Structure and function of Kv4-family transient potassium channels

Physiological Reviews

Volumn 84, Issue 3, 2004, Pages 803-833

  Birnbaum, Shari G ^a   Varga, Andrew W ^a   Yuan, Li Lian ^a   Anderson, Anne E ^a   Sweatt, J David ^a   Schrader, Laura A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; MINK RELATED PEPTIDE 1; POSTSYNAPTIC DENSITY PROTEIN 95; POTASSIUM CHANNEL; POTASSIUM CHANNEL ACCESSORY PROTEIN; POTASSIUM CHANNEL INTERACTING PROTEIN; POTASSIUM ION; PROTEIN SUBUNIT; SHAL POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ALZHEIMER DISEASE; BINDING KINETICS; BRAIN; DROSOPHILA; ENZYME REGULATION; EPILEPSY; HEART; HEART DISEASE; INTRACELLULAR TRANSPORT; MEMBRANE DEPOLARIZATION; MEMBRANE TRANSPORT; NERVOUS SYSTEM; NONHUMAN; PALMITOYLATION; PATHOPHYSIOLOGY; POTASSIUM CHANNEL KV4.2; POTASSIUM CHANNEL SHAL TYPE; POTASSIUM CURRENT; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; VOLTAGE CLAMP;

ALZHEIMER DISEASE; ANIMALS; BRAIN; CELL PHYSIOLOGY; EPILEPSY; HEART DISEASES; HUMANS; MOLECULAR STRUCTURE; MYOCARDIUM; NEURONS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SHAL POTASSIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS;

EID: 2942588558     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00039.2003     Document Type: Review

References (234)

1. Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, and Goldstein SA. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104: 217-231, 2001.
2. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, and Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187, 1999.
3. Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, and Sweatt JD. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. J Neurochem 75: 2277-2287, 2000.
4. Adams PR and Galvan M. Voltage-dependent currents of vertebrate neurons and their role in membrane excitability. Adv Neurol 44: 137-170, 1986.
5. + channel. Neuron 16: 1169-1177, 1996.
6. Alonso G and Widmer H. Clustering of Kv4.2 potassium channels in postsynaptic membrane of rat supraoptic neurons: an ultrastructural study. Neuroscience 77: 617-621, 1997.
7. Amberg GC, Baker SA, Koh SD, Hatton WJ, Murray KJ, Horowitz B, and Sanders KM. Characterization of the A-type potassium current in murine gastric antrum. J Physiol 544: 417-428, 2002.
8. Amberg GC, Koh SD, Hatton WJ, Murray KJ, Monaghan K, Horowitz B, and Sanders KM. Contribution of Kv4 channels toward the A-type potassium current in murine colonic myocytes. J Physiol 544: 403-415, 2002.
9. Amberg GC, Koh SD, Imaizumi Y, Ohya S, and Sanders KM. A-type potassium currents in smooth muscle. Am J Physiol Cell Physiol 284: C583-C595, 2003.
10. Amberg GC, Koh SD, Perrino BA, Hatton WJ, and Sanders KM. Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity. Am J Physiol Cell Physiol 281: C2020-C2028, 2001.
11. Am WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, and Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403: 553-556, 2000.
12. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, and Sweatt JD. Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem 275: 5337-5346, 2000.
13. + current in rat ventricular myocytes. Proc Natl Acad Sci USA 85: 8756-8760, 1988.
14. + channel blocker. Neurosci Lett 139: 34-40, 1992.
15. Bahring R, Boland LM, Varghese A, Gebauer M, and Pongs O. Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels. J Physiol 535: 65-81, 2001.
16. Bahring R, Dannenberg J, Peters HC, Leicher T, Pongs O, and Isbrandt D. Conserved N-terminal Kv4 domain critical for effects of KChIP2.2 on channel expression and gating. J Biol Chem 276: 23888-23894, 2001.
17. Bahring R, Milligan CJ, Vardanyan V, Engeland B, Young BA, Dannenberg J, Waldschutz R, Edwards JP, Wray D, and Pongs O. Coupling of voltage-dependent potassium channel inactivation and oxidoreductase active site of Kvbeta subunits. J Biol Chem 9: 9, 2001.
