-
2
-
-
0038076054
-
+ channel
-
+ channel of a thermophilic archaebacteria at 3.2. Å, and of the isolated voltage-sensor domain at 1.9 Å. The voltage-sensor may be more flexible than previously thought, and may 'paddle' through the lipid bilayer from the intra- to the extracellular side during gating.
-
(2003)
Nature
, vol.423
, Issue.6935
, pp. 33-41
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Ruta, V.4
Cadene, M.5
Chait, B.T.6
MacKinnon, R.7
-
3
-
-
0033605385
-
ca channel, IKCa1
-
ca channel, IKCa1. J Biol Chem (1999) 274(9):5746-5754.
-
(1999)
J Biol Chem
, vol.274
, Issue.9
, pp. 5746-5754
-
-
Fanger, C.M.1
Ghanshani, S.2
Logsdon, N.J.3
Rauer, H.4
Kalman, K.5
Zhou, J.6
Beckingham, K.7
Chandy, K.G.8
Cahalan, M.D.9
Aiyar, J.10
-
5
-
-
0034987611
-
Potassium channels in T lymphocytes: Toxins to therapeutic immunosuppressants
-
Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA: Potassium channels in T lymphocytes: Toxins to therapeutic immunosuppressants. Toxicon (2001) 39(9):1269-1276. A comprehensive review on Kv1.3- and IKCa1-blocking toxins.
-
(2001)
Toxicon
, vol.39
, Issue.9
, pp. 1269-1276
-
-
Chandy, K.G.1
Cahalan, M.2
Pennington, M.3
Norton, R.S.4
Wulff, H.5
Gutman, G.A.6
-
6
-
-
0038481183
-
+ channel in effector memory T cells as new target for MS
-
CM cells. As myelin-reactive T-cells of MS patients predominantly exhibit this phenotype, the authors suggest Kv1.3 blockers as possible therapeutics for the treatment of MS and other T-cell-mediated autoimmune diseases.
-
(2003)
J Clin Invest
, vol.111
, Issue.11
, pp. 1703-1713
-
-
Wulff, H.1
Calabresi, P.A.2
Allie, R.3
Yun, S.4
Pennington, M.5
Beeton, C.6
Chandy, K.G.7
-
7
-
-
0034608869
-
+ channel, IKCa1: A potential immunosuppressant
-
+ channel, IKCa1: A potential immunosuppressant. Proc Natl Acad Sci USA (2000) 97(14):8151-8156.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.14
, pp. 8151-8156
-
-
Wulff, H.1
Miller, M.J.2
Hansel, W.3
Grissmer, S.4
Cahalan, M.D.5
Chandy, K.G.6
-
8
-
-
0034711234
-
Up-regulation of the IKCal potassium channel during T-cell activation. Molecular mechanism and functional consequences
-
Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG: Up-regulation of the IKCal potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem (2000) 275(47):37137-37149.
-
(2000)
J Biol Chem
, vol.275
, Issue.47
, pp. 37137-37149
-
-
Ghanshani, S.1
Wulff, H.2
Miller, M.J.3
Rohm, H.4
Neben, A.5
Gutman, G.A.6
Cahalan, M.D.7
Chandy, K.G.8
-
9
-
-
0032487929
-
+ channels: Synthesis and photoreactivity
-
+ channels: Synthesis and photoreactivity. J Med Chem (1998) 41 (23):4542-4549.
-
(1998)
J Med Chem
, vol.41
, Issue.23
, pp. 4542-4549
-
-
Wulff, H.1
Rauer, H.2
Düring, T.3
Hanselmann, C.4
Ruff, K.5
Wrisch, A.6
Grissmer, S.7
Hänsel, W.8
-
10
-
-
0035848581
-
Angular methoxy-subsituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3
-
Butenschön I, Möller K, Hänsel W: Angular methoxy-subsituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. J Med Chem (2001) 44(8):1249-1256.
-
(2001)
J Med Chem
, vol.44
, Issue.8
, pp. 1249-1256
-
-
Butenschön, I.1
Möller, K.2
Hänsel, W.3
-
11
-
-
0033586731
-
Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3
-
Felix JP, Bugianesi RM, Schmalhofer WA, Borris R, Goetz MA, Hensens OD, Bao JM, Kayser F, Parsons WH, Rupprecht K, Garcia ML et al: Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry (1999) 38(16):4922-4930. This paper describes the discovery and characterization of correolide.
