메뉴 건너뛰기




Volumn 8, Issue 12, 2009, Pages 982-1001

Voltage-gated potassium channels as therapeutic targets

Author keywords

[No Author keywords available]

Indexed keywords

2' (4 METHOXYPHENYLACETAMIDOMETHYL) N [2 (3 PYRIDYL)ETHYL] 2 BIPHENYLCARBOXAMIDE; 4 AMINOPYRIDINE; AMIODARONE; AZIMILIDE; CLOFAZIMINE; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV1.5; POTASSIUM CHANNEL KV1.6; POTASSIUM CHANNEL KV1.7; POTASSIUM CHANNEL KV1.8; POTASSIUM CHANNEL KV2.1; POTASSIUM CHANNEL KV2.2; POTASSIUM CHANNEL KV3.1; POTASSIUM CHANNEL KV3.2; POTASSIUM CHANNEL KV3.3; POTASSIUM CHANNEL KV3.4; POTASSIUM CHANNEL KV4.1; POTASSIUM CHANNEL KV4.2; POTASSIUM CHANNEL KV4.3; POTASSIUM CHANNEL KV7.1; POTASSIUM CHANNEL KV7.2; POTASSIUM CHANNEL KV7.3; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERNAKALANT; VOLTAGE GATED POTASSIUM CHANNEL; ANTIBODY; PEPTIDE; VENOM;

EID: 73449119314     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2983     Document Type: Review
Times cited : (632)

References (260)
  • 1
    • 58149183694 scopus 로고    scopus 로고
    • IUPHAR-DB: The IUPHAR database of G protein-coupled receptors and ion channels
    • Harmar, A. J. et al. IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res. 37, D680-D685 (2009).
    • (2009) Nucleic Acids Res. , vol.37
    • Harmar, A.J.1
  • 2
    • 0023225798 scopus 로고
    • Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila
    • Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science 237, 749-753 (1987).
    • (1987) Science , vol.237 , pp. 749-753
    • Papazian, D.M.1    Schwarz, T.L.2    Tempel, B.L.3    Jan, Y.N.4    Jan, L.Y.5
  • 4
    • 23244441222 scopus 로고    scopus 로고
    • Voltage sensor of Kv1.2: Structural basis of electromechanical coupling
    • Long, S. B., Campbell, E. B. & Mackinnon, R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science 309, 903-908 (2005).
    • (2005) Science , vol.309 , pp. 903-908
    • Long, S.B.1    Campbell, E.B.2    MacKinnon, R.3
  • 5
    • 9944226711 scopus 로고    scopus 로고
    • Towards a structural view of gating in potassium channels
    • Swartz, K. J. Towards a structural view of gating in potassium channels. Nature Rev. Neurosci. 5, 905-916 (2004).
    • (2004) Nature Rev. Neurosci. , vol.5 , pp. 905-916
    • Swartz, K.J.1
  • 6
    • 55049099359 scopus 로고    scopus 로고
    • Ion channels: From conductance to structure
    • Bezanilla, F. Ion channels: from conductance to structure. Neuron 60, 456-468 (2008).
    • (2008) Neuron , vol.60 , pp. 456-468
    • Bezanilla, F.1
  • 7
    • 41149095488 scopus 로고    scopus 로고
    • How membrane proteins sense voltage
    • Bezanilla, F. How membrane proteins sense voltage. Nature Rev. Mol. Cell Biol. 9, 323-332 (2008).
    • (2008) Nature Rev. Mol. Cell Biol. , vol.9 , pp. 323-332
    • Bezanilla, F.1
  • 8
    • 29844437655 scopus 로고    scopus 로고
    • International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
    • Gutman, G. A. et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57, 473-508 (2005).
    • (2005) Pharmacol. Rev. , vol.57 , pp. 473-508
    • Gutman, G.A.1
  • 9
    • 44849093511 scopus 로고    scopus 로고
    • + channel modulators for the treatment of neurological disorders and autoimmune diseases
    • + channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem. Rev. 108, 1744-1773 (2008).
    • (2008) Chem. Rev. , vol.108 , pp. 1744-1773
    • Wulff, H.1    Zhorov, B.S.2
  • 10
    • 2142700028 scopus 로고    scopus 로고
    • Potassium channels as targets for specific immunomodulation
    • Chandy, K. G. et al. Potassium channels as targets for specific immunomodulation. Trends Pharmacol. Sci. 25, 280-289 (2004).
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 280-289
    • Chandy, K.G.1
  • 11
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179-185 (2006).
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1
  • 12
    • 0033570146 scopus 로고    scopus 로고
    • +channels
    • +channels. EMBO J. 18, 5540-5547 (1999).
    • (1999) EMBO J. , vol.18 , pp. 5540-5547
    • Pardo, L.A.1
  • 13
    • 58649109591 scopus 로고    scopus 로고
    • Orai1 and STIM1 are critical for breast tumour cell migration and metastasis
    • Yang, S., Zhang, J. J. & Huang, X. Y. Orai1 and STIM1 are critical for breast tumour cell migration and metastasis. Cancer Cell 15, 124-134 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 124-134
    • Yang, S.1    Zhang, J.J.2    Huang, X.Y.3
  • 14
    • 60849118922 scopus 로고    scopus 로고
    • Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation
    • Monet, M. et al. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim. Biophys. Acta 1793, 528-539 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 528-539
    • Monet, M.1
  • 17
    • 33748943301 scopus 로고    scopus 로고
    • Non-conducting functions of voltage-gated ion channels
    • Kaczmarek, L. K. Non-conducting functions of voltage-gated ion channels. Nature Rev. Neurosci. 7, 761-771 (2006).
    • (2006) Nature Rev. Neurosci. , vol.7 , pp. 761-771
    • Kaczmarek, L.K.1
  • 18
    • 61349091749 scopus 로고    scopus 로고
    • Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumours
    • Downie, B. R. et al. Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumours. J. Biol. Chem. 283, 36234-36240 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 36234-36240
    • Downie, B.R.1
  • 19
    • 12944294332 scopus 로고    scopus 로고
    • Molecular diversity and regulation of renal potassium channels
    • Hebert, S. C., Desir, G., Giebisch, G. & Wang, W. Molecular diversity and regulation of renal potassium channels. Physiol. Rev. 85, 319-371 (2005).
    • (2005) Physiol. Rev. , vol.85 , pp. 319-371
    • Hebert, S.C.1    Desir, G.2    Giebisch, G.3    Wang, W.4
  • 20
    • 0031900727 scopus 로고    scopus 로고
    • Specific antibodies to the external vestibule of voltage-gated potassium channels block current
    • Zhou, B. Y., Ma, W. & Huang, X. Y. Specific antibodies to the external vestibule of voltage-gated potassium channels block current. J. Gen. Physiol. 111, 555-563 (1998).
    • (1998) J. Gen. Physiol. , vol.111 , pp. 555-563
    • Zhou, B.Y.1    Ma, W.2    Huang, X.Y.3
  • 21
    • 33846925321 scopus 로고    scopus 로고
    • Monte Carlo-energy minimization of correolide in the Kv1.3 channel: Possible role of potassium ion in ligand-receptor interactions
    • Bruhova, I. & Zhorov, B. S. Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions. BMC Struct. Biol. 7, 5 (2007).
    • (2007) BMC Struct. Biol. , vol.7 , pp. 5
    • Bruhova, I.1    Zhorov, B.S.2
  • 24
    • 33645317063 scopus 로고    scopus 로고
    • HERG potassium channels and cardiac arrhythmia
    • Sanguinetti, M. C. & Tristani-Firouzi, M. hERG potassium channels and cardiac arrhythmia. Nature 440, 463-469 (2006).
    • (2006) Nature , vol.440 , pp. 463-469
    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
  • 25
    • 15744400656 scopus 로고    scopus 로고
    • The new anticonvulsant retigabine favours voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
    • Wuttke, T. V., Seebohm, G., Bail, S., Maljevic, S. & Lerche, H. The new anticonvulsant retigabine favours voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol. Pharmacol. 67, 1009-1017 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1009-1017
    • Wuttke, T.V.1    Seebohm, G.2    Bail, S.3    Maljevic, S.4    Lerche, H.5
  • 26
    • 3142679665 scopus 로고    scopus 로고
    • Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue
    • Zhang, Z. H., Rhodes, K. J., Childers, W. E., Argentieri, T. M. & Wang, Q. Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue. J. Biol. Chem. 279, 29226-29230 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 29226-29230
    • Zhang, Z.H.1    Rhodes, K.J.2    Childers, W.E.3    Argentieri, T.M.4    Wang, Q.5
  • 27
    • 40949124740 scopus 로고    scopus 로고
    • Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators)
    • Lu, Q. et al. Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators). Bioorg. Med. Chem. 16, 3067-3075 (2008).
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 3067-3075
    • Lu, Q.1
  • 29
  • 31
    • 0032055649 scopus 로고    scopus 로고
    • V1.1 potassium channel causes epilepsy in mice
    • V1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819 (1998).
    • (1998) Neuron , vol.20 , pp. 809-819
    • Smart, S.L.1
  • 32
    • 34548772882 scopus 로고    scopus 로고
    • Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons
    • Brew, H. M. et al. Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J. Neurophysiol. 98, 1501-1525 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 1501-1525
    • Brew, H.M.1
  • 33
    • 0032895470 scopus 로고    scopus 로고
    • A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy
    • Zuberi, S. M. et al. A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy. Brain 122, 817-825 (1999).
    • (1999) Brain , vol.122 , pp. 817-825
    • Zuberi, S.M.1
  • 34
    • 33344456574 scopus 로고    scopus 로고
    • The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvβ1
    • Schulte, U. et al. The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvβ1. Neuron 49, 697-706 (2006).
    • (2006) Neuron , vol.49 , pp. 697-706
    • Schulte, U.1
  • 35
    • 73949118075 scopus 로고    scopus 로고
    • Ion channels and protein-protein interactions: Novel approaches to mining validated targets
    • Hogg, D. S., Ryan, R. & Kozlowski, R. Z. Ion channels and protein-protein interactions: novel approaches to mining validated targets. Drug Discov. Int. 2007, 20-22 (2007).
