake H, Parganas E, Ihle JN. Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol. Cell. Biol. 28(5), 1792 - 1801 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.5 , pp. 1792-1801
    • Funakoshi-Tago, M.1    Pelletier, S.2    Moritake, H.3    Parganas, E.4    Ihle, J.N.5
  • 31
    • 52149086993 scopus 로고    scopus 로고
    • Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway
    • Funakoshi-Tago M, Tago K, Kasahara T, Parganas E, Ihle JN. Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway. Cell. Signal. 20(11), 1995-2001 (2008).
    • (2008) Cell. Signal. , vol.20 , Issue.11 , pp. 1995-2001
    • Funakoshi-Tago, M.1    Tago, K.2    Kasahara, T.3    Parganas, E.4    Ihle, J.N.5
  • 32
    • 49549117079 scopus 로고    scopus 로고
    • G-CSF stimulates Jak2- dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation
    • Wang L, Xue J, Zadorozny EV, Robinson LJ. G-CSF stimulates Jak2- dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation. Cell. Signal. 20(10), 1890-1899 (2008).
    • (2008) Cell. Signal. , vol.20 , Issue.10 , pp. 1890-1899
    • Wang, L.1    Xue, J.2    Zadorozny, E.V.3    Robinson, L.J.4
  • 33
    • 0842287505 scopus 로고    scopus 로고
    • JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor
    • Radosevic N, Winterstein D, Keller JR et al. JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor. Exp. Hematol. 32(2), 149-156 (2004).
    • (2004) Exp. Hematol. , vol.32 , Issue.2 , pp. 149-156
    • Radosevic, N.1    Winterstein, D.2    Keller, J.R.3
  • 34
    • 13744252629 scopus 로고    scopus 로고
    • Stem cell factor synergistically enhances thrombopoietininduced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase
    • Drayer AL, Boer AK, Los EL, Esselink MT, Vellenga E. Stem cell factor synergistically enhances thrombopoietininduced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase. Stem Cells 23(2), 240-251 (2005).
    • (2005) Stem Cells , vol.23 , Issue.2 , pp. 240-251
    • Drayer, A.L.1    Boer, A.K.2    Los, E.L.3    Esselink, M.T.4    Vellenga, E.5
  • 35
    • 22144464506 scopus 로고    scopus 로고
    • Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor
    • Arcasoy MO, Jiang X. Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor. Br. J. Haematol. 130(1), 121-129 (2005).
    • (2005) Br. J. Haematol. , vol.130 , Issue.1 , pp. 121-129
    • Arcasoy, M.O.1    Jiang, X.2
  • 36
    • 39749198165 scopus 로고    scopus 로고
    • JAK and MPL mutations in myeloid malignancies
    • Tefferi A. JAK and MPL mutations in myeloid malignancies. Leuk. Lymphoma 49(3), 388-397 (2008).
    • (2008) Leuk. Lymphoma , vol.49 , Issue.3 , pp. 388-397
    • Tefferi, A.1
  • 37
    • 41949118675 scopus 로고    scopus 로고
    • Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2 V617F
    • Lu X, Huang LJ, Lodish HF. Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2 V617F. J. Biol. Chem. 283(9), 5258-5266 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.9 , pp. 5258-5266
    • Lu, X.1    Huang, L.J.2    Lodish, H.F.3
  • 38
    • 25444513652 scopus 로고    scopus 로고
    • JAK2 in myeloproliferative disorders is not just another kinase
    • Tefferi A, Gilliland DG. JAK2 in myeloproliferative disorders is not just another kinase. Cell Cycle 4(8), 1053-1056 (2005).
    • (2005) Cell Cycle , vol.4 , Issue.8 , pp. 1053-1056
    • Tefferi, A.1    Gilliland, D.G.2
  • 40
    • 33846660947 scopus 로고    scopus 로고
    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
    • Scott LM, Tong W, Levine RL et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N. Engl. J. Med. 356(5), 459-468 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , Issue.5 , pp. 459-468
    • Scott, L.M.1    Tong, W.2    Levine, R.L.3
  • 41
    • 52049084111 scopus 로고    scopus 로고
    • BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair
    • Cramer K, Nieborowska-Skorska M, Koptyra M et al. BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Res. 68(17), 6884-6888 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.17 , pp. 6884-6888
    • Cramer, K.1    Nieborowska-Skorska, M.2    Koptyra, M.3
  • 42
    • 0035282956 scopus 로고    scopus 로고
    • Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3
    • Tomasson MH, Williams IR, Li S et al. Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3. Blood 97(5), 1435-1441 (2001).
    • (2001) Blood , vol.97 , Issue.5 , pp. 1435-1441
    • Tomasson, M.H.1    Williams, I.R.2    Li, S.3
  • 43
    • 0032530972 scopus 로고    scopus 로고
    • Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
    • Schwaller J, Frantsve J, Aster J et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 17(18), 5321-5333 (1998).
    • (1998) EMBO J. , vol.17 , Issue.18 , pp. 5321-5333
    • Schwaller, J.1    Frantsve, J.2    Aster, J.3
  • 44
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278(5341), 1309-1312 (1997).
    • (1997) Science , vol.278 , Issue.5341 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3
  • 45
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood 108(10), 3472-3476 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3
  • 46
    • 33746437130 scopus 로고    scopus 로고
    • MPL W515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
    • Pikman Y, Lee BH, Mercher T et al. MPL W515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 3(7), e270 (2006).
    • (2006) PLoS Med. , vol.3 , Issue.7
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3
  • 47
    • 36748999351 scopus 로고    scopus 로고
    • Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    • Yoshihara H, Arai F, Hosokawa K et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 1(6), 685-697 (2007).
    • (2007) Cell Stem Cell , vol.1 , Issue.6 , pp. 685-697
    • Yoshihara, H.1    Arai, F.2    Hosokawa, K.3
  • 48
    • 33645103515 scopus 로고    scopus 로고
    • The hematopoietic stem cell in its place
    • Adams GB, Scadden DT. The hematopoietic stem cell in its place. Nat. Immunol. 7(4), 333-337 (2006).
    • (2006) Nat. Immunol. , vol.7 , Issue.4 , pp. 333-337
    • Adams, G.B.1    Scadden, D.T.2
  • 49
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore KA, Lemischka IR. Stem cells and their niches. Science 311(5769), 1880-1885 (2006).
    • (2006) Science , vol.311 , Issue.5769 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 52
    • 55249089939 scopus 로고    scopus 로고
    • Familial chronic myeloproliferative disorders: The state of the art
    • Rumi E. Familial chronic myeloproliferative disorders: the state of the art. Hematol. Oncol. 26(3), 131-138 (2008).
    • (2008) Hematol. Oncol. , vol.26 , Issue.3 , pp. 131-138
    • Rumi, E.1
  • 53
    • 33746833594 scopus 로고    scopus 로고
    • Familial infantile myelofibrosis as an autosomal recessive disorder: Preponderance among children from Saudi Arabia
    • Rossbach HC. Familial infantile myelofibrosis as an autosomal recessive disorder: preponderance among children from Saudi Arabia. Pediatr. Hematol. Oncol. 23(5), 453-454 (2006).
    • (2006) Pediatr. Hematol. Oncol. , vol.23 , Issue.5 , pp. 453-454
    • Rossbach, H.C.1
  • 54
    • 1542316951 scopus 로고    scopus 로고
    • Fatal familial infantile myelofibrosis
    • Sheikha A. Fatal familial infantile myelofibrosis. J. Pediatr. Hematol. Oncol. 26(3), 164-168 (2004).
    • (2004) J. Pediatr. Hematol. Oncol. , vol.26 , Issue.3 , pp. 164-168
    • Sheikha, A.1
  • 56
    • 0029080356 scopus 로고
    • Genetic analysis of chromosome 13 deletions in BCR/ABL negative chronic myeloproliferative disorders
    • Pastore C, Nomdedeu J, Volpe G et al. Genetic analysis of chromosome 13 deletions in BCR/ABL negative chronic myeloproliferative disorders. Genes Chromosomes Cancer 14(2), 106-111 (1995).
    • (1995) Genes Chromosomes Cancer , vol.14 , Issue.2 , pp. 106-111
    • Pastore, C.1    Nomdedeu, J.2    Volpe, G.3
  • 57
    • 0030748326 scopus 로고    scopus 로고
    • Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: A study of 106 cases
    • Reilly JT, Snowden JA, Spearing RL et al. Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: a study of 106 cases. Br. J. Haematol. 98(1), 96-102 (1997).
