JAK2 inhibitor therapy in myeloproliferative disorders: Rationale, preclinical studies and ongoing clinical trials

Leukemia

Volumn 22, Issue 1, 2008, Pages 23-30

  Pardanani, A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; AT 9283; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DASATINIB; ERLOTINIB; HYDROXYUREA; IMATINIB; INCB 018424; INTERFERON; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; JANUS KINASE INHIBITOR; LENALIDOMIDE; LESTAURTINIB; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN KINASE INHIBITOR; TG 101209; TG 101348; UNCLASSIFIED DRUG; XL 019;

ABSENCE OF SIDE EFFECTS; ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC STEM CELL TRANSPLANTATION; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CONTINUOUS INFUSION; CYTOPENIA; DOSE RESPONSE; DRUG MECHANISM; DRUG SAFETY; DRUG WITHDRAWAL; ENZYME INHIBITION; GASTROINTESTINAL DISEASE; GENE MUTATION; GRAFT REJECTION; HEMATOLOGIC MALIGNANCY; HUMAN; LOW DRUG DOSE; MYELOID METAPLASIA; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; THROMBOCYTHEMIA; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

EID: 38349053791     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404948     Document Type: Review

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