    • (2007) Drug Discov. Int. , vol.2007 , pp. 20-22
    • Hogg, D.S.1    Ryan, R.2    Kozlowski, R.Z.3
  • 37
    • 0035696121 scopus 로고    scopus 로고
    • Mechanisms of axonal dysfunction after spinal cord injury: With an emphasis on the role of voltage-gated potassium channels
    • Nashmi, R. & Fehlings, M. G. Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels. Brain Res. 38, 165-191 (2001).
    • (2001) Brain Res. , vol.38 , pp. 165-191
    • Nashmi, R.1    Fehlings, M.G.2
  • 38
    • 12344297545 scopus 로고    scopus 로고
    • The use of 4-aminopyridine (fampridine) in demyelinating disorders
    • Hayes, K. C. The use of 4-aminopyridine (fampridine) in demyelinating disorders. CNS Drug Rev. 10, 295-316 (2004).
    • (2004) CNS Drug Rev. , vol.10 , pp. 295-316
    • Hayes, K.C.1
  • 39
    • 1242272905 scopus 로고    scopus 로고
    • Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: Implications for axonal pathophysiology after neurotrauma
    • Karimi-Abdolrezaee, S., Eftekharpour, E. & Fehlings, M. G. Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: implications for axonal pathophysiology after neurotrauma. Eur. J. Neurosci. 19, 577-589 (2004).
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 577-589
    • Karimi-Abdolrezaee, S.1    Eftekharpour, E.2    Fehlings, M.G.3
  • 40
    • 52949119587 scopus 로고    scopus 로고
    • Sustained-release fampridine for symptomatic treatment of multiple sclerosis
    • Korenke, A. R., Rivey, M. P. & Allington, D. R. Sustained-release fampridine for symptomatic treatment of multiple sclerosis. Ann. Pharmacother. 42, 1458-1465 (2008).
    • (2008) Ann. Pharmacother. , vol.42 , pp. 1458-1465
    • Korenke, A.R.1    Rivey, M.P.2    Allington, D.R.3
  • 41
    • 60649090430 scopus 로고    scopus 로고
    • Sustained-release oral fampridine in multiple sclerosis: A randomised, double-blind, controlled trial
    • Goodman, A. D. et al. Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet 373, 732-738 (2009).
    • (2009) Lancet , vol.373 , pp. 732-738
    • Goodman, A.D.1
  • 42
    • 0028124225 scopus 로고
    • Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene KCNA1
    • Browne, D. L. et al. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nature Genet. 8, 136-140 (1994).
    • (1994) Nature Genet. , vol.8 , pp. 136-140
    • Browne, D.L.1
  • 43
    • 65249096581 scopus 로고    scopus 로고
    • A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
    • Glaudemans, B. et al. A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J. Clin. Invest. 19, 936-942 (2009).
    • (2009) J. Clin. Invest. , vol.19 , pp. 936-942
    • Glaudemans, B.1
  • 45
    • 0021260968 scopus 로고
    • K channels in T lymphocytes: A patch clamp study using monoclonal antibody adhesion
    • Matteson, D. R. & Deutsch, C. K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature 307, 468-471 (1984).
    • (1984) Nature , vol.307 , pp. 468-471
    • Matteson, D.R.1    Deutsch, C.2
  • 46
    • 0027400621 scopus 로고
    • Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation
    • Lin, C. S. et al. Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J. Exp. Med. 177, 637-645 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 637-645
    • Lin, C.S.1
  • 47
    • 0031157738 scopus 로고    scopus 로고
    • Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo
    • Koo, G. C. et al. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J. Immunol. 158, 5120-5128 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 5120-5128
    • Koo, G.C.1
  • 48
    • 27144515996 scopus 로고    scopus 로고
    • 2+ store to the plasma membrane
    • 2+ store to the plasma membrane. Nature 437, 902-905 (2005).
    • (2005) Nature , vol.437 , pp. 902-905
    • Zhang, S.L.1
  • 49
    • 33744479684 scopus 로고    scopus 로고
    • 2+ entry
    • 2+ entry. Science 312, 1220-1223 (2006).
    • (2006) Science , vol.312 , pp. 1220-1223
    • Vig, M.1
  • 50
    • 34548233165 scopus 로고    scopus 로고
    • Calcium signalling in lymphocyte activation and disease
    • Feske, S. Calcium signalling in lymphocyte activation and disease. Nature Rev. Immunol. 7, 690-702 (2007).
    • (2007) Nature Rev. Immunol. , vol.7 , pp. 690-702
    • Feske, S.1
  • 51
    • 0142059887 scopus 로고    scopus 로고
    • Potassium channels as therapeutic targets for autoimmune disorders
    • Wulff, H., Beeton, C. & Chandy, K. G. Potassium channels as therapeutic targets for autoimmune disorders. Curr. Opin. Drug Discov. Devel. 6, 640-647 (2003).
    • (2003) Curr. Opin. Drug Discov. Devel. , vol.6 , pp. 640-647
    • Wulff, H.1    Beeton, C.2    Chandy, K.G.3
  • 52
    • 0037037585 scopus 로고    scopus 로고
    • Modulation of Kv channel expression and function by TCR and co-stimulatory signals during peripheral CD4+ lymphocyte differentiation
    • Liu, Q.-H. et al. Modulation of Kv channel expression and function by TCR and co-stimulatory signals during peripheral CD4+ lymphocyte differentiation. J. Exp. Med. 196, 897-909 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 897-909
    • Liu, Q.-H.1
  • 53
    • 27544460565 scopus 로고    scopus 로고
    • Potassium channels, memory T cells and multiple sclerosis
    • Beeton, C. & Chandy, K. G. Potassium channels, memory T cells and multiple sclerosis. Neuroscientist 11, 550-562 (2005).
    • (2005) Neuroscientist , vol.11 , pp. 550-562
    • Beeton, C.1    Chandy, K.G.2
  • 54
    • 0038481183 scopus 로고    scopus 로고
    • + channel in effector memory T cells as new target for MS
    • + channel in effector memory T cells as new target for MS. J. Clin. Invest. 111, 1703-1713 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1703-1713
    • Wulff, H.1
  • 55
    • 33751232672 scopus 로고    scopus 로고
    • Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    • Beeton, C. et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc. Natl Acad. Sci. USA 103, 17414-17419 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 17414-17419
    • Beeton, C.1
  • 56
    • 53349102834 scopus 로고    scopus 로고
    • Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block
    • Matheu, M. P. et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity 29, 602-614 (2008).
    • (2008) Immunity , vol.29 , pp. 602-614
    • Matheu, M.P.1
  • 57
    • 34447625549 scopus 로고    scopus 로고
    • Targeting effector memory T-cells with Kv1.3 blockers
    • Wulff, H. & Pennington, M. Targeting effector memory T-cells with Kv1.3 blockers. Curr. Opin. Drug Discov. Devel. 10, 438-445 (2007).
    • (2007) Curr. Opin. Drug Discov. Devel. , vol.10 , pp. 438-445
    • Wulff, H.1    Pennington, M.2
  • 59
    • 0036212794 scopus 로고    scopus 로고
    • GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes
    • Viglietta, V., Kent, S. C., Orban, T. & Hafler, D. A. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J. Clin. Invest. 109, 895-903 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 895-903
    • Viglietta, V.1    Kent, S.C.2    Orban, T.3    Hafler, D.A.4
  • 60
    • 11144357340 scopus 로고    scopus 로고
    • Expression of CCR7 in multiple sclerosis: Implications for CNS immunity
    • Kivisakk, P. et al. Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann. Neurol. 55, 627-638 (2004).
    • (2004) Ann. Neurol. , vol.55 , pp. 627-638
    • Kivisakk, P.1
  • 61
    • 23344438440 scopus 로고    scopus 로고
    • The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain
    • Rus, H. et al. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc. Natl Acad. Sci. USA 102, 11094-11099 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11094-11099
    • Rus, H.1
  • 62
    • 0035923519 scopus 로고    scopus 로고
    • + channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
    • + channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc. Natl Acad. Sci. USA 98, 13942-13947 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 13942-13947
    • Beeton, C.1
  • 63
    • 20144366005 scopus 로고    scopus 로고
    • Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
    • Beeton, C. et al. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol. Pharmacol. 67, 1369-1381 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1369-1381
    • Beeton, C.1
  • 65
    • 27544454783 scopus 로고    scopus 로고
    • Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases
    • Schmitz, A. et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol. Pharmacol. 68, 1254-1270 (2005).
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1254-1270
    • Schmitz, A.1
  • 66
    • 1842729411 scopus 로고    scopus 로고
    • Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: Synthesis and immunosuppressive activity
    • Baell, J. B. et al. Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. J. Med. Chem. 47, 2326-2336 (2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 2326-2336
    • Baell, J.B.1
  • 67
    • 33144478897 scopus 로고    scopus 로고
    • A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4-or 7-position of khellinone
    • Harvey, A. J., Baell, J. B., Toovey, N., Homerick, D. & Wulff, H. A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4-or 7-position of khellinone. J. Med. Chem. 49, 1433-1441 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 1433-1441
    • Harvey, A.J.1    Baell, J.B.2    Toovey, N.3    Homerick, D.4    Wulff, H.5
  • 68
    • 34248599015 scopus 로고    scopus 로고
    • Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis
    • Azam, P., Sankaranarayanan, A., Homerick, D., Griffey, S. & Wulff, H. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis. J. Invest. Dermatol. 127, 1419-1429 (2007).
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 1419-1429
    • Azam, P.1    Sankaranarayanan, A.2    Homerick, D.3    Griffey, S.4    Wulff, H.5
  • 69
    • 58049211941 scopus 로고    scopus 로고
    • Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes
    • Ren, Y. R. et al. Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. PLoS ONE 3, e4009 (2008).
    • (2008) PLoS ONE , vol.3
    • Ren, Y.R.1
  • 70
    • 0037339936 scopus 로고    scopus 로고
    • The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight
    • Xu, J. et al. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Hum. Mol. Gen. 12, 551-559 (2003).