    • (1997) Br. J. Haematol. , vol.98 , Issue.1 , pp. 96-102
    • Reilly, J.T.1    Snowden, J.A.2    Spearing, R.L.3
  • 58
    • 0032103266 scopus 로고    scopus 로고
    • Detection of RB1 deletions by fluorescence in situ hybridization in malignant hematologic disorders
    • Juneau AL, Kaehler M, Christensen ER et al. Detection of RB1 deletions by fluorescence in situ hybridization in malignant hematologic disorders. Cancer Genet. Cytogenet. 103(2), 117-123 (1998).
    • (1998) Cancer Genet. Cytogenet. , vol.103 , Issue.2 , pp. 117-123
    • Juneau, A.L.1    Kaehler, M.2    Christensen, E.R.3
  • 59
    • 0015984794 scopus 로고
    • Chromosomal aberrations and neoplasm - A family study
    • Wurster-Hill DH, Cornwell GG 3rd, McIntyre OR. Chromosomal aberrations and neoplasm - a family study. Cancer 33(1), 72-81 (1974).
    • (1974) Cancer , vol.33 , Issue.1 , pp. 72-81
    • Wurster-Hill, D.H.1    Cornwell III, G.G.2    McIntyre, O.R.3
  • 60
    • 50949117772 scopus 로고    scopus 로고
    • Recurrent der(9;18) in essential thrombocythemia with JAK2 V617F is highly linked to myelofibrosis development
    • Ohyashiki K, Kodama A, Ohyashiki JH. Recurrent der(9;18) in essential thrombocythemia with JAK2 V617F is highly linked to myelofibrosis development. Cancer Genet. Cytogenet. 186(1), 6-11 (2008).
    • (2008) Cancer Genet. Cytogenet. , vol.186 , Issue.1 , pp. 6-11
    • Ohyashiki, K.1    Kodama, A.2    Ohyashiki, J.H.3
  • 61
    • 51649121491 scopus 로고    scopus 로고
    • Primary myelofibrosis is the most frequent myeloproliferative neoplasm associated with del(5q): Clinicopathologic comparison of del(5q)-positive and -negative cases
    • Santana-Davila R, Tefferi A, Holtan SG et al. Primary myelofibrosis is the most frequent myeloproliferative neoplasm associated with del(5q): clinicopathologic comparison of del(5q)-positive and -negative cases. Leuk. Res. 32(12), 1927-1930 (2008).
    • (2008) Leuk. Res. , vol.32 , Issue.12 , pp. 1927-1930
    • Santana-Davila, R.1    Tefferi, A.2    Holtan, S.G.3
  • 62
    • 0028849992 scopus 로고
    • C-kit point mutation of extracellular domain in patients with myeloproliferative disorders
    • Nakata Y, Kimura A, Katoh O, Kawaishi K, Hyodo H. c-kit point mutation of extracellular domain in patients with myeloproliferative disorders. Br. J. Hematol. 91(3), 661-663 (1995).
    • (1995) Br. J. Hematol. , vol.91 , Issue.3 , pp. 661-663
    • Nakata, Y.1    Kimura, A.2    Katoh, O.3    Kawaishi, K.4    Hyodo, H.5
  • 63
    • 0030914402 scopus 로고    scopus 로고
    • C-kit Point mutation in patients with myeloproliferative disorders
    • Kimura A, Nakata Y, Katoh O, Hyodo H. c-kit Point mutation in patients with myeloproliferative disorders. Leuk. Lymphoma 25(3-4), 281-287 (1997).
    • (1997) Leuk. Lymphoma , vol.25 , Issue.3-4 , pp. 281-287
    • Kimura, A.1    Nakata, Y.2    Katoh, O.3    Hyodo, H.4
  • 64
    • 13044305857 scopus 로고    scopus 로고
    • Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis
    • Longley BJ, Jr., Metcalfe DD, Tharp M et al. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc. Natl Acad. Sci. USA 96(4), 1609-1614 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.4 , pp. 1609-1614
    • Longley Jr., B.J.1    Metcalfe, D.D.2    Tharp, M.3
  • 65
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
    • Longley BJ, Tyrrell L, Lu SZ et al. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat. Genet. 12(3), 312-314 (1996).
    • (1996) Nat. Genet. , vol.12 , Issue.3 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3
  • 66
    • 39149093030 scopus 로고    scopus 로고
    • Requirement for p85a regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT
    • Munugalavadla V, Sims EC, Chan RJ, Lenz SD, Kapur R. Requirement for p85a regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT. Exp. Hematol. 36(3), 301-308 (2008).
    • (2008) Exp. Hematol. , vol.36 , Issue.3 , pp. 301-308
    • Munugalavadla, V.1    Sims, E.C.2    Chan, R.J.3    Lenz, S.D.4    Kapur, R.5
  • 67
    • 48449091213 scopus 로고    scopus 로고
    • The proto-oncogene expression varies over the course of chronic myeloid leukemia
    • Vidovic A, Jankovic G, Colovic M et al. The proto-oncogene expression varies over the course of chronic myeloid leukemia. Hematology 13(1), 34-40 (2008).
    • (2008) Hematology , vol.13 , Issue.1 , pp. 34-40
    • Vidovic, A.1    Jankovic, G.2    Colovic, M.3
  • 68
    • 33745707099 scopus 로고    scopus 로고
    • On the molecular origins of the chronic myeloproliferative disorders: It all makes sense
    • Kaushansky K. On the molecular origins of the chronic myeloproliferative disorders: it all makes sense. Hematology Am. Soc. Hematol. Educ. Program 2005, 533-537 (2005).
    • (2005) Hematology Am. Soc. Hematol. Educ. Program , vol.2005 , pp. 533-537
    • Kaushansky, K.1
  • 69
    • 41249098776 scopus 로고    scopus 로고
    • Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
    • Geron I, Abrahamsson AE, Barroga CF et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell 13(4), 321-330 (2008).
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 321-330
    • Geron, I.1    Abrahamsson, A.E.2    Barroga, C.F.3
  • 70
    • 38349053791 scopus 로고    scopus 로고
    • JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials
    • Pardanani A. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia 22(1), 23-30 (2008).
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 23-30
    • Pardanani, A.1
  • 71
    • 33646540122 scopus 로고    scopus 로고
    • Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis
    • Schulze H, Korpal M, Hurov J et al. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 107(10), 3868-3875 (2006).
    • (2006) Blood , vol.107 , Issue.10 , pp. 3868-3875
    • Schulze, H.1    Korpal, M.2    Hurov, J.3
  • 72
    • 38949178835 scopus 로고    scopus 로고
    • Angiogenesis is regulated by a novel mechanism: Pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    • Italiano JE Jr, Richardson JL, Patel-Hett S et al. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Blood 111(3), 1227-1233 (2008).
    • (2008) Blood , vol.111 , Issue.3 , pp. 1227-1233
    • Italiano Jr., J.E.1    Richardson, J.L.2    Patel-Hett, S.3
  • 73
    • 0032701822 scopus 로고    scopus 로고
    • Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis
    • Le Bousse-Kerdiles MC, Martyre MC. Dual implication of fibrogenic cytokines in the pathogenesis of fibrosis and myeloproliferation in myeloid metaplasia with myelofibrosis. Ann. Hematol. 78(10), 437-444 (1999).
    • (1999) Ann. Hematol. , vol.78 , Issue.10 , pp. 437-444
    • Le Bousse-Kerdiles, M.C.1    Martyre, M.C.2
  • 74
    • 0037111643 scopus 로고    scopus 로고
    • Prominent role of TGF-b 1 in thrombopoietin-induced myelofibrosis in mice
    • Chagraoui H, Komura E, Tulliez M et al. Prominent role of TGF-b 1 in thrombopoietin-induced myelofibrosis in mice. Blood 100(10), 3495-3503 (2002).
    • (2002) Blood , vol.100 , Issue.10 , pp. 3495-3503
    • Chagraoui, H.1    Komura, E.2    Tulliez, M.3
  • 75
    • 0037606007 scopus 로고    scopus 로고
    • Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO
    • Chagraoui H, Tulliez M, Smayra T et al. Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO. Blood 101(8), 2983-2989 (2003).
