Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

Immunity

Volumn 25, Issue 6, 2006, Pages 977-988

  Sugiyama, Tatsuki ^a   Kohara, Hiroshi ^a   Noda, Mamiko ^a   Nagasawa, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

MOLIMMUNO; SIGNALING

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1;

ADULTHOOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW TOXICITY; CELL CONTACT; CELL COUNT; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE DELETION; HEMATOPOIETIC STEM CELL; MALE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RETICULUM CELL; SIGNAL TRANSDUCTION; STROMA CELL; VASCULARIZATION;

ADOPTIVE TRANSFER; ANIMALS; BONE MARROW; CHEMOKINES, CXC; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; MICE; MICE, MUTANT STRAINS; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROMAL CELLS;

EID: 33845445939     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.10.016     Document Type: Article

References (51)

1. Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K., and Nagasawa T. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity 19 (2003) 257-267
2. Arai F., Hirao A., Ohmura M., Sato H., Matsuoka S., Takubo K., Ito K., Gou Y.K., and Suda T. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118 (2004) 149-161
3. Avecilla S.T., Hattori K., Heissig B., Tejada R., Liao F., Shido K., Jin D.K., Dias S., Zhang F., Hartman T.E., et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat. Med. 10 (2004) 64-71
4. Broxmeyer H.E., Kohli L., Kim C.H., Lee Y., Mantel C., Cooper S., Hangoc G., Shaheen M., Li X., and Clapp D.W. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J. Leukoc. Biol. 73 (2003) 630-638
5. Broxmeyer H.E., Orschell C.M., Clapp D.W., Hangoc G., Cooper S., Plett P.A., Liles W.C., Li X., Graham-Evans B., Campbell T.B., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J. Exp. Med. 201 (2005) 1307-1318
6. Calvi L.M., Adams G.B., Weibrecht K.W., Weber J.M., Olson D.P., Knight M.C., Martin R.P., Schipani E., Divieti P., Bringhurst F.R., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425 (2003) 841-846
7. Camargo F.D., Chambers S.M., Drew E., McNagny K.M., and Goodell M.A. Hematopoietic stem cells do not engraft with absolute efficiencies. Blood 107 (2006) 501-507
8. Cashman J., Dykstra B., Clark-Lewis I., Eaves A., and Eaves C. Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. J. Exp. Med. 196 (2002) 1141-1149
9. Cheshier S.H., Morrison S.J., Liao X., and Weissman I.L. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 96 (1999) 3120-3125
10. Dar A., Goichberg P., Shinder V., Kalinkovich A., Kollet O., Netzer N., Margalit R., Zsak M., Nagler A., Hardan I., et al. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat. Immunol. 6 (2005) 1038-1046
11. Gerber H.P., Malik A.K., Solar G.P., Sherman D., Liang X.H., Meng G., Hong K., Marsters J.C., and Ferrara N. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417 (2002) 954-958
12. Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., and Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133 (1984) 1710-1715
13. Gidali J., Feher I., and Talas M. Proliferation inhibition of murine pluripotent haemopoietic stem cells by interferon or poly I:C. Cell Tissue Kinet. 14 (1981) 1-7
14. Goodell M.A., Brose K., Paradis G., Conner A.S., and Mulligan R.C. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183 (1996) 1797-1806
15. Goodell M.A., Rosenzweig M., Kim H., Marks D.F., DeMaria M., Paradis G., Grupp S.A., Sieff C.A., Mulligan R.C., and Johnson R.P. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat. Med. 3 (1997) 1337-1345
16. Jung Y., Wang J., Schneider A., Sun Y.X., Koh-Paige A.J., Osman N.I., McCauley L.K., and Taichman R.S. Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone 38 (2006) 497-508
17. Katayama Y., Battista M., Kao W.M., Hidalgo A., Peired A.J., Thomas S.A., and Frenette P.S. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124 (2006) 407-421
18. Kawabata K., Ujikawa M., Egawa T., Kawamoto H., Tachibana K., Iizasa H., Katsura Y., Kishimoto T., and Nagasawa T. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc. Natl. Acad. Sci. USA 96 (1999) 5663-5667
19. Kiel M.J., Yilmaz O.H., Iwashita T., Yilmaz O.H., Terhorst C., and Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121 (2005) 1109-1121
20. Kuhn R., Schwenk F., Aguet M., and Rajewsky K. Inducible gene targeting in mice. Science 269 (1995) 1427-1429