18. Banks MI, Haberly LB, and Jackson MB. Layer-specific properties of the transient K current (IA) in piriform cortex. J Neurosci 16: 3862-3876, 1996.
19. + channels? Circ Res 77: 361-369, 1995.
20. Barry DM, Xu H, Schuessler RB, and Nerbonne JM. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res 83: 560-567, 1998.
21. +]: a tale of two inactivation mechanisms. Neuron 15: 951-960, 1995.
22. Beck H, Clusmann H, Kral T, Schramm J, Heinemann U, and Elger CE. Potassium currents in acutely isolated human hippocampal dentate granule cells. J Physiol 498: 73-85, 1997.
23. + channels in human atrium. Basic Res Cardiol 97: 424-433, 2002.
24. Bezanilla F. Voltage sensor movements. J Gen Physiol 120: 465-473, 2002.
25. + current changes and action potential duration. J Am Coll Cardiol 41: 1611-1622, 2003.
26. Bosch RF, Scherer CR, Rub N, Wohrl S, Steinmeyer K, Haase H, Busch AE, Seipel L, and Kuhlkamp V. Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits. J Am Coll Cardiol 41: 858-869, 2003.
27. + currents in rat atrial myocytes. J Physiol 517: 407-420, 1999.
28. Bourque CW. Transient calcium-dependent potassium current in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol 397: 331-347, 1988.
29. to) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol 113: 581-600, 1999.
30. + channels. J Am Coll Cardiol 37: 926-932, 2001.
31. Burridge K and Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol 12: 463-518, 1996.
32. 2+/calmodulin- dependent kinase II alpha-subunit mutation. Proc Natl Acad Sci USA 92: 6852-6855, 1995.
33. Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, and Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med 4: 1177-1181, 1998.
34. +-conductance. Brain Res 271: 358-364, 1983.
35. 2+-regulated transcriptional repressor. Nature 398: 80-84, 1999.
36. Castro PA, Cooper EC, Lowenstein DH, and Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci 21: 6626-6634, 2001.
37. Cha A, Snyder GE, Selvin PR, and Bezanilla F. Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy. Nature 402: 809-813, 1999.
38. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ, and Leppert M. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18: 53-55, 1998.
39. Choi EK, Zaidi NF, Miller JS, Crowley AC, Merriam DE, Lilliehook C, Buxbaum JD, and Wasco W. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem 276: 19197-19204, 2001.
40. + channels. Proc Natl Acad Sci USA 88: 5092-5095, 1991.
41. Christie JM and Westbrook GL. Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. J Neurophysiol 89: 2466-2472, 2003.
42. + channels. Ann NY Acad Sci 868: 233-285, 1999.
43. Crill WE and Schwindt PC. Role of persistent inward and outward membrane currents in epileptiform bursting in mammalian neurons. Adv Neurol 44: 225-233, 1986.
44. Cushman SJ, Nanao MH, Jahng AW, DeRubeis D, Choe S, and Pfaffinger PJ. Voltage dependent activation of potassium channels is coupled to T1 domain structure. Nat Struct Biol 7: 403-407, 2000.
45. + channel behaves like an open-channel blocker. Neuron 7: 743-753, 1991.
46. Deng L, Huang B, Qin D, Ganguly K, and El-Sherif N. Calcineurin inhibition ameliorates structural, contractile, and electrophysiologic consequences of postinfarction remodeling. J Cardiovasc Electrophysiol 12: 1055-1061, 2001.
47. Deschenes I, DiSilvestre D, Juang GJ, Wu RC, An WF, and Tomaselli GF. Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? Circulation 106: 423-429, 2002.
48. Deschenes I and Tomaselli GF. Modulation of Kv4. 3 current by accessory subunits. FEBS Lett 528: 183-188, 2002.
49. Diochot S, Drici MD, Moinier D, Fink M, and Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol 126: 251-263, 1999.
50. Dixon JE and McKinnon D. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res 75: 252-260, 1994.
51. + channel in ventricular muscle. A molecular correlate for the transient outward. Circ Res 79: 659-668, 1996.
52. + conduction and selectivity. Science 280: 69-77, 1998.