    • (2003) Hum. Mol. Gen. , vol.12 , pp. 551-559
    • Xu, J.1
  • 71
    • 1542357667 scopus 로고    scopus 로고
    • The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity
    • Xu, J. et al. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc. Natl Acad. Sci. USA 101, 3112-3117 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3112-3117
    • Xu, J.1
  • 72
    • 49449088093 scopus 로고    scopus 로고
    • Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice
    • Tucker, K., Overton, J. M. & Fadool, D. A. Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice. Int. J. Obes. 32, 1222-1232 (2008).
    • (2008) Int. J. Obes. , vol.32 , pp. 1222-1232
    • Tucker, K.1    Overton, J.M.2    Fadool, D.A.3
  • 73
    • 0024509852 scopus 로고
    • Voltage-gated potassium channels in brown fat cells
    • Lucero, M. T. & Pappone, P. A. Voltage-gated potassium channels in brown fat cells. J. Gen. Physiol. 93, 451-472 (1989).
    • (1989) J. Gen. Physiol. , vol.93 , pp. 451-472
    • Lucero, M.T.1    Pappone, P.A.2
  • 74
    • 0027477494 scopus 로고
    • Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells
    • Pappone, P. A. & Ortiz-Miranda, S. I. Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells. Am. J. Physiol. 264, C1014-C1019 (1993).
    • (1993) Am. J. Physiol. , vol.264
    • Pappone, P.A.1    Ortiz-Miranda, S.I.2
  • 76
    • 0347995064 scopus 로고    scopus 로고
    • Human adipose cells have voltage-dependent potassium currents
    • Ramirez-Ponce, M. P., Mateos, J. C. & Bellido, J. A. Human adipose cells have voltage-dependent potassium currents. J. Membr. Biol. 196, 129-134 (2003).
    • (2003) J. Membr. Biol. , vol.196 , pp. 129-134
    • Ramirez-Ponce, M.P.1    Mateos, J.C.2    Bellido, J.A.3
  • 77
    • 0025853971 scopus 로고
    • + channel cDNAs from human ventricle
    • + channel cDNAs from human ventricle. FASEB J. 5, 331-337 (1991).
    • (1991) FASEB J. , vol.5 , pp. 331-337
    • Tamkun, M.M.1
  • 78
    • 0028533272 scopus 로고
    • + channel from vascular and visceral smooth muscles
    • + channel from vascular and visceral smooth muscles. Am. J. Physiol. 267, C1231-C1238 (1994).
    • (1994) Am. J. Physiol. , vol.267
    • Overturf, K.E.1
  • 79
    • 0032104119 scopus 로고    scopus 로고
    • + channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
    • + channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J. Clin. Invest. 101, 2319-2330 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 2319-2330
    • Archer, S.L.1
  • 80
    • 0027376226 scopus 로고
    • + current similar to Kv1.5 cloned channel currents
    • + current similar to Kv1.5 cloned channel currents. Cir. Res. 73, 1061-1076 (1993).
    • (1993) Cir. Res. , vol.73 , pp. 1061-1076
    • Wang, Z.1    Fermini, B.2    Nattel, S.3
  • 82
    • 5444232406 scopus 로고    scopus 로고
    • Role of IKur in controlling action potential shape and contractility in the human atrium: Influence of chronic atrial fibrillation
    • Wettwer, E. et al. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation 110, 2299-2306 (2004).
    • (2004) Circulation , vol.110 , pp. 2299-2306
    • Wettwer, E.1
  • 83
    • 2342605426 scopus 로고    scopus 로고
    • Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias
    • Brendel, J. & Peukert, S. Blockers of the Kv1.5 channel for the treatment of atrial arrhythmias. Curr. Med. Chem. 1, 273-287 (2003).
    • (2003) Curr. Med. Chem. , vol.1 , pp. 273-287
    • Brendel, J.1    Peukert, S.2
  • 85
    • 56149117926 scopus 로고    scopus 로고
    • New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): Rationale, pharmacology and evidence for potential therapeutic value
    • Ford, J. W. & Milnes, J. T. New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): rationale, pharmacology and evidence for potential therapeutic value. J. Cardiovas. Pharmacol. 52, 105-120 (2008).
    • (2008) J. Cardiovas. Pharmacol. , vol.52 , pp. 105-120
    • Ford, J.W.1    Milnes, J.T.2
  • 86
    • 34247332707 scopus 로고    scopus 로고
    • Aryl sulphonamido indane inhibitors of the Kv1.5 ion channel
    • Gross, M. F. et al. Aryl sulphonamido indane inhibitors of the Kv1.5 ion channel. Bioorg. Med. Chem. Lett. 17, 2849-2853 (2007).
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2849-2853
    • Gross, M.F.1
  • 87
    • 34249329586 scopus 로고    scopus 로고
    • Benzopyran sulphonamides as KV1.5 potassium channel blockers
    • Lloyd, J. et al. Benzopyran sulphonamides as KV1.5 potassium channel blockers. Bioorg. Med. Chem. Lett. 17, 3271-3275 (2007).
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3271-3275
    • Lloyd, J.1
  • 88
    • 0036033595 scopus 로고    scopus 로고
    • Kr blockers dofetilide, azimilide, d, l-sotalol and ibutilide
    • Kr blockers dofetilide, azimilide, d, l-sotalol and ibutilide. Naunyn-Schmiedeberg. Arch. Pharmacol. 366, 482-487 (2002).
    • (2002) Naunyn-Schmiedeberg. Arch. Pharmacol. , vol.366 , pp. 482-487
    • Knobloch, K.1
  • 89
    • 0242627436 scopus 로고    scopus 로고
    • +-channel-blocker AVE0118 in anesthetized pigs
    • +-channel- blocker AVE0118 in anesthetized pigs. Cardiovasc. Res. 60, 298-306 (2003).
    • (2003) Cardiovasc. Res. , vol.60 , pp. 298-306
    • Wirth, K.J.1
  • 90
    • 5444269839 scopus 로고    scopus 로고
    • Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels
    • Gogelein, H. et al. Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. Naunyn-Schmiedeberg. Arch. Pharmacol. 370, 183-192 (2004).
    • (2004) Naunyn-Schmiedeberg. Arch. Pharmacol. , vol.370 , pp. 183-192
    • Gogelein, H.1
  • 91
    • 33845368736 scopus 로고    scopus 로고
    • Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation
    • Trotter, B. W. et al. Design and synthesis of novel isoquinoline-3- nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. J. Med. Chem. 49, 6954-6957 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 6954-6957
    • Trotter, B.W.1
  • 93
    • 37349055424 scopus 로고    scopus 로고
    • Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)m ethyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1, 1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure
    • Regan, C. P. et al. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)m ethyl]-6-methoxy-2-methyl-4- phenylisoquinolin-1(2H)-one and 2-phenyl-1, 1-dipyridin-3-yl-2-pyrrolidin-1-yl- ethanol in dogs with underlying heart failure. J. Pharmacol. Exp. Ther. 324, 322-330 (2008).
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 322-330
    • Regan, C.P.1
  • 95
    • 33750689149 scopus 로고    scopus 로고
    • Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers
    • Wu, S. et al. Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers. Bioorg. Med. Chem. Lett. 16, 6213-6218 (2006).
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 6213-6218
    • Wu, S.1
  • 96
    • 36349035224 scopus 로고    scopus 로고
    • The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels
    • Eldstrom, J. et al. The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels. Mol. Pharmacol. 72, 1522-1534 (2007).
    • (2007) Mol. Pharmacol. , vol.72 , pp. 1522-1534
    • Eldstrom, J.1
  • 97
    • 34147105609 scopus 로고    scopus 로고
    • Vernakalant (RSD1235): A novel, atrial-selective antifibrillatory agent
    • Fedida, D. Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent. Expert. Opin. Investig. Drugs 16, 519-532 (2007).
    • (2007) Expert. Opin. Investig. Drugs , vol.16 , pp. 519-532
    • Fedida, D.1
  • 98
    • 51649104101 scopus 로고    scopus 로고
    • Vernakalant: Pharmacology electrophysiology, safety and efficacy
    • Naccarelli, G. V. et al. Vernakalant: pharmacology electrophysiology, safety and efficacy. Drugs Today 44, 325-329 (2008).
    • (2008) Drugs Today , vol.44 , pp. 325-329
    • Naccarelli, G.V.1
  • 100
    • 34247252024 scopus 로고    scopus 로고
    • In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231
    • Wirth, K. J. et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. J. Cardiovasc. Pharmacol. 49, 197-206 (2007).
    • (2007) J. Cardiovasc. Pharmacol. , vol.49 , pp. 197-206
    • Wirth, K.J.1
  • 101
    • 42449161575 scopus 로고    scopus 로고
    • Characterization of human cardiac Kv1.5 inhibition by the novel atrial-selective antiarrhythmic compound AVE1231
    • Ehrlich, J. R. et al. Characterization of human cardiac Kv1.5 inhibition by the novel atrial-selective antiarrhythmic compound AVE1231. J. Cardiovasc. Pharmacol. 51, 380-387 (2008).
    • (2008) J. Cardiovasc. Pharmacol. , vol.51 , pp. 380-387
    • Ehrlich, J.R.1
  • 102
    • 33751530605 scopus 로고    scopus 로고
    • Electrophysiological and atrial antiarrhythmic effects of a novel IKur/Kv1.5 blocker in dogs
    • Rivard, L. et al. Electrophysiological and atrial antiarrhythmic effects of a novel IKur/Kv1.5 blocker in dogs. Heart Rhythm 2, S180 (2005).
    • (2005) Heart Rhythm , vol.2
    • Rivard, L.1
  • 103
    • 33751515811 scopus 로고    scopus 로고
    • Electrophysiological and atrial antiarrhythmic effects of a novel IKUR/Kv1.5 blocker in dogs with atrial tachycardia remodeling
    • Shiroshita-Takeshita, A., Maltais, C., Ford, J., Madge, D. & Nattel, S. Electrophysiological and atrial antiarrhythmic effects of a novel IKUR/Kv1.5 blocker in dogs with atrial tachycardia remodeling. Heart Rhythm 3, S183-S183 (2005).
