-
1
-
-
0027163065
-
Hematologic abnormalities in children with Down syndrome
-
Roizen NJ, Amarose AP. Hematologic abnormalities in children with Down syndrome. Am J Med Genet. 1993;46:510-512.
-
(1993)
Am J Med Genet
, vol.46
, pp. 510-512
-
-
Roizen, N.J.1
Amarose, A.P.2
-
2
-
-
0029987146
-
Peripheral blood cell counts in infants with Down's syndrome
-
Kivivuori SM, Rajantie J, Siimes MA. Peripheral blood cell counts in infants with Down's syndrome. Clin Genet. 1996;49:15-19.
-
(1996)
Clin Genet
, vol.49
, pp. 15-19
-
-
Kivivuori, S.M.1
Rajantie, J.2
Siimes, M.A.3
-
3
-
-
0942287758
-
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
-
Gurbuxani S, Vyas P, Crispino JD. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood. 2004;103:399-406.
-
(2004)
Blood
, vol.103
, pp. 399-406
-
-
Gurbuxani, S.1
Vyas, P.2
Crispino, J.D.3
-
4
-
-
0037906527
-
Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder
-
Groet J, McElwaine S, Spinelli M, et al. Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet. 2003;361:1617-1620.
-
(2003)
Lancet
, vol.361
, pp. 1617-1620
-
-
Groet, J.1
McElwaine, S.2
Spinelli, M.3
-
5
-
-
0038142390
-
Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis
-
Mundschau G, Gurbuxani S, Gamis AS, Greene ME, Arceci RJ, Crispino JD. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood. 2003;101:4298-4300.
-
(2003)
Blood
, vol.101
, pp. 4298-4300
-
-
Mundschau, G.1
Gurbuxani, S.2
Gamis, A.S.3
Greene, M.E.4
Arceci, R.J.5
Crispino, J.D.6
-
6
-
-
0042243593
-
Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21
-
Rainis L, Bercovich D, Strehl S, et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood. 2003;102:981-986.
-
(2003)
Blood
, vol.102
, pp. 981-986
-
-
Rainis, L.1
Bercovich, D.2
Strehl, S.3
-
7
-
-
0141889275
-
Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome
-
Xu G, Nagano M, Kanezaki R, et al. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome. Blood. 2003;102:2960-2968.
-
(2003)
Blood
, vol.102
, pp. 2960-2968
-
-
Xu, G.1
Nagano, M.2
Kanezaki, R.3
-
8
-
-
0036727413
-
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
-
Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 2002;32:148-152.
-
(2002)
Nat Genet
, vol.32
, pp. 148-152
-
-
Wechsler, J.1
Greene, M.2
McDevitt, M.A.3
-
9
-
-
0033780541
-
The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
-
Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol. 2000;110:512-524.
-
(2000)
Br J Haematol
, vol.110
, pp. 512-524
-
-
Lange, B.1
-
10
-
-
0029558618
-
Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor
-
Calligaris R, Bottardi S, Cogoi S, Apezteguia I, Santoro C. Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor. Proc Natl Acad Sci U S A. 1995;92:11598-11602.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 11598-11602
-
-
Calligaris, R.1
Bottardi, S.2
Cogoi, S.3
Apezteguia, I.4
Santoro, C.5
-
11
-
-
33749021334
-
A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia
-
Majewski IJ, Metcalf D, Mielke LA, et al. A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc Natl Acad Sci U S A. 2006;103:14146-14151.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 14146-14151
-
-
Majewski, I.J.1
Metcalf, D.2
Mielke, L.A.3
-
12
-
-
20044381309
-
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
-
Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005;37:613-619.
-
(2005)
Nat Genet
, vol.37
, pp. 613-619
-
-
Li, Z.1
Godinho, F.J.2
Klusmann, J.H.3
Garriga-Canut, M.4
Yu, C.5
Orkin, S.H.6
-
13
-
-
33745579586
-
An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis
-
Hollanda LM, Lima CS, Cunha AF, et al. An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis. Nat Genet. 2006;38:807-812.