53. Dun W, Chandra P, Danilo P Jr, Rosen MR, and Boyden PA. Chronic atrial fibrillation does not further decrease outward currents. It increases them. Am J Physiol Heart Circ Physiol 285: H1378-H1384, 2003.
54. + channels. J Membr Biol 188: 73-86, 2002.
55. El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, and Bredt DS. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J Cell Biol 148: 159-172, 2000.
56. + channel beta subunit expressed in human heart. Proc Natl Acad Sci USA 92: 6309-6313, 1995.
57. + channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem 271: 26341-26348, 1996.
58. + current in rat ventricle. J Physiol 500: 51-64, 1997.
59. + current in acutely isolated supraoptic neurons from adult rat. Adv Exp Med Biol 449: 97-106, 1998.
60. Francis J, Jugloff DG, Mingo NS, Wallace MC, Jones OT, Burnham WM, and Eubanks JH. Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene. Neurosci Lett 232: 91-94, 1997.
61. Franz P, Galvan M, and Constanti A. Calcium-dependent action potentials and associated inward currents in guinea-pig neocortical neurons in vitro. Brain Res 366: 262-271, 1986.
62. Gandhi CS and Isacoff EY. Molecular models of voltage sensing. J Gen Physiol 120: 455-463, 2002.
63. + channel blocker-induced seizures. Brain Res 495: 189-192, 1989.
64. Glauner KS, Mannuzzu LM, Gandhi CS, and Isacoff EY. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature 402: 813-817, 1999.
65. Gong Q, Anderson CL, January CT, and Zhou Z. Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am J Physiol Heart Circ Physiol 283: H77-H84, 2002.
66. Grammer JB, Bosch RF, Kuhlkamp V, and Seipel L. Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation. J Cardiovasc Electrophysiol 11: 626-633, 2000.
67. + channel beta subunit. Cell 97: 943-952, 1999.
68. Guo W, Kamiya K, and Toyama J. Effect of chronic hypoxia on ion channel development in cultured cardiac cells. Environ Med 39: 57-60, 1995.
69. + currents. Circ Res 90: 586-593, 2002.
70. Guo W, Malin SA, Johns DC, Jeromin A, and Nerbonne JM. Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1. J Biol Chem 277: 26436-26443, 2002.
71. Hart G. Exercise-induced cardiac hypertrophy: a substrate for sudden death in athletes? Exp Physiol 88: 639-644, 2003.
72. Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, and Shapira SK. Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome. Epilepsia 42: 1103-1111, 2001.
73. Heinemann SH, Rettig J, Wunder F, and Pongs O. Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit. FEBS Lett 377: 383-389, 1995.
74. Helenius A and Aebi M. Intracellular functions of N-linked glycans. Science 291: 2364-2369, 2001.
75. Hille B. Ionic Channels of Excitable Membranes (2nd ed.). Sunderland, MA: Sinauer, 1992.
76. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J Neurosci 18: 3521-3528, 1998.
77. Hoffman DA and Johnston D. Neurotransmitter modulation of dendritic action potentials. J Neurophysiol 81: 408-411, 1999.
78. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387: 869-875, 1997.
79. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, and An WF. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci USA 99: 1035-1040, 2002.
80. Holmqvist MH, Cao J, Knoppers MH, Jurman ME, Distefano PS, Rhodes KJ, Xie Y, and An WF. Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins. J Neurosci 21: 4154-4161, 2001.
81. Hong YM, Jo DG, Lee MC, Kim SY, and Jung YK. Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients. Neurosci Lett 340: 33-36, 2003.
82. Horn R. A new twist in the saga of charge movement in voltage-dependent ion channels. Neuron 25: 511-514, 2000.
83. Hoshi T, Zagotta WN, and Aldrich RW. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250: 533-538, 1990.
84. + channels: effects of alterations in the carboxy-terminal region. Neuron 7: 547-556, 1991.
85. Hsueh YP and Sheng M. Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4. J Biol Chem 274: 532-536, 1999.
86. http://genecards.bcgsc.ca/. Genecard identifier: GC01M111189.
