The very small-conductance K+ channel K(V)LQT1 and epithelial function

Pflugers Archiv European Journal of Physiology

Volumn 440, Issue 2, 2000, Pages 202-206

  Bleich, Markus ^a   Warth, Richard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Cl secretory epithelia; Epithelial tissue; K(V)LQT1; Very small conductance K+ channel

Indexed keywords

CALCIUM ION; CHLORIDE ION; CYCLIC AMP; INOSITOL 1,4,5 TRISPHOSPHATE; MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM ION; REGULATOR PROTEIN;

COLON; EPITHELIUM; GENE SEQUENCE; HUMAN; INNER EAR; KIDNEY; NONHUMAN; PANCREAS; POTASSIUM CURRENT; PRIORITY JOURNAL; RECTUM GLAND; RESPIRATORY EPITHELIUM; REVIEW; SMALL INTESTINE;

ANIMALS; EAR, INNER; EPITHELIAL CELLS; INTESTINES; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KIDNEY; PANCREAS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RESPIRATORY MUCOSA;

EID: 0034043143     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240051040     Document Type: Review

References (52)

1. 1. Aggeli A, Bannister ML, Bell M, Boden N, Findlay JB, Hunter M, Knowles PF, Yang JC (1998) Conformation and ion-channeling activity of a 27-residue peptide modeled on the single-transmembrane segment of the IsK (minK) protein. Biochemistry 37:8121-8131
2. Ks cardiac potassium current. Nature 384:78-80
3. 3. Beschorner U, von Hahn T, Hopf A, Hübner M, Unsöld B, Bleich M, Kerst G, Schreiber R, Warth R, Waldegger S, Kunzelmann K, Greger R (1999) Properties of KvLQT-1 channels of Squalus acanthias expressed in CHO cells and Xenopus laevis oocytes (abstract). Pflügers Arch 437 [Suppl.]:R91
4. + channel blocker 293B. Pflügers Arch 434: 499-501
5. + channels in the basolateral membrane of the shark rectal gland tubule (abstract). Kidney Blood Press Res 21:81
6. Ks channel complex. Br J Pharmacol 122:187-189
7. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. EMBO J 16:5472-5479
8. - secretion in rat and rabbit colon. Cell Physiol Biochem 5:204-210
9. 9. Folander K, Smith JS, Antanavage J, Bennett C, Stein RB, Swanson R (1990) Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus. Proc Natl Acad Sci USA 87:2975-2979
10. 10. Greger R, Bleich M, Leipziger J, Ecke D, Mall M, Kunzelmann K (1997) Regulation of ion transport in colonic crypts. News Physiol Sci 12:62-66
11. - secretion. Comp Biochem Physiol 118A:271-275
12. 12. Greger R, Schlatter E, Gögelein H (1986) Sodium chloride secretion in rectal gland of dogfish Squalus acanthias. News Physiol Sci 1:134-136
13. 13. Hübner M, Schreiber R, Garty H, Levy-Holzman R, Greger R, Kunzelmann K (1999) Cloning and expression of KvLQT-1 from rat colon (abstract). Pflügers Arch 437 [Suppl.]:R91
14. + channels in the basolateral membrane of rat tracheal epithelia. J Membr Biol 154:251-257
15. 15. Kaczmarek LK, Blumenthal EM (1997) Properties and regulation of the minK potassium channel protein. Physiol Rev 77:627-641
16. i is inverted by the presence of minK (abstract). Kidney Blood Press Res 22:203
17. Ks) and its augmentation by carbachol in rat pancreatic acini. Pflügers Arch 438:604-611
18. + channel of very small conductance in the basolateral membrane of rat pancreatic acinar cells. Pflügers Arch 438:597-603
19. + conductance. Pflügers Arch 429:517-530
20. - secretion in murine nasal and colonic epithelia. J Physiol (Lond) 510:237-247
21. + conductance. Pflügers Arch 432:516-522
22. sK/KvLQT1 channel via protein kinase C in vestibular dark cells. Am J Physiol 273: C2022-C2029