    • (2003) Blood , vol.101 , Issue.8 , pp. 2983-2989
    • Chagraoui, H.1    Tulliez, M.2    Smayra, T.3
  • 76
    • 20944437340 scopus 로고    scopus 로고
    • A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-b1 in the development of myelofibrosis
    • Vannucchi AM, Bianchi L, Paoletti F et al. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-b1 in the development of myelofibrosis. Blood 105(9), 3493-3501 (2005).
    • (2005) Blood , vol.105 , Issue.9 , pp. 3493-3501
    • Vannucchi, A.M.1    Bianchi, L.2    Paoletti, F.3
  • 77
    • 0028109801 scopus 로고
    • Transforming growth factor b in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor b in tissue fibrosis. N. Engl. J. Med. 331(19), 1286-1292 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , Issue.19 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 78
    • 0024419833 scopus 로고
    • Transforming growth factor-b regulates growth as well as collagen and fibronectin synthesis of human marrow fibroblasts
    • Kimura A, Katoh O, Hyodo H, Kuramoto A. Transforming growth factor-b regulates growth as well as collagen and fibronectin synthesis of human marrow fibroblasts. Br. J. Haematol. 72(4), 486-491 (1989).
    • (1989) Br. J. Haematol. , vol.72 , Issue.4 , pp. 486-491
    • Kimura, A.1    Katoh, O.2    Hyodo, H.3    Kuramoto, A.4
  • 79
    • 0022471924 scopus 로고
    • Transforming growth factor type b: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
    • Roberts AB, Sporn MB, Assoian RK et al. Transforming growth factor type b: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl Acad. Sci. USA 83(12), 4167-4171 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , Issue.12 , pp. 4167-4171
    • Roberts, A.B.1    Sporn, M.B.2    Assoian, R.K.3
  • 80
    • 52249099513 scopus 로고    scopus 로고
    • Platelets, petechiae, and preservation of the vascular wall
    • Nachman RL, Rafii S. Platelets, petechiae, and preservation of the vascular wall. N. Engl. J. Med. 359(12), 1261-1270 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.12 , pp. 1261-1270
    • Nachman, R.L.1    Rafii, S.2
  • 81
    • 0031029290 scopus 로고    scopus 로고
    • Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    • Mohle R, Green D, Moore MA, Nachman RL, Rafii S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl Acad. Sci. USA 94(2), 663-668 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.2 , pp. 663-668
    • Mohle, R.1    Green, D.2    Moore, M.A.3    Nachman, R.L.4    Rafii, S.5
  • 82
    • 24044524612 scopus 로고    scopus 로고
    • Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis
    • Vannucchi AM, Pancrazzi A, Guglielmelli P et al. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. Am. J. Pathol. 167(3), 849-858 (2005).
    • (2005) Am. J. Pathol. , vol.167 , Issue.3 , pp. 849-858
    • Vannucchi, A.M.1    Pancrazzi, A.2    Guglielmelli, P.3
  • 83
    • 0032227812 scopus 로고    scopus 로고
    • Transcription factor GATA-1 in megakaryocyte development
    • Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development. Stem Cells 16(Suppl. 2), 79-83 (1998).
    • (1998) Stem Cells , vol.16 , Issue.SUPPL. 2 , pp. 79-83
    • Orkin, S.H.1    Shivdasani, R.A.2    Fujiwara, Y.3    McDevitt, M.A.4
  • 84
    • 0026696583 scopus 로고
    • The frequency and significance of megakaryocytic emperipolesis in myeloproliferative and reactive states
    • Cashell AW, Buss DH. The frequency and significance of megakaryocytic emperipolesis in myeloproliferative and reactive states. Ann. Hematol. 64(6), 273-276 (1992).
    • (1992) Ann. Hematol. , vol.64 , Issue.6 , pp. 273-276
    • Cashell, A.W.1    Buss, D.H.2
  • 85
    • 0034663044 scopus 로고    scopus 로고
    • Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis
    • Schmitt A, Jouault H, Guichard J et al. Pathologic interaction between megakaryocytes and polymorphonuclear leukocytes in myelofibrosis. Blood 96(4), 1342-1347 (2000).
    • (2000) Blood , vol.96 , Issue.4 , pp. 1342-1347
    • Schmitt, A.1    Jouault, H.2    Guichard, J.3
  • 86
    • 0034663758 scopus 로고    scopus 로고
    • NF-k B as a central mediator in the induction of TGF-b in monocytes from patients with idiopathic myelofibrosis: An inflammatory response beyond the realm of homeostasis
    • Rameshwar P, Narayanan R, Qian J et al. NF-k B as a central mediator in the induction of TGF-b in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. J. Immunol. 165(4), 2271-2277 (2000).
    • (2000) J. Immunol. , vol.165 , Issue.4 , pp. 2271-2277
    • Rameshwar, P.1    Narayanan, R.2    Qian, J.3
  • 87
    • 24644505162 scopus 로고    scopus 로고
    • Isolation of TPO-dependent subclones from the multipotent 32D cell line
    • Amabile G, Di Noia A, Alfani E et al. Isolation of TPO-dependent subclones from the multipotent 32D cell line. Blood Cells Mol. Dis. 35(2), 241-252 (2005).
    • (2005) Blood Cells Mol. Dis. , vol.35 , Issue.2 , pp. 241-252
    • Amabile, G.1    Di Noia, A.2    Alfani, E.3
  • 88
    • 33744490974 scopus 로고    scopus 로고
    • Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
    • Wernig G, Mercher T, Okabe R et al. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood 107(11), 4274-4281 (2006).
    • (2006) Blood , vol.107 , Issue.11 , pp. 4274-4281
    • Wernig, G.1    Mercher, T.2    Okabe, R.3
  • 89
    • 33745721197 scopus 로고    scopus 로고
    • JAK2 V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis
    • Lacout C, Pisani DF, Tulliez M et al. JAK2 V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood 108(5), 1652-1660 (2006).
    • (2006) Blood , vol.108 , Issue.5 , pp. 1652-1660
    • Lacout, C.1    Pisani, D.F.2    Tulliez, M.3
  • 90
    • 36348999273 scopus 로고    scopus 로고
    • Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis
    • Chaligne R, James C, Tonetti C et al. Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis. Blood 110(10), 3735-3743 (2007).
    • (2007) Blood , vol.110 , Issue.10 , pp. 3735-3743
    • Chaligne, R.1    James, C.2    Tonetti, C.3
  • 91
    • 0030992486 scopus 로고    scopus 로고
    • Characterization of Lnk. An adaptor protein expressed in lymphocytes
    • Takaki S, Watts JD, Forbush KA et al. Characterization of Lnk. An adaptor protein expressed in lymphocytes. J. Biol. Chem. 272(23), 14562-14570 (1997).
    • (1997) J. Biol. Chem. , vol.272 , Issue.23 , pp. 14562-14570
    • Takaki, S.1    Watts, J.D.2    Forbush, K.A.3
  • 92
    • 0029587597 scopus 로고
    • Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C g 1, Grb2, and phosphatidylinositol 3-kinase
    • Huang X, Li Y, Tanaka K, Moore KG, Hayashi JI. Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C g 1, Grb2, and phosphatidylinositol 3-kinase. Proc. Natl Acad. Sci. USA 92(25), 11618-11622 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , Issue.25 , pp. 11618-11622
    • Huang, X.1    Li, Y.2    Tanaka, K.3    Moore, K.G.4    Hayashi, J.I.5
  • 93
    • 0037124306 scopus 로고    scopus 로고
    • Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice
    • Velazquez L, Cheng AM, Fleming HE et al. Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J. Exp. Med. 195(12), 1599-1611 (2002).
    • (2002) J. Exp. Med. , vol.195 , Issue.12 , pp. 1599-1611
    • Velazquez, L.1    Cheng, A.M.2    Fleming, H.E.3
  • 94
    • 19944400789 scopus 로고    scopus 로고
    • Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
    • Ema H, Sudo K, Seita J et al. Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8(6), 907-914 (2005).
    • (2005) Dev. Cell , vol.8 , Issue.6 , pp. 907-914
    • Ema, H.1    Sudo, K.2    Seita, J.3
  • 95
    • 0037148516 scopus 로고    scopus 로고
    • Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein
    • Takaki S, Morita H, Tezuka Y, Takatsu K. Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J. Exp. Med. 195(2), 151-160 (2002).