87. + channel genes and currents in the postinfarction heart. J Cardiovasc Electrophysiol 11: 1252-1261, 2000.
88. Huang B, Qin D, and El-Sherif N. Spatial alterations of Kv channels expression and K(+) currents in post-MI remodeled rat heart. Cardiovasc Res 52: 246-254, 2001.
89. Isacoff EY, Jan YN, and Jan LY. Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature 345: 530-534, 1990.
90. + channel. Nature 353: 86-90, 1991.
91. Jan LY and Jan YN. Cloned potassium channels from eukaryotes and prokaryotes. Annu Rev Neurosci 20: 91-123, 1997.
92. + channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophys J 72: 163-174, 1997.
93. Jerng HH, Shahidullah M, and Covarrubias M. Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. J Gen Physiol 113: 641-660, 1999.
94. Jiang Y, Lee A, Chen J, Cadene M, Chait BT, and MacKinnon R. The open pore conformation of potassium channels. Nature 417: 523-526, 2002.
95. + channel. Nature 423: 33-41, 2003.
96. + channel. Nature 423: 42-48, 2003.
97. + channel-blocking scorpion venom peptide toxins tityus-toxin-K(alpha) and pandinustoxin-K(alpha). Epilepsy Res 34: 177-186, 1999.
98. Kaab S, Dixon J, Duc J, Ashen D, Nabauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, and Tomaselli GF. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 rnRNA correlates with a reduction in current density. Circulation 98: 1383-1393, 1998.
99. Kamb A, Tseng-Crank J, and Tanouye MA. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron 1: 421-430, 1988.
100. Kamiya K, Guo W, and Toyama J. Modulation of potassium channels by chronic hypoxia in neonatal rat cultured ventricular myocytes. Environ Med 41: 60-62, 1997.
101. Kamiya K, Guo W, Yasui K, and Toyama J. Hypoxia inhibits the changes in action potentials and ion channels during primary culture of neonatal rat ventricular myocytes. J Mol Cell Cardiol 31: 1591-1598, 1999.
102. i in rat ventricular myocytes following myocardial infarction. J Physiol 517: 229-245, 1999.
103. Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, and Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circ Res 90: 578-585, 2002.
104. Khanna R, Myers MP, Laine M, and Papazian DM. Glycosylation increases potassium channel stability and surface expression in mammalian cells. J Biol Chem 276: 34028-34034, 2001.
105. to: further diversity by alternative mRNA splicing. Am J Physiol Heart Circ Physiol 275: H1903-H1970, 1998.
106. Kreusch A, Pfaffinger PJ, Stevens CF, and Choe S. Crystal structure of the tetramerization domain of the Shaker potassium channel. Nature 392: 945-948, 1998.
107. Kuo A, Gulbis JM, Autcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, and Doyle DA. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300: 1922-1926, 2003.
108. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyen-Tran VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, and Chien KR. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 107: 801-813, 2001.
109. + channels. Am J Physiol Cell Physiol 278: C931-C941, 2000.
110. Kuryshev YA, Wible BA, Gudz TI, Ramirez AN, and Brown AM. KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol 281: C290-C299, 2001.
111. Laine M, Lin MA, Bannister JP, Silverman WR, Mock AF, Roux B, and Papazian DM. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron 39: 467-481, 2003.
112. + channels that are located in apical membrane. Am J Physiol Cell Physiol 284: C1614-C1624, 2003.
113. Leicher T, Bahring R, Isbrandt D, and Pongs O. Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. J Biol Chem 273: 35095-35101, 1998.
114. Leppert M and Singh N. Benign familial neonatal epilepsy with mutations in two potassium channel genes. Curr Opin Neurol 12: 143-147, 1999.
115. Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, and Schlessinger J. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 376: 737-745, 1995.
116. + channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton. J Biol Chem 271: 29321-29328, 1996.
117. Lien CC, Martina M, Schultz JH, Ehmke H, and Jonas P. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol 538: 405-419, 2002.
118. Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, and Roeper J. Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3 1 transcription. EMBO J 20: 5715-5724, 2001.
119. + channel during gating. Neuron 16: 859-867, 1996.
