Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice

Developmental Cell

Volumn 8, Issue 6, 2005, Pages 907-914

  Ema, Hideo ^a   Sudo, Kazuhiro ^a   Seita, Jun ^a   Matsubara, Azusa ^a   Morita, Yohei ^a   Osawa, Mitsujiro ^a   Takatsu, Kiyoshi ^a   Takaki, Satoshi ^a   Nakauchi, Hiromitsu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; PROTEIN LNK; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL REGENERATION; CELL RENEWAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOLECULAR CLONING; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; QUANTITATIVE ASSAY; SIGNAL TRANSDUCTION; WILD TYPE;

AGE FACTORS; ANIMALS; ANTIGENS, CD34; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; COCULTURE TECHNIQUES; FLOW CYTOMETRY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; MICE, KNOCKOUT; PROTEINS; RADIATION CHIMERA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 19944400789     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2005.03.019     Document Type: Article

References (55)

1. Z. Ahmed and T.S. Pillay Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase, and phosphoinositide 3-kinase-dependent signalling Biochem. J. 371 2003 405-412
2. R.C. Allsopp G.B. Morin R. DePinho C.B. Harley and I.L. Weissman Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation Blood 102 2003 517-520
3. R.C. Allsopp G.B. Morin J.W. Horner R. DePinho C.B. Harley and I.L. Weissman Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells Nat. Med. 9 2003 369-371
4. J. Antonchuk G. Sauvageau and R.K. Humphries HOXB4-induced expansion of adult hematopoietic stem cells ex vivo Cell 109 2002 39-45
5. J.M. Bjornsson N. Larsson A.C. Brun M. Magnusson E. Andersson P. Lundstrom J. Larsson E. Repetowska M. Ehinger R.K. Humphries and S. Karlsson Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4 Mol. Cell. Biol. 23 2003 3872-3883
6. L.M. Calvi G.B. Adams K.W. Weibrecht J.M. Weber D.P. Olson M.C. Knight R.P. Martin E. Schipani P. Divieti F.R. Bringhurst et al. Osteoblastic cells regulate the haematopoietic stem cell niche Nature 425 2003 841-846
7. G. Cudkowicz A.C. Upton G.M. and Shearer W.L. Hughes Lymphocyte content and proliferative capacity of serially transplanted mouse bone marrow Nature 201 1964 165-167
8. J.E. Dick M.C. Magli D. Huszar R.A. Phillips and A. Bernstein Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice Cell 42 1985 71-79
9. H. Ema and H. Nakauchi Expansion of hematopoietic stem cells in the developing liver of a mouse embryo Blood 95 2000 2284-2288
10. H. Ema H. Takano K. Sudo and H. Nakauchi In vitro self-renewal division of hematopoietic stem cells J. Exp. Med. 192 2000 1281-1288
11. M.A. Goodell K. Brose G. Paradis A.S. Conner and R.C. Mulligan Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo J. Exp. Med. 183 1996 1797-1806
12. D.E. Harrison and C.M. Astle Loss of stem cell repopulating ability upon transplantation J. Exp. Med. 156 1982 1767-1779
13. D.E. Harrison M. Stone and C.M. Astle Effects of transplantation on the primitive immunohematopoietic stem cell J. Exp. Med. 172 1990 431-437
14. D.E. Harrison C.T. Jordan R.K. Zhong and C.M. Astle Primitive hemopoietic stem cells: Direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations Exp. Hematol. 21 1993 206-219
15. S. Hellman L.E. Botnick E.C. Hannon and R.M. Vigneulle Proliferative capacity of murine hematopoietic stem cells Proc. Natl. Acad. Sci. USA 75 1978 490-494
16. X. Huang Y. Li K. Tanaka K.G. Moore and J.I. Hayashi Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase Proc. Natl. Acad. Sci. USA 92 1995 11618-11622
17. N.N. Iscove and K. Nawa Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion Curr. Biol. 7 1997 805-808
18. A. Iwama H. Oguro M. Negishi Y. Kato Y. Morita H. Tsukui H. Ema T. Kamijo Y. Katoh-Fukui H. Koseki et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1 Immunity 21 2004 843-851
19. G. Keller and R. Snodgrass Life span of multipotential hematopoietic stem cells in vivo J. Exp. Med. 171 1990 1407-1418
20. G. Keller C. Paige E. Gilboa and E.F. Wagner Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors Nature 318 1985 149-154
21. S. Kimura A.W. Roberts D. Metcalf and W.S. Alexander Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin Proc. Natl. Acad. Sci. USA 95 1998 1195-1200
22. I.R. Lemischka D.H. Raulet and R.C. Mulligan Developmental potential and dynamic behavior of hematopoietic stem cells Cell 45 1986 917-927
23. J. Lessard and G. Sauvageau Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells Nature 423 2003 255-260
24. Y. Li X. He J. Schembri-King S. Jakes and J. Hayashi Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation J. Immunol. 164 2000 5199-5206
25. M.T. McManus and P.A. Sharp Gene silencing in mammals by small interfering RNAs Nat. Rev. Genet. 3 2002 737-747
26. H.S. Micklem C.E. Ford E.P. Evans D.A. Ogden and D.S. Papworth Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice J. Cell. Physiol. 79 1972 293-298