    • (2002) Lnk. J. Exp. Med. , vol.195 , Issue.2 , pp. 151-160
    • Takaki, S.1    Morita, H.2    Tezuka, Y.3    Takatsu, K.4
  • 96
    • 52449135483 scopus 로고    scopus 로고
    • Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals
    • Takizawa H, Eto K, Yoshikawa A et al. Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals. Exp. Hematol. 36(7), 897-906 (2008).
    • (2008) Exp. Hematol. , vol.36 , Issue.7 , pp. 897-906
    • Takizawa, H.1    Eto, K.2    Yoshikawa, A.3
  • 97
    • 0037103206 scopus 로고    scopus 로고
    • Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice)
    • Vannucchi AM, Bianchi L, Cellai C et al. Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1low mice). Blood 100(4), 1123-1132 (2002).
    • (2002) Blood , vol.100 , Issue.4 , pp. 1123-1132
    • Vannucchi, A.M.1    Bianchi, L.2    Cellai, C.3
  • 98
    • 20144387545 scopus 로고    scopus 로고
    • Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment
    • Toki T, Katsuoka F, Kanezaki R et al. Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Blood 105(8), 3100-3108 (2005).
    • (2005) Blood , vol.105 , Issue.8 , pp. 3100-3108
    • Toki, T.1    Katsuoka, F.2    Kanezaki, R.3
  • 99
    • 34250331610 scopus 로고    scopus 로고
    • A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor g deficiency
    • Walkley CR, Olsen GH, Dworkin S et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor g deficiency. Cell 129(6), 1097-1110 (2007).
    • (2007) Cell , vol.129 , Issue.6 , pp. 1097-1110
    • Walkley, C.R.1    Olsen, G.H.2    Dworkin, S.3
  • 100
    • 34250363611 scopus 로고    scopus 로고
    • Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
    • Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129(6), 1081-1095 (2007).
    • (2007) Cell , vol.129 , Issue.6 , pp. 1081-1095
    • Walkley, C.R.1    Shea, J.M.2    Sims, N.A.3    Purton, L.E.4    Orkin, S.H.5
  • 101
    • 0030024685 scopus 로고    scopus 로고
    • Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin
    • de Sauvage FJ, Carver-Moore K, Luoh SM et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183(2), 651-656 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.2 , pp. 651-656
    • De Sauvage, F.J.1    Carver-Moore, K.2    Luoh, S.M.3
  • 102
    • 0029035985 scopus 로고
    • Thrombopoietin: The primary regulator of platelet production
    • Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 86(2), 419-431 (1995).
    • (1995) Blood , vol.86 , Issue.2 , pp. 419-431
    • Kaushansky, K.1
  • 103
    • 22644441241 scopus 로고    scopus 로고
    • Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation
    • Burmester H, Wolber EM, Freitag P, Fandrey J, Jelkmann W. Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation. J. Interferon Cytokine Res. 25(7), 407-413 (2005).
    • (2005) J. Interferon Cytokine Res. , vol.25 , Issue.7 , pp. 407-413
    • Burmester, H.1    Wolber, E.M.2    Freitag, P.3    Fandrey, J.4    Jelkmann, W.5
  • 105
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky K. The molecular mechanisms that control thrombopoiesis. J. Clin. Invest. 115(12), 3339-3347 (2005).
    • (2005) J. Clin. Invest. , vol.115 , Issue.12 , pp. 3339-3347
    • Kaushansky, K.1
  • 106
    • 0141609830 scopus 로고    scopus 로고
    • Thrombopoietin: A tool for understanding thrombopoiesis
    • Kaushansky K. Thrombopoietin: a tool for understanding thrombopoiesis. J. Thromb. Haemost. 1(7), 1587-1592 (2003).
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.7 , pp. 1587-1592
    • Kaushansky, K.1
  • 107
    • 0002184519 scopus 로고    scopus 로고
    • Thrombopoietin: Biology and clinical applications
    • Kuter DJ. Thrombopoietin: biology and clinical applications. Oncologist 1(1-2), 98-106 (1996).
    • (1996) Oncologist , vol.1 , Issue.1-2 , pp. 98-106
    • Kuter, D.J.1
  • 108
    • 0029897491 scopus 로고    scopus 로고
    • Systemic hematologic effects of PEGrHuMGDF- induced megakaryocyte hyperplasia in mice
    • Ulich TR, del Castillo J, Senaldi G et al. Systemic hematologic effects of PEGrHuMGDF- induced megakaryocyte hyperplasia in mice. Blood 87(12), 5006-5015 (1996).
    • (1996) Blood , vol.87 , Issue.12 , pp. 5006-5015
    • Ulich, T.R.1    Del Castillo, J.2    Senaldi, G.3
  • 109
    • 6844250789 scopus 로고    scopus 로고
    • The role of transforming growth factor-b in PEGrHuMGDF- induced reversible myelofibrosis in rats
    • Yanagida M, Ide Y, Imai A et al. The role of transforming growth factor-b in PEGrHuMGDF- induced reversible myelofibrosis in rats. Br. J. Haematol. 99(4), 739-745 (1997).
    • (1997) Br. J. Haematol. , vol.99 , Issue.4 , pp. 739-745
    • Yanagida, M.1    Ide, Y.2    Imai, A.3
  • 110
    • 0031963996 scopus 로고    scopus 로고
    • Adenovector-mediated expression of human thrombopoietin cDNA in immunecompromised mice: Insights into the pathophysiology of osteomyelofibrosis
    • Frey BM, Rafii S, Teterson M et al. Adenovector-mediated expression of human thrombopoietin cDNA in immunecompromised mice: insights into the pathophysiology of osteomyelofibrosis. J. Immunol. 160(2), 691-699 (1998).
    • (1998) J. Immunol. , vol.160 , Issue.2 , pp. 691-699
    • Frey, B.M.1    Rafii, S.2    Teterson, M.3
  • 111
    • 0032080851 scopus 로고    scopus 로고
    • Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO
    • Abina MA, Tulliez M, Duffour MT et al. Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO. J. Immunol. 160(9), 4481-4489 (1998).
    • (1998) J. Immunol. , vol.160 , Issue.9 , pp. 4481-4489
    • Abina, M.A.1    Tulliez, M.2    Duffour, M.T.3
  • 112
    • 0030963223 scopus 로고    scopus 로고
    • Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA
    • Cannizzo SJ, Frey BM, Raffi S et al. Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA. Nat. Biotechnol. 15(6), 570-573 (1997).
    • (1997) Nat. Biotechnol. , vol.15 , Issue.6 , pp. 570-573
    • Cannizzo, S.J.1    Frey, B.M.2    Raffi, S.3
  • 113
    • 0029770391 scopus 로고    scopus 로고
    • In vivo adenovirus vectormediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapyinduced bone marrow suppression
    • Ohwada A, Rafii S, Moore MA, Crystal RG. In vivo adenovirus vectormediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapyinduced bone marrow suppression. Blood 88(3), 778-784 (1996).
    • (1996) Blood , vol.88 , Issue.3 , pp. 778-784
    • Ohwada, A.1    Rafii, S.2    Moore, M.A.3    Crystal, R.G.4
  • 114
    • 33646882019 scopus 로고    scopus 로고
    • Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin
    • Wagner-Ballon O, Chagraoui H, Prina E et al. Monocyte/macrophage dysfunctions do not impair the promotion of myelofibrosis by high levels of thrombopoietin. J. Immunol. 176(11), 6425-6433 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.11 , pp. 6425-6433
    • Wagner-Ballon, O.1    Chagraoui, H.2    Prina, E.3
  • 115
    • 0030718597 scopus 로고    scopus 로고
    • High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice
    • Villeval JL, Cohen-Solal K, Tulliez M et al. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood 90(11), 4369-4383 (1997).
    • (1997) Blood , vol.90 , Issue.11 , pp. 4369-4383
    • Villeval, J.L.1    Cohen-Solal, K.2    Tulliez, M.3
  • 116
    • 0028843848 scopus 로고
    • Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineagespecific growth and differentiation of megakaryocytes in mice
    • Yan XQ, Lacey D, Fletcher F et al. Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineagespecific growth and differentiation of megakaryocytes in mice. Blood 86(11), 4025-4033 (1995).
    • (1995) Blood , vol.86 , Issue.11 , pp. 4025-4033
    • Yan, X.Q.1    Lacey, D.2    Fletcher, F.3
  • 117
    • 0031020240 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment
    • Zhou W, Toombs CF, Zou T, Guo J, Robinson MO. Transgenic mice overexpressing human c-mpl ligand exhibit chronic thrombocytosis and display enhanced recovery from 5-fluorouracil or antiplatelet serum treatment. Blood 89(5), 1551-1559 (1997).