    • (2005) Heart Rhythm , vol.3
    • Shiroshita-Takeshita, A.1    Maltais, C.2    Ford, J.3    Madge, D.4    Nattel, S.5
  • 105
    • 0037062485 scopus 로고    scopus 로고
    • Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome
    • Ottschytsch, N., Raes, A., Van Hoorick, D. & Snyders, D. J. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl Acad. Sci. USA 99, 7986-7991 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 7986-7991
    • Ottschytsch, N.1    Raes, A.2    Van Hoorick, D.3    Snyders, D.J.4
  • 106
    • 34548266670 scopus 로고    scopus 로고
    • Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion
    • Jacobson, D. A. et al. Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metabol. 6, 229-235 (2007).
    • (2007) Cell Metabol. , vol.6 , pp. 229-235
    • Jacobson, D.A.1
  • 107
    • 66949157288 scopus 로고    scopus 로고
    • SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability
    • Dai, X. Q., Kolic, J., Marchi, P., Sipione, S. & Macdonald, P. E. SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability. J. Cell Sci. 122, 775-779 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 775-779
    • Dai, X.Q.1    Kolic, J.2    Marchi, P.3    Sipione, S.4    MacDonald, P.E.5
  • 108
    • 35348946444 scopus 로고    scopus 로고
    • + channels: Tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins
    • + channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins. Endocr. Rev. 28, 653-663 (2007).
    • (2007) Endocr. Rev. , vol.28 , pp. 653-663
    • Leung, Y.M.1    Kwan, E.P.2    Ng, B.3    Kang, Y.4    Gaisano, H.Y.5
  • 109
    • 59249088421 scopus 로고    scopus 로고
    • SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells
    • Zhuang, G. Q. et al. SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells. Biochem. Biophys. Res. Commun. 379, 812-816 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 812-816
    • Zhuang, G.Q.1
  • 110
    • 0028886969 scopus 로고
    • Immunohistochemical localization of five members of the Kv1 channel subunits: Contrasting subcellular locations and neuron-specific co-localizations in rat brain
    • Veh, R. W. et al. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. Eur. J. Neurosci. 7, 2189-2205 (1995).
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 2189-2205
    • Veh, R.W.1
  • 111
    • 0035951404 scopus 로고    scopus 로고
    • MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis
    • Abbott, G. W. et al. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104, 217-231 (2001).
    • (2001) Cell , vol.104 , pp. 217-231
    • Abbott, G.W.1
  • 112
    • 7244236833 scopus 로고    scopus 로고
    • Upregulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease
    • Angulo, E. et al. Upregulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. J. Neurochem. 91, 547-557 (2004).
    • (2004) J. Neurochem. , vol.91 , pp. 547-557
    • Angulo, E.1
  • 113
    • 34548318679 scopus 로고    scopus 로고
    • Upregulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death
    • Pannaccione, A. et al. Upregulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol. Pharmacol. 72, 665-673 (2007).
    • (2007) Mol. Pharmacol. , vol.72 , pp. 665-673
    • Pannaccione, A.1
  • 114
    • 33750594839 scopus 로고    scopus 로고
    • Role of potassium channels in Aβ (1-40)-activated apoptotic pathway in cultured cortical neurons
    • Yu, H. B., Li, Z. B., Zhang, H. X. & Wang, X. L. Role of potassium channels in Aβ (1-40)-activated apoptotic pathway in cultured cortical neurons. J. Neurosci. Res. 84, 1475-1484 (2006).
    • (2006) J. Neurosci. Res. , vol.84 , pp. 1475-1484
    • Yu, H.B.1    Li, Z.B.2    Zhang, H.X.3    Wang, X.L.4
  • 115
    • 16844369151 scopus 로고    scopus 로고
    • + channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus
    • + channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus. Neuropharmacology 48, 810-821 (2005).
    • (2005) Neuropharmacology , vol.48 , pp. 810-821
    • Ogita, K.1
  • 116
    • 2942588558 scopus 로고    scopus 로고
    • Structure and function of Kv4-family transient potassium channels
    • Birnbaum, S. G. et al. Structure and function of Kv4-family transient potassium channels. Physiol. Rev. 84, 803-833 (2004).
    • (2004) Physiol. Rev. , vol.84 , pp. 803-833
    • Birnbaum, S.G.1
  • 117
    • 0029797238 scopus 로고    scopus 로고
    • + channel in ventricular muscle. A molecular correlate for the transient outward current
    • + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ. Res. 79, 659-668 (1996).
    • (1996) Circ. Res. , vol.79 , pp. 659-668
    • Dixon, J.E.1
  • 118
    • 3242751339 scopus 로고    scopus 로고
    • Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter
    • Hohnloser, S. H., Dorian, P., Straub, M., Beckmann, K. & Kowey, P. Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter. J. Am. Col. Cardiol. 44, 99-104 (2004).
    • (2004) J. Am. Col. Cardiol. , vol.44 , pp. 99-104
    • Hohnloser, S.H.1    Dorian, P.2    Straub, M.3    Beckmann, K.4    Kowey, P.5
  • 119
    • 33646014745 scopus 로고    scopus 로고
    • The Kv4.2 potassium channel subunit is required for pain plasticity
    • Hu, H. J. et al. The Kv4.2 potassium channel subunit is required for pain plasticity. Neuron 50, 89-100 (2006).
    • (2006) Neuron , vol.50 , pp. 89-100
    • Hu, H.J.1
  • 120
    • 29144529013 scopus 로고    scopus 로고
    • The KCNQ1 potassium channel: From gene to physiological function
    • Jespersen, T., Grunnet, M. & Olesen, S. P. The KCNQ1 potassium channel: from gene to physiological function. Physiology 20, 408-416 (2005).
    • (2005) Physiology , vol.20 , pp. 408-416
    • Jespersen, T.1    Grunnet, M.2    Olesen, S.P.3
  • 121
    • 68749110672 scopus 로고    scopus 로고
    • Neural KCNQ (Kv7) channels
    • Brown, D. A. & Passmore, G. M. Neural KCNQ (Kv7) channels. Br. J. Pharmacol. 156, 1185-1195 (2009).
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 1185-1195
    • Brown, D.A.1    Passmore, G.M.2
  • 122
    • 0029854263 scopus 로고    scopus 로고
    • Ks potassium channel
    • Ks potassium channel. Nature 384, 80-83 (1996).
    • (1996) Nature , vol.384 , pp. 80-83
    • Sanguinetti, M.C.1
  • 123
    • 45549085318 scopus 로고    scopus 로고
    • Kv7.1 (KCNQ1) properties and channelopathies
    • Peroz, D. et al. Kv7.1 (KCNQ1) properties and channelopathies. J. Physiol. (Lond). 586, 1785-1789 (2008).
    • (2008) J. Physiol. (Lond). , vol.586 , pp. 1785-1789
    • Peroz, D.1
  • 124
    • 0031936234 scopus 로고    scopus 로고
    • Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome
    • Duggal, P. et al. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome. Circulation 97, 142-146 (1998).
    • (1998) Circulation , vol.97 , pp. 142-146
    • Duggal, P.1
  • 125
    • 2542491002 scopus 로고    scopus 로고
    • Mutation in the KCNQ1 gene leading to the short QT-interval syndrome
    • Bellocq, C. et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation 109, 2394-2397 (2004).
    • (2004) Circulation , vol.109 , pp. 2394-2397
    • Bellocq, C.1
  • 126
    • 0037428218 scopus 로고    scopus 로고
    • KCNQ1 gain-of-function mutation in familial atrial fibrillation
    • Chen, Y. H. et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science 299, 251-254 (2003).
    • (2003) Science , vol.299 , pp. 251-254
    • Chen, Y.H.1
  • 127
    • 0032797045 scopus 로고    scopus 로고
    • Sensitivity of the slow component of the delayed rectifier potassium current (IKs) to potassium channel blockers: Implications for clinical reverse use-dependent effects
    • Lai, L., Su, M., Tseng, Y. & Lien, W. Sensitivity of the slow component of the delayed rectifier potassium current (IKs) to potassium channel blockers: implications for clinical reverse use-dependent effects. J. Biomed. Sci. 6, 251-259 (1999).
    • (1999) J. Biomed. Sci. , vol.6 , pp. 251-259
    • Lai, L.1    Su, M.2    Tseng, Y.3    Lien, W.4
  • 128
    • 0032029143 scopus 로고    scopus 로고
    • Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties
    • Nattel, S., Liu, L. & St-Georges, D. Effects of the novel antiarrhythmic agent azimilide on experimental atrial fibrillation and atrial electrophysiologic properties. Cardiovasc. Res. 37, 627-635 (1998).
    • (1998) Cardiovasc. Res. , vol.37 , pp. 627-635
    • Nattel, S.1    Liu, L.2    St-Georges, D.3
  • 129
    • 4644250616 scopus 로고    scopus 로고
    • Blockers of the slowly delayed rectifier potassium IKs channel: Potential antiarrhythmic agents
    • Gerlach, U. Blockers of the slowly delayed rectifier potassium IKs channel: potential antiarrhythmic agents. Curr. Med. Chem. 1, 243-252 (2003).
    • (2003) Curr. Med. Chem. , vol.1 , pp. 243-252
    • Gerlach, U.1
  • 130
    • 1342265974 scopus 로고    scopus 로고
    • Azimilide for atrial fibrillation: Clinical trial results and implications
    • Pritchett, E. L. & Marcello, S. R. Azimilide for atrial fibrillation: clinical trial results and implications. Card. Electrophysiol. Rev. 7, 215-219 (2003).
    • (2003) Card. Electrophysiol. Rev. , vol.7 , pp. 215-219
    • Pritchett, E.L.1    Marcello, S.R.2
  • 131
    • 33646097672 scopus 로고    scopus 로고
    • Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm
    • Pritchett, E. L. et al. Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm. Am. Heart J. 151, 1043-1049 (2006).
