A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 13, 1997, Pages 6781-6785

  McDevitt, Michael A ^a,b   Shivdasani, Ramesh A ^a,c   Fujiwara, Yuko ^a,b   Yang, Haidi ^a   Orkin, Stuart H ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cre recombinase; Gene dosage; Hematopoiesis; Homologous recombination

Indexed keywords

CIS ACTING ELEMENT; DEOXYRIBONUCLEASE I; RECOMBINASE; TRANSCRIPTION FACTOR GATA 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BURST FORMING UNIT E; CELL DIFFERENTIATION; CELL MATURATION; COLONY FORMING UNIT E; CONTROLLED STUDY; EMBRYO; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; FETUS; FETUS LIVER; GENE DOSAGE; GENE TARGETING; GENETIC RECOMBINATION; HEMATOPOIETIC STEM CELL; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; TRANSGENE; YOLK SAC;

ALLELES; ANIMALS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); ERYTHROID-SPECIFIC DNA-BINDING FACTORS; ERYTHROPOIESIS; GATA1 TRANSCRIPTION FACTOR; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; MICE; MUTATION; RECOMBINATION, GENETIC; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0030963918     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.13.6781     Document Type: Article

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