-
(2006)
Nat Genet
, vol.38
, pp. 807-812
-
-
Hollanda, L.M.1
Lima, C.S.2
Cunha, A.F.3
-
14
-
-
7444231620
-
A chromosome 21 critical region does not cause specific Down syndrome phenotypes
-
Olson LE, Richtsmeier JT, Leszl J, Reeves RH. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science. 2004;306:687-690.
-
(2004)
Science
, vol.306
, pp. 687-690
-
-
Olson, L.E.1
Richtsmeier, J.T.2
Leszl, J.3
Reeves, R.H.4
-
15
-
-
0030061554
-
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
-
Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996;84:321-330.
-
(1996)
Cell
, vol.84
, pp. 321-330
-
-
Okuda, T.1
van Deursen, J.2
Hiebert, S.W.3
Grosveld, G.4
Downing, J.R.5
-
16
-
-
0032822953
-
The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance
-
Downing JR. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance. Br J Haematol. 1999;106:296-308.
-
(1999)
Br J Haematol
, vol.106
, pp. 296-308
-
-
Downing, J.R.1
-
17
-
-
0029019659
-
AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia
-
Nucifora G, Rowley JD. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood. 1995;86:1-14.
-
(1995)
Blood
, vol.86
, pp. 1-14
-
-
Nucifora, G.1
Rowley, J.D.2
-
18
-
-
0032830638
-
Haplo-insufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
-
Song WJ, Sullivan MG, Legare RD, et al. Haplo-insufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet. 1999;23:166-175.
-
(1999)
Nat Genet
, vol.23
, pp. 166-175
-
-
Song, W.J.1
Sullivan, M.G.2
Legare, R.D.3
-
19
-
-
24744468832
-
The protooncogene ERG in megakaryoblastic leukemias
-
Rainis L, Toki T, Pimanda JE, et al. The protooncogene ERG in megakaryoblastic leukemias. Cancer Res. 2005;65:7596-7602.
-
(2005)
Cancer Res
, vol.65
, pp. 7596-7602
-
-
Rainis, L.1
Toki, T.2
Pimanda, J.E.3
-
20
-
-
0033980511
-
Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice
-
Richtsmeier JT, Baxter LL, Reeves RH. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn. 2000;217:137-145.
-
(2000)
Dev Dyn
, vol.217
, pp. 137-145
-
-
Richtsmeier, J.T.1
Baxter, L.L.2
Reeves, R.H.3
-
21
-
-
0036467052
-
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome
-
Richtsmeier JT, Zumwalt A, Carlson EJ, Epstein CJ, Reeves RH. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet. 2002;107:317-324.
-
(2002)
Am J Med Genet
, vol.107
, pp. 317-324
-
-
Richtsmeier, J.T.1
Zumwalt, A.2
Carlson, E.J.3
Epstein, C.J.4
Reeves, R.H.5
-
22
-
-
0029114706
-
A mouse model for Down syndrome exhibits learning and behaviour deficits
-
Reeves RH, Irving NG, Moran TH, et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet. 1995;11:177-184.
-
(1995)
Nat Genet
, vol.11
, pp. 177-184
-
-
Reeves, R.H.1
Irving, N.G.2
Moran, T.H.3
-
23
-
-
0027719985
-
Segmental trisomy as a mouse model for Down syndrome
-
Davisson MT, Schmidt C, Reeves RH, et al. Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-133.
-
(1993)
Prog Clin Biol Res
, vol.384
, pp. 117-133
-
-
Davisson, M.T.1
Schmidt, C.2
Reeves, R.H.3
-
24
-
-
33749576059
-
Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model
-
Moore CS. Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mamm Genome. 2006;17:1005-1012.
-
(2006)
Mamm Genome
, vol.17
, pp. 1005-1012
-
-
Moore, C.S.1
-
25
-
-
33748191708
-
The growth capacity of bone marrow CD34 positive cells in culture is drastically reduced in a murine model of Down syndrome
-
Jablonska B, Ford D, Trisler D, Pessac B. The growth capacity of bone marrow CD34 positive cells in culture is drastically reduced in a murine model of Down syndrome. C R Biol. 2006;329:726-732.