    • (2006) Am. Heart J. , vol.151 , pp. 1043-1049
    • Pritchett, E.L.1
  • 132
    • 67649823667 scopus 로고    scopus 로고
    • Pharmacological therapy for atrial fibrillation: Current options and new agents
    • Viswanathan, M. N. & Page, R. L. Pharmacological therapy for atrial fibrillation: current options and new agents. Expert Opin. Investig. Drugs 18, 417-431 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 417-431
    • Viswanathan, M.N.1    Page, R.L.2
  • 134
    • 12244262775 scopus 로고    scopus 로고
    • HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current
    • Thomas, G. P., Gerlach, U. & Antzelevitch, C. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J. Cardiovasc. Pharmacol. 41, 140-147 (2003).
    • (2003) J. Cardiovasc. Pharmacol. , vol.41 , pp. 140-147
    • Thomas, G.P.1    Gerlach, U.2    Antzelevitch, C.3
  • 135
    • 33744497032 scopus 로고    scopus 로고
    • Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles
    • So, P. P., Hu, X. D., Backx, P. H., Puglisi, J. L. & Dorian, P. Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. Br. J. Pharmacol. 148, 255-263 (2006).
    • (2006) Br. J. Pharmacol. , vol.148 , pp. 255-263
    • So, P.P.1    Hu, X.D.2    Backx, P.H.3    Puglisi, J.L.4    Dorian, P.5
  • 136
    • 25144497685 scopus 로고    scopus 로고
    • Ks-blocking agent HMR 1556 restores sinus rhythm and prevents heart failure in pigs with persistent atrial fibrillation
    • Ks-blocking agent HMR 1556 restores sinus rhythm and prevents heart failure in pigs with persistent atrial fibrillation. Basic Res. Cardiol. 100, 270-278 (2005).
    • (2005) Basic Res. Cardiol. , vol.100 , pp. 270-278
    • Bauer, A.1
  • 137
    • 1342324061 scopus 로고    scopus 로고
    • In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: Potential insights into class III actions
    • Nakashima, H., Gerlach, U., Schmidt, D. & Nattel, S. In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions. Cardiovasc. Res. 61, 705-714 (2004).
    • (2004) Cardiovasc. Res. , vol.61 , pp. 705-714
    • Nakashima, H.1    Gerlach, U.2    Schmidt, D.3    Nattel, S.4
  • 138
    • 0033517795 scopus 로고    scopus 로고
    • Ks, in canine models of malignant ischemic ventricular arrhythmia
    • Ks, in canine models of malignant ischemic ventricular arrhythmia. Circulation 100, 1917-1922 (1999).
    • (1999) Circulation , vol.100 , pp. 1917-1922
    • Lynch Jr., J.J.1
  • 139
    • 0028034402 scopus 로고
    • Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes
    • Busch, A. E. et al. Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes. Mol. Pharmacol. 46, 750-753 (1994).
    • (1994) Mol. Pharmacol. , vol.46 , pp. 750-753
    • Busch, A.E.1
  • 140
    • 33645873929 scopus 로고    scopus 로고
    • + current in canine ventricular cardiomyocytes
    • + current in canine ventricular cardiomyocytes. Naunyn-Schmiedeberg. Arch. Pharmacol. 373, 85-89 (2006).
    • (2006) Naunyn-Schmiedeberg. Arch. Pharmacol. , vol.373 , pp. 85-89
    • Magyar, J.1
  • 142
    • 0034642569 scopus 로고    scopus 로고
    • A constitutively open potassium channel formed by KCNQ1 and KCNE3
    • Schroeder, B. C. et al. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403, 196-199 (2000).
    • (2000) Nature , vol.403 , pp. 196-199
    • Schroeder, B.C.1
  • 143
    • 0034043143 scopus 로고    scopus 로고
    • + channel KvLQT1 and epithelial function
    • + channel KvLQT1 and epithelial function. Pflugers Arch. 440, 202-206 (2000).
    • (2000) Pflugers Arch. , vol.440 , pp. 202-206
    • Bleich, M.1    Warth, R.2
  • 144
    • 0033831564 scopus 로고    scopus 로고
    • - secretion in human airway epithelia
    • - secretion in human airway epithelia. Am. J. Respir. Cell. Mol. Biol. 23, 283-289 (2000).
    • (2000) Am. J. Respir. Cell. Mol. Biol. , vol.23 , pp. 283-289
    • Mall, M.1
  • 145
    • 29144482537 scopus 로고    scopus 로고
    • KCNQ1-dependent transport in renal and gastrointestinal epithelia
    • Vallon, V. et al. KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc. Natl Acad. Sci. USA 102, 17864-17869 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17864-17869
    • Vallon, V.1
  • 146
    • 50449085998 scopus 로고    scopus 로고
    • Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
    • Yasuda, K. et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genet. 40, 1092-1097 (2008).
    • (2008) Nature Genet. , vol.40 , pp. 1092-1097
    • Yasuda, K.1
  • 147
    • 67049115995 scopus 로고    scopus 로고
    • Enhanced insulin sensitivity of gene targeted mice lacking functional KCNQ1
    • Boini, K. M. et al. Enhanced insulin sensitivity of gene targeted mice lacking functional KCNQ1. Am. J. Physiol. 296, R1695-R1701 (2009).
    • (2009) Am. J. Physiol. , vol.296
    • Boini, K.M.1
  • 148
    • 0031001337 scopus 로고    scopus 로고
    • Control of M-current
    • Marrion, N. V. Control of M-current. Ann. Rev. Physiol. 59, 483-504 (1997).
    • (1997) Ann. Rev. Physiol. , vol.59 , pp. 483-504
    • Marrion, N.V.1
  • 149
    • 0032536030 scopus 로고    scopus 로고
    • A potassium channel mutation in neonatal human epilepsy
    • Biervert, C. et al. A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406 (1998).
    • (1998) Science , vol.279 , pp. 403-406
    • Biervert, C.1
  • 150
    • 0032483972 scopus 로고    scopus 로고
    • KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel
    • Wang, H. S. et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890-1893 (1998).
    • (1998) Science , vol.282 , pp. 1890-1893
    • Wang, H.S.1
  • 151
    • 0034604631 scopus 로고    scopus 로고
    • KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
    • Schroeder, B. C., Hechenberger, M., Weinreich, F., Kubisch, C. & Jentsch, T. J. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J. Biol. Chem. 275, 24089-24095 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 24089-24095
    • Schroeder, B.C.1    Hechenberger, M.2    Weinreich, F.3    Kubisch, C.4    Jentsch, T.J.5
  • 152
    • 0033524936 scopus 로고    scopus 로고
    • KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
    • Kubisch, C. et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96, 437-446 (1999).
    • (1999) Cell , vol.96 , pp. 437-446
    • Kubisch, C.1
  • 153
    • 33748999299 scopus 로고    scopus 로고
    • KCNQ4: A gene for age-related hearing impairment?
    • Van Eyken, E. et al. KCNQ4: a gene for age-related hearing impairment? Hum. Mutat. 27, 1007-1016 (2006).
    • (2006) Hum. Mutat. , vol.27 , pp. 1007-1016
    • Van Eyken, E.1
  • 154
    • 0027942427 scopus 로고
    • Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission
    • Fontana, D. J., Inouye, G. T. & Johnson, R. M. Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission. Pharmacol. Biochem. Behav. 49, 1075-1082 (1994).
    • (1994) Pharmacol. Biochem. Behav. , vol.49 , pp. 1075-1082
    • Fontana, D.J.1    Inouye, G.T.2    Johnson, R.M.3
  • 155
    • 18844482739 scopus 로고    scopus 로고
    • Linopirdine (DUP 996): Cholinergic treatment of older adults using successive and non-successive tests
    • Borjesson, A., Karlsson, T., Adolfsson, R., Ronnlund, M. & Nilsson, L. Linopirdine (DUP 996): cholinergic treatment of older adults using successive and non-successive tests. Neuropsychobiology 40, 78-85 (1999).
    • (1999) Neuropsychobiology , vol.40 , pp. 78-85
    • Borjesson, A.1    Karlsson, T.2    Adolfsson, R.3    Ronnlund, M.4    Nilsson, L.5
  • 156
    • 0031809240 scopus 로고    scopus 로고
    • Two new potent neurotransmitter release enhancers, 10,10-bis(4- pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)- 9(10H)-anthracenone: Comparison to linopirdine
    • Zaczek, R. et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4- pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J. Pharmacol. Exp. Ther. 285, 724-730 (1998).
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 724-730
    • Zaczek, R.1
  • 157
    • 0033862433 scopus 로고    scopus 로고
    • Retigabine a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
    • Wickenden, A. D., Yu, W., Zou, A., Jegla, T. & Wagoner, P. K. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol. Pharmacol. 58, 591-600 (2000).
    • (2000) Mol. Pharmacol. , vol.58 , pp. 591-600
    • Wickenden, A.D.1    Yu, W.2    Zou, A.3    Jegla, T.4    Wagoner, P.K.5
  • 158
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    • Rundfeldt, C. & Netzer, R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits. Neurosci. Lett. 282, 73-76 (2000).
    • (2000) Neurosci. Lett. , vol.282 , pp. 73-76
    • Rundfeldt, C.1    Netzer, R.2
  • 159
    • 0033916576 scopus 로고    scopus 로고
    • Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine
    • Main, M. J. et al. Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol. Pharmacol. 58, 253-262 (2000).
    • (2000) Mol. Pharmacol. , vol.58 , pp. 253-262
    • Main, M.J.1
  • 161
    • 33745604940 scopus 로고    scopus 로고
    • Retigabine: In partial seizures
    • Plosker, G. L. & Scott, L. J. Retigabine: in partial seizures. CNS Drugs 20, 601-610 (2006).
    • (2006) CNS Drugs , vol.20 , pp. 601-610
    • Plosker, G.L.1    Scott, L.J.2
  • 163
    • 71949089013 scopus 로고    scopus 로고
    • 1200 mg/day retigabine as adjunctive therapy in adults with refractory partial-onset seizures
    • Seattle, Washington
    • French, J. & Mansbach, H. 1200 mg/day retigabine as adjunctive therapy in adults with refractory partial-onset seizures. American Epilepsy Society Meeting (Seattle, Washington, 2008).
