Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

EMBO Journal

Volumn 17, Issue 18, 1998, Pages 5321-5333

  Schwaller, Juerg ^a   Frantsve, Julie ^a   Aster, Jon ^b   Williams, Ifor R ^c   Tomasson, Michael H ^a   Ross, Theodora S ^a   Peeters, Pieter ^e   Van Rompaey, Luc ^e   Van Etten, Richard A ^a   Ilaia Jr , Robert ^a   Marynen, Peter ^e   Gilliland, D Gary ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e NONE

Author keywords

Animal model; Leukemogenesis; Stat 5; TEL JAK2 fusion gene; Transformation

Indexed keywords

GROWTH FACTOR; INTERLEUKIN 3; ONCOPROTEIN; PHOSPHOTRANSFERASE; PHOSPHOTYROSINE; STAT5 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL TRANSFORMATION; CELL TRANSPLANTATION; CHIMERA; CHROMOSOME 12P; CHROMOSOME 9P; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; GENE FUSION; GENETIC TRANSDUCTION; HEMATOPOIETIC CELL; IMMUNOBLOTTING; IMMUNOPHENOTYPING; LEUKEMIA; LEUKEMOGENESIS; LYMPHOPROLIFERATIVE DISEASE; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RETROVIRUS; SURVIVAL TIME; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIVISION; CELL LINE, TRANSFORMED; DNA; DNA, RECOMBINANT; DNA, VIRAL; DNA-BINDING PROTEINS; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-3; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, TRANSGENIC; MILK PROTEINS; MYELOPROLIFERATIVE DISORDERS; ONCOGENE PROTEINS, FUSION; RETROVIRIDAE; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMATION, GENETIC; VIRUS INTEGRATION;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0032530972     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.18.5321     Document Type: Article

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