Mechanisms of axonal dysfunction after spinal cord injury: With an emphasis on the role of voltage-gated potassium channels

Brain Research Reviews

Volumn 38, Issue 1-2, 2001, Pages 165-191

  Nashmi, Raad ^a,b   Fehlings, Michael G ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Axonal dysfunction; Kv1.1; Kv1.2; Potassium channel; Safety factor; Spinal cord injury

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CHLORIDE; DENDROTOXIN; NITRIC OXIDE; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION; TETRYLAMMONIUM;

AXONAL INJURY; CELL ACTIVATION; CELL INTERACTION; CELL SURVIVAL; CELL ULTRASTRUCTURE; CHANNEL GATING; CHLORIDE CURRENT; CLINICAL TRIAL; CONTUSION; CYTOSKELETON; DEMYELINATION; DISEASE COURSE; DRUG MECHANISM; ELECTROPHYSIOLOGY; GLIA CELL; HUMAN; MORPHOMETRICS; MULTIPLE SCLEROSIS; MYELIN SHEATH; NERVE CONDUCTION; NERVE DEGENERATION; NERVE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMYELINIZATION; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

4-AMINOPYRIDINE; ANIMALS; AXONS; HUMANS; KV1.1 POTASSIUM CHANNEL; KV1.2 POTASSIUM CHANNEL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; SPINAL CORD INJURIES; SYNAPTIC TRANSMISSION;

EID: 0035696121     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(01)00134-5     Document Type: Review

References (214)

1. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
2. Role of L and N-type calcium channels in the pathophysiology of traumatic spinal cord white matter injury
3. Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury
4. + channels
5. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis
6. Function and distribution of three types of rectifying channel in rat spinal root myelinated axons
7. + channel
8. Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat
9. Calcium current in cortical astrocytes: Induction by cAMP and neurotransmitters and permissive effect of serum factors
10. Ion channel expression by white matter glia: The type-1 astrocyte
11. Ion channel expression by white matter glia: The O-2A glial progenitor cell
12. Intracellular recording from vertebrate myelinated axons: Mechanism of the depolarizing afterpotential
13. Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat
14. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
15. After-effects of nerve impulses on signalling in the central nervous system of the leech
16. Changes in extracellular potassium concentration produced by neuronal activity in the central nervous system of the leech
17. Chemical and electrical synaptic connexions between cutaneous mechanoreceptor neurones in the central nervous system of the leech
18. Toxin I from the snake Dendroaspis polylepis polylepis: A highly specific blocker of one type of potassium channel in myelinated nerve fiber
19. + channels in insulin-producing cells. Analysis by polymerase chain reaction
20. The current status of studies of aminopyridines in patients with multiple sclerosis
21. A calcium-activated potassium channel causes frequency-dependent action-potential failures in a mammalian nerve terminal
22. A voltage- and time-dependent rectification in rat dorsal spinal root axons
23. Differentiation of nerve terminals in the crayfish opener muscle and its functional significance
24. Ion channel organization of the myelinated fiber
25. Quantitative examination of internodal length of remyelinated nerve fibres in the central nervous system
26. Axonal physiology of chronic spinal cord injury in the cat: Intracellular recording in vitro
27. Cellular morphology of chronic spinal cord injury in the cat: Analysis of myelinated axons by line-sampling
28. Computer simulation of action potentials and afterpotentials in mammalian myelinated axons: The case for a lower resistance myelin sheath
29. Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury
30. Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage
31. Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology
32. Augmentation by 4-aminopyridine of vestibulospinal free fall responses in chronic spinal-injured cats
33. The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: A phase I clinical trial
34. Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells
35. Activity-dependent excitability changes in normal and demyelinated rat spinal root axons
36. Continuous conduction in demyelinated mammalian nerve fibers
37. The internodal axon membrane: Electrical excitability and continuous conduction in segmental demyelination
38. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres
39. Physiological effects of 4-aminopyridine on demyelinated mammalian motor and sensory fibers
40. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study
41. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-Year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial
42. + channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: Binding and voltage-clamp experiments
43. Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination
44. Observations on the pathology of several types of human spinal cord injury, with emphasis on the astrocyte response to penetrating injuries
45. Simplified gene nomenclature
46. The regulation and modulation of pH in the nervous system
47. Asymmetry currents in the mammalian myelinated nerve
48. On the physiological role of internodal potassium channels and the security of conduction in myelinated nerve fibres
49. Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres
50. Sodium and potassium currents in acutely demyelinated internodes of rabbit sciatic nerves
51. Expression of a cloned rat brain potassium channel in Xenopus oocytes
52. Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits
53. Chloride conductance and extracellular potassium concentration interact to modify the excitability of rat optic nerve fibres
54. + accumulation in the developing rat optic nerve
55. + channels in rat myelinated nerve fibres and their sensitivity to dendrotoxin
56. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
57. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury
58. Activation of internodal potassium conductance in rat myelinated axons
59. Evidence that action potentials activate an internodal potassium conductance in lizard myelinated axons
60. + conductance in hippocampus
61. Composition of axolemma-enriched fractions isolated from bovine CNS myelinated axons
62. Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo
63. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
64. + channel in ventricular muscle. A molecular correlate for the transient outward current
65. Membrane currents in isolated frog nerve fibre under voltage clamp conditions
66. + channels in the frog node of Ranvier
67. Anatomical correlates of return of locomotor function after partial spinal cord lesions in cats
68. Relationship between residual hindlimb-assisted locomotion and surviving axons after incomplete spinal cord injuries
69. Current-clamp analysis of a time-dependent rectification in rat optic nerve
70. Development of 4-AP and TEA sensitivities in mammalian myelinated nerve fibers
71. Increased numbers of sodium channels form along demyelinated axons
72. Changed distribution of sodium channels along demyelinated axons
73. Abnormal distributions of potassium channels in human neuromas
74. Changes in pharmacological sensitivity of the spinal cord to potassium channel blockers following acute spinal cord injury
75. The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury
76. The action potential in the myelinated nerve fibre of xenopus laevis as computed on the basis of voltage clamp data
77. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning
78. Measurement of myelin sheath resistances: Implications for axonal conduction and pathophysiology
79. Recovery of motor function after spinal-cord injury - A randomized, placebo-controlled trial with GM-1 ganglioside
80. Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1
81. Morphological characteristics of central demyelination and remyelination: A single-fiber study
82. Evidence for the presence of two types of potassium channels in the rat optic nerve
83. Nerve fibres in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial 5 weeks
84. + channel gene
85. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
86. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family
87. 4-Aminopyridine in chronic spinal cord injury: A controlled, double-blind, crossover study in eight patients
88. Preclinical trial of 4-aminopyridine in patients with chronic spinal cord injury
89. Neuropathology of human spinal cord injury sustained in sports-related activities
90. The physiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons
91. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenous Schwann cells
92. Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor
93. Evidence for saltatory conduction in peripheral myelinated nerve fibres
94. + channel with unique localizations in mammalian brain: Molecular cloning and characterization
95. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy
96. Recovery of neurofilament expression selectively in regenerating reticulospinal neurons
97. Conductance changes, an electrogenic pump and the hyperpolarization of leech neurones following impulses
98. Evidence for increased nitric oxide production in multiple sclerosis
99. ATP-sensitive and Ca-activated K channels in vertebrate axons: Novel links between metabolism and excitability
100. Review of oxidative stress in brain and spinal cord injury: Suggestions for pharmacological and nutritional management strategies
101. Ouabain reverses conduction disturbances in single demyelinated nerve fibers
102. The applied neuropathology of human spinal cord injury
103. Pathology of spinal injuries
104. A review of the neuropathology of human spinal cord injury with emphasis on special features
105. Induction and its spread of apoptosis in rat spinal cord after mechanical trauma
106. Pharmacological modification of axon membrane molecules and cell transplantation as approaches to the restoration of conduction in demyelinated axons
