Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO

Journal of Immunology

Volumn 160, Issue 9, 1998, Pages 4481-4489

  Abina, Mohammed Amine ^a,d   Tulliez, Micheline ^c   Duffour, Marie Thérèse ^b   Debili, Najet ^a   Lacout, Catherine ^a   Villeval, Jean Luc ^a   Wendling, Françoise ^a   Vainchenker, William ^a   Haddada, Hedi ^b  

^a Inst Natl S et de la Rech Med

^b INSTITUT GUSTAVE ROUSSY   (France)

^c Hôpital Cochin ^*  (France)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; THROMBOPOIETIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CROSS REACTION; DISEASE ASSOCIATION; GENE EXPRESSION; GENE TRANSFER; HUMAN; IMMUNE RESPONSE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; THROMBOCYTOSIS;

ADENOVIRIDAE; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CROSS REACTIONS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MICE; RECOMBINANT PROTEINS; THROMBOCYTOPENIA; THROMBOPOIETIN;

EID: 0032080851     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Ali, M., N. R. Lemoine, and C. J. A. Ring. 1994. The use of DNA viruses as vectors for gene therapy. Gene Ther. 1:367.
2. Horwitz, M. S. 1996. Adenoviridae and their replication. In Virology, 3rd Ed. B. N. Fields, D. M. Knipe, and P. M. Howley, eds. Raven Press, New York, pp. 2149-2171.
3. Yang, Y., F. A. Nunes, K. Berencsi, E. E. Furth, E. Gonczol, and J. M. Wilson. 1994. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407.
4. Yang, Y., H. C. J. Ertl, and J. M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433.
5. Dai, Y., E. Schwarz, D. Gu, W.-W. Zhang, N. Sarvetnick, and I. M. Verma. 1995. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc. Natl. Acad. Sci. USA 92:1401.
6. Yang, Y., L. Qin, H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004.
7. Yang, Y., and J. Wilson. 1996. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273:1862.
8. Juillard, V., P. Villefroy, D. Godfrin, A. Pavirani, A. Venet, and J.-G. Guillet. 1995. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur. J. Immunol. 25:3467.
9. Kay, M. A., A.-X. Holterman, L. Meuse, A. Gown, H. D. Ochs, P. S. Linsley, and C. B. Wilson. 1995. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat. Genet. 11:191.
10. Gahery-Segard, H., V. Juillard, J. Gaston, R. Lengagne, A. Pavirani, P. Boulanger, and J.-G. Guillet. 1997. Humoral immune response to the capsid components of recombinant adenoviruses: routes of immunization modulate virus-induced Ig subclass shifts. Eur. J. Immunol. 27:653.
11. Tripathy, S., H. B. Black, E. Goldwasser, and J. M. Leiden. 1996. Immune response to transgene-encoded proteins limits the stability of gene expression after injection of replication-defective adenovirus vectors. Nat. Med. 2:545.
12. Wendling, F., E. Maraskovsky, N. Debili, C. Florindo, M. Teepe, M. Titeux, N. Methia, J. Breton-Gorius, D. Cosman, and W. Vainchenker. 1994. c-MPL ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571.
13. Casadevall, N., E. Dupuy, P. Molho-Sabatier, G. Tobelem, B. Varet, and P. Mayeux. 1996. Autoantibodies against erythropoietin in a patient with pure red-cell aplasia. N. Engl. J. Med. 334:630.
14. Peces, R., M. De La Torre, R. Alcazar, and J. M. Urra. 1996. Antibodies against recombinant human erythropoietin in a patient with erythropoietin resistant anemia. N. Engl. J. Med. 335:523.
15. Stratford-Perricaudet, L. D., M. Levrero, J.-F. Chasse, M. Perricaudet, and P. Briand. 1990. Evaluation of the transfer and expression in mice of an enzyme encoding gene using a human adenovirus vector. Hum. Gene Ther. 1:241.
16. Gough, N. M., D. Metcalf, J. Gough, D. Grail, and A. R. Dunn. 1985. Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor. EMBO J. 4:645.
17. Ohwada, A., S. Rafii, M. A. S. Moore, and R. G. Crystal. 1996. In vivo adenovirus vector-mediated transfer of the human thrombopoietin cDNA maintains platelet levels during radiation-and chemotherapy-induced bone marrow suppression. Blood 88:778.
18. Guo, Z. S., L.-H. Wang, R. C. Eisensmith, and S. L. C. Woo. 1996. Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer. Gene Ther. 3:802.
19. Gurney, A. L., K. Carver-Moore, F. de Sauvage, and M. W. Moore. 1994. Thrombocytopenia in c-mpl-deficient mice. Science 265:1445.
20. Alexander, W., A. Roberts, N. A. Nicola, R. Li, and D. Metcalf. 1996. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 87:2162.
21. Carver-Moore, K., H. E. Broxmeyer, S. M. Luoh, S. Cooper, J. Peng, S. A. Burstein, M. W. Moore, and F. J. de Sauvage. 1996. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 88: 803.
22. de Sauvage, F. J., K. Carver-Moore, S.-M. Luoh, A. Ryan, M. Dowd, D. L. Eaton, and M. W. Moore. 1996. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183:651.
23. Hassan, N. M. R., and R. S. Neiman. 1985. The pathogeny of the spleen in steroid treated immune thrombocytopenic purpura. Am. J. Clin. Pathol. 84:433.
24. Sungaran, R., B. Markovic, and B. H. Chong. 1997. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 1:101.
