Retinoid receptors in health and disease: Co-regulators and the chromatin connection

Seminars in Cell and Developmental Biology

Volumn 10, Issue 2, 1999, Pages 215-225

  Minucci, Saverio ^a   Pelicci, Pier Giuseppe ^a,b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Histone acetylation; Nuclear co activators; Nuclear co repressors; Retinoids; RXR RAR heterodimers

Indexed keywords

ACYLTRANSFERASE; DNA; DNA BINDING PROTEIN; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; LIGAND; NUCLEAR PROTEIN; NUCLEAR RECEPTOR CO REPRESSOR 1; NUCLEAR RECEPTOR CO REPRESSOR 2; NUCLEAR RECEPTOR CO-REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 2; ONCOPROTEIN; REPRESSOR PROTEIN; RETINOIC ACID RECEPTOR; RETINOID; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSACTIVATOR PROTEIN;

ACETYLATION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHEMISTRY; CHROMATIN; DIMERIZATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; NUCLEOSOME; PHYSIOLOGY; PROMYELOCYTIC LEUKEMIA; PROTEIN PROCESSING; REGULATORY SEQUENCE; REVIEW; ULTRASTRUCTURE;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; BINDING SITES; CHROMATIN; DIMERIZATION; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, LEUKEMIC; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, GENETIC; NUCLEAR PROTEINS; NUCLEOSOMES; ONCOGENE PROTEINS, FUSION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, RETINOIC ACID; REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; RETINOIDS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC;

EID: 0033109775     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.1999.0303     Document Type: Article

References (97)

