Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3

Biochemistry

Volumn 38, Issue 16, 1999, Pages 4922-4930

  Felix, John P ^a   Bugianesi, Randal M ^a   Schmalhofer, William A ^a   Borris, Robert ^a   Goetz, Michael A ^a   Hensens, Otto D ^a   Bao, Jian Ming ^a   Kayser, Frank ^a   Parsons, William H ^a   Rupprecht, Kathleen ^a   Garcia, Maria L ^a   Kaczorowski, Gregory J ^a   Slaughter, Robert S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORREOLIDE; DIHYDROCORREOLIDE; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RUBIDIUM 86; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; INCUBATION TIME; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; RECEPTOR SENSITIVITY; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BINDING SITES; CELL LINE; CHARYBDOTOXIN; CHO CELLS; CRICETINAE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ION CHANNEL GATING; KV1.3 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; NEUROTOXINS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RUBIDIUM RADIOISOTOPES; SCORPION VENOMS; SYNAPTIC MEMBRANES; T-LYMPHOCYTES; TRITERPENES;

EID: 0033586731     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982954w     Document Type: Article

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