120. Ma D and Jan LY. ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol 12: 287-292, 2002.
121. Magee JC and Carruth M. Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons. J Neurophysiol 82: 1895-1901, 1999.
122. + channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15: 3840-3851, 1995.
123. + channel currents in mammalian cells. Neurobiol Disorders 4: 398-409, 1998.
124. + channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus. J Neurosci 18: 8111-8125, 1998.
125. Matsu-ura T, Konishi Y, Aoki T, Naranjo JR, Mikoshiba K, and Tamura TA. Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain. Brain Res 109: 198-206, 2002.
126. + channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem 277: 13219-13228, 2002.
127. Meier T and Wallace BG. Formation of the neuromuscular junction: molecules and mechanisms. Bioessays 20: 819-829, 1998.
128. Meis S, Biella G, and Pape HC. Interaction between low voltage-activated currents in reticular thalamic neurons in a rat model of absence epilepsy. Eur J Neurosci 8: 2090-2097, 1996.
129. Melis R, Stauffer D, Zhao X, Zhu XL, Albrecht B, Pongs O, Brothman A, and Leppert M. Physical and genetic localization of a Shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2. Genomics 25: 285-287, 1995.
130. Meszaros J, Ryder KO, and Hart G. Transient outward current in catecholamine-induced cardiac hypertrophy in the rat. Am J Physiol Heart Circ Physiol 271: H2360-H2367, 1996.
131. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, and Iwatsubo T. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 277: 14965-14975, 2002.
132. Morozov A, Muzzio IA, Bourtchouladze R, Van-Strien N, Lapidus K, Yin D, Winder DG, Adams JP, Sweatt JD, and Kandel ER. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron 39: 309-325, 2003.
133. Nadal MS, Amarillo Y, Vega-Saenz de Miera E, and Rudy B. Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor. J Physiol 537: 801-809, 2001.
134. Nadal MS, Ozaita A, Amarillo Y, de Miera EV, Ma Y, Mo W, Goldberg EM, Misumi Y, Ikehara Y, Neubert TA, and Rudy B. The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K(+) channels. Neuron 37: 449-461, 2003.
135. Nagaya N and Papazian DM. Potassinm channel alpha and beta subunits assemble in the endoplasmic reticulum. J Biol Chem 272: 3022-3027, 1997.
136. + channel beta-subunits with alpha-subunits. J Biol Chem 271: 7084-7089, 1996.
137. + current, by PKC. Am J Physiol Heart Circ Physiol 273: H1775-H1786, 1997.
138. +-currents. Proc Natl Acad Sci USA 98: 12808-12813, 2001.
139. + channels, in mouse heart. Pediatr Res 53: 554-557, 2003.
140. + channel diversity in the mammalian myocardium. J Physiol 525: 285-298, 2000.
141. Nerbonne JM and Guo W. Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias. J Cardiovasc Electrophysiol 13: 406-409, 2002.
142. Ogielska EM, Zagotta WN, Hoshi T, Heinemann SH, Haab J, and Aldrich RW. Cooperative subunit interactions in C-type inactivation of K channels. Biophys J 69: 2449-2457, 1995.
143. O'Grady SM and Lee SY. Chloride and potassium channel function in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 284: L689-L700, 2003.
144. 2+ BP superfamilies in murine gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol 283: G1290-G1297, 2002.
145. + channel alpha-subunit, Kv4.3 in the rat. FEBS Lett 420: 47-53, 1997.
146. + channel occurs by a cooperative mechanism. Biophys J 69: 896-903, 1995.
147. Papazian DM, Schwarz TL, Tempel BL, Jan YN, and Jan LY. Cloning of genomic and complementary DNA from Shaker, a pu-tative potassium channel gene from Drosophila. Science 237: 749-753, 1987.
148. Patel SP, Campbell DL, Morales MJ, and Strauss HC. Heterogeneous expression of KChIP2 isoforms in the ferret heart. J Physiol 539: 649-656, 2002.
149. 2 sensitivity to Kv4.2 but not to Shaker channels. J Gen Physiol 113: 897-907, 1999.
150. + currents in mammalian cell lines and cardiac myocytes. Pflügers Arch 437: 381-392, 1999.
