Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo

Journal of Experimental Medicine

Volumn 195, Issue 11, 2002, Pages 1387-1395

  Yu, Channing ^a   Cantor, Alan B ^a   Yang, Haidi ^a   Browne, Carol ^a   Wells, Richard A ^a   Fujiwara, Yuko ^a   Orkin, Stuart H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Eosinophil; GATA 1; Gene targeting; Hematopoiesis; Transcription

Indexed keywords

TRANSCRIPTION FACTOR GATA 1;

ALLERGIC DISEASE; ARTICLE; AUTOREGULATION; BINDING SITE; EOSINOPHIL; GENE DELETION; GENE TARGETING; HEMATOPOIESIS; INFLAMMATORY DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; EOSINOPHILS; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; ERYTHROPOIESIS; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; INTERLEUKIN-5; LEUKOPOIESIS; MALE; MAST CELLS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; RNA, MESSENGER; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

EID: 0037013924     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020656     Document Type: Article

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