    • (2008) American Epilepsy Society Meeting
    • French, J.1    Mansbach, H.2
  • 164
    • 76649091437 scopus 로고    scopus 로고
    • Retigabine 600 or 900 mg/day as adjunctive therapy in adults with partial-onset seizures
    • Seattle, Washington
    • Brodie, M. & Mansbach, H. Retigabine 600 or 900 mg/day as adjunctive therapy in adults with partial-onset seizures. American Epilepsy Society Meeting (Seattle, Washington, 2008).
    • (2008) American Epilepsy Society Meeting
    • Brodie, M.1    Mansbach, H.2
  • 165
    • 40849085408 scopus 로고    scopus 로고
    • N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A novel, selective KCNQ2/Q3 potassium channel activator
    • Wickenden, A. D. et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol. Pharmacol. 73, 977-986 (2008).
    • (2008) Mol. Pharmacol. , vol.73 , pp. 977-986
    • Wickenden, A.D.1
  • 166
    • 53849148633 scopus 로고    scopus 로고
    • In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro- benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models
    • Roeloffs, R. et al. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3- yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J. Pharmacol. Exp. Ther. 326, 818-828 (2008).
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 818-828
    • Roeloffs, R.1
  • 167
    • 73949083321 scopus 로고    scopus 로고
    • Results of phase 1 program for ICA-105665, drug candidate for the treatment of epilepsy and neuropathic pain
    • Coral Gables, Florida
    • Rigdon, G. C. Results of phase 1 program for ICA-105665, drug candidate for the treatment of epilepsy and neuropathic pain. Antiepileptic Drug Trials X Conference (Coral Gables, Florida, 2009).
    • (2009) Antiepileptic Drug Trials X Conference
    • Rigdon, G.C.1
  • 168
    • 0043127363 scopus 로고    scopus 로고
    • KCNQ/M currents in sensory neurons: Significance for pain therapy
    • Passmore, G. M. et al. KCNQ/M currents in sensory neurons: significance for pain therapy. J. Neurosci. 23, 7227-7236 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 7227-7236
    • Passmore, G.M.1
  • 169
    • 73949144281 scopus 로고    scopus 로고
    • Sub-type selective activation of KCNQ2/3 channels modulates the excitability of nociceptive dorsal root ganglion neurons
    • San Diego, California
    • Gerlach, A., Stoehr, S. J. & Rigdon, G. C. Sub-type selective activation of KCNQ2/3 channels modulates the excitability of nociceptive dorsal root ganglion neurons. Society of Neuroscience Meeting (San Diego, California, 2007).
    • (2007) Society of Neuroscience Meeting
    • Gerlach, A.1    Stoehr, S.J.2    Rigdon, G.C.3
  • 170
    • 34250209086 scopus 로고    scopus 로고
    • Kv7 (KCNQ) channel modulators and neuropathic pain
    • Munro, G. & Dalby-Brown, W. Kv7 (KCNQ) channel modulators and neuropathic pain. J. Med. Chem. 50, 2576-2582 (2007).
    • (2007) J. Med. Chem. , vol.50 , pp. 2576-2582
    • Munro, G.1    Dalby-Brown, W.2
  • 171
    • 67650577094 scopus 로고    scopus 로고
    • Kv7 channels as targets for the treatment of pain
    • Wickenden, A. D. & McNaughton-Smith, G. Kv7 channels as targets for the treatment of pain. Curr. Pharm. Des. 15, 1773-1798 (2009).
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 1773-1798
    • Wickenden, A.D.1    McNaughton-Smith, G.2
  • 173
    • 0037462422 scopus 로고    scopus 로고
    • The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain
    • Blackburn-Munro, G. & Jensen, B. S. The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur. J. Pharmacol. 460, 109-116 (2003).
    • (2003) Eur. J. Pharmacol. , vol.460 , pp. 109-116
    • Blackburn-Munro, G.1    Jensen, B.S.2
  • 174
    • 33846675852 scopus 로고    scopus 로고
    • Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice
    • Hirano, K. et al. Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. Neurosci. Lett. 413, 159-162 (2007).
    • (2007) Neurosci. Lett. , vol.413 , pp. 159-162
    • Hirano, K.1
  • 175
    • 73949085884 scopus 로고    scopus 로고
    • Activity of a KCNQ2/3 opener in rat models of inflammatory pain
    • San Diego, California
    • Leventhal, L. et al. Activity of a KCNQ2/3 opener in rat models of inflammatory pain. Society of Neuroscience Meeting (San Diego, California, 2007).
    • (2007) Society of Neuroscience Meeting
    • Leventhal, L.1
  • 176
    • 73949109575 scopus 로고    scopus 로고
    • Activity of a KCNQ2/3 opener in rat models of neuropathic pain
    • San Diego, California
    • Mark, L. et al. Activity of a KCNQ2/3 opener in rat models of neuropathic pain. Society of Neuroscience Meeting (San Diego, California, 2007).
    • (2007) Society of Neuroscience Meeting
    • Mark, L.1
  • 178
    • 14544271983 scopus 로고    scopus 로고
    • Recent developments on KCNQ potassium channel openers
    • Wua, Y. J. & Dworetzky, S. I. Recent developments on KCNQ potassium channel openers. Curr. Med. Chem. 12, 453-460 (2005).
    • (2005) Curr. Med. Chem. , vol.12 , pp. 453-460
    • Wua, Y.J.1    Dworetzky, S.I.2
  • 180
    • 15744362456 scopus 로고    scopus 로고
    • Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties
    • Peretz, A. et al. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol. Pharmacol. 67, 1053-1066 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1053-1066
    • Peretz, A.1
  • 181
    • 44349189844 scopus 로고    scopus 로고
    • A tale of switched functions: From cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives
    • Peretz, A. et al. A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives. PLoS ONE 2, e1332 (2007).
    • (2007) PLoS ONE , vol.2
    • Peretz, A.1
  • 182
    • 45549093780 scopus 로고    scopus 로고
    • Kv7 channels: Interaction with dopaminergic and serotonergic neurotransmission in the CNS
    • Hansen, H. H. et al. Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS. J. Physiol. (Lond). 586, 1823-1832 (2008).
    • (2008) J. Physiol. (Lond). , vol.586 , pp. 1823-1832
    • Hansen, H.H.1
  • 183
    • 59649097444 scopus 로고    scopus 로고
    • Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania
    • Redrobe, J. P. & Nielsen, A. N. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. Behav. Brain Res. 198, 481-485 (2009).
    • (2009) Behav. Brain Res. , vol.198 , pp. 481-485
    • Redrobe, J.P.1    Nielsen, A.N.2
  • 184
    • 62449333567 scopus 로고    scopus 로고
    • Antipsychotic-like effect of retigabine [N-(2-amino-4-(fluorobenzylamino) -phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission
    • Sotty, F. et al. Antipsychotic-like effect of retigabine [N-(2-amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission. J. Pharmacol. Exp. Ther. 328, 951-962 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 951-962
    • Sotty, F.1
  • 188
    • 33750390132 scopus 로고    scopus 로고
    • Overexpression of Eag1 potassium channels in clinical tumours
    • Haemmerlein, B. et al. Overexpression of Eag1 potassium channels in clinical tumours. Mol. Can. 5, 41 (2006).
    • (2006) Mol. Can. , vol.5 , pp. 41
    • Haemmerlein, B.1
  • 189
    • 0031671522 scopus 로고    scopus 로고
    • Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion
    • Occhiodoro, T. et al. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 434, 177-182 (1998).
    • (1998) FEBS Lett. , vol.434 , pp. 177-182
    • Occhiodoro, T.1
  • 190
    • 49249108871 scopus 로고    scopus 로고
    • Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain
    • Martin, S. et al. Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Neurosci. 155, 833-844 (2008).
    • (2008) Neurosci. , vol.155 , pp. 833-844
    • Martin, S.1
  • 191
    • 0032532188 scopus 로고    scopus 로고
    • + current, ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts
    • + current, ih-eag, contributes to the hyperpolarization of human fusion-competent myoblasts. J. Physiol. (Lond.) 512, 317-323 (1998).
    • (1998) J. Physiol. (Lond.) , vol.512 , pp. 317-323
    • Bijlenga, P.1
  • 193
    • 34247135947 scopus 로고    scopus 로고
    • Aberrant expression of ether a go-go potassium channel in colorectal cancer patients and cell lines
    • Ding, X. W., Yan, J. J., An, P., Lu, P. & Luo, H. S. Aberrant expression of ether a go-go potassium channel in colorectal cancer patients and cell lines. World J. Gastroenterol. 13, 1257-1261 (2007).
    • (2007) World J. Gastroenterol. , vol.13 , pp. 1257-1261
    • Ding, X.W.1    Yan, J.J.2    An, P.3    Lu, P.4    Luo, H.S.5
  • 194
    • 36048960918 scopus 로고    scopus 로고
    • Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines
    • Ding, X. W., Luo, H. S., Jin, X., Yan, J. J. & Ai, Y. W. Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines. Med. Oncol. 24, 345-350 (2007).
    • (2007) Med. Oncol. , vol.24 , pp. 345-350
    • Ding, X.W.1    Luo, H.S.2    Jin, X.3    Yan, J.J.4    Ai, Y.W.5
  • 195
    • 33750419308 scopus 로고    scopus 로고
    • Ether a go-go potassium channel expression in soft tissue sarcoma patients
    • Mello de Queiroz, F., Suarez-Kurtz, G., Stuhmer, W. & Pardo, L. A. Ether a go-go potassium channel expression in soft tissue sarcoma patients. Mol. Cancer 5, 42 (2006).