151. Petrecca K, Miller DM, and Shrier A. Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. J Neurosci 20: 8736-8744, 2000.
152. Po SS, Wu RC, Juang GJ, Kong W, and Tomaselli GF. Mechanism of alpha-adrenergic regulation of expressed hKv4.3 currents. Am J Physiol Heart Circ Physiol 281: H2518-H2527, 2001.
153. Pongs O, Kecskemethy N, Muller R, Krah-Jentgens I, Baumann A, Kiltz HH, Canal I, Llamazares S, and Ferrus A. Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila. EMBO J 7: 1087-1096, 1988.
154. + channel beta subunits. Ann NY Acad Sci 868: 344-355, 1999.
155. Potreau D, Gomez JP, and Fares N. Depressed transient outward current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart. Cardiovasc Res 30: 440-448, 1995.
156. Qin D, Huang B, Deng L, El-Adawi H, Ganguly K, Sowers JR, and El-Sherif N. Downregulation of K(+) channel genes expression in type I diabetic cardiomyopathy. Biochem Biophys Res Commun 283: 549-553, 2001.
157. Qin D, Zhang ZH, Caref EB, Boutjdir M, Jain P, and el-Sherif N. Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium. Circ Res 79: 461-473, 1996.
158. + channels altered by presence of beta-subunit. Nature 369: 289-294, 1994.
159. + channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. J Neurosci 16: 4846-4860, 1996.
160. + channels mediates dendritic targeting. Nat Neurosci 6: 243-250, 2003.
161. Rosati B, Grau F, Rodriguez S, Li H, Nerbonne JM, and McKinnon D. Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 548: 815-822, 2003.
162. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, and McKinnon D. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533: 119-125, 2001.
163. + current of ventricular myocytes in rats with chronic myocardial infarction. Am J Physiol Heart Circ Physiol 274: H259-H265, 1998.
164. Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Sewing S, and Pongs O. Heteromultimeric channels formed by rat brain potassium-channel proteins. Nature 345: 535-537, 1990.
165. 2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation 105: 1850-1856, 2002.
166. + current and cardiac hypertrophy: causal relationship or epiphenomenon? Circ Res 90: 497-499, 2002.
167. Sanguinetti MC, Johnson JH, Hammerland LG, Kelbaugh PR, Volkmann RA, Saccomano NA, and Mueller AL. Heteropoda-toxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol 51: 491-498, 1997.
168. Santacruz-Toloza L, Huang Y, John SA, and Papazian DM. Glycosylation of Shaker potassium channel protein in insect cell culture and in Xenopus oocytes. Biochemistry 33: 5607-5613, 1994.
169. Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, and Sweatt JD. PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. J Neurosci 22: 10123-10133, 2002.
170. Schrader LA and Tasker JG. Modulation of multiple potassium currents by metabotropic glutamate receptors in neurons of the hypothalamic supraoptic nucleus. J Neurophysiol 78: 3428-3437, 1997.
171. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, and Jentsch TJ. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403: 196-199, 2000.
172. Schwartzkroin PA and Wyler AR. Mechanisms underlying epileptiform burst discharge. Ann Neurol 7: 95-107, 1980.
173. Scott DB, Blanpied TA, Swanson GT, Zhang C, and Ehlers MD. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 21: 3063-3072, 2001.
174. + channels from bovine brain. Proc Natl Acad Sci USA 91: 1637-1641, 1994.
175. + channel. Neuron 16: 1159-1167, 1996.
176. Serodio P, Kentros C, and Rudy B. Identification of molecular components of A-type channels activating at subthreshold potentials. J Neurophysiol 72: 1516, 1994.
177. + (A-type) currents in rat brain. J Neurophysiol 79: 1081-1091, 1998.
178. + channels operating at subthreshold potentials with unique expression in heart and brain. J Neurophysiol 75: 2174-2179, 1996.
179. + channels properties in gene subfamilies. In: Handbook of Membrane Channels. New York: Academic, 1994, p. 5-16.
180. + channel subunit proteins. Neuron 14: 625-633, 1995.
181. + channel proteins in rat central neurons. Neuron 9: 271-284, 1992.
