G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Nature Immunology

Volumn 3, Issue 7, 2002, Pages 687-694

  Petit, Isabelle ^a   Ponomaryov, Tanya ^a   Zipori, Dov ^a   Tsvee, Lapidot ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GRANULOCYTE COLONY STIMULATING FACTOR; LEUKOCYTE ELASTASE; NEUTRALIZING ANTIBODY; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ARTICLE; BONE MARROW; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL MOBILIZATION; TREATMENT OUTCOME;

ANIMALS; BONE MARROW; BONE MARROW CELLS; CELL LINE; CELL MOVEMENT; CHEMOKINES, CXC; GENE EXPRESSION; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; LYMPHOMA; MICE; MICE, INBRED BALB C; OSTEOBLASTS; PANCREATIC ELASTASE; RECEPTORS, CXCR4; RNA, MESSENGER; STROMAL CELLS; UP-REGULATION;

EID: 0036302147     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni813     Document Type: Article

References (64)

1. The biology of hematopoietic stem cells
2. The biology and clinical uses of blood stem cells
3. Mechanisms of granulocyte colony-stimulating factor-induced hematopoietic progenitor-cell mobilization
4. Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability
5. Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-I, VEGF, and angiopoietin-I
6. Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence
7. Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: Evidence for selectin-dependent and independent mechanisms
8. Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines
9. The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from peripheral blood
10. + hematopoietic progenitor cells: Comparison of cytokine mobilized blood stem cells with normal bone marrow and peripheral blood
11. Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9)
12. Anti-VLA4/VCAM-I-induced mobilization required cooperative signaling through the kit/kit ligand pathway
13. + progenitors to the peripheral blood
14. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
15. + stem cells to the spleen and bone marrow of immune deficient mice within 1-6 hours
16. Plasma elevation of stromal-derived factor-I induces mobilization of mature and immature hematopoietic progenitor and stem cells
17. CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells
18. Sulfated polysaccharides increase plasma levels of SDF-I in monkeys and mice: Involvement in mobilization of stem/progenitor cells
19. + cells in mobilized peripheral blood of non-Hodgkin's lymphoma patients
20. + cells is related to hematopoietic recovery after autologous stem cell transplantation
21. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-I
22. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
23. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-I-deficient mice
24. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment
25. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution
26. Presentation of chemokine SDF-I α by fibronectin mediates directed migration of T cells
27. Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines
28. Active movement of T cells away from a chemokine
29. Increased expression of the chemokine SDF-I following DNA damage: Relevance for human stem cell function
30. Vascular cell adhesion molecule-I (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
31. Rapid inactivation of stromal cell-derived factor-I by cathepsin G associated with lymphocytes
32. Matrix metalloproteinase activity inactivates the CXC chemokine Stromal Cell-Derived Factor I
33. Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells
34. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140
35. + progenitor cells mobilized into peripheral blood in humans
36. Processing by CD26/dipeptyl-peptidase IV reduces the chemotactic and anti-HIV-I activity of stromal-cell-derived factor-Iα
37. Leukocyte elastase negatively regulates Stromal cell-derived factor-I (SDF-I)/CXCR4 binding and functions by amino-terminal processing of SDF-I and CXCR4
38. SDF-Iα is inactivated by proteolytic cleavage in the bone marrow of mice mobilized by either G-CSF or cyclophosphamide
39. Proteolytic cleavage of ICAM-I by human neutrophil elastase
40. Extracellular matrix moieties, cytokines, and enzymes: Dynamic effects on immune cell behavior and inflammation
41. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia
42. + T lymphocytes are regulated by interleukin-4 and interleukin-10
43. + T lymphocytes and enhance HIV-I replication
44. Immunologic profiles of effector cells and peripheral blood stem cells mobilized with different hematopoietic growth factors
45. Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers
46. Leukocytosis and mobilization of pluripotent hematopoietic progenitor cells in healthy volunteers induced by single dose administration of AMD-3100, a CXCR4 antagonist
47. Interference of the SDF-I/CXCR4 axis in mice with AMD3100 induces rapid high level mobilization of hematopoietic progenitor cells, and AMD3100 acts synergistically with G-CSF and MIP-1α to mobilize progenitors
48. Kinetic investigation of chemokine truncation by CD26/dipeptyl peptidase IV reveals a striking selectivity within chemokine family
49. Stromal cell-derived factor-I α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: Potential mechanism for cooperative induction of chemotaxis
50. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: Stromal cell-derived factor-I, steel factor, and the bone marrow environment
51. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
52. + cells in response to chemokines
53. Human mast cells transmigrate through human umbilical vein endothelial monolayers and selectively produce IL-8 in response to stromal cell-derived factor-Iα
54. Endogeneous interleukin-8 (IL-8) surge in granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization
55. + cells and their transmigration through reconstituted basement membrane
56. + cells: Role in transendothelial/stromal migration and engraftment of NOD/SCID mice
57. + cell proliferation in synergy with cytokines: Possible role in progenitor survival
58. Stromal-derived factor I inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice
59. Enhanced myelopoiesis in SDF-I-transgenic mice: SDF-I modulates myelopoiesis by regulating progenitor cell survival and inhibitory effects of myelosuppressive chemokines
60. The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not Flt-3 ligand
61. Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition and interactions with normal and leukemic cells
62. Stromal cell-derived factor I (SDF-I) and antenatal human B cell lymphopoiesis: Expression of SDF-I by mesothelial cells and biliary ductal plate epithelial cells
63. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
64. + cell count in human immunodeficiency virus type I-infected individuals