    • (1997) Blood , vol.89 , Issue.5 , pp. 1551-1559
    • Zhou, W.1    Toombs, C.F.2    Zou, T.3    Guo, J.4    Robinson, M.O.5
  • 118
    • 20344393115 scopus 로고    scopus 로고
    • Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis
    • Kakumitsu H, Kamezaki K, Shimoda K et al. Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. Leuk. Res. 29(7), 761-769 (2005).
    • (2005) Leuk. Res. , vol.29 , Issue.7 , pp. 761-769
    • Kakumitsu, H.1    Kamezaki, K.2    Shimoda, K.3
  • 119
    • 22144451506 scopus 로고    scopus 로고
    • Osteosclerosis in advanced chronic idiopathic myelofibrosis is associated with endothelial overexpression of osteoprotegerin
    • Bock O, Loch G, Schade U et al. Osteosclerosis in advanced chronic idiopathic myelofibrosis is associated with endothelial overexpression of osteoprotegerin. Br. J. Haematol. 130(1), 76-82 (2005).
    • (2005) Br. J. Haematol. , vol.130 , Issue.1 , pp. 76-82
    • Bock, O.1    Loch, G.2    Schade, U.3
  • 120
    • 77953399643 scopus 로고    scopus 로고
    • Increased myelofibrosis in thrombospondin-1 null mice is associated with enhanced TGF-b1-mediated response by bone marrow fibroblasts
    • San Fransisco CA, USA 6-9 December
    • Evrard S, Tulliez M, Zetterberg E et al. Increased myelofibrosis in thrombospondin-1 null mice is associated with enhanced TGF-b1-mediated response by bone marrow fibroblasts. In: American Society of Hematology 50th Annual Meeting. San Fransisco, CA, USA 6-9 December (2008)
    • (2008) American Society of Hematology 50th Annual Meeting
    • Evrard, S.1    Tulliez, M.2    Zetterberg, E.3
  • 121
    • 4544277651 scopus 로고    scopus 로고
    • Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
    • Tong W, Lodish HF. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J. Exp. Med. 200(5), 569-580 (2004).
    • (2004) J. Exp. Med. , vol.200 , Issue.5 , pp. 569-580
    • Tong, W.1    Lodish, H.F.2
  • 122
    • 20444426803 scopus 로고    scopus 로고
    • Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    • Tong W, Zhang J, Lodish HF. Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105(12), 4604-4612 (2005).
    • (2005) Blood , vol.105 , Issue.12 , pp. 4604-4612
    • Tong, W.1    Zhang, J.2    Lodish, H.F.3
  • 123
    • 54049113023 scopus 로고    scopus 로고
    • Adaptor protein Lnk associates with Tyr(568) in c-Kit
    • Gueller S, Gery S, Nowak V et al. Adaptor protein Lnk associates with Tyr(568) in c-Kit. Biochem. J. 415(2), 241-245 (2008).
    • (2008) Biochem. J. , vol.415 , Issue.2 , pp. 241-245
    • Gueller, S.1    Gery, S.2    Nowak, V.3
  • 124
    • 58149147644 scopus 로고    scopus 로고
    • Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells
    • Simon C, Dondi E, Chaix A et al. Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells. Blood 112(10), 4039-4047 (2008).
    • (2008) Blood , vol.112 , Issue.10 , pp. 4039-4047
    • Simon, C.1    Dondi, E.2    Chaix, A.3
  • 125
    • 36148995898 scopus 로고    scopus 로고
    • Adaptor protein Lnk negatively regulates the mutant MPL,MPL W515L associated with myeloproliferative disorders
    • Gery S, Gueller S, Chumakova K et al. Adaptor protein Lnk negatively regulates the mutant MPL, MPL W515L associated with myeloproliferative disorders. Blood 110(9), 3360-3364 (2007).
    • (2007) Blood , vol.110 , Issue.9 , pp. 3360-3364
    • Gery, S.1    Gueller, S.2    Chumakova, K.3
  • 126
    • 46749137278 scopus 로고    scopus 로고
    • Transgenic expression of JAK2 V617F causes myeloproliferative disorders in mice
    • Xing S, Wanting TH, Zhao W et al. Transgenic expression of JAK2 V617F causes myeloproliferative disorders in mice. Blood 111(10), 5109-5117 (2008).
    • (2008) Blood , vol.111 , Issue.10 , pp. 5109-5117
    • Xing, S.1    Wanting, T.H.2    Zhao, W.3
  • 127
    • 33750936941 scopus 로고    scopus 로고
    • Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
    • Kennedy JA, Barabe F, Patterson BJ et al. Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo. Proc. Natl Acad. Sci. USA 103(45), 16930-16935 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.45 , pp. 16930-16935
    • Kennedy, J.A.1    Barabe, F.2    Patterson, B.J.3
  • 128
    • 0035542766 scopus 로고    scopus 로고
    • The TEL/PDGFbR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5- independent pathways
    • Sternberg DW, Tomasson MH, Carroll M et al. The TEL/PDGFbR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5- independent pathways. Blood 98(12), 3390-3397 (2001).
    • (2001) Blood , vol.98 , Issue.12 , pp. 3390-3397
    • Sternberg, D.W.1    Tomasson, M.H.2    Carroll, M.3
  • 129
    • 0032589693 scopus 로고    scopus 로고
    • The Tel-PDGFRb fusion gene produces a chronic myeloproliferative syndrome in transgenic mice
    • Ritchie KA, Aprikyan AA, Bowen- Pope DF et al. The Tel-PDGFRb fusion gene produces a chronic myeloproliferative syndrome in transgenic mice. Leukemia 13(11), 1790 - 1803 (1999).
    • (1999) Leukemia , vol.13 , Issue.11 , pp. 1790-1803
    • Ritchie, K.A.1    Aprikyan, A.A.2    Bowen-Pope, D.F.3
  • 130
    • 0033999917 scopus 로고    scopus 로고
    • Fatal myeloproliferation, induced in mice by TEL/PDGFbR expression, depends on PDGFbR tyrosines 579/581
    • Tomasson MH, Sternberg DW, Williams IR et al. Fatal myeloproliferation, induced in mice by TEL/PDGFbR expression, depends on PDGFbR tyrosines 579/581. J. Clin. Invest. 105(4), 423-432 (2000).
    • (2000) J. Clin. Invest. , vol.105 , Issue.4 , pp. 423-432
    • Tomasson, M.H.1    Sternberg, D.W.2    Williams, I.R.3
  • 131
    • 0037013924 scopus 로고    scopus 로고
    • Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo
    • Yu C, Cantor AB, Yang H et al. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J. Exp. Med. 195(11), 1387-1395 (2002).
    • (2002) J. Exp. Med. , vol.195 , Issue.11 , pp. 1387-1395
    • Yu, C.1    Cantor, A.B.2    Yang, H.3
  • 133
    • 0037415557 scopus 로고    scopus 로고
    • GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant
    • Migliaccio AR, Rana RA, Sanchez M et al. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J. Exp. Med. 197(3), 281-296 (2003).
    • (2003) J. Exp. Med. , vol.197 , Issue.3 , pp. 281-296
    • Migliaccio, A.R.1    Rana, R.A.2    Sanchez, M.3
  • 134
    • 0025271480 scopus 로고
    • Megakaryocytic and erythrocytic lineages share specific transcription factors
    • Romeo PH, Prandini MH, Joulin V et al. Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature 344(6265), 447-449 (1990).
    • (1990) Nature , vol.344 , Issue.6265 , pp. 447-449
    • Romeo, P.H.1    Prandini, M.H.2    Joulin, V.3
  • 135
    • 0024373139 scopus 로고
    • Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
    • Tsai SF, Martin DI, Zon LI et al. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature 339(6224), 446-451 (1989).
    • (1989) Nature , vol.339 , Issue.6224 , pp. 446-451
    • Tsai, S.F.1    Martin, D.I.2    Zon, L.I.3
  • 136
    • 0031061692 scopus 로고    scopus 로고
    • The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery
    • Whyatt DJ, Karis A, Harkes IC et al. The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery. Genes Funct. 1(1), 11-24 (1997).