21. Ladd A.C., Pyatt R., Gothot A., Rice S., McMahel J., Traycoff C.M., and Srour E.F. Orderly process of sequential cytokine stimulation is required for activation and maximal proliferation of primitive human bone marrow CD34+ hematopoietic progenitor cells residing in G0. Blood 90 (1997) 658-668
22. Ma Q., Jones D., and Springer T.A. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity 10 (1999) 463-471
23. Matsuzaki Y., Kinjo K., Mulligan R.C., and Okano H. Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20 (2004) 87-93
24. Moore K.A., and Lemischka I.R. Stem cells and their niches. Science 311 (2006) 1880-1885
25. Morrison S.J., Wandycz A.M., Akashi K., Globerson A., and Weissman I.L. The aging of hematopoietic stem cells. Nat. Med. 2 (1996) 1011-1016
26. Nagasawa T. Microenvironmental niches in the bone marrow for B-cell development. Nat. Rev. Immunol. 6 (2006) 107-116
27. Nagasawa T., Kikutani H., and Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl. Acad. Sci. USA 91 (1994) 2305-2309
28. Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H., and Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382 (1996) 635-638
29. Nakauchi H., Takano H., Ema H., and Osawa M. Further characterization of CD34-low/negative mouse hematopoietic stem cells. Ann. N Y Acad. Sci. 872 (1999) 57-70
30. Osawa M., Hanada K., Hamada H., and Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273 (1996) 242-245
31. Passegue E., Wagner E.F., and Weissman I.L. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119 (2004) 431-443
32. Peled A., Petit I., Kollet O., Magid M., Ponomaryov T., Byk T., Nagler A., Ben-Hur H., Many A., Shultz L., et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283 (1999) 845-848
33. Ploemacher R.E., van der Sluijs J.P., Voerman J.S., and Brons N.H. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood 74 (1989) 2755-2763
34. Ponomaryov T., Peled A., Petit I., Taichman R.S., Habler L., Sandbank J., Arenzana-Seisdedos F., Magerus A., Caruz A., Fujii N., et al. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J. Clin. Invest. 106 (2000) 1331-1339
35. Raz E. Primordial germ cell development: the zebrafish perspective. Nat. Rev. Genet. 4 (2003) 690-700
36. Rouleau M.F., Mitchell J., and Goltzman D. Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones. J. Bone Miner. Res. 5 (1990) 1043-1053
37. Sato T., Laver J.H., and Ogawa M. Reversible expression of CD34 by murine hematopoietic stem cells. Blood 94 (1999) 2548-2554
38. Schwarz B.A., and Bhandoola A. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5 (2004) 953-960
39. Sipkins D.A., Wei X., Wu J.W., Runnels J.M., Cote D., Means T.K., Luster A.D., Scadden D.T., and Lin C.P. In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature 435 (2005) 969-973
40. Stier S., Ko Y., Forkert R., Lutz C., Neuhaus T., Grünewald E., Cheng T., Dombkowski D., Calvi L.M., Rittling S.R., and Scadden D.T. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J. Exp. Med. 201 (2005) 1781-1791
41. Sudo K., Ema H., Morita Y., and Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192 (2000) 1273-1280
42. Suzuki N., Ohneda O., Minegishi N., Nishikawa M., Ohta T., Takahashi S., Engel J.D., and Yamamoto M. Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. Proc. Natl. Acad. Sci. USA 103 (2006) 2202-2207
43. Szilvassy S.J., Humphries R.K., Lansdorp P.M., Eaves A.C., and Eaves C.J. Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc. Natl. Acad. Sci. USA 87 (1990) 8736-8740
44. Tachibana K., Hirota S., Iizasa H., Yoshida H., Kawabata K., Kataoka Y., Kitamura Y., Matsushima K., Yoshida N., Nishikawa S., et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393 (1998) 591-594
45. Takakura N., Watanabe T., Suenobu S., Yamada Y., Noda T., Ito Y., Satake M., and Suda T. A role for hematopoietic stem cells in promoting angiogenesis. Cell 102 (2000) 199-209
46. Tokoyoda K., Egawa T., Sugiyama T., Choi B.I., and Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20 (2004) 707-718
47. Visnjic D., Kalajzic A., Rowe D.W., Katavic V., Lorenzo J., and Aguila H.L. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 103 (2004) 3258-3264
48. Wilson A., and Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6 (2006) 93-106
49. Wright D.E., Wagers A.J., Gulati A.P., Johnson F.L., and Weissman I.L. Physiological migration of hematopoietic stem and progenitor cells. Science 294 (2001) 1933-1936
50. Zhang J., Niu C., Ye L., Huang H., He X., Tong W.G., Ross J., Haug J., Johnson T., Feng J.Q., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425 (2003) 836-841
51. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., and Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393 (1998) 595-599