182. + channel surface expression through effects early in biosynthesis. Neuron 16: 843-852, 1996.
183. Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, and Trimmer JS. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem 278: 36445-36454, 2003.
184. + current mediated by the Kv4 channel regulates the generation of action potential in developing cerebellar granule cells. J Neurosci 20: 4145-4155, 2000.
185. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, Bjerre I, Quattlebaum T, Murphy JV, McHarg ML, Gagnon D, Rosales TO, Peiffer A, Anderson VE, and Leppert M. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 18: 25-29, 1998.
186. Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, Schwartzkroin PA, Messing A, and Tempel BL. Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20: 809-819, 1998.
187. Song M, Helguera G, Eghbali M, Zhu N, Zarei MM, Olcese R, Toro L, and Stefani E. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones, J Biol Chem 276: 31883-31890, 2001.
188. Song WJ, Tkatch T, Baranauskas G, Ichinohe N, Kitai ST, and Surmeier DJ. Somatodendritic depolarization-activated potassium currents in rat neostriatal cholinergic interneurons are predominantly of the A type and attributable to coexpression of Kv4.2 and Kv4 1 subunits. J Neurosci 18: 3124-3137, 1998.
189. Spruston N, Schiller Y, Stuart G, and Sakmann B. Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268: 297-300 1995.
190. + channel. J Gen Physiol 117: 469-490, 2001.
191. + channel. Neuron 19: 1319-1327, 1997.
192. Takeuchi S, Takagishi Y, Yasui K, Murata Y, Toyama J, and Kodama I. Voltage-gated K(+) channel, Kv4.2, localizes predominantly to the transverse-axial tubular system of the rat myocyte. J Mol Cell Cardiol 32: 1361-1369, 2000.
193. + channel subunit mRNAs in ventricles of renovascular hypertensive rats. Circ Res 81: 533-539, 1997.
194. Takimoto K, Yang EK, and Conforti L. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. J Biol Chem 277: 26904-26911, 2002.
195. Tiffany AM, Manganas LN, Kim E, Hsueh YP, Sheng M, and Trimmer JS. PSD-95 and SAP97 exhibit distinct mechanisms for regulating K(+) channel surface expression and clustering. J Cell Biol 148: 147-158, 2000.
196. Tinel N, Diochot S, Borsotto M, Lazdunski M, and Barhanin J. KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19: 6326-6330, 2000.
197. Tkatch T, Baranauskas G, and Surmeier DJ. Kv4.2 mRNA abundance and A-type K(+) current amplitude are linearly related in basal ganglia and basal forebrain neurons. J Neurosci 20: 579-588, 2000.
198. + channel Kv1.4. Neuron 20: 125-134, 1998.
199. Trimmer JS. Regulation of ion channel expression by cytoplasmic subunits. Curr Opin Neurobiol 8: 370-374, 1998,
200. a. Tristani-Firouzi M, Chen J, Mitcheson JS, and Sanguinetti MC. Molecular biology of K(+) channels and their role in cardiac arrhythmias. Am J Med 110: 50-59, 2001.
201. + channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron 8: 1055-1067, 1992.
202. Tseng-Crank JC, Tseng GN, Schwartz A, and Tanouye MA. Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library. FEBS Lett 268: 63-68, 1990.
203. Ufret-Vincenty CA, Baro DJ, and Santana LF. Differential contribution of sialic acid to the function of repolarizing K(+) currents in ventricular myocytes. Am J Physiol Cell Physiol 281: C464-C474, 2001.
204. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res 80: 772-781, 1997.
205. Varga AW, Anderson AE, Adams JP, Vogel H, and Sweatt JD. Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain, Learn Mem 7: 321-332, 2000.
206. Vasilyev DV and Barish ME. Regulation of an inactivating potassium current (IA) by the extracellular matrix protein vitronectin in embryonic mouse hippocampal neurones. J Physiol 547: 859-871, 2003.
207. Walden J, Altrup U, Reith H, and Speckmann EJ. Effects of valproate on early and late potassium currents of single neurons. Eur Neuropsychopharmacol 3: 137-141, 1993.
208. + current in rabbit and human atrial myocytes. Circ Res 84: 551-561, 1999.
