Adaptor protein Lnk associates with Tyr568 in c-Kit

Biochemical Journal

Volumn 415, Issue 2, 2008, Pages 241-245

  Gueller, Saskia ^a,b   Gery, Sigal ^a   Nowak, Verena ^a   Liu, Liqin ^c   Serve, Hubert ^b   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c AMGEN INC   (United States)

Author keywords

Adaptor protein; c Kit; Lnk; Protein protein interaction; Receptor tyrosine kinase; Signal transduction

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; CELLS; COBALT; COBALT COMPOUNDS; ENZYME INHIBITION; PEPTIDES; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION;

ADAPTOR PROTEIN; ADAPTOR PROTEINS; ANIMAL MODELS; C-KIT; CYTOKINE RECEPTORS; CYTOKINES; DIFFERENT DOMAINS; DOWNSTREAM; ERYTHROPOIETIN RECEPTORS; FUSION PROTEINS; GLUTATHIONE TRANSFERASES; GROWTH FACTORS; IMMUNOPRECIPITATION; JUXTAMEMBRANE DOMAINS; LNK; PHOSPHORYLATED TYROSINES; PHOSPHOTYROSINE RESIDUES; POINT MUTATIONS; RECEPTOR TYROSINE KINASE; SH2 DOMAINS; SIGNALLING PATHWAYS; SRC HOMOLOGY 2; STEM CELL FACTORS; STRUCTURAL MOTIFS; TRANSDUCING;

BINDING SITES;

ADAPTOR PROTEIN; GLUTATHIONE TRANSFERASE; LINKER OF T CELL RECEPTOR PATHWAYS PROTEIN; PHENYLALANINE; PHOSPHOTYROSINE; STEM CELL FACTOR RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MUTANT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

CELL LINE; HUMANS; IMMUNOPRECIPITATION; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; SRC HOMOLOGY DOMAINS; TYROSINE;

ANIMALIA;

EID: 54049113023     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080102     Document Type: Article

References (21)

1. Qiu, F. H., Ray, P., Brown, K., Barker, P. E., Jhanwar, S., Ruddle, F. H. and Besmer, P. (1988) Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J. 7, 1003-1011
2. Yarden, Y., Kuang, W. J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., Chen, E., Schlessinger, J., Francke. U. and Ullrich, A. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6, 3341-3351
3. Lennartsson, J., Jelacic, T., Linnekin, D. and Shivakrupa, R. (2005) Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 23, 16-43
4. Roskoski, Jr, R. (2005) Signaling by Kit protein-tyrosine kinase: the stem cell factor receptor. Biochem. Biophys. Res. Commun. 337, 1-13
5. Ema, H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, K., Takaki, S. and Nakauchi, H. (2005) Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8, 907-914
6. Nobuhisa, I., Takizawa, M., Takaki, S., Inoue, H., Okita, K., Ueno, M., Takatsu. K. and Taga, T. (2003) Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol. Cell. Biol. 23, 8486-8494
7. Takaki, S., Sauer, K., Iritani, B. M., Chien, S., Ebihara, Y., Tsuji, K.. Takatsu, K. and Perlmutter, R. M. (2000) Control of B cell production by the adaptor protein Ink: definition of a conserved family of signal-modulating proteins. Immunity 13, 599-609
8. Takaki, S., Morita, H., Tezuka, Y. and Takatsu, K. (2002) Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J. Exp. Med. 195, 151-160
9. Takaki, S., Tezuka, Y., Sauer, K., Kubo, C., Kwon, S. M., Armstead, E., Nakao, K., Katsuki, M., Perlmutter, R. M. and Takatsu, K. (2003) Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein. J. Immunol. 170, 703-710
10. Velazquez, L., Cheng, A. M., Fleming, H. E., Furlonger, C., Vesely, S., Bernstein, A., Paige, C. J. and Pawson, T. (2002) Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J. Exp. Med. 195, 1599-1611
11. Tong, W., Zhang, J. and Lodish, H. F. (2005) Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood 105, 4604-4612
12. Tong, W. and Lodish. H. F. (2004) Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J. Exp. Med. 200, 569-580
13. Huang, X., Li, Y., Tanaka, K., Moore, K. G. and Hayashi, J. I. (1995) Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase Cy1, Grb2, and phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U.S.A. 92, 11618-11622
14. Li, Y., He, X., Schembri-King, J., Jakes, S. and Hayashi, J. (2000) Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J. Immunol. 164, 5199-5206
15. Takaki, S., Watts. J. D., Forbush, K. A., Nguyen, N. T., Hayashi, J., Alberola-Ila, J., Aebersold, R. and Perlmutter, R. M. (1997) Characterization of Lnk. An adaptor protein expressed in lymphocytes. J. Biol. Chem. 272, 14562-14570
16. Wollberg, P., Lennartsson, J., Gottfridsson, E., Yoshimura, A. and Ronnstrand, L. (2003) The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem. J. 370, 1033-1038
17. Roskoski, Jr, R. (2005) Structure and regulation of Kit protein-tyrosine kinase: the stem cell factor receptor. Biochem. Biophys. Res. Commun. 338, 1307-1315
18. Kozlowski, M., Larose, L., Lee, F., Le, D. M., Rottapel, R. and Siminovitch, K. A. (1998) SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol. Cell. Biol. 18, 2089-2099
19. Levkowitz, G., Waterman, H., Ettenberg. S. A., Katz, M., Tsygankov, A. Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A. et al. (1999) Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1, Mol. Cell 4, 1029-1040
20. Yokouchi, M., Wakioka, T., Sakamoto, H., Yasukawa, H., Ohtsuka, S., Sasaki, A., Ohtsubo, M., Valius, M., Inoue, A., Komiya, S. and Yoshimura, A. (1999) APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. Oncogene 18, 759-767
21. 936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem. J. 399, 59-67