1. Beato M, Herrlich P, Schütz G (1995) Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
2. Chambon P (1996) A decade of molecular biology of retinoid receptors. FASEB J 10:940-954
3. Mangelsdorf DJ, Evans RM (1995) The RXR heterodimers and orphan receptors. Cell 83:841-850
4. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans P (1995) The nuclear hormone receptor superfamily: the second decade. Cell 83:835-840
5. Minucci S, Ozato K (1996) Retinoid receptors in transcriptional regulation. Curr Opin Gen Dev 6:567-574
6. Perlmann T, Evans RM (1997) Nuclear receptors in Sicily: all in the famiglia. Cell 90:391-397.
7. Blumberg B, Evans RM (1998) Orphan nuclear receptors-new ligands and new possibilities. Genes Dev 12:3149-3155
8. Kastner P, Mark M, Chambon P (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their roles in real life? Cell 83:859-871
9. Glass CK, Rose DW, Rosenfeld MG (1997) Nuclear receptor coactivators. Curr Opin Cell Biol 9:222-232.
10. Torchia J, Glass C, Rosenfeld MG (1998) Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol 10:373-383
11. Alland L, Muhle R, Hou H, Chin L, Schreiber-Agus N, DePinho RA (1997) Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387:49-55
12. Chen D, Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457
13. Heinzel T, Lavinsky R, Mullen T-M, Soderstrom M, Laherty CD, Torchia J, Yang W, Brard G, Ngo S, Davie JR, Seto E, Eisenmann RN, Rose DW, Glass CK, Rosenfeld MG (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387:43-49
14. Horlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-403
15. Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89:373-380
16. Sande S, Privalsky, ML (1996) Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. Mol Endocrinol 10:813-825
17. Pazin MJ, Kadonaga JT (1997) What's up and down with histone deacetylation and transcription? Cell 89:325-328
18. Wolffe AP (1997) Sinful repression. Nature 387:16-17
19. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580
20. Oñate SA, Tsai SY, Tsai M-J, O'Malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357
21. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387:677-684
22. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996) A CBP Integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414
23. Blanco JC, Minucci S, Lu J, Yang XJ, Walker KK, Chen H, Evans RM, Nakatani Y, Ozato K (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev 12:1638-1651
24. Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279:703-707
25. vom Baur E, Harbers M, Um SJ, Benecke A, Chambon P, Losson R (1998) The yeast Ada complex mediates the ligand-dependent activation function AF-2 of retinoid X and estrogen receptors. Genes Dev 12:1278-1289
26. Muchardt C, Yaniv M (1993) A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J 12:4279-4290
27. Yoshinaga SK, Peterson C, Herskowitz I, Yamamoto KR (1992) Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Science 258:1598-1604
28. Schwabe JWR (1996) How nuclear receptors get turned on. Curr Biol 6:372-374
29. Wurtz J-M, Bourguet W, Renaud J-P, Vivat V, Chambon P, Moras D, Gronemeyer H (1996) A canonical structure for the ligand-binding domain of nuclear receptors. Nat Struct Biol 3:87-94
30. Hager GL, Smith CL, Fragoso G, Wolford R, Walker D, BarsonyJ, Htun H (1998) Intranuclear trafficking and gene targeting by members of the steroid/nuclear receptor superfamily. J Steroid Biochem Mol Biol 65:125-132
31. Zhu X-G, Hanover JA, Hager GL, Cheng S-Y (1998) Hormone-induced translocation of thyroid hormone receptors in living cells visualized using a receptor green fluorescent protein chimera. J Biol Chem 273:27058-27063
32. Dong D, Noy N (1998) Heterodimer formation by retinoid X receptor: regulation by ligands and by the receptor's self-association properties. Biochemistry 37:10691-10700
33. Chen JY, Clifford J, Zusi C, Starrett JE, Tortolani D, Ostrowski J, Reczek P, Chambon P, Gronemeyer H (1996) Two distinct actions of retinoid-receptor ligands. Nature 382:819-822
34. Dey A, Minucci S, Ozato K (1994) Ligand-dependent occupancy of the retinoic acid receptor-β 2 promoter in vivo. Mol Cell Biol 12:3590-3599
35. Minucci S, Zand DJ, Dey A, Marks MS, Nagata T, Grippo JF, Ozato K (1994) Dominant negative retinoid X receptor β inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells. Mol Cell Biol 14:360-372
36. Minucci S, Leid M, Toyama R, Saint-Jeannet J-P, Peterson V, Horn V, Ismael J, Bhattacharyya N, Dey A, Dawid IB, Ozato K. (1997) RXR within the RXR-RAR heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol Cell Biol 17:644-655
37. Wolffe AP, Wong J, Pruss D (1997) Activators and repressers: making use of chromatin to regulate transcription. Genes Cells 2:291-302
38. Wong J, Shi YB, Wolffe AP (1995) A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor. Genes Dev 9:2696-2711
39. Minucci S, Wong J, Blanco JC, Shi YB, Wolffe AP, Ozato K (1998) Retinoid receptor-induced alteration of the chromatin assembled on a ligand-responsive promoter in Xenopus oocytes. Mol Endocrinol 12:315-324
40. Becker PB (1995) Drosophila chromatin and transcription. Semin Cell Biol 6:185-190
41. Fryer CJ, Archer, TK (1998) Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nature 393:88-91
42. Grant PA, Duggan L, Cote J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11:1640-1650
43. Grant PA, Sterner DE, Duggan LJ, Workman JL, Berger SL (1998) The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes. Trends Cell Biol 8:193-197
44. LeRoy G, Orphanides G, Lane WS, Reinberg D (1998) Requirement of RSF and FACT for transcription of chromatin templates in vitro. Science 282:1900-1904
45. Kraus WL, Kadonaga, JT (1998) p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. Genes Dev 12:331-342
46. Fondell JD, Ge H, Roeder RG (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci USA 93:8329-8333
47. Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP (1998) A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev 12:1787-1800
48. Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (1998) The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Nad Acad Sci USA 95:7939-7944
49. Almouzni G, Wolffe AP (1993) Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo. Genes Dev 7:2033-2047
50. Wong J, Shi YB, Wolffe AP (1997) Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptional activation. Embo J 16:3158-3171
51. Bhattacharyya N, Dey A, Minucci S, Zimmer A, John S, Hager G, Ozato K (1997) Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter. Mol Cell Biol 17:6481-6490
52. Truss M, Bartsch J, Schelbert A, Hache RJ, Beato M (1995) Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. Embo J 14:1737-1751
