A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Nature

Volumn 441, Issue 7090, 2006, Pages 179-185

  Feske, Stefan ^a,b   Gwack, Yousang ^a,b   Prakriya, Murali ^c   Srikanth, Sonal ^a,b   Puppel, Sven Holger ^a   Tanasa, Bogdan ^a   Hogan, Patrick G ^a   Lewis, Richard S ^d   Daly, Mark ^e,f   Rao, Anjana ^a,b  

^a CENTER FOR BLOOD RESEARCH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELLS; GENETIC ENGINEERING; MUTAGENESIS; PATHOLOGY; RNA;

GENOME-WIDE APPROACHES; POLYMORPHISM ARRAYS; SCID PATIENTS; SEVERE COMBINED IMMUNE DEFICIENCY (SCID);

IMMUNOLOGY;

CALCIUM CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CELL PROTEIN; PROTEIN ORAI1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANTIGEN; GENOME; IMMUNE RESPONSE; MUTATION; PATHOGEN; POLYMORPHISM; PROTEIN; RNA;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; DROSOPHILA; FEMALE; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOSTIMULATION; LINKAGE ANALYSIS; MALE; MISSENSE MUTATION; NONHUMAN; NUCLEAR IMPORT; ORAI1 GENE; PEDIGREE; PRIORITY JOURNAL; RNA INTERFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE;

ANIMALIA;

EID: 33646576875     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04702     Document Type: Article

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