CRACM1 is a plasma membrane protein essential for store-operated Ca 2+ entry

Science

Volumn 312, Issue 5777, 2006, Pages 1220-1223

  Vig, M ^a   Peinelt, C ^b   Beck, A ^b   Koomoa, D L ^b   Rabah, D ^a   Koblan Huberson, M ^a   Kraft, S ^a   Turner, H ^b   Fleig, A ^b   Penner, R ^b   Kinet, J P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; ENZYME INHIBITION; GENETIC ENGINEERING; MOLECULAR BIOLOGY; PLASMAS; RNA;

HUMAN ORTHOLOG; PATCH CLAMP SCREEN; PLASMA MEMBRANE PROTEIN; SIGNALING MACHINERY;

PROTEINS;

CALCIUM CHANNEL; CALCIUM ION; CELL MEMBRANE PROTEIN; PROTEIN CRACM1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

GENOME; INSECT; PROTEIN; RNA;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL STRAIN HEK293; DROSOPHILA; FLJ14466 GENE; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; ORTHOLOGY; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA INTERFERENCE; STORE OPERATED CALCIUM ENTRY;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CELL LINE; CELL MEMBRANE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPLASMIC RETICULUM; HUMANS; ION TRANSPORT; JURKAT CELLS; MEMBRANE PROTEINS; PATCH-CLAMP TECHNIQUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 33744479684     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1127883     Document Type: Article

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16. We thank B. Mathey-Prevot, N. Ramadan, M. Booker, and staff at the Drosophila RNAi Screening Center at Harvard Medical School for assistance with the screen; V. Yu and W. Xie (Synta Pharmaceutical, Lexington, MA) for help with using FLIPR; M. Bellinger for help with cell culture; and A. Dani for stimulating discussions and help with imaging experiments. Supported in part by NIH grants 5-R37-GM053950 (J.P.K.), R01-AI050200 and R01-N5040927 (R.P.), R01-GM065360 (A.F.).