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Volumn 430, Issue 1, 2001, Pages 147-148
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[3H]dofetilide binding to HERG transfected membranes: A potential high throughput preclinical screen
a
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Author keywords
3H dofetilide; HERG; QT interval
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Indexed keywords
1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE;
ANTIARRHYTHMIC AGENT;
CLOFILIUM;
DOFETILIDE;
ETHYLHEPTYL[4 (4 NITROPHENYL)BUTYL]AMINE;
HALOPERIDOL;
N METHYL N [2 [METHYL(1 METHYL 1H BENZIMIDAZOL 2 YL)AMINO]ETHYL] 4 [(METHYLSULFONYL)AMINO]BENZENESULFONAMIDE;
PIMOZIDE;
POTASSIUM CHANNEL;
SOTALOL;
TERFENADINE;
TRITIUM;
UNCLASSIFIED DRUG;
BENZIMIDAZOLE DERIVATIVE;
CATION TRANSPORT PROTEIN;
DNA BINDING PROTEIN;
ERG PROTEIN, HUMAN;
ERG1 POTASSIUM CHANNEL;
KCNH2 PROTEIN, HUMAN;
KCNH6 PROTEIN, HUMAN;
PHENETHYLAMINE DERIVATIVE;
POTASSIUM CHANNEL BLOCKING AGENT;
POTASSIUM CHANNEL HERG;
QUATERNARY AMMONIUM DERIVATIVE;
SULFANILAMIDE DERIVATIVE;
SULFONAMIDE;
TRANSACTIVATOR PROTEIN;
VOLTAGE GATED POTASSIUM CHANNEL;
ARTICLE;
CELL LINE;
CONTROLLED STUDY;
DRUG BINDING;
EMBRYO;
GENE EXPRESSION;
HUMAN;
HUMAN CELL;
LONG QT SYNDROME;
PRIORITY JOURNAL;
QT INTERVAL;
RADIOACTIVITY;
SCREENING;
BINDING COMPETITION;
CELL MEMBRANE;
DRUG SCREENING;
ELECTROCARDIOGRAPHY;
GENETIC TRANSFECTION;
GENETICS;
METABOLISM;
METHODOLOGY;
PATCH CLAMP;
ANTI-ARRHYTHMIA AGENTS;
BENZIMIDAZOLES;
BINDING, COMPETITIVE;
CATION TRANSPORT PROTEINS;
CELL LINE;
CELL MEMBRANE;
DNA-BINDING PROTEINS;
DRUG EVALUATION, PRECLINICAL;
ELECTROCARDIOGRAPHY;
ETHER-A-GO-GO POTASSIUM CHANNELS;
HALOPERIDOL;
HUMANS;
PATCH-CLAMP TECHNIQUES;
PHENETHYLAMINES;
PIMOZIDE;
POTASSIUM CHANNEL BLOCKERS;
POTASSIUM CHANNELS;
POTASSIUM CHANNELS, VOLTAGE-GATED;
QUATERNARY AMMONIUM COMPOUNDS;
SULFANILAMIDES;
SULFONAMIDES;
TERFENADINE;
TRANS-ACTIVATORS;
TRANSFECTION;
TRITIUM;
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EID: 0035955293
PISSN: 00142999
EISSN: None
Source Type: Journal
DOI: 10.1016/S0014-2999(01)01362-0 Document Type: Article |
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Times cited : (130)
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References (8)
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