Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation

Journal of Interferon and Cytokine Research

Volumn 25, Issue 7, 2005, Pages 407-413

  Burmester, Helen ^a   Wolber, Eva Maria ^b   Freitag, Patricia ^c   Fandrey, Joachim ^c   Jelkmann, Wolfgang ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; THROMBOPOIETIN; TURPENTINE OIL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; INFLAMMATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS;

ACUTE DISEASE; ANIMALS; BLOOD CELL COUNT; INFLAMMATION; INTERLEUKIN-6; KIDNEY; LIVER; MALE; MICE; MICE, KNOCKOUT; RNA, MESSENGER; THROMBOPOIETIN;

EID: 22644441241     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2005.25.407     Document Type: Article

References (43)

1. Kuter DJ, Rosenberg RD. The reciprocal relationship of thrombopoietin (c-Mp1 ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995;85: 2720-2730.
2. Fielder PJ, Gurney AL, Stefanich E, Marian M, Moore MW, Carver-Moore K, De Sauvage FJ. Regulation of thrombopoietin levels by c-mp1-mediated binding to platelets. Blood 1996;87: 2154-2161.
3. Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mp1 ligand transcripts during thrombocytopenia or thrombocytosis. Blood 1996;88:2578-2584.
4. Emmons RV, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 1996;87: 4068-4071.
5. McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995;86:3668-3675.
6. Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using In situ hybridization. Blood 1997;89: 101-107.
7. Cerutti A, Custodi P, Duranti M, Cazzola M, Balduini CL. Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant. Clin. Lab. Haematol. 1999;21:271-275.
8. Jelkmann W. The role of the liver in the production of thrombopoietin compared to erythropoietin. Eur. J. Gastroenterol. Hepatol. 2001;13:791-801.
9. Ishiguro A, Suzuki Y, Mito M, Shimbo T, Matsubara K, Kato T, Miyazaki H. Elevation of serum thrombopoietin precedes thrombocytosis in acute infections. Br. J. Haematol. 2002;116:612-618.
10. Hsu Hc, Tsai WH, Jiang ML, Ho CH, Hsu ML, Ho CK, Wang SY. Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis. J. Lab. Clin. Med. 1999;134:392-397.
11. Zakynthinos SG, Papanikolaou S, Theodoridis T, Zakynthinos EG, Christopoulou-Kokkinou V, Katsaris G, Mavrommatis AC. Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients. Crit. Care Med. 2004;32:1004-1010.
12. Wolber E-M, Jelkmann W. Interleukin-6 increases thrombopoietin production in human hepatoma cells HepG2 and Hep3B. J. Interferon Cytokine Res. 2000;20:499-506.
13. Gershenwald JE, Fong YM, Fahey TJ, Galvano SE, Chizzonite R, Kilian PL, Lowry SF, Moldawer LL. Interleukin 1 receptor blockade attenuates the host inflammatory response. Proc. Natl. Acad. Sci. USA 1990;87:4966-4970.
14. Boelen A, Maas MA, Lowik CW, Platvoet MC, Wiersinga WM. Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3′-triiodothyronine syndrome. Endocrinology 1996;137:5250-5254.
15. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Köhler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994;368:339-342.
16. Wördermann M, Fandrey J, Jelkmann W. Tumor necrosis factor-α production by human hepatoma cell lines is resistant to drugs that are inhibitory to macrophages. J. Interferon Cylokine Res. 1998;18:1069-1075.
17. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987;162:156-159.
18. Wolber E-M, Dame C, Fahnenstich H, Hofmann D, Bartmann P, Jelkmann W, Fandrey J. Expression of the thrombopoietin gene in human fetal and neonatal tissues. Blood 1999;94:97-105.
19. Wolber E-M, Ganschow R, Burdelski M, Jelkmann W. Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood. Hepatology 1999;29:1739-1742.
20. Wolber E-M, Fandrey J, Frackowski U, Jelkmann W. Hepatic thrombopoietin mRNA is increased in acute inflammation. Thromb. Haemost. 2001;86:1421-1424.
21. Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, Theurl I, Widder R, Molnar C, Ludwiczek O, Atkins MB, Mier JW, Tilg H. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood 2001;98:2720-2725.
22. Heits F, Katschinski DM, Wilmsen U, Wiedemann GJ, Jelkmann W. Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia. Eur. J. Haematol. 1997;59;53-58.
23. Cerutti A, Custodi P, Duranti M, Noris P, Balduini CL. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br. J. Haematol. 1997;99:281-284.
24. Wang JC, Chen C, Lou LH, Mora M. Blood thrombopoietin. IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia 1997;11:1827-1832.
25. Heits F, Stahl M, Ludwig D, Stange EF, Jelkmann W. Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. J. Interferon Cytokine Res. 1999;19:757-760.
26. Bjerre A, Avstebo R, Kierulf P, Halvorsen S, Brandtzaeg P. Fulminant meningococcal septicemia: dissociation between plasma thrombopoietin levels and platelet counts. Clin. Infect. Dis. 2000;30:643-647.
27. Folman CC, Ooms M, Kuenen B, De Jong SM, Vet RJWM, De Haas M, Von Dem Borne AE. The role of thrombopoietin in post-operative thrombocytosis. Br. J. Haematol. 2001;114:126-133.
28. Hino M, Nishizawa Y, Tagawa S, Yamane T, Morii H, Tatsumi N. Constitutive expression of the thrombopoietin gene in a human hepatoma cell line. Biochem. Biophys. Res. Commun. 1995; 217:475-481.
29. Peck-Radosavljevic M, Wichlas M, Pidlich J, Sims P, Meng G, Zacherl J, Garg S, Datz C, Gangl A, Ferenci P. Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis C. Hepatology 1998;28:1424-1429.
30. Wolber E-M, Haase B, Jelkmann W. Thrombopoietin production in human hepatic cell cultures (HepG2) is resistant to interferon-α, -β and -γ, treatment. J. Interferon Cytokine Res. 2002;22: 1185-1189.
31. Yamashita K, Matsuoka H, Ochiai T, Matsushita R, Kubuki Y, Suzuki M, Tsubouchi H. Hepatocyte growth factor/scatter factor enhances the thrombopoietin mRNA expression in rat hepatocytes and cirrhotic rat livers. J. Gastroenterol. Hepatol. 2000;15:83-90.
32. Ishikawa T, Ichida T, Matsuda Y, Sugitani S, Sugiyama M, Kato T, Miyazaki H, Asakura H. Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirhosis. J. Gastroenterol. Hepatol. 2000;15:647-653.
33. Ando M, Iwamoto Y, Suda A, Tsuchiya K, Nihei H. New insights into the thrombopoietic status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels. Blood 2001;97:915-921.
34. Linthorst GE, Folman CC, Van Olden RW, Von Dem Borne AE. Plasma thrombopoietin levels in patients with chronic renal failure. Hematol. J. 2002;3:38-42.
35. Ulich TR, Del Castillo J, Yin SM, Egrie JC. The erythropoietic effects of interleukin 6 and erythropoietin in vivo. Exp. Hematol. 1991;19:29-34.
36. Atkins MB, Kappler K, Mier JW, Isaacs RE, Berkman EM. Interleukin-6-associated anemia: determination of the underlying mechanism. Blood 1995;86:1288-1291.
37. Weber J, Yang JC, Topalian SL, Parkinson DR, Schwartzentruber DS, Ettinghausen SE, Gunn H, Mixon A, Kim H, Cole D, Levin R, Rosenberg SA. Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J. Clin. Oncol. 1993;11: 499-506.
38. Gordon MS, Nemunaitis J, Hoffman R, Paquette RL, Rosenfeld C, Manfreda S, Isaacs R, Nimer SD. A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia. Blood 1995;85:3066-3076.
39. Moshage H. Cytokines and the hepatic acute-phase response. J. Pathol. 1997;181:257-266.
40. Yeaman MR. The role of platelets in antimicrobial host defense. Clin. Infect. Dis. 1997;25:951-968.
41. Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J. Interferon Cytokine Res. 2002;22:913-922.
42. Youssefian T, Drouin A, Masse JM, Guichard J, Cramer EM. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002;99:4021-4029.
43. Krijgsveld J, Zaat SA, Meeldijk J, Van Veelen PA, Fang G, Poolman B, Brandt E, Ehlert JE, Kuijpers AJ, Engbers GH, Feijen J, Dankert J. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J. Biol. Chem. 2000;275:20374-20381.