    • (1997) Genes Funct. , vol.1 , Issue.1 , pp. 11-24
    • Whyatt, D.J.1    Karis, A.2    Harkes, I.C.3
  • 137
    • 0035480007 scopus 로고    scopus 로고
    • Hematopoietic development: A balancing act
    • Cantor AB, Orkin SH. Hematopoietic development: a balancing act. Curr. Opin. Genet. Dev. 11(5), 513-519 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , Issue.5 , pp. 513-519
    • Cantor, A.B.1    Orkin, S.H.2
  • 138
    • 0025977563 scopus 로고
    • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
    • Pevny L, Simon MC, Robertson E et al. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349(6306), 257-260 (1991).
    • (1991) Nature , vol.349 , Issue.6306 , pp. 257-260
    • Pevny, L.1    Simon, M.C.2    Robertson, E.3
  • 139
    • 0036668278 scopus 로고    scopus 로고
    • The GATA family (vertebrates and invertebrates)
    • Patient RK, McGhee JD. The GATA family (vertebrates and invertebrates). Curr. Opin. Genet. Dev. 12(4), 416-422 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , Issue.4 , pp. 416-422
    • Patient, R.K.1    McGhee, J.D.2
  • 140
    • 0037071383 scopus 로고    scopus 로고
    • Transcriptional regulation of erythropoiesis: An affair involving multiple partners
    • Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21(21), 3368-3376 (2002).
    • (2002) Oncogene , vol.21 , Issue.21 , pp. 3368-3376
    • Cantor, A.B.1    Orkin, S.H.2
  • 141
    • 0942266030 scopus 로고    scopus 로고
    • Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
    • Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 103(2), 583-585 (2004).
    • (2004) Blood , vol.103 , Issue.2 , pp. 583-585
    • Fujiwara, Y.1    Chang, A.N.2    Williams, A.M.3    Orkin, S.H.4
  • 142
    • 38449104294 scopus 로고    scopus 로고
    • Regulation of GATA1 gene expression
    • Kobayashi M, Yamamoto M. Regulation of GATA1 gene expression. J. Biochem. 142(1), 1-10 (2007).
    • (2007) J. Biochem. , vol.142 , Issue.1 , pp. 1-10
    • Kobayashi, M.1    Yamamoto, M.2
  • 143
    • 0030963918 scopus 로고    scopus 로고
    • "Knockdown"mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
    • McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc. Natl Acad. Sci. USA 94(13), 6781-6785 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.13 , pp. 6781-6785
    • McDevitt, M.A.1    Shivdasani, R.A.2    Fujiwara, Y.3    Yang, H.4    Orkin, S.H.A.5
  • 144
    • 0030926006 scopus 로고    scopus 로고
    • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development
    • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 16(13), 3965-3973 (1997).
    • (1997) EMBO J. , vol.16 , Issue.13 , pp. 3965-3973
    • Shivdasani, R.A.1    Fujiwara, Y.2    McDevitt, M.A.3    Orkin, S.H.4
  • 145
    • 0033134831 scopus 로고    scopus 로고
    • Consequences of GATA-1 deficiency in megakaryocytes and platelets
    • Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood 93(9), 2867-2875 (1999).
    • (1999) Blood , vol.93 , Issue.9 , pp. 2867-2875
    • Vyas, P.1    Ault, K.2    Jackson, C.W.3    Orkin, S.H.4    Shivdasani, R.A.5
  • 146
    • 28844472535 scopus 로고    scopus 로고
    • Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds
    • Martelli F, Ghinassi B, Panetta B et al. Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds. Blood 106(13), 4102-4113 (2005).
    • (2005) Blood , vol.106 , Issue.13 , pp. 4102-4113
    • Martelli, F.1    Ghinassi, B.2    Panetta, B.3
  • 147
    • 0032857069 scopus 로고    scopus 로고
    • Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    • Persons DA, Paulson RF, Loyd MR et al. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat. Genet. 23(2), 159-165 (1999).
    • (1999) Nat. Genet. , vol.23 , Issue.2 , pp. 159-165
    • Persons, D.A.1    Paulson, R.F.2    Loyd, M.R.3
  • 148
    • 0014824519 scopus 로고
    • Fv-2: Identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice
    • Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J. Natl Cancer Inst. 45(1), 163-169 (1970).
    • (1970) J. Natl Cancer Inst. , vol.45 , Issue.1 , pp. 163-169
    • Lilly, F.1
  • 149
    • 33846917131 scopus 로고    scopus 로고
    • The hypomorphic Gata1low mutation alters the proliferation/ differentiation potential of the common megakaryocytic-erythroid progenitor
    • Ghinassi B, Sanchez M, Martelli F et al. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 109(4), 1460-1471 (2007).
    • (2007) Blood , vol.109 , Issue.4 , pp. 1460-1471
    • Ghinassi, B.1    Sanchez, M.2    Martelli, F.3
  • 150
    • 9244264090 scopus 로고    scopus 로고
    • Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    • Centurione L, Di Baldassarre A, Zingariello M et al. Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice. Blood 104(12), 3573-3580 (2004).
    • (2004) Blood , vol.104 , Issue.12 , pp. 3573-3580
    • Centurione, L.1    Di Baldassarre, A.2    Zingariello, M.3
  • 151
    • 0033525730 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3
    • Kobayashi A, Ito E, Toki T et al. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J. Biol. Chem. 274(10), 6443-6452 (1999)
    • (1999) J. Biol. Chem. , vol.274 , Issue.10 , pp. 6443-6452
    • Kobayashi, A.1    Ito, E.2    Toki, T.3
  • 152
    • 8244250764 scopus 로고    scopus 로고
    • Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
    • Toki T, Itoh J, Kitazawa J et al. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Oncogene 14(16), 1901-1910 (1997).
    • (1997) Oncogene , vol.14 , Issue.16 , pp. 1901-1910
    • Toki, T.1    Itoh, J.2    Kitazawa, J.3
  • 153
    • 0032518256 scopus 로고    scopus 로고
    • Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1
    • Ohira M, Seki N, Nagase T et al. Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1. Genomics 47(2), 300-306 (1998).
    • (1998) Genomics , vol.47 , Issue.2 , pp. 300-306
    • Ohira, M.1    Seki, N.2    Nagase, T.3
  • 154
    • 2642683201 scopus 로고    scopus 로고
    • Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1
    • Blouin JL, Duriaux Sail G, Guipponi M et al. Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. Hum. Genet. 102(3), 282-288 (1998).
    • (1998) Hum. Genet. , vol.102 , Issue.3 , pp. 282-288
    • Blouin, J.L.1    Duriaux Sail, G.2    Guipponi, M.3
  • 155
    • 0034578109 scopus 로고    scopus 로고
    • Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin
    • Terui K, Takahashi Y, Kitazawa J et al. Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. Tohoku J. Exp. Med. 192(4), 259-273 (2000).
    • (2000) Tohoku J. Exp. Med. , vol.192 , Issue.4 , pp. 259-273
    • Terui, K.1    Takahashi, Y.2    Kitazawa, J.3
  • 156
    • 0029805130 scopus 로고    scopus 로고
    • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    • Oyake T, Itoh K, Motohashi H et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol. Cell. Biol. 16(11), 6083-6095 (1996).
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.11 , pp. 6083-6095
    • Oyake, T.1    Itoh, K.2    Motohashi, H.3
  • 157
    • 0025365230 scopus 로고
    • Detailed analysis of the site 3 region of the human β-globin dominant control region
    • Talbot D, Philipsen S, Fraser P, Grosveld F. Detailed analysis of the site 3 region of the human b-globin dominant control region. Embo. J. 9(7), 2169-2177 (1990). (Pubitemid 20198960)
    • (1990) EMBO Journal , vol.9 , Issue.7 , pp. 2169-2177
    • Talbot, D.1    Philipsen, S.2    Fraser, P.3    Grosveld, F.4
  • 158
    • 0025905166 scopus 로고
    • The 5́HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites
    • Talbot D, Grosveld F. The 5́HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites. EMBO J. 10(6), 1391-1398 (1991).
    • (1991) EMBO J. , vol.10 , Issue.6 , pp. 1391-1398
    • Talbot, D.1    Grosveld, F.2
  • 159
    • 0025291510 scopus 로고
    • Tandem AP-1-binding sites within the human b-globin dominant control region function as an inducible enhancer in erythroid cells
    • Ney PA, Sorrentino BP, McDonagh KT, Nienhuis AW. Tandem AP-1-binding sites within the human b-globin dominant control region function as an inducible enhancer in erythroid cells. Genes Dev. 4(6), 993-1006 (1990).
