Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

Journal of Clinical Investigation

Volumn 105, Issue 4, 2000, Pages 423-432

  Tomasson, Michael H ^a   Sternberg, David W ^a   Williams, Ifor R ^b   Carroll, Martin ^c   Cain, Danielle ^a,d   Aster, Jon C ^a   Ilaria Jr , Robert L ^d   Van Etten, Richard A ^e   Gilliland, D Gary ^a,f,g  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e CENTER FOR BLOOD RESEARCH   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^g HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; DISEASE ASSOCIATION; HISTOPATHOLOGY; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033999917     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8902     Document Type: Article

References (30)

1. Golub, T.R., Barker, G.F., Lovett, M., and Gilliland, D.G. 1994. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 77:307-316.
2. Lichtman, M.A., and Brennan, J.K. 1983. Dyshemopoietic (preleukemic) disorders. In Hematology. 3rd edition. W.J. Williams, E. Beutler, A.J. Ersley, and M.A. Lichtman, editors. McGraw-Hill. New York, NY. 175-184.
3. Carroll, M., Tomasson, M., Barker, G.F., Golub, T.R., and Gilliland, D.G. 1996. The TEL-PDGFβR fusion protein dimerizes and transforms hematopoietic cells through acrivation of PDGFβR dependent signaling pathways. Proc. Natl. Acad. Sci. USA, 93:14845-14850.
4. Claesson-Welsh, L. 1994. Platelet-derived growth factor receptor signals. J. Biol. Chem. 269:32023-32026.
5. Heldin, C.-H., Östman, A., and Rönnstrand, L. 1998. Signal transduction via platelet-derived growth factor receptors. Biochem. Biophys. Acta. 1378:79-113.
6. Valius, M., and Kazlauskas, A. 1993. Phospholipase C-gammal and phospharidyhnositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 73:321-334.
7. Hawley, R.G., Fong, A.Z., Burns, B.F., and Hattley, T.S. 1992. Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J. Exp. Med. 176:1149-1163.
8. Miller, A., and Rosman, G. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques. 7:980-990.
9. Davis, R.W. 1980. Rapid DNA isolations for encymatic and hybridization analysis. Methods Enzymol. 65:404-411.
10. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY. 9.31-9.57.
11. Tomasson, M.H., et al. 1999. TEL/PDGFβR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor. Blood. 93:1707-1714.
12. Ritchie, K., et al. 1999. The tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice. Leukemia. 13:1790-1803.
13. Lerza, R., Castello, G., Sessarego, M., Cavallini, D., and Pannacciulli, I. 1992. Myelodysplastic syndrome associated with increased bone marrow-fibrosis and translocation (5;12;(q33;p12-13). Br. J. Haematol. 82:476-477.
14. Wessels, J.W., et al. 1993. t(5;12)(q31;p12): a clinical entity with features of both myeloid leukemia and chronic myelomonocytic leukemia. Cancer Genet. Cytogenet. 65:7-11.
15. Hawley, R.G., Lieu, H.H., Fong, A.Z., and Hawley, T.S. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1:136-138.
16. Daley, G.Q., Van Etten, R.A., and Baltimore, D. 1990. Induction of chronic myelogenous leukemia in mice by the p210 bcr/abl gene of the Philadelphia chromosome. Science: 247:824-830.
17. Schwaller, J., et al. 1998. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myeloid- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion gene. EMBO J. 17:5321-5333.
18. Westervelt, P., and Ley, T.J. 1999. Seed vs. soil: the importance of the target cell for transgenic models of human leukemias. Blood. 93:2143-2148.
19. Ross, T.S., Bernard, O.A., Berger, R., and Gilliland, D.G. 1998. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor β receptor (PDGFβR) in chronic myelomonocyte leukemia with t(5;7)(q33;q11.2). Blood. 91:4419-4426.
20. Anastasiadou, E., et al. 1999. H4(10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor β receptor (PDGFβR) gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22). Blood. 94(Suppl. 1):51a. (Abstr.)
21. Mori, S., et al. 1993. Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with Src family tyrosine kinases. EMBO J. 12:2257-2264.
22. Valgeirsdottir, S., Paukku, K., Silvennoinen, O., Heldin, C.-H., and Claeson-Welsh, L. 1998. Activation of STAT5 by platelet-derived growth factor (PDGF) is dependent on phosphorylarion sites in PDGF β-receptor juxtamembrane and kinase insert domains. Oncogene. 16:505-515.
23. Sachsenmaier, C., Sadowski, H.B., and Cooper, J.A. 1999. STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene. 18:3583-3592.
24. Barone, M.V., and Courtneidge, S.A. 1995. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature. 378:509-512.
25. Bourgeade, M.-F., Défachelles, A.-S., and Cayre, Y.E. 1998. Myc is essential for transformation by TEL/platelet-derived growth factor receptor β (PDGFRβ). Blood. 91:3333-3339.
26. Carlesso, N., Frank, D., and Griffin, J. 1996. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J. Exp. Med. 183:811-820.
27. Okuda, K., Gollub, T.R., Gilliland, D.G., and Griffin, J. 1996. p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. Oncogene. 13:1147-1152.
28. Ross, T.S., and Gilliland, D.G. 1999. Transforming properties of the Huntingtin interacting protein 1/platelet-derived growth factor β receptor fusion protein. J. Biol. Chem. 274:22328-22336.
29. Schwaller, J., et al. 1999. Stat5a/b, but not Stat1, is essential for induction of a lethal myelo- and lymphoproliferative disease in mice by the TEL/JAK2 fusion protein associated with human leukemia. Blood. 94(Suppl. 1):380a. (Absrr.)
30. Fambrough, D., McClurr, K., Kazlauskas, A., and Lander, E.S. 1999. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97:727-741.