-
(2006)
C R Biol
, vol.329
, pp. 726-732
-
-
Jablonska, B.1
Ford, D.2
Trisler, D.3
Pessac, B.4
-
26
-
-
33845436745
-
The myeloproliferative disorders
-
Campbell PJ, Green AR. The myeloproliferative disorders. N Engl J Med. 2006;355:2452-2466.
-
(2006)
N Engl J Med
, vol.355
, pp. 2452-2466
-
-
Campbell, P.J.1
Green, A.R.2
-
28
-
-
0036660179
-
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
-
Kogan SC, Ward JM, Anver MR, et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002;100:238-245.
-
(2002)
Blood
, vol.100
, pp. 238-245
-
-
Kogan, S.C.1
Ward, J.M.2
Anver, M.R.3
-
29
-
-
33646546386
-
The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation
-
Jamieson CH, Gotlib J, Durocher JA, et al. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006;103:6224-6229.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6224-6229
-
-
Jamieson, C.H.1
Gotlib, J.2
Durocher, J.A.3
-
30
-
-
3943088431
-
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
-
Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351:657-667.
-
(2004)
N Engl J Med
, vol.351
, pp. 657-667
-
-
Jamieson, C.H.1
Ailles, L.E.2
Dylla, S.J.3
-
31
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365:1054-1061.
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
-
32
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
33
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387-397.
-
(2005)
Cancer Cell
, vol.7
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
-
34
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-1790.
-
(2005)
N Engl J Med
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
-
35
-
-
20744460045
-
Identification of an acquired JAK2 mutation in polycythemia vera
-
Zhao R, Xing S, Li Z, et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005;280:22788-22792.
-
(2005)
J Biol Chem
, vol.280
, pp. 22788-22792
-
-
Zhao, R.1
Xing, S.2
Li, Z.3
-
36
-
-
33745713168
-
Activating alleles of JAK3 in acute megakaryoblastic leukemia
-
Walters DK, Mercher T, Gu TL, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006;10:65-75.
-
(2006)
Cancer Cell
, vol.10
, pp. 65-75
-
-
Walters, D.K.1
Mercher, T.2
Gu, T.L.3
-
37
-
-
0025350375
-
The Philadelphia chromosome translocation: A paradigm for understanding leukemia
-
Rowley JD. The Philadelphia chromosome translocation: a paradigm for understanding leukemia. Cancer. 1990;65:2178-2184.
-
(1990)
Cancer
, vol.65
, pp. 2178-2184
-
-
Rowley, J.D.1
-
38
-
-
33644759290
-
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling
-
Bourquin JP, Subramanian A, Langebrake C, et al. Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proc Natl Acad Sci U S A. 2006;103:3339-3344.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3339-3344
-
-
Bourquin, J.P.1
Subramanian, A.2
Langebrake, C.3
-
39
-
-
28844486209
-
Intrinsic abnormalities of lymphocyte counts in children with down syndrome
-
de Hingh YC, van der Vossen PW, Gemen EF, et al. Intrinsic abnormalities of lymphocyte counts in children with down syndrome. J Pediatr. 2005;147:744-747.
-
(2005)
J Pediatr
, vol.147
, pp. 744-747
-
-
de Hingh, Y.C.1
van der Vossen, P.W.2
Gemen, E.F.3
-
40
-
-
38349185425
-
A genome-wide retroviral insertional mutagenesis screen for genes cooperating with truncated, oncogenic GATA1s. Blood
-
Li Z, Klusmann J-H, Godinho FJ, Lee H-W, Reinhardt D, Orkin SH. A genome-wide retroviral insertional mutagenesis screen for genes cooperating with truncated, oncogenic GATA1s. Blood. 2005;106:2990 [abstract].
-
(2005)
2990 [abstract]
, vol.106
-
-
Li, Z.1
Klusmann, J.-H.2
Godinho, F.J.3
Lee, H.-W.4
Reinhardt, D.5
Orkin, S.H.6
-
41
-
-
4444347949
-
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome
-
Taub JW, Mundschau G, Ge Y, et al. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood. 2004;104:1588-1589.
-
(2004)
Blood
, vol.104
, pp. 1588-1589
-
-
Taub, J.W.1
Mundschau, G.2
Ge, Y.3
|