    • (2006) Mol. Cancer , vol.5 , pp. 42
    • Mello De Queiroz, F.1    Suarez-Kurtz, G.2    Stuhmer, W.3    Pardo, L.A.4
  • 196
    • 65949083785 scopus 로고    scopus 로고
    • Estrogens and human papilloma virus oncogenes regulate human ether-a-go-go-1 potassium channel expression
    • Diaz, L. et al. Estrogens and human papilloma virus oncogenes regulate human ether-a-go-go-1 potassium channel expression. Cancer Res. 69, 3300-3307 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3300-3307
    • Diaz, L.1
  • 197
    • 33744961342 scopus 로고    scopus 로고
    • Silencing the activity and proliferative properties of the human Eag1 potassium channel by RNAi
    • Weber, C. et al. Silencing the activity and proliferative properties of the human Eag1 potassium channel by RNAi. J. Biol. Chem. 281, 13033-13037 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 13033-13037
    • Weber, C.1
  • 198
    • 34250888071 scopus 로고    scopus 로고
    • + currents of cells expressing human ether a go-go channels
    • + currents of cells expressing human ether a go-go channels. Life Sci. 81, 255-265 (2007).
    • (2007) Life Sci. , vol.81 , pp. 255-265
    • Toral, C.1
  • 199
    • 0037098907 scopus 로고    scopus 로고
    • Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells
    • Gavrilova-Ruch, O. et al. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J. Membr. Biol. 188, 137-149 (2002).
    • (2002) J. Membr. Biol. , vol.188 , pp. 137-149
    • Gavrilova-Ruch, O.1
  • 202
    • 50249099700 scopus 로고    scopus 로고
    • The hERG potassium channel and hERG screening for drug-induced torsades de pointes
    • Hancox, J. C., McPate, M. J., El Harchi, A. & Zhang, Y. H. The hERG potassium channel and hERG screening for drug-induced torsades de pointes. Pharmacol. Ther. 11 9, 118-132 (2008).
    • (2008) Pharmacol. Ther. , vol.11 , Issue.9 , pp. 118-132
    • Hancox, J.C.1    McPate, M.J.2    El Harchi, A.3    Zhang, Y.H.4
  • 203
    • 33748297461 scopus 로고    scopus 로고
    • Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide
    • Gomez-Varela, D. et al. Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. FEBS Lett. 580, 5059-5066 (2006).
    • (2006) FEBS Lett. , vol.580 , pp. 5059-5066
    • Gomez-Varela, D.1
  • 204
    • 34547636154 scopus 로고    scopus 로고
    • Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumour activity
    • Gomez-Varela, D. et al. Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumour activity. Cancer Res. 67, 7343-7349 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 7343-7349
    • Gomez-Varela, D.1
  • 205
    • 61849158750 scopus 로고    scopus 로고
    • HERG1 channel activators: A new anti-arrhythmic principle
    • Grunnet, M., Hansen, R. S. & Olesen, S. P. hERG1 channel activators: a new anti-arrhythmic principle. Prog. Biophys. Mol. Biol. 98, 347-362 (2008).
    • (2008) Prog. Biophys. Mol. Biol. , vol.98 , pp. 347-362
    • Grunnet, M.1    Hansen, R.S.2    Olesen, S.P.3
  • 206
    • 0029002969 scopus 로고
    • A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
    • Sanguinetti, M. C., Jiang, C., Curran, M. E. & Keating, M. T. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81, 299-307 (1995).
    • (1995) Cell , vol.81 , pp. 299-307
    • Sanguinetti, M.C.1    Jiang, C.2    Curran, M.E.3    Keating, M.T.4
  • 207
    • 43049173412 scopus 로고    scopus 로고
    • The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death
    • Kamath, G. S. & Mittal, S. The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death. Prog. Cardiovasc. Dis. 50, 439-448 (2008).
    • (2008) Prog. Cardiovasc. Dis. , vol.50 , pp. 439-448
    • Kamath, G.S.1    Mittal, S.2
  • 208
    • 30044441212 scopus 로고    scopus 로고
    • Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
    • Hansen, R. S. et al. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl- phenyl)-urea (NS1643). Mol Pharmacol. 69, 266-277 (2006).
    • (2006) Mol Pharmacol. , vol.69 , pp. 266-277
    • Hansen, R.S.1
  • 209
    • 33748936880 scopus 로고    scopus 로고
    • Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'- trifluoromethylphenyl)urea]
    • Hansen, R. S. et al. Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5- yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol. Pharmacol. 70, 1319-1329 (2006).
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1319-1329
    • Hansen, R.S.1
  • 210
    • 20144373180 scopus 로고    scopus 로고
    • + channel
    • + channel. Mol. Pharmacol. 67, 827-836 (2005).
    • (2005) Mol. Pharmacol. , vol.67 , pp. 827-836
    • Kang, J.1
  • 211
    • 23944441185 scopus 로고    scopus 로고
    • Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity
    • Zhou, J. et al. Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol. Pharmacol. 68, 876-884 (2005).
    • (2005) Mol. Pharmacol. , vol.68 , pp. 876-884
    • Zhou, J.1
  • 212
    • 62549106559 scopus 로고    scopus 로고
    • Electrophysiologic characterization of a novel hERG channel activator
    • Su, Z. et al. Electrophysiologic characterization of a novel hERG channel activator. Biochem. Pharmacol. 77, 1383-1390 (2009).
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1383-1390
    • Su, Z.1
  • 213
    • 33751168514 scopus 로고    scopus 로고
    • Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator
    • Zeng, H. et al. Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator. J. Pharmacol. Exp. Ther. 319, 957-962 (2006).
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 957-962
    • Zeng, H.1
  • 214
    • 0033756336 scopus 로고    scopus 로고
    • Early repolarization syndrome: Clinical characteristics and possible cellular and ionic mechanisms
    • Gussak, I. & Antzelevitch, C. Early repolarization syndrome: clinical characteristics and possible cellular and ionic mechanisms. J. Electrocardiol. 33, 299-309 (2000).
    • (2000) J. Electrocardiol. , vol.33 , pp. 299-309
    • Gussak, I.1    Antzelevitch, C.2
  • 215
    • 33644851751 scopus 로고    scopus 로고
    • Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
    • Anderson, C. L. et al. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 11 3, 365-373 (2006).
    • (2006) Circulation , vol.11 , Issue.3 , pp. 365-373
    • Anderson, C.L.1
  • 216
    • 0033615646 scopus 로고    scopus 로고
    • Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome
    • Zhou, Z., Gong, Q. & January, C. T. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. J. Biol. Chem. 274, 31123-31126 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 31123-31126
    • Zhou, Z.1    Gong, Q.2    January, C.T.3
  • 217
    • 36749056453 scopus 로고    scopus 로고
    • HERG channel trafficking: Novel targets in drug-induced long QT syndrome
    • Dennis, A., Wang, L., Wan, X. & Ficker, E. hERG channel trafficking: novel targets in drug-induced long QT syndrome. Biochem. Soc. Trans. 35, 1060-1063 (2007).
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 1060-1063
    • Dennis, A.1    Wang, L.2    Wan, X.3    Ficker, E.4
  • 218
    • 66749174141 scopus 로고    scopus 로고
    • A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    • Huffaker, S. J. et al. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Med. 15, 509-518 (2009).
    • (2009) Nature Med. , vol.15 , pp. 509-518
    • Huffaker, S.J.1
  • 219
    • 23844547384 scopus 로고    scopus 로고
    • Expression and role of hERG channels in cancer cells
    • Arcangeli, A. Expression and role of hERG channels in cancer cells. Novartis Found. Symp. 266, 225-232 (2005).
    • (2005) Novartis Found. Symp. , vol.266 , pp. 225-232
    • Arcangeli, A.1
  • 220
    • 18844467600 scopus 로고    scopus 로고
    • + current highly conserved in tumours of different histogenesis-a selective advantage for cancer cells?
    • + current highly conserved in tumours of different histogenesis-a selective advantage for cancer cells? Cancer Res. 58, 815-822 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 815-822
    • Bianchi, L.1
  • 221
    • 17744393426 scopus 로고    scopus 로고
    • HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium
    • Cherubini, A. et al. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br. J. Cancer 83, 1722-1729 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 1722-1729
    • Cherubini, A.1
  • 222
    • 0036738165 scopus 로고    scopus 로고
    • HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic haemopoietic progenitors
    • Pillozzi, S. et al. HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic haemopoietic progenitors. Leukemia 16, 1791-1798 (2002).
    • (2002) Leukemia , vol.16 , pp. 1791-1798
    • Pillozzi, S.1
  • 223
    • 9144274941 scopus 로고    scopus 로고
    • Herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumour cells
    • Lastraioli, E. et al. herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumour cells. Cancer Res. 64, 606-611 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 606-611
    • Lastraioli, E.1
  • 224
    • 27144531556 scopus 로고    scopus 로고
    • HERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines
    • Masi, A. et al. hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. Br. J. Cancer 93, 781-792 (2005).
    • (2005) Br. J. Cancer , vol.93 , pp. 781-792
    • Masi, A.1
  • 225
    • 33749252189 scopus 로고    scopus 로고
    • HERG1 channels in human esophagus: Evidence for their aberrant expression in the malignant progression of Barrett's esophagus
    • Lastraioli, E. et al. hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus. J. Cell. Physiol. 209, 398-404 (2006).
    • (2006) J. Cell. Physiol. , vol.209 , pp. 398-404
    • Lastraioli, E.1
  • 226
    • 34548036519 scopus 로고    scopus 로고
    • + channel form a macromolecular signalling complex in acute myeloid leukemia: Role in cell migration and clinical outcome
    • + channel form a macromolecular signalling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood 11 0, 1238-1250 (2007).
    • (2007) Blood , vol.11 , Issue.0 , pp. 1238-1250
    • Pillozzi, S.1
  • 227
    • 0037474225 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumour cells
    • Crociani, O. et al. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumour cells. J. Biol. Chem. 278, 2947-2955 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 2947-2955
    • Crociani, O.1
  • 228
    • 49449109702 scopus 로고    scopus 로고
    • + channel expression and hERG1 current density in tumour cells
    • + channel expression and hERG1 current density in tumour cells. Mol. Cell. Biol. 28, 5043-5060 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 5043-5060
    • Guasti, L.1
  • 229
    • 65649088361 scopus 로고    scopus 로고
    • State-dependent block of HERG potassium channels by R-roscovitine: Implications for cancer therapy
    • Ganapathi, S. B., Kester, M. & Elmslie, K. S. State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy. Am. J. Physiol. Cell. Physiol. 296, C701-C710 (2009).
