Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice

Neuroscience Letters

Volumn 413, Issue 2, 2007, Pages 159-162

  Hirano, Kazufumi ^a   Kuratani, Kazuyoshi ^a   Fujiyoshi, Masato ^b   Tashiro, Nobuhiko ^b   Hayashi, Etsuko ^a   Kinoshita, Mine ^a  

^a Tsukuba Research Laboratories   (Japan)

^b Development and Medical Affairs Division   (Japan)

Author keywords

Capsaicin; KCNQ; Licking; Nociception; Visceral pain

Indexed keywords

CAPSAICIN; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; RETIGABINE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; ANTICONVULSIVE AGENT; CARBAMIC ACID DERIVATIVE; PHENYLENEDIAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CELL MEMBRANE CONDUCTANCE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; HYPERPOLARIZATION; LICKING; M CURRENT; MOUSE; NERVE POTENTIAL; NOCICEPTIVE STIMULATION; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; SENSORY SYSTEM; SPINAL CORD; SPINAL GANGLION; VISCERAL PAIN; ANIMAL; COLON; DRUG ANTAGONISM; DRUG POTENTIATION; INNERVATION; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; NOCICEPTIVE RECEPTOR; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; SENSORY NERVE; SENSORY RECEPTOR;

ANIMALS; ANTICONVULSANTS; CAPSAICIN; CARBAMATES; COLON; KCNQ2 POTASSIUM CHANNEL; MALE; MICE; MICE, INBRED ICR; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PHENYLENEDIAMINES; REACTION TIME; RECEPTORS, SENSORY; VISCERAL AFFERENTS;

EID: 33846675852     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.11.043     Document Type: Article

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