Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5258-5266

  Lu, Xiaohui ^a   Huang, Lily Jun Shen ^b   Lodish, Harvey F ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH (MATERIALS);

CYTOKINE; CYTOKINE RECEPTORS; DO-MAINS; JUXTAMEMBRANE; MYELOPROLIFERATIVE DISORDERS; OVEREXPRESSION; REGULATORY MOTIFS;

DIMERIZATION;

BCR ABL PROTEIN; CYTOKINE RECEPTOR; CYTOKINE RECEPTOR EPOR; JANUS KINASE 2; MUTANT PROTEIN; MUTANT PROTEIN JAK2V617F; UNCLASSIFIED DRUG; ERYTHROPOIETIN RECEPTOR; JAK2 PROTEIN, HUMAN; JAK2 PROTEIN, MOUSE;

ARTICLE; BINDING AFFINITY; CELL TRANSFORMATION; CONTROLLED STUDY; DIMERIZATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR UPREGULATION; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; ENZYME ACTIVATION; GENETICS; METABOLISM; MISSENSE MUTATION; MOUSE;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DIMERIZATION; ENZYME ACTIVATION; HUMANS; JANUS KINASE 2; MICE; MUTATION, MISSENSE; RECEPTORS, ERYTHROPOIETIN;

EID: 41949118675     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707125200     Document Type: Article

References (34)