    • (2009) Am. J. Physiol. Cell. Physiol. , vol.296
    • Ganapathi, S.B.1    Kester, M.2    Elmslie, K.S.3
  • 230
    • 33845680648 scopus 로고    scopus 로고
    • + channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway
    • + channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway. FASEB J. 20, 1531-1533 (2006).
    • (2006) FASEB J. , vol.20 , pp. 1531-1533
    • Wang, X.1
  • 231
    • 0034126582 scopus 로고    scopus 로고
    • Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    • Watanabe, H. et al. Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J. Neurochem. 75, 28-33 (2000).
    • (2000) J. Neurochem. , vol.75 , pp. 28-33
    • Watanabe, H.1
  • 232
    • 16644379267 scopus 로고    scopus 로고
    • Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behaviour
    • Peters, H. C., Hu, H., Pongs, O., Storm, J. F. & Isbrandt, D. Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behaviour. Nature Neurosci. 8, 51-60 (2005).
    • (2005) Nature Neurosci. , vol.8 , pp. 51-60
    • Peters, H.C.1    Hu, H.2    Pongs, O.3    Storm, J.F.4    Isbrandt, D.5
  • 233
    • 2342566988 scopus 로고    scopus 로고
    • Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms?
    • Nerbonne, J. M. Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms? Trends Cardiovasc. Med. 14, 83-93 (2004).
    • (2004) Trends Cardiovasc. Med. , vol.14 , pp. 83-93
    • Nerbonne, J.M.1
  • 234
    • 0032753963 scopus 로고    scopus 로고
    • A unified nomenclature for short-chain peptides isolated from scorpion venoms: Alpha-KTx molecular subfamilies
    • Tytgat, J. et al. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol. Sci. 20, 444-447 (1999).
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 444-447
    • Tytgat, J.1
  • 235
    • 0024426645 scopus 로고
    • Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor
    • MacKinnon, R. & Miller, C. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science 245, 1382-1385 (1989).
    • (1989) Science , vol.245 , pp. 1382-1385
    • MacKinnon, R.1    Miller, C.2
  • 236
    • 0025644364 scopus 로고
    • Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor
    • MacKinnon, R., Heginbotham, L. & Abramson, T. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron 5, 767-771 (1990).
    • (1990) Neuron , vol.5 , pp. 767-771
    • MacKinnon, R.1    Heginbotham, L.2    Abramson, T.3
  • 237
    • 0034987611 scopus 로고    scopus 로고
    • Potassium channels in T lymphocytes: Toxins to therapeutic immuno-suppressants
    • Chandy, K. G. et al. Potassium channels in T lymphocytes: toxins to therapeutic immuno-suppressants. Toxicon 39, 1269-1276 (2001).
    • (2001) Toxicon , vol.39 , pp. 1269-1276
    • Chandy, K.G.1
  • 238
    • 0030952979 scopus 로고    scopus 로고
    • + channel through multiple binding sites
    • + channel through multiple binding sites. Neuron 18, 665-673 (1997).
    • (1997) Neuron , vol.18 , pp. 665-673
    • Swartz, K.J.1    MacKinnon, R.2
  • 239
    • 33846444703 scopus 로고    scopus 로고
    • Tarantula toxins interacting with voltage sensors in potassium channels
    • Swartz, K. J. Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon 49, 213-230 (2007).
    • (2007) Toxicon , vol.49 , pp. 213-230
    • Swartz, K.J.1
  • 240
    • 23844463536 scopus 로고    scopus 로고
    • Voltage-sensor activation with a tarantula toxin as cargo
    • Phillips, L. R. et al. Voltage-sensor activation with a tarantula toxin as cargo. Nature 436, 857-860 (2005).
    • (2005) Nature , vol.436 , pp. 857-860
    • Phillips, L.R.1
  • 241
    • 3142580385 scopus 로고    scopus 로고
    • A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom
    • Lee, S. Y. & MacKinnon, R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430, 232-235 (2004).
    • (2004) Nature , vol.430 , pp. 232-235
    • Lee, S.Y.1    MacKinnon, R.2
  • 242
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85-100 (1981).
    • (1981) Pflugers Arch. , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.J.5
  • 243
    • 0030951463 scopus 로고    scopus 로고
    • V1.3 expressed in CHO cells
    • V1.3 expressed in CHO cells. Biochemistry 36, 3737-3744 (1997).
    • (1997) Biochemistry , vol.36 , pp. 3737-3744
    • Helms, L.M.1
  • 244
    • 0033586731 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3
    • Felix, J. P. et al. Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry 38, 4922-4930 (1999).
    • (1999) Biochemistry , vol.38 , pp. 4922-4930
    • Felix, J.P.1
  • 246
    • 0032903174 scopus 로고    scopus 로고
    • UK-78282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation
    • Hanson, D. C. et al. UK-78282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br. J. Pharmacol. 126, 1707-1716 (1999).
    • (1999) Br. J. Pharmacol. , vol.126 , pp. 1707-1716
    • Hanson, D.C.1
  • 247
    • 10244239414 scopus 로고    scopus 로고
    • Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the Ion Channel Reader 8000
    • Wang, K. et al. Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the Ion Channel Reader 8000. Assay Drug Dev. Technol. 2, 525-534 (2004).
    • (2004) Assay Drug Dev. Technol. , vol.2 , pp. 525-534
    • Wang, K.1
  • 248
    • 16844367241 scopus 로고    scopus 로고
    • A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells
    • Weaver, C. D., Harden, D., Dworetzky, S. I., Robertson, B. & Knox, R. J. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J. Biomol. Screen. 9, 671-677 (2004).
    • (2004) J. Biomol. Screen. , vol.9 , pp. 671-677
    • Weaver, C.D.1    Harden, D.2    Dworetzky, S.I.3    Robertson, B.4    Knox, R.J.5
  • 249
    • 0346337290 scopus 로고    scopus 로고
    • Comparative study of membrane potential-sensitive fluorescent probes and their use in ion channel screening assays
    • Wolff, C., Fuks, B. & Chatelain, P. Comparative study of membrane potential-sensitive fluorescent probes and their use in ion channel screening assays. J. Biomol. Screen. 8, 533-543 (2003).
    • (2003) J. Biomol. Screen. , vol.8 , pp. 533-543
    • Wolff, C.1    Fuks, B.2    Chatelain, P.3
  • 250
    • 58149216783 scopus 로고    scopus 로고
    • Automated voltage-clamp technique
    • Ghetti, A., Guia, A. & Xu, J. Automated voltage-clamp technique. Methods Mol. Biol. 403, 59-69 (2007).
    • (2007) Methods Mol. Biol. , vol.403 , pp. 59-69
    • Ghetti, A.1    Guia, A.2    Xu, J.3
  • 253
    • 62649105798 scopus 로고    scopus 로고
    • Port-a-patch and patchliner: High fidelity electrophysiology for secondary screening and safety pharmacology
    • Farre, C. et al. Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology. Combin. Chem. High Throughput Screen. 12, 24-37 (2009).
    • (2009) Combin. Chem. High Throughput Screen. , vol.12 , pp. 24-37
    • Farre, C.1
  • 254
    • 36549021087 scopus 로고    scopus 로고
    • Validation of a medium-throughput electro physiological assay for KCNQ2/3 channel enhancers using IonWorks H T
    • Jow, F. et al. Validation of a medium-throughput electro physiological assay for KCNQ2/3 channel enhancers using IonWorks H T. J. Biomol. Screen. 12, 1059-1067 (2007).
    • (2007) J. Biomol. Screen. , vol.12 , pp. 1059-1067
    • Jow, F.1
  • 255
    • 34548856200 scopus 로고    scopus 로고
    • Population patch clamp electrophysiology: A breakthrough technology for ion channel screening
    • Dale, T. J., Townsend, C., Hollands, E. C. & Trezise, D. J. Population patch clamp electrophysiology: a breakthrough technology for ion channel screening. Mol. Biosyst. 3, 714-722 (2007).
    • (2007) Mol. Biosyst. , vol.3 , pp. 714-722
    • Dale, T.J.1    Townsend, C.2    Hollands, E.C.3    Trezise, D.J.4
  • 256
    • 41649104559 scopus 로고    scopus 로고
    • Impact of novel screening technologies on ion channel drug discovery
    • Lu, Q. & An, W. F. Impact of novel screening technologies on ion channel drug discovery. Combin. Chem. High Throughput Screen. 11, 185-194 (2008).
    • (2008) Combin. Chem. High Throughput Screen. , vol.11 , pp. 185-194
    • Lu, Q.1    An, W.F.2
  • 257
    • 70349336981 scopus 로고    scopus 로고
    • Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research
    • Southan, A. & Clark, G. Recent advances in electrophysiology-based screening technology and the impact upon ion channel discovery research. Methods Mol. Biol. 565, 187-208 (2009).
    • (2009) Methods Mol. Biol. , vol.565 , pp. 187-208
    • Southan, A.1    Clark, G.2
  • 258
    • 10744231935 scopus 로고    scopus 로고
    • Kv1.3 channel gene-targeted deletion produces "super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics
    • Fadool, D. A. et al. Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics. Neuron 41, 389-404 (2004).
    • (2004) Neuron , vol.41 , pp. 389-404
    • Fadool, D.A.1
  • 259
    • 0141925769 scopus 로고    scopus 로고
    • Compensatory anion currents in Kv1.3 channel-deficient thymocytes
    • Koni, P. A. et al. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. J. Biol. Chem. 278, 39443-39451 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 39443-39451
    • Koni, P.A.1
  • 260
    • 67649867439 scopus 로고    scopus 로고
    • A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol
    • Kopljar, I. et al. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proc. Natl Acad. Sci. USA 106, 9896-9901 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9896-9901
    • Kopljar, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.