107. Functional differences between 4-aminopyridine and tetraethylammonium-sensitive potassium channels in myelinated axons
108. Mammalian optic nerve fibers display two pharmacologically distinct potassium channels
109. Maturation of mammalian myelinated fibers: Changes in action-potential characteristics following 4-aminopyridine application
110. Absence of potassium conductance in central myelinated axons
111. Regenerating mammalian nerve fibres: Changes in action potential waveform and firing characteristics following blockage of potassium conductance
112. A TEA-insensitive flickering potassium channel active around the resting potential in myelinated nerve
113. + channels localized in the nodal region of myelinated axons of Xenopus
114. + channels in myelinated nerve fibers of Xenopus laevis
115. + channels and axonal geometry in the gating of action potential propagation along CA3 pyramidal cell axons: A simulation study
116. Calcium signaling of glial cells along mammalian axons
117. Axonal activation-induced calcium transients in myelinating Schwann cells, sources, and mechanisms
118. +-dependent communication between central nervous system myelinated axons and oligodendrocytes revealed by voltage-sensitive dyes
119. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord
120. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter
121. Mechanisms of glutamate activation of axon-to-Schwann cell signaling in the squid
122. Neuronal and glial apoptosis after traumatic spinal cord injury
123. Junctional intercellular communication: The cell-to-cell membrane channel
124. Acetoacetate and glucose as lipid precursors and energy substrates in primary cultures of astrocytes and neurons from mouse cerebral cortex
125. Shaw-like rat brain potassium channel cDNAs with divergent 3′ ends
126. + channel diversity in the mammalian central nervous system
127. Determination of the subunit stoichiometry of a voltage-activated potassium channel
128. Voltage-dependent calcium channels in glial cells
129. Nerve impulses increase glial intercellular permeability
130. Histopathological changes at central nodes of Ranvier after stretch-injury
131. Loss of axonal microtubules and neurofilaments after stretch-injury to guinea pig optic nerve fibers
132. + channel genes in mammals
133. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
134. + channel expression after spinal cord injury
135. Changes in axonal physiology and morphology after chronic compressive injury of the thoracic spinal cord
136. Role of potassium channels in axonal dysfunction after spinal cord injury: Molecular and electrophysiological evidence
137. Serial recording of somatosensory and myoelectric motor evoked potentials: Role in assessing functional recovery after graded spinal cord injury in the rat
138. + channels after chronic spinal cord injury
139. Sodium currents and sodium-current fluctuations in rat myelinated nerve fibres
140. Specific modalities and receptive fields of sensory neurons in CNS of the leech
141. A new voltage clamp method for Ranvier nodes
142. Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: Role of nitric oxide
143. Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia
144. + channel with conserved delayed-rectifier properties
145. Depolarization-induced alkalinization (DIA) in rat hippocampal astrocytes
146. Invited review: Motor neuropathies, motor neuron disorders, and antiglycolipid antibodies
147. Synaptic efficacy enhanced by glial cells in vitro
148. Potassium currents in cultured glia of the frog optic nerve
149. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina
150. Molecular biology of voltage-dependent potassium channels
151. Astrocytic neurotransmitter receptors in situ and in vivo
152. Randomized double-blind crossover trial of fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury
153. Dendrotoxin blocks accommodation in frog myelinated axons
154. Evidence for a sodium-dependent potassium conductance in frog myelinated axon
155. An examination of frog myelinated axons using intracellular microelectrode recording: The role of voltage-dependent and leak conductances on the steady-state electrical properties
156. Different voltage-dependent potassium conductances regulate action potential repolarization and excitability in frog myelinated axon
157. The astroglial response to Wallerian degeneration after spinal cord injury in humans
158. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide
159. Glial-neuronal interactions in non-synaptic areas of the brain: Studies in the optic nerve
160. Potassium channel distribution, clustering, and function in remyelinating rat axons
161. Internodal conduction in undissected demyelinated nerve fibres
162. Nitric oxide donors reversibly block axonal conduction: Demyelinated axons are especially susceptible
163. Characterization of a Shaw-related potassium channel family in rat brain
164. Sodium and potassium channels in regenerating and developing mammalian myelinated nerves
165. Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart
166. Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres
167. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion
168. A theory of the effects of fibre size in medullated nerve
169. Single voltage-dependent potassium channels in rat peripheral nerve membrane
170. The thickness of the myelin sheaths of normal and regenerating peripheral nerve fibres
171. Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain
172. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres
173. Conduction block in acute and chronic spinal cord injury: Different dose-response characteristics for reversal by 4-aminopyridine
174. The distribution of sodium and potassium channels in single demyelinated axons of the frog
175. Nerve conduction block by nitric oxide that is mediated by the axonal environment
176. Mechanisms of action potential propagation failure at sites of axon branching in the crayfish
177. Myelinated nerve fibers: Computed effect of myelin thickness on conduction velocity
178. + channels
179. Channel expression correlates with differentiation stage during the development of oligodendrocytes from their precursor cells in culture
180. + current types
181. Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: Blockade by protein synthesis inhibition
182. Gap junctional conductance is a simple and sensitive function of intracellular pH
183. 4-Aminopyridine improves clinical signs in multiple sclerosis
184. A chloride channel in rat and human axons
185. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain
186. Modulation of impulse conduction along the axonal tree
187. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain
188. + currents in isolated rat myelinated nerve fibers
189. Cloning of a probable potassium channel gene from mouse brain
190. Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library
191. Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns
192. Glia-neuron intercommunications and synaptic plasticity
193. Effects of tubocurarine and eserine on the axon-Schwann cell relationship in the squid nerve fibre
194. + channel expression in mouse mutants shiverer and Trembler
195. Demyelination in spinal cord injury and multiple sclerosis: What can we do to enhance functional recovery?
196. Sodium channel blockade by antibodies: A new mechanism of neurological disease?
197. Low density of sodium channels supports action potential conduction in axons of neonatal rat optic nerve
198. Conduction through demyelinated plaques in multiple sclerosis: Computer simulations of facilitation by short internodes
199. Molecular dissection of the myelinated axon
200. Anti-GM1 antibodies can block neuronal voltage-gated sodium channels
201. Nerve impulse-enhanced release of amino acids from non-synaptic regions of peripheral and central nerve trunks of bullfrog
202. The release of amino acids from nerve during stimulation
203. Myelin gene expression after experimental contusive spinal cord injury
204. Resolving three types of chloride channels in demyelinated Xenopus axons
205. Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite
206. Traumatically induced reactive change as visualized through the use of monoclonal antibodies targeted to neurofilament subunits
207. + channel
208. Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs
209. The pathophysiology of acute optic neuritis. An association of gadolinium leakage with clinical and electrophysiological deficits
210. A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein
211. Experimental spinal cord injury: Wallerian degeneration in the dorsal column is followed by revascularization, glial proliferation, and nerve regeneration