25. Theofilopoulos, A. N. 1995. The basis of autoimmunity: part I mechanisms of aberrant sel-recognition. Immunol. Today 16:90.
26. Gianani, R., and N. Sarvetnick. 1996. Viruses, cytokines, antigens, and autoimmunity. Proc. Natl. Acad. Sci. USA 93:2257.
27. Hemmer, B., B. T. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K. H. Wiesmuller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651.
28. Tiensiwakul, P., and N. Khoobbyarian. 1983. Adenovirus fiber protein produces synthesis of interferon in mouse spleen and macrophage culture. Intervirology 20:52.
29. Coutelier, J.-P., J. Van Broeck, and S. F. Wolf. 1996. Interleukin-12 gene expression after viral infection in the mouse. J. Virol. 69:1955.
30. Savertnick, N., J. Shizuru, D. Liggitt, L. Martin, B. McIntyre, A. Gregory, T. Parslow, and T. Stewart. 1990. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 346:844.
31. Trembleau, S., T. Germann, K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
32. Leonard, J. P., K. E. Wadburg, and S. J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381.
33. Von Herrath, M. G., and M. B. A. Oldstone. 1997. Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:531.
34. Bartley, T. D., J. Bogenberger, P. Hunt, Y.-S. Li, H. S. Lu, F. Martin, M.-S. Chang, B. Samal, J. L. Nichol, S. Swift, M. J. Johnson, R.-Y. Hsu, V. P. Parker, S. Suggs, J. D. Skrine, L. A. Merewether, C. Clogston, E. Hsu, M. M. Hokom, A. Hornkohl, E. Choi, M. Pangelinan, Y. Sun, V. Mar, J. McNinch, L. Simonet, F. Jacobsen, C. Xie, J. Shutter, H. Chute, R. Basu, L. Selander, D. Trollinger, L. Sieu, D. Padilla, G. Trail, G. Elliott, R. Izumi, T. Covey, J. Crouse, A. Garcia, W. Xu, J. Del Castillo, J. Biron, S. Cole, M. C.-T. Hu, R. Pacifici, I. Ponting, C. Saris, D. Wen, Y. P. Yung, H. Lin, and R. A. Bosselman. 1994. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117.
35. de Sauvage, F. J., P. E. Hass, S. D. Spencer, B. E. Malloy, A. L. Gurney, S. A. Spencer, W. C. Darbonne, W. J. Henzel, S. C. Wong, W.-J. Kuang, K. J. Oles, B. Hultgren, L. A. Solberg Jr., D. V. Goeddel, and D. L. Eaton. 1994. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533.
36. Ulich, T. R., J. del Castillo, G. Senaldi, O. Kinstler, S. Yin, S. Kaufman, J. Tarpley, E. Choi, T. Kirley, P. Hunt, and W. P. Sheridan. 1996. Systemic hematologic effects of PEG-rHuMGDF-induced megacaryocyte hyperplasia in mice. Blood 87:5006.
37. Hokom, M. M., D. Lancey, O. B. Kinstler, E. Choi, S. Kaufman, J. Faust, C. Rowan, E. Dwyer, J. L. Nichol, T. Grasel, J. Wilson, R. Steinbrink, R. Hecht, D. Winters, T. Boone, and P. Hunt. 1995. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombopenia associated with carboplatin and irradiation in mice. Blood 86:4486.
38. Dale, D. C., J. L. Nichol, D. A. Rich, D. M. Best, S. J. Slichter, W. Sheridan, and P. Hunt. 1997. Chronic thrombocytopenia is induced in dogs by development of cross-reacting antibodies to the Mpl ligand. Blood 90:3456.
39. Bachmann, M. F., and R. M. Zinkernagel. 1996. The influence of virus structure on antibody responses and virus serotype formation. Immunol. Today 17:553.
40. Michou, A. I., L. Santoro, M. Christ, A. Pavirani, and M. Mehtali. 1997. Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression. Gene Ther. 4:473.
41. Wadsworth, S. C., H. Zhou, A. E. Smith, and J. M. Kaplan. 1997. Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo. J. Virol. 71:5189.
42. Field, E. H., Z. X. Ye, and T. M. Rouse. 1996. Mechanisms of tolerance induction, splenocytes from total lymphoid irradiated mice inhibit the IL-2 pathway in TCR-activated CD4 cells. J. Immunol. 157:3796.
43. Jooss, K., Y. Yang, and J. M. Wilson. 1996. Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. Hum. Gene Ther. 7:1555.
44. Lochmuller, H., B. J. Petrof, G. Pari, N. Larochelle, V. Dodelet, Q. Wang, C. Allen, S. Prescott, B. Massie, J. Nalbantoglu, and G. Karpati. 1996. Transient immunosuppression by FK506 permits a sustained high-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscles of adult dystrophic (mdx) mice. Gene Ther. 3:706.
45. Smith, T. A., B. D. White, J. M. Gardner, M. Kaleko, and A. McClelland. 1996. Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther. 3:496.
46. Kolls, J. K., D. Lei, G. Odom, S. Nelson, W. R. Summer, M. A. Gerber, and J. E. Shellito. 1996. Use of transient CD4 lymphocyte depletion to prolong trans-gene expression of E1-deleted adenoviral vectors. Hum. Gene Ther. 7:489.
47. Kiefel, V., S. Santoso, and C. Mueller-Eckhardt. 1992. Serological, biochemical, and molecular aspects of platelet autoantigens. Semin. Hematol. 29:26.
48. Nichol, J. L. 1997. Serum levels of thrombopoietin in health and disease. In Thrombopoiesis and Thrombopoietins. D. J. Kuter, P. Hunt, W. Sheridan, and D. S. Zucker-Franklin, eds. Humana Press, Totowa, pp. 359-375.
49. Abina, M. A., M. Tulliez, C. Lacout, N. Debili, J.-L. Villeval, F. Pflumio, F. Wendling, W. Vainchenker, and H. Haddada. Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression. Gene Ther. In press.