209. Wang Z, Kutschke W, Richardson KE, Karimi M, and Hill JA. Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin. Circulation 104: 1657-1663, 2001.
210. Watabe AM, Zaki PA, and O'Dell TJ. Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region. J Neurosci 20: 5924-5931, 2000.
211. + channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci USA 99: 8366-8371, 2002.
212. + channel regulatory protein, KChAP. J Biol Chem 273: 11745-11751, 1998.
213. + current in rat ventricle. Am J Physiol Heart Circ Physiol 276: H1599-H1607, 1999.
214. Wickenden AD, Kaprielian R, You XM, and Backx PH. The thyroid hormone analog DITPA restores I(to) in rats after myocardial infarction. Am J Physiol Heart Circ Physiol 278: H1105-H1116, 2000.
215. Wickenden AD, Lee P, Sah R, Huang Q, Fishman GI, and Backx PH. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circ Res 85: 1067-1076, 1999.
216. Winder DG, Martin KC, Muzzio IA, Rohrer D, Chruscinski A, Kobilka B, and Kandel ER. ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. Neuron 24: 715-726, 1999.
217. Wong W, Newell EW, Jugloff DG, Jones OT, and Schlichter LC. Cell surface targeting and clustering interactions between heterologously expressed PSD-95 and the Shal voltage-gated potassium channel, Kv4.2. J Biol Chem 277: 20423-20430, 2002.
218. Wulfsen I, Hauber HP, Schiemann D, Bauer CK, and Schwarz JR. Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J Neuroendocrinol 12: 263-272, 2000.
219. Xu C, Lu Y, Tang G, and Wang R. Expression of voltage-dependent K(+) channel genes in mesenteric artery smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 277: G1055-G1003, 1999.
220. + channels in smooth muscle cells from rat tail artery. Life Sci 66: 2023-2033, 2000.
221. + currents in adult mouse ventricular myocytes. J Gen Physiol 113: 661-678, 1999.
222. Xu H, Li H, and Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 alpha subunit. J Physiol 519: 11-21, 1999.
223. + current in ventricular myocytes from diabetic rats. Am J Physiol Heart Circ Physiol 271: H2190-H2196, 1996.
224. Yamashita T, Murakawa Y, Hayami N, Fukui E, Kasaoka Y, Inoue M, and Omata M. Short-term effects of rapid pacing on mRNA level of voltage-dependent K(+) channels in rat atrium: electrical remodeling in paroxysmal atrial tachycardia. Circulation 101: 2007-2014, 2000.
225. Yang EK, Alvira MR, Levitan ES, and Takimoto K. Kvbeta subunits increase expression of Kv4.3 channels by interacting with their C termini. J Biol Chem 276: 4839, 2001.
226. Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, Wu CP, and Lu B. GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons. Nat Neurosci 4: 1071-1078, 2001.
227. Yao JA, Jiang M, Fan JS, Zhou YY, and Tseng GN. Heterogeneous changes in K currents in rat ventricles three days after myocardial infarction. Cardiovasc Res 44: 132-145, 1999.
228. + channels in hippocampus involves a mitogen-activated protein kinase pathway. J Neurosci 22: 4860-4868, 2002.
229. Yue L, Melnyk P, Gaspo R, Wang Z, and Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res 84: 776-784, 1999.
230. Zagotta WN, Hoshi T, and Aldrich RW. Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA. Proc Natl Acad Sci USA 80: 7243-7247, 1989.
231. Zerangue N, Schwappach B, Jan YN, and Jan LY. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22: 537-548, 1999.
232. Zhang M, Jiang M, and Tseng GN. minK-related peptide 1 associates with Kv4.2 and modulates its gating function: potential role as beta subunit of cardiac transient outward channel? Circ Res 88: 1012, 2001.
233. Zona C, Tancredi V, Longone P, D'Arcangelo G, D'Antuono M, Manfredi M, and Avoli M. Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine. Epilepsia 43: 685-690, 2002.
234. Zona C, Tancredi V, Palma E, Pirrone GC, and Avoli M. Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine. Can J Physiol Pharmacol 68: 545-547, 1990.