1. Yamaoka, K., Saharinen, P., Pesu, M., Holt, V. E., 3rd, Silvennoinen, O., and O'Shea, J. J. (2004) Genome Biol. 5, 253
2. Saharinen, P., Takaluoma, K., and Silvennoinen, O. (2000) Mol. Cell Biol. 20, 3387-3395
3. Huang, L. J., Constantinescu, S. N., and Lodish, H. F. (2001) Mol. Cell 8, 1327-1338
4. Zhou, Y. J., Chen, M., Cusack, N. A., Kimmel, L. H., Magnuson, K. S., Boyd, J. G., Lin, W., Roberts, J. L., Lengi, A., Buckley, R. H., Geahlen, R. L., Candotti, F., Gadina, M., Changelian, P. S., and O'Shea, J. J. (2001) Mol. Cell 8, 959-969
5. Ihle, J. N., and Gilliland, D. G. (2007) Curr. Opin. Genet. Dev. 17, 8-14
6. Schwaller, J., Frantsve, J., Aster, J., Williams, I. R., Tomasson, M. H., Ross, T. S., Peeters, P., Van Rompaey, L., Van Etten, R. A., Ilaria, R., Jr., Marynen, P., and Gilliland, D. G. (1998) EMBO J. 17, 5321-5333
7. Lacronique, V., Boureux, A., Valle, V. D., Poirel, H., Quang, C. T., Mauchauffe, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J., and Bernard, O. A. (1997) Science 278, 1309-1312
8. Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., Adelsperger, J., Koo, S., Lee, J. C., Gabriel, S., Mercher, T., D'Andrea, A., Frohling, S., Dohner, K., Marynen, P., Vandenberghe, P., Mesa, R. A., Tefferi, A., Griffin, J. D., Eck, M. J., Sellers, W. R., Meyerson, M., Golub, T. R., Lee, S. J., and Gilliland, D. G. (2005) Cancer Cell 7, 387-397
9. Kralovics, R., Passamonti, F., Buser, A. S., Teo, S. S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., and Skoda, R. C. (2005) N. Engl. J. Med. 352, 1779-1790
10. James, C., Ugo, V., Le Couedic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garcon, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., and Vainchenker, W. (2005) Nature 434, 1144-1148
11. Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., Scott, M. A., Erber, W. N., and Green, A. R. (2005) Lancet 365, 1054-1061
12. Scott, L. M., Campbell, P. J., Baxter, E. J., Todd, T., Stephens, P., Edkins, S., Wooster, R., Stratton, M. R., Futreal, P. A., and Green, A. R. (2005) Blood 106, 2920-2921
13. Ohyashiki, K., Aota, Y., Akahane, D., Gotoh, A., Miyazawa, K., Kimura, Y., and Ohyashiki, J. H. (2005) Leukemia 19, 2359-2360
14. Levine, R. L., Loriaux, M., Huntly, B. J., Loh, M. L., Beran, M., Stoffregen, E., Berger, R., Clark, J. J., Willis, S. G., Nguyen, K. T., Flores, N. J., Estey, E., Gattermann, N., Armstrong, S., Look, A. T., Griffin, J. D., Bernard, O. A., Heinrich, M. C., Gilliland, D. G., Druker, B., and Deininger, M. W. (2005) Blood 106, 3377-3379
15. Lee, J. W., Kim, Y. G., Soung, Y. H., Han, K. J., Kim, S. Y., Rhim, H. S., Min, W. S., Nam, S. W., Park, W. S., Lee, J. Y., Yoo, N. J., and Lee, S. H. (2006) Oncogene 25, 1434-1436
16. Johan, M. F., Goodeve, A. C., Bowen, D. T., Frew, M. E., and Reilly, J. T. (2005) Br. J. Haematol. 130, 968
17. Scott, L. M., Tong, W., Levine, R. L., Scott, M. A., Beer, P. A., Stratton, M. R., Futreal, P. A., Erber, W. N., McMullin, M. F., Harrison, C. N., Warren, A. J., Gilliland, D. G., Lodish, H. F., and Green, A. R. (2007) N. Engl. J. Med. 356, 459-468
18. Walters, D. K., Mercher, T., Gu, T. L., O'Hare, T., Tyner, J. W., Loriaux, M., Goss, V. L., Lee, K. A., Eide, C. A., Wong, M. J., Stoffregen, E. P., McGreevey, L., Nardone, J., Moore, S. A., Crispino, J., Boggon, T. J., Heinrich, M. C., Deininger, M. W., Polakiewicz, R. D., Gilliland, D. G., and Druker, B. J. (2006) Cancer Cell 10, 65-75
19. Mercher, T., Wernig, G., Moore, S. A., Levine, R. L., Gu, T. L., Frohling, S., Cullen, D., Polakiewicz, R. D., Bernard, O. A., Boggon, T. J., Lee, B. H., and Gilliland, D. G. (2006) Blood 108, 2770-2779
20. Lu, X., Levine, R., Tong, W., Wernig, G., Pikman, Y., Zarnegar, S., Gilliland, D. G., and Lodish, H. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 18962-18967
21. Ren, R. (2005) Nat. Rev. Cancer 5, 172-183
22. Bumm, T. G., Elsea, C., Corbin, A. S., Loriaux, M., Sherbenou, D., Wood, L., Deininger, J., Silver, R. T., Druker, B. J., and Deininger, M. W. (2006) Cancer Res. 66, 11156-11165
23. Staerk, J., Kallin, A., Demoulin, J. B., Vainchenker, W., and Constantinescu, S. N. (2005) J. Biol. Chem. 280, 41893-41899
24. Funakoshi-Tago, M., Pelletier, S., Matsuda, T., Parganas, E., and Ihle, J. N. (2006) EMBO J. 25, 4763-4772
25. Zhang, X., and Ren, R. (1998) Blood 92, 3829-3840
26. Liu, X., Constantinescu, S. N., Sun, Y., Bogan, J. S., Hirsch, D., Weinberg, R. A., and Lodish, H. F. (2000) Anal. Biochem. 280, 20-28
27. Constantinescu, S. N., Huang, L. J., Nam, H., and Lodish, H. F. (2001) Mol. Cell 7, 377-385
28. Barber, D. L., DeMartino, J. C., Showers, M. O., and D'Andrea, A. D. (1994) Mol. Cell Biol. 14, 2257-2265
29. Tefferi, A., and Gilliland, D. G. (2007) Cell Cycle 6, 550-566
30. Naoe, T., and Kiyoi, H. (2004) Cell Mol. Life Sci. 61, 2932-2938
31. Krause, D. S., and Van Etten, R. A. (2005) N. Engl. J. Med. 353, 172-187
32. Constantinescu, S. N., Keren, T., Socolovsky, M., Nam, H., Henis, Y. I., and Lodish, H. F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 4379-4384
33. Lindauer, K., Loerting, T., Liedl, K. R., and Kroemer, R. T. (2001) Protein Eng. 14, 27-37
34. Syed, R. S., Reid, S. W., Li, C., Cheetham, J. C., Aoki, K. H., Liu, B., Zhan, H., Osslund, T. D., Chirino, A. J., Zhang, J., Finer-Moore, J., Elliott, S., Sitney, K., Katz, B. A., Matthews, D. J., Wendoloski, J. J., Egrie, J., and Stroud, R. M. (1998) Nature 395, 511-516