    • (1990) Genes Dev. , vol.4 , Issue.6 , pp. 993-1006
    • Ney, P.A.1    Sorrentino, B.P.2    McDonagh, K.T.3    Nienhuis, A.W.4
  • 160
    • 0025080566 scopus 로고
    • Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein
    • Ney PA, Sorrentino BP, Lowrey CH, Nienhuis AW. Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein. Nucleic Acids Res. 18(20), 6011-6017 (1990).
    • (1990) Nucleic Acids Res. , vol.18 , Issue.20 , pp. 6011-6017
    • Ney, P.A.1    Sorrentino, B.P.2    Lowrey, C.H.3    Nienhuis, A.W.4
  • 161
    • 0029051295 scopus 로고
    • Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
    • Shivdasani RA, Rosenblatt MF, Zucker- Franklin D et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81(5), 695-704 (1995).
    • (1995) Cell , vol.81 , Issue.5 , pp. 695-704
    • Shivdasani, R.A.1    Rosenblatt, M.F.2    Zucker- Franklin, D.3
  • 162
    • 58149387662 scopus 로고    scopus 로고
    • Normal bone anatomy and physiology
    • Clarke B. Normal bone anatomy and physiology. Clin. J. Am. Soc. Nephrol. 3(Suppl. 3), S131-S139 (2008).
    • (2008) Clin. J. Am. Soc. Nephrol. , vol.3 , Issue.SUPPL. 3
    • Clarke, B.1
  • 163
    • 6344226562 scopus 로고    scopus 로고
    • Interaction between osteoblast and osteoclast: Impact in bone disease
    • Phan TC, Xu J, Zheng MH. Interaction between osteoblast and osteoclast: impact in bone disease. Histol. Histopathol. 19(4), 1325-1344 (2004).
    • (2004) Histol. Histopathol. , vol.19 , Issue.4 , pp. 1325-1344
    • Phan, T.C.1    Xu, J.2    Zheng, M.H.3
  • 164
    • 3142669441 scopus 로고    scopus 로고
    • Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    • Kacena MA, Shivdasani RA, Wilson K et al. Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J. Bone Miner. Res. 19(4), 652-660 (2004).
    • (2004) J. Bone Miner. Res. , vol.19 , Issue.4 , pp. 652-660
    • Kacena, M.A.1    Shivdasani, R.A.2    Wilson, K.3
  • 165
    • 0942277099 scopus 로고    scopus 로고
    • Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients
    • Beerepoot LV, Mehra N, Vermaat JS et al. Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients. Ann. Oncol. 15(1), 139-145 (2004).
    • (2004) Ann. Oncol. , vol.15 , Issue.1 , pp. 139-145
    • Beerepoot, L.V.1    Mehra, N.2    Vermaat, J.S.3
  • 166
    • 7044233458 scopus 로고    scopus 로고
    • Characterization of blood vessels in bone marrow from patients with chronic myeloid leukemia and polycythemia vera
    • Zetterberg E, Lundberg LG, Palmblad J. Characterization of blood vessels in bone marrow from patients with chronic myeloid leukemia and polycythemia vera. Scand. J. Clin. Lab. Invest. 64(7), 641-647 (2004).
    • (2004) Scand. J. Clin. Lab. Invest. , vol.64 , Issue.7 , pp. 641-647
    • Zetterberg, E.1    Lundberg, L.G.2    Palmblad, J.3
  • 167
    • 34347393001 scopus 로고    scopus 로고
    • Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows
    • Zetterberg E, Vannucchi AM, Migliaccio AR et al. Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows. Haematologica 92(5), 597-604 (2007).
    • (2007) Haematologica , vol.92 , Issue.5 , pp. 597-604
    • Zetterberg, E.1    Vannucchi, A.M.2    Migliaccio, A.R.3
  • 168
    • 33845445939 scopus 로고    scopus 로고
    • Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
    • Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 25(6), 977-988 (2006).
    • (2006) Immunity , vol.25 , Issue.6 , pp. 977-988
    • Sugiyama, T.1    Kohara, H.2    Noda, M.3    Nagasawa, T.4
  • 169
    • 0042432054 scopus 로고    scopus 로고
    • Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny
    • Ara T, Tokoyoda K, Sugiyama T et al. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity 19(2), 257-267 (2003).
    • (2003) Immunity , vol.19 , Issue.2 , pp. 257-267
    • Ara, T.1    Tokoyoda, K.2    Sugiyama, T.3
  • 170
  • 171
    • 0031985282 scopus 로고    scopus 로고
    • In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: Stromal cell-derived factor-1, steel factor, and the bone marrow environment
    • Kim CH, Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment. Blood 91(1), 100-110 (1998).
    • (1998) Blood , vol.91 , Issue.1 , pp. 100-110
    • Kim, C.H.1    Broxmeyer, H.E.2
  • 172
    • 27144443385 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells
    • Dar A, Goichberg P, Shinder V et al. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat. Immunol. 6(10), 1038-1046 (2005).
    • (2005) Nat. Immunol. , vol.6 , Issue.10 , pp. 1038-1046
    • Dar, A.1    Goichberg, P.2    Shinder, V.3
  • 173
    • 0034672426 scopus 로고    scopus 로고
    • Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases
    • Lane WJ, Dias S, Hattori K et al. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood 96(13), 4152-4159 (2000).
    • (2000) Blood , vol.96 , Issue.13 , pp. 4152-4159
    • Lane, W.J.1    Dias, S.2    Hattori, K.3
  • 174
    • 0032482926 scopus 로고    scopus 로고
    • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
    • Ma Q, Jones D, Borghesani PR et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Natl Acad. Sci. USA 95(16), 9448-9453 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.16 , pp. 9448-9453
    • Ma, Q.1    Jones, D.2    Borghesani, P.R.3
  • 175
    • 0036092976 scopus 로고    scopus 로고
    • Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: Involvement in mobilization of stem/progenitor cells
    • Sweeney EA, Lortat-Jacob H, Priestley GV, Nakamoto B, Papayannopoulou T. Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells. Blood 99(1), 44-51 (2002).
    • (2002) Blood , vol.99 , Issue.1 , pp. 44-51
    • Sweeney, E.A.1    Lortat-Jacob, H.2    Priestley, G.V.3    Nakamoto, B.4    Papayannopoulou, T.5
  • 176
    • 13844311525 scopus 로고    scopus 로고
    • The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor
    • Pelus LM, Bian H, Fukuda S et al. The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor. Exp. Hematol. 33(3), 295-307 (2005).
    • (2005) Exp. Hematol. , vol.33 , Issue.3 , pp. 295-307
    • Pelus, L.M.1    Bian, H.2    Fukuda, S.3
  • 177
    • 0036302147 scopus 로고    scopus 로고
    • G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    • Petit I, Szyper-Kravitz M, Nagler A et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 3(7), 687-694 (2002).
    • (2002) Nat. Immunol. , vol.3 , Issue.7 , pp. 687-694
    • Petit, I.1    Szyper-Kravitz, M.2    Nagler, A.3
  • 178
    • 24944563475 scopus 로고    scopus 로고
    • Circulating CD34+,CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia
    • Massa M, Rosti V, Ramajoli I et al. Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia. J. Clin. Oncol. 23(24), 5688-5695 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5688-5695
    • Massa, M.1    Rosti, V.2    Ramajoli, I.3
  • 179
    • 21144457074 scopus 로고    scopus 로고
    • + cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases
    • DOI 10.1182/blood-2004-08-3238
    • Xu M, Bruno E, Chao J et al. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases. Blood 105(11), 4508-4515 (2005). (Pubitemid 40720801)
    • (2005) Blood , vol.105 , Issue.11 , pp. 4508-4515
    • Xu, M.1    Bruno, E.2    Chao, J.3    Huang, S.4    Finazzi, G.5    Fruchtman, S.M.6    Popat, U.7    Prchal, J.T.8    Barosi, G.9    Hoffman, R.10
  • 180
    • 0242299235 scopus 로고    scopus 로고
    • Clinical utility of the absolute number of circulating CD34-positive cells in patients with chronic myeloproliferative disorders
    • Passamonti F, Vanelli L, Malabarba L et al. Clinical utility of the absolute number of circulating CD34-positive cells in patients with chronic myeloproliferative disorders. Haematologica 88(10), 1123-1129 (2003).
