The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways

Blood

Volumn 98, Issue 12, 2001, Pages 3390-3397

  Sternberg, David W ^a   Tomasson, Michael H ^a   Carroll, Martin ^a   Curley, David P ^a   Barker, George ^a   Caprio, Michael ^a   Wilbanks, Alyson ^a   Kazlauskas, Andrius ^a   Gary Gilliland, D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; HYBRID PROTEIN; INTERLEUKIN 3; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN P85; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETV6; TYROSINE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DNA BINDING PROTEINS; MAMMARY GLAND SPECIFIC NUCLEAR FACTOR; MAMMARY GLAND-SPECIFIC NUCLEAR FACTOR; ONCOPROTEIN; PHOSPHOTYROSINE; TEL PDGFRBETA FUSION PROTEIN; TEL-PDGFRBETA FUSION PROTEIN; TRANS ACTIVATORS; TRANSACTIVATOR PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BONE MARROW TRANSPLANTATION; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEMATOPOIETIC CELL; LEUKEMOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMISTRY; CHRONIC MYELOMONOCYTIC LEUKEMIA; GENETICS; METABOLISM; MOUSE; MUTATION; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMAL; BINDING SITES; CELL LINE; DNA-BINDING PROTEINS; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MICE; MUTATION; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATORS;

EID: 0035542766     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.12.3390     Document Type: Article

References (40)

1. Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of the PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77:307-316.
2. Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG. The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways. Proc Natl Acad Sci U S A. 1996;93:14845-14850.
3. Jousset C, Carron C, Boureux A, et al. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFβR oncoprotein. EMBO J. 1997;16:69-82.
4. Lemmon MA, Schlessinger J. Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem Sci. 1994;19:459-463.
5. Palacios R, Steinmetz M. IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germline configuration, and generate B lymphocytes in vivo. Cell. 1985;41:727-734.
6. Buchdunger E, Zimmerman J, Mett H, et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a proteintyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc Natl Acad Sci U S A. 1995;92:2558-2562.
7. Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood. 1997;90:4947-4952.
8. Ross TS, Bernard OA, Berger R, Gilliland DG. Fusion of Huntington interacting protein 1 to platelet-derived growth factor beta receptor (PDGFβR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood. 1998;91:4419-4426.
9. Ross TS, Gilliland DG. Transforming properties of the Huntington interacting protein 1/platelet-derived growth factor beta receptor fusion protein. J Biol Chem. 1999;274:22328-22336.
10. Schwaller J, Anastasiadou E, Cain D, et al. H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22). Blood. 2001;97:3910-3918.
11. Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem. 1994;269:32023-32026.
12. Heldin C-H. Structural and functional studies on platelet-derived growth factor. EMBO J. 1992;11:4251-4259.
13. Kazlauskas A. Receptor tyrosine kinases and their targets. Curr Opin Genet Dev. 1994;4:5-14.
14. Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol. 1996;16:1759-1769.
15. Darnell JE Jr. STATs and gene regulation. Science. 1997;277:1630-1635.
16. BCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem. 1996;271:31704-31710.
17. Lacronique V, Boureux A, Della Valle V, et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997;278:1309-1312.
18. Schwaller J, Frantsve J, Aster J, et al. Transformation of hematopoietic cells lines to growth-factor independence and induction of a fatal myeloand lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 1998;17:5321-5333.
19. Ho JM-Y, Beattie BK, Squire JA, Frank DA, Barber DL. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood. 1999;93:4354-4364.
20. Wilbanks AM, Mahajan S, Frank DA, Druker BJ, Gilliland DG, Carroll M. TEL/PDGFβR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins. Exp Hematol. 2000;28:584-593.
21. Tomasson MH, Sternberg DW, Williams I, et al. TEL/PDGFβR causes a fatal myeloproliferative disorder in mice that requires tyrosines 579/581 of PDGFβR. J Clin Invest. 2000;105:423-432.
22. Vaillancourt RR, Heasley LE, Zamarripa J, et al. Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol. 1995;15:3644-3653.
23. Hunter T, Sefton BM. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A. 1980;77:1311-1315.
24. Valgeirsdottir SS, Paukku K, Silvennoinen O, Heldin C-H, Claesson-Welsh L. Activation of STAT5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF betareceptor juxtamembrane and kinase insert domains. Oncogene. 1998;16:505-515.
25. Fantl WJ, Escobedo JA, Martin GA, et al. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell. 1992;69:413-423.
26. Kazlauskas A, Kashishian A, Cooper JA, Valius M. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit. Mol Cell Biol. 1992;12:2534-2544.
27. Kashishian A, Kazlauskas A, Cooper JA. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J. 1992;11:1373-1382.
28. Arvidsson AK, Rupp E, Nanberg E, et al. Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol Cell Biol. 1994;14:6715-6726.
29. Benjamin CW, Jones DA. Platelet-derived growth factor stimulates growth factor receptor binding protein-2 association with Shc in vascular smooth muscle cells. J Biol Chem. 1994;269:30911-30916.
30. Yokote K, Mori S, Hansen K, et al. Direct interaction between Shc and the platelet-derived growthfactor β-receptor. J Biol Chem. 1994;269:15337-15343.
31. Li W, Nishimura R, Kashishian A, et al. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol. 1994;14:509-517.
32. Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc Natl Acad Sci U S A. 1994;91:7335-7339.
33. Mori S, Rönnstrand L, Yokote K, et al. Identification of two juxtamembrane autophosphorylation sites in the PDGF β-receptor: involvement in the interaction with Src family tyrosine kinases. EMBO J. 1993;12:2257-2264.
34. Drummond-Barbosa D, Vaillancourt RR, Kazlauskas A, DiMaio D. Ligand-independent activation of the platelet-derived growth factor β receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol Cell Biol. 1995;15:2570-2581.
35. Kazlauskas A, Cooper JA. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interaction with cell proteins. Cell. 1989;58:1121-1133.
36. Valius M, Kazlauskas A. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 1993;73:321-334.
37. Sjöblom T, Boureux A, Rönnstrand L, Heldin C-H, Ghysdael J, Östman A. Characterization of the chronic myelomonocytic leukemia associated TEL/PDGFβR fusion protein. Oncogene. 1999;18:7055-7062.
38. Besancψon F, Atfi A, Gespach C, Cayre YE, Bourgeade M-F. Evidence for a role of NF-κB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor β fusion protein. Proc Natl Acad Sci U S A. 1998;95:8081-8086.
39. Atfi A, Prunier C, Mazars A, et al. The oncogenic TEL/PDGFRβ fusion protein induces cell death through JNK/SAPK pathway. Oncogene. 1999;18:3878-3885.
40. Fambrough D, McClure K, Kazlauskas A, Lander ES. Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell. 1999;97:727-741.