23. 23. Neyroud N, Richard P, Vignier N, Donger C, Denjoy I, Demay L, Shkolnikova M, Pesce R, Chevalier P, Hainque B, Coumel P, Schwartz K, Guicheney P (1999) Genomic organization of the KCNQ1 K+ channel gene and identification of C-terminal mutations in the long-QT syndrome. Circ Res 84:290-297
24. 24. Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C, Barhanin J, Faure S, Gary F, Coumel P, Petit C, Schwartz K, Guicheney P (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nature Genet 15:186-189
25. 25. Pusch M (1998) Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK. Pflügers Arch 437:172-174
26. 26. Pusch M, Magrassi R, Wollnik B, Conti F (1998) Activation and inactivation of homomeric KvLQT1 potassium channels. Biophys J 75:785-792
27. 27. Romey G, Attali B, Chouabe C, Abitbol I, Guillemare E, Barhanin J, Lazdunski M (1997) Molecular mechanism and functional significance of the minK control of the KvLQT channel activity. J Biol Chem 272:16713-16716
28. Ks potassium channel. Nature 384:80-83
29. 29. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403:196-199
30. 30. Sesti F, Goldstein SAN (1998) Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome. J Gen Physiol 112:651-663
31. 31. Shen Z, Marcus DC (1998) Divalent cations inhibit IsK/KvLQT1 channels in excised membrane patches of striai marginal cells. Hear Res 123:157-167
32. 32. Silva P, Stoff J, Field M, Fine L, Forrest JN, Epstein FH (1977) Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport. Am J Physiol 233:F298-F306
33. 33. Slawik M, Zdebik A, Hug MJ, Kerstan D, Leipziger J, Greger R (1996) Whole-cell conductive properties of rat pancreatic acini. Pflügers Arch 432:112-120
34. sK channels in epithelia. FEBS Lett 396:271-275
35. sk (minK) and KvLQT1 proteins. Rev Physiol Biochem Pharmacol 137:191-226
36. 36. Sugimoto T, Tanabe Y, Shigemoto R, Iwai M, Takumi T, Ohkubo H, Nakanishi S (1990) Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells. J Membr Biol 113:39-47
37. + secretion via activation of apical IsK/KvLQT1 channels in striai marginal cells. Hear Res 114:107-116
38. + secretion in vestibular dark cells. J Membr Biol 156:25-35
39. 39. Tai KK, Goldstein SA (1998) The conduction pore of a cardiac potassium channel. Nature 391:605-608
40. 40. Takumi T, Ohkubo H, Nakanishi S (1988) Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 242:1042-1045
41. + channel (minK) subunits. J Physiol (Lond) 510:37-45
42. 42. Tyson J, Tranebjaerg L, Bellman S, Wren C, Taylor JF, Bathen J, Aslaksen B, Sorland SJ, Lund O, Malcolm S, Pembrey M, Bhattacharya S, Bitner-Glindzicz M (1997) IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome. Hum Mol Genet 6:2179-2185
43. 43. Tzounopoulos T, Guy HR, Durell S, Adelman JP, Maylie J (1995) min K channels form by assembly of at least 14 subunits. Proc Natl Acad Sci USA 92:9593-9597
44. 44. Tzounopoulos T, Maylie J, Adelman JP (1998) Gating of I(sK) channels expressed in Xenopus oocytes. Biophys J 74:2299-2305
45. sK gene. Neuron 17:1251-1264
46. 46. Waldegger S, Fakler B, Bleich M, Barth P, Hopf A, Schulte U, Busch AE, Aller SG, Forrest JN Jr., Greger R, Lang F (1999) Molecular and functional characterization of s-KCNQ1 potassium channel from rectal gland of Squalus acanthias. Pflügers Arch 437:298-304
47. 47. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genet 12:17-23
48. 48. Wang W, Xia J, Kass RS (1998) MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channel. J Biol Chem 273:34069-34074
49. + secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro. Hear Res 84:19-29
50. + channel (rSK4) of colonic crypts. Pflügers Arch 438:437-444
51. + conductance of rat colonic crypt base cells. Pflügers Arch 432:81-88
52. Ks potassium channels. J Gen Physiol 112:665-678