53. Lee HL, Archer TK (1998) Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter. Embo J 17:1454-1466
54. Fragoso G, John S, Roberts MS, Hager GL (1995) Nucleosome positioning on the MMTV LTR results from the frequency-biased occupancy of multiple frames. Genes Dev 9:1933-1947
55. Venditti P, Di Croce L, Kauer M, Blank T, Becker PB, Beato M (1998) Assembly of MMTV promoter minichromosomes with positioned nucleosomes precludes NF1 access but not restriction enzyme cleavage. Nucleic Acids Res 26:3657-3666
56. Liu M, Iavarone A, Freedman LP (1996) Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J Biol Chem 271:31723-31728
57. Langston AW, Gudas LJ (1992) Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech Dev 38:217-227
58. Heery DM, Kalkhoven E, Hoare S, Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736
59. Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (1998) Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev 12:3488-3498
60. Zwijsen RM, Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides RJ (1997) CDK-independent activation of estrogen receptor by cyclin D1. Cell 88:405-415
61. Anzick SL, KononenJ, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965-968
62. Kurokawa R, Kalafus D, Ogliastro MH, Kioussi C, Xu L, Torchia J, Rosenfeld, MG, Glass CK (1998) Differential use of CREB binding protein-coactivator complexes. Science 279:700-703
63. Kawasaki H, Eckner R, Yao TP, Taira K, Chiu R, Livingston DM, Yokoyama KK (1998) Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature 393:284-289
64. Puri PL, Sartorelli V, Yang XJ, Hamamori Y, Ogryzko VV, Howard BH, Kedes L, Wang JY, Graessmann A, Nakatani Y, Levrero M (1997) Differential roles of p300 and PCAF acetyl-transferases in muscle differentiation. Mol Cell 1:35-45
65. Davie JR (1998) Covalent modifications of histones: expression from chromatin templates. Curr Opin Genet Dev 8:173-178
66. Turner BM, O'Neill LP (1995) Histone acetylation in chromatin and chromosomes. Semin Cell Biol 6:229-236
67. Zamir I, Zhang J, Lazar MA (1997) Stoichiometric and steric principles governing repression by nuclear hormone receptors. Genes Dev 11:835-846
68. Lavinsky RM, Jepsen K, Heinzel T, Torchia J, Mullen TM, Schiff R, Del-Rio AL, Ricote M, Ngo S, Gemsch J, Hilsenbeck SG, Osborne CK, Glass CK, Rosenfeld MG, Rose DW (1998) Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proc Natl Acad Sci USA 95:2920-2925
69. Zhang J, Guenther MG, Carthew RW, Lazar MA (1998) Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev 12:1775-1780
70. Soderstrom M, Vo A, Heinzel T, Lavinsky RM, Yang WM, Seto E, Peterson DA, Rosenfeld MG, Glass CK (1997) Differential effects of nuclear receptor corepressor (N-CoR) expression levels on retinoic acid receptor-mediated repression support the existence of dynamically regulated corepressor complexes. Mol Endocrinol 11:682-692
71. Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL (1998) The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937
72. Hassig C, Fleischer T, Billin A, Schreiber S, Ayer D (1997) Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89:341-348
73. Guidez F, Ivins S, Zhu J, Soderstrom M, Waxman S, Zelent A (1998) Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91:2634-2642
74. Hong SH, David G, Wong CW, Dejean A, Privalsky ML (1997) SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:9028-9033
75. Lin RJ, Nagy L, Inoue S, Shao W, Miller WH Jr, Evans RM (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811-814
76. Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (1998) SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell 2:33-42
77. Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998) Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 395:917-921
78. Xue Y, Wong J, Moreno GT, Young MK, Cote J, Wang W (1998) NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 2:851-861
79. Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998) The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell 95:279-289
80. Yoshida M, Horinouchi S, Beppu T (1995) Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17:423-430
81. Wong J, Patterton D, Imhof A, Guschin D, Shi YB, Wolffe AP (1998) Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. Embo J 17:520-534
82. Minucci S, Horn V, Bhattacharyya N, Gabriele L, Ogryzko V, Howard B, Ozato K (1997) A historic deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Proc Natl Acad Sci USA 94:11295-11300
83. Fondell JD, Brunei F, Hisatake K, Roeder RG (1996) Unliganded thyroid hormone receptor alpha can target TATA-binding protein for transcriptional repression. Mol Cell Biol 16:281-287
84. Fondell JD, Roy AL, Roeder RG (1993) Unliganded Thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for gene repression. Genes Dev 7:1400-1410
85. Wong CW, Privalsky ML (1998) Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. Mol Cell Biol 18:5500-5510
86. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389
87. Parkhurst SM (1998) Groucho: making its Marx as a tran-scriptional co-repressor. Trends Genet 14:130-132
88. Chen Z, Brand N, Chen A, Tong J, Wang Z, Waxman S, Zelent A (1993) Fusion between a novel Krüppel-like zinc finger gene and retinoic acid receptor - a locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 12:1161-1167
89. Grignani F, Fagioli M, Alcalay M, Longo L, Pandolfi PP, Donti E, Biondi A, Lo CF, Grignani F, Pelicci PG (1994) Acute promyelocytic leukemia: from genetics to treatment. Blood 83:10-25
90. Warrell RPJ, de The H, Wang ZY, Degos L (1993) Acute promyelocytic leukaemia. New Engl J Med 324:177-189
91. Grignani F, De MS, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG (1998) Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391:815-818
92. He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP (1998) Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressers determine differential responses to RA in APL. Nat Genet 18:126-135
93. Warrell RP Jr, He LZ, Richon V, Calleja E, Pandolfi PP (1998) Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst 90:1621-1625
94. Hiebert SW, Downing JR, Lenny N, Meyers S (1996) Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO. Curr Top Microbiol Immunol 211:253-258
95. Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, Lazar MA (1998) Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 18:7185-7191
96. Lutterbach B, Westendorf JJ, Linggi B, Patten A, Moniwa M, Davie JR, Huynh KD, Bardwell VJ, Lavinsky RM, Rosenfeld MG, Glass C, Seto E, Hiebert SW (1998) ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 18:7176-7184
97. Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998) ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA 95:10860-10865