27. H.K. Mikkola J. Klintman H. Yang H. Hock T.M. Schlaeger Y. Fujiwara and S.H. Orkin Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/ tal-1 gene Nature 421 2003 547-551
28. C.L. Miller V.I. Rebel M.E. Lemieux C.D. Helgason P.M. Lansdorp and C.J. Eaves Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells Exp. Hematol. 24 1996 185-194
29. T. Nakano H. Kodama and T. Honjo In vitro development of primitive and definitive erythrocytes from different precursors Science 272 1996 722-724
30. D.A. Ogden and H.S. Micklem The fate of serially transplanted bone marrow cell populations from young and old donors Transplantation 22 1976 287-293
31. H. Ohta A. Sawada J.Y. Kim S. Tokimasa S. Nishiguchi R.K. Humphries J. Hara and Y. Takihara Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells J. Exp. Med. 195 2002 759-770
32. T. Okuda K. Takeda Y. Fujita M. Nishimura S. Yagyu M. Yoshida S. Akira J.R. Downing and T. Abe Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy Mol. Cell. Biol. 20 2000 319-328
33. M. Osawa K.-i. Hanada H. Hamada and H. Nakauchi Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell Science 273 1996 242-245
34. M. Osawa S. Miyoshi N.G. Copeland D.J. Gilbert N.A. Jenkins T. Hiroyama T. Motohashi Y. Nakamura A. Iwama and H. Nakauchi Characterization of the mouse interleukin-13 receptor alpha1 gene Immunogenetics 51 2000 974-981
35. I.K. Park D. Qian M. Kiel M.W. Becker M. Pihalja I.L. Weissman S.J. Morrison and M.F. Clarke Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells Nature 423 2003 302-305
36. R. Pawliuk C. Eaves and R.K. Humphries Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo Blood 88 1996 2852-2858
37. T. Reya A.W. Duncan L. Ailles J. Domen D.C. Scherer K. Willert L. Hintz R. Nusse and I.L. Weissman A role for Wnt signalling in self-renewal of haematopoietic stem cells Nature 423 2003 409-414
38. M. Rosendaal G.S. Hodgson and T.R. Bradley Organization of haemopoietic stem cells: The generation-age hypothesis Cell Tissue Kinet. 12 1979 17-29
39. G. Sauvageau U. Thorsteinsdottir C.J. Eaves H.J. Lawrence C. Largman P.M. Lansdorp and R.K. Humphries Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo Genes Dev. 9 1995 1753-1765
40. L. Sminovitch J.E. Till and E.A. McCulloch Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice J. Cell. Comp. Physiol. 64 1964 23-32
41. K. Sudo H. Ema Y. Morita and H. Nakauchi Age-associated characteristics of murine hematopoietic stem cells J. Exp. Med. 192 2000 1273-1280
42. S.J. Szilvassy R.K. Humphries P.M. Lansdorp A.C. Eaves and C.J. Eaves Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy Proc. Natl. Acad. Sci. USA 87 1990 8736-8740
43. S. Takaki K. Sauer B.M. Iritani S. Chien Y. Ebihara K. Tsuji K. Takatsu and R.M. Perlmutter Control of B cell production by the adaptor protein lnk. Definition of a conserved family of signal-modulating proteins Immunity 13 2000 599-609
44. S. Takaki H. Morita Y. Tezuka and K. Takatsu Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk J. Exp. Med. 195 2002 151-160
45. S. Takaki J.D. Watts K.A. Forbush N.T. Nguyen J. Hayashi J. Alberola-Ila R. Aebersold and R.M. Perlmutter Characterization of Lnk. An adaptor protein expressed in lymphocytes J. Biol. Chem. 272 1997 14562-14570
46. H. Takano H. Ema K. Sudo and H. Nakauchi Asymmetric division and lineage commitment at the level of hematopoietic stem cells: Inference from differentiation in daughter cell and granddaughter cell pairs J. Exp. Med. 199 2004 295-302
47. M. TeKippe D.E. Harrison and J. Chen Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice Exp. Hematol. 31 2003 521-527
48. F.Y. Tsai G. Keller F.C. Kuo M. Weiss J. Chen M. Rosenblatt F.W. Alt and S.H. Orkin An early haematopoietic defect in mice lacking the transcription factor GATA-2 Nature 371 1994 221-226
49. B. Varnum-Finney L. Xu C. Brashem-Stein C. Nourigat D. Flowers S. Bakkour W.S. Pear and I.D. Bernstein Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling Nat. Med. 6 2000 1278-1281
50. L. Velazquez A.M. Cheng H.E. Fleming C. Furlonger S. Vesely A. Bernstein C.J. Paige and T. Pawson Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice J. Exp. Med. 195 2002 1599-1611
51. A.J. Warren W.H. Colledge M.B. Carlton M.J. Evans A.J. Smith and T.H. Rabbitts The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development Cell 78 1994 45-57
52. M. Yokouchi R. Suzuki M. Masuhara S. Komiya A. Inoue and A. Yoshimura Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation Oncogene 15 1997 7-15
53. Y. Yuan H. Shen D.S. Franklin D.T. Scadden and T. Cheng In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C Nat. Cell Biol. 6 2004 436-442
54. J. Zhang C. Niu L. Ye H. Huang X. He W.G. Tong J. Ross J. Haug T. Johnson J.Q. Feng et al. Identification of the haematopoietic stem cell niche and control of the niche size Nature 425 2003 836-841
55. S. Zhou J.D. Schuetz K.D. Bunting A.M. Colapietro J. Sampath J.J. Morris I. Lagutina G.C. Grosveld M. Osawa H. Nakauchi and B.P. Sorrentino The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype Nat. Med. 7 2001 1028-1034