    • (2003) Haematologica , vol.88 , Issue.10 , pp. 1123-1129
    • Passamonti, F.1    Vanelli, L.2    Malabarba, L.3
  • 181
    • 0035874050 scopus 로고    scopus 로고
    • Effects of human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues on CD34+ stem cells
    • Brouty-Boye D, Briard D, Azzarone B et al. Effects of human fibroblasts from myelometaplasic and non-myelometaplasic hematopoietic tissues on CD34+ stem cells. Int. J. Cancer 92(4), 484-488 (2001).
    • (2001) Int. J. Cancer , vol.92 , Issue.4 , pp. 484-488
    • Brouty-Boye, D.1    Briard, D.2    Azzarone, B.3
  • 182
    • 0037360381 scopus 로고    scopus 로고
    • Impaired NK cell differentiation of blood-derived CD34+ progenitors from patients with myeloid metaplasia with myelofibrosis
    • Briard D, Brouty-Boye D, Giron-Michel J et al. Impaired NK cell differentiation of blood-derived CD34+ progenitors from patients with myeloid metaplasia with myelofibrosis. Clin. Immunol. 106(3), 201-212 (2003).
    • (2003) Clin. Immunol. , vol.106 , Issue.3 , pp. 201-212
    • Briard, D.1    Brouty-Boye, D.2    Giron-Michel, J.3
  • 183
    • 38349018496 scopus 로고    scopus 로고
    • Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease
    • Migliaccio AR, Martelli F, Verrucci M et al. Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1low mouse model of the disease. Exp. Hematol. 36(2), 158-171 (2008).
    • (2008) Exp. Hematol. , vol.36 , Issue.2 , pp. 158-171
    • Migliaccio, A.R.1    Martelli, F.2    Verrucci, M.3
  • 184
    • 34047097012 scopus 로고    scopus 로고
    • The expression of CXCR4 is downregulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia
    • Rosti V, Massa M, Vannucchi AM et al. The expression of CXCR4 is downregulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia. Blood Cells Mol. Dis. 38(3), 280-286 (2007).
    • (2007) Blood Cells Mol. Dis. , vol.38 , Issue.3 , pp. 280-286
    • Rosti, V.1    Massa, M.2    Vannucchi, A.M.3
  • 185
    • 34547946425 scopus 로고    scopus 로고
    • Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis
    • Ciurea SO, Merchant D, Mahmud N et al. Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood 110(3), 986-993 (2007).
    • (2007) Blood , vol.110 , Issue.3 , pp. 986-993
    • Ciurea, S.O.1    Merchant, D.2    Mahmud, N.3
  • 186
    • 0041806587 scopus 로고    scopus 로고
    • GATA-1- dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    • Grass JA, Boyer ME, Pal S et al. GATA-1- dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl Acad. Sci. USA 100(15), 8811-8816 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.15 , pp. 8811-8816
    • Grass, J.A.1    Boyer, M.E.2    Pal, S.3
  • 187
    • 0037968549 scopus 로고    scopus 로고
    • Gene expression analysis of purified hematopoietic stem cells and committed progenitors
    • Terskikh AV, Miyamoto T, Chang C, Diatchenko L, Weissman IL. Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 102(1), 94-101 (2003).
    • (2003) Blood , vol.102 , Issue.1 , pp. 94-101
    • Terskikh, A.V.1    Miyamoto, T.2    Chang, C.3    Diatchenko, L.4    Weissman, I.L.5
  • 188
    • 0027136262 scopus 로고
    • Transcriptional and posttranscriptional regulation of the expression of the erythropoietin receptor gene in human erythropoietin-responsive cell lines
    • Migliaccio AR, Jiang Y, Migliaccio G et al. Transcriptional and posttranscriptional regulation of the expression of the erythropoietin receptor gene in human erythropoietin-responsive cell lines. Blood 82(12), 3760-3769 (1993).
    • (1993) Blood , vol.82 , Issue.12 , pp. 3760-3769
    • Migliaccio, A.R.1    Jiang, Y.2    Migliaccio, G.3
  • 189
    • 0742288407 scopus 로고    scopus 로고
    • Coregulator-dependent facilitation of chromatin occupancy by GATA-1
    • Pal S, Cantor AB, Johnson KD et al. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc. Natl Acad. Sci. USA 101(4), 980-985 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.4 , pp. 980-985
    • Pal, S.1    Cantor, A.B.2    Johnson, K.D.3
  • 190
    • 0030979027 scopus 로고    scopus 로고
    • Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene
    • Takahashi S, Onodera K, Motohashi H et al. Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene. J. Biol. Chem. 272(19), 12611-12615 (1997).
    • (1997) J. Biol. Chem. , vol.272 , Issue.19 , pp. 12611-12615
    • Takahashi, S.1    Onodera, K.2    Motohashi, H.3
  • 191
    • 33846268788 scopus 로고    scopus 로고
    • Molecular insights into Down syndrome-associated leukemia
    • Vyas P, Crispino JD. Molecular insights into Down syndrome-associated leukemia. Curr. Opin. Pediatr. 19(1), 9-14 (2007).
    • (2007) Curr. Opin. Pediatr. , vol.19 , Issue.1 , pp. 9-14
    • Vyas, P.1    Crispino, J.D.2
  • 192
    • 0033780541 scopus 로고    scopus 로고
    • The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
    • Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br. J. Haematol. 110(3), 512-524 (2000).
    • (2000) Br. J. Haematol. , vol.110 , Issue.3 , pp. 512-524
    • Lange, B.1
  • 193
    • 20044381309 scopus 로고    scopus 로고
    • Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    • Li Z, Godinho FJ, Klusmann JH et al. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat. Genet. 37(6), 613-619 (2005).
    • (2005) Nat. Genet. , vol.37 , Issue.6 , pp. 613-619
    • Li, Z.1    Godinho, F.J.2    Klusmann, J.H.3
  • 194
    • 38349119730 scopus 로고    scopus 로고
    • Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
    • Kirsammer G, Jilani S, Liu H et al. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111(2), 767-775 (2008).
    • (2008) Blood , vol.111 , Issue.2 , pp. 767-775
    • Kirsammer, G.1    Jilani, S.2    Liu, H.3
  • 195
    • 0033109775 scopus 로고    scopus 로고
    • Retinoid receptors in health and disease: Co-regulators and the chromatin connection
    • Minucci S, Pelicci PG. Retinoid receptors in health and disease: co-regulators and the chromatin connection. Semin. Cell Dev. Biol. 10(2), 215-225 (1999).
    • (1999) Semin. Cell Dev. Biol. , vol.10 , Issue.2 , pp. 215-225
    • Minucci, S.1    Pelicci, P.G.2
  • 196
    • 0026716167 scopus 로고
    • The retinoblastoma gene and gene product
    • Weinberg RA. The retinoblastoma gene and gene product. Cancer Surv. 12, 43-57 (1992).
    • (1992) Cancer Surv. , vol.12 , pp. 43-57
    • Weinberg, R.A.1
  • 197
    • 0025311424 scopus 로고
    • The retinoblastoma gene and cell growth control
    • Weinberg RA. The retinoblastoma gene and cell growth control. Trends Biochem. Sci. 15(5), 199-202 (1990).
    • (1990) Trends Biochem. Sci. , vol.15 , Issue.5 , pp. 199-202
    • Weinberg, R.A.1
  • 198
    • 66349107219 scopus 로고    scopus 로고
    • TET2 is a novel tumor suppressor gene inactivated in myeloproliferative neoplasms: Identification of a Pre-JAK2 V617F event. (ASH annual meeting abstracts)
    • Abstract 3
    • Delhommeau F, Dupont S, James C et al. TET2 is a novel tumor suppressor gene inactivated in myeloproliferative neoplasms: identification of a Pre-JAK2 V617F event. (ASH annual meeting abstracts). Blood 112, (2008) (Abstract 3).
    • (2008) Blood , vol.112
    • Delhommeau, F.1    Dupont, S.2    James, C.3
  • 199
    • 25444469138 scopus 로고    scopus 로고
    • VEGF receptor 1 signaling essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice
    • Niida S, Kondo T, Hiratsuka S et al. VEGF receptor 1 signaling essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. Proc. Natl Acad. Sci. USA 102, 14016-14021 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14016-14021
    • Niida, S.1    Kondo, T.2    Hiratsuka, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.