-
(1999)
Biochemistry
, vol.38
, Issue.16
, pp. 4922-4930
-
-
Felix, J.P.1
Bugianesi, R.M.2
Schmalhofer, W.A.3
Borris, R.4
Goetz, M.A.5
Hensens, O.D.6
Bao, J.M.7
Kayser, F.8
Parsons, W.H.9
Rupprecht, K.10
Garcia, M.L.11
-
12
-
-
0033520473
-
Binding of correolide to Kv1 family potassium channels. Mapping the domains of high affinity interaction
-
Hanner M, Schmalhofer WA, Green B, Bordallo C, Liu J, Slaughter RS, Kaczorowski GJ, Garcia ML: Binding of correolide to Kv1 family potassium channels. Mapping the domains of high affinity interaction. J Biol Chem (1999) 274(36):25237-25244.
-
(1999)
J Biol Chem
, vol.274
, Issue.36
, pp. 25237-25244
-
-
Hanner, M.1
Schmalhofer, W.A.2
Green, B.3
Bordallo, C.4
Liu, J.5
Slaughter, R.S.6
Kaczorowski, G.J.7
Garcia, M.L.8
-
13
-
-
18444373237
-
Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties
-
Schmalhofer WA, Bao J, McManus OB, Green B, Matyskiela M, Wunderler D, Bugianesi RM, Felix JP, Hanner M, Linde-Arias AR, Ponte CG et al: Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties. Biochemistry (2002) 41(24):7781-7794. This paper describes the synthesis, structure-activity relationship and functional characterization of the PAC derivatives.
-
(2002)
Biochemistry
, vol.41
, Issue.24
, pp. 7781-7794
-
-
Schmalhofer, W.A.1
Bao, J.2
McManus, O.B.3
Green, B.4
Matyskiela, M.5
Wunderler, D.6
Bugianesi, R.M.7
Felix, J.P.8
Hanner, M.9
Linde-Arias, A.R.10
Ponte, C.G.11
-
14
-
-
0035797891
-
Binding of correolide to the Kv1.3 potassium channel: Characterization of the binding domain by site-directed mutagenesis
-
Hanner M, Green B, Gao YD, Schmalhofer W, Matyskiela M, Durand DJ, Felix JP, Linde AR, Bordallo C, Kaczorowski GJ, Kohler M et al: Binding of correolide to the Kv1.3 potassium channel: Characterization of the binding domain by site-directed mutagenesis. Biochemistry (2001) 40(39):11687-11697.
-
(2001)
Biochemistry
, vol.40
, Issue.39
, pp. 11687-11697
-
-
Hanner, M.1
Green, B.2
Gao, Y.D.3
Schmalhofer, W.4
Matyskiela, M.5
Durand, D.J.6
Felix, J.P.7
Linde, A.R.8
Bordallo, C.9
Kaczorowski, G.J.10
Kohler, M.11
-
15
-
-
0037472141
-
Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel Kv1.3
-
Schmalhofer WA, Slaugther RS, Matyskiela M, Felix JP, Tang YS, Rupprecht K, Kaczorowski GJ, Garcia ML: Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel Kv1.3. Biochemistry (2003) 42(16):4733-4743.
-
(2003)
Biochemistry
, vol.42
, Issue.16
, pp. 4733-4743
-
-
Schmalhofer, W.A.1
Slaugther, R.S.2
Matyskiela, M.3
Felix, J.P.4
Tang, Y.S.5
Rupprecht, K.6
Kaczorowski, G.J.7
Garcia, M.L.8
-
16
-
-
0032903174
-
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation
-
Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC et al:. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol (1999) 126(8):1707-1716.
-
(1999)
Br J Pharmacol
, vol.126
, Issue.8
, pp. 1707-1716
-
-
Hanson, D.C.1
Nguyen, A.2
Mather, R.J.3
Rauer, H.4
Koch, K.5
Burgess, L.E.6
Rizzi, J.P.7
Donovan, C.B.8
Bruns, M.J.9
Canniff, P.C.10
Cunningham, A.C.11
-
18
-
-
0035959933
-
+ permeability of erythrocytes
-
+ permeability of erythrocytes. J Med Chem (2001) 44(20):3244-3253.
-
(2001)
J Med Chem
, vol.44
, Issue.20
, pp. 3244-3253
-
-
Roxburgh, C.J.1
Ganellin, C.R.2
Athmani, S.3
Bisi, A.4
Quaglia, W.5
Benton, D.C.6
Shiner, M.A.7
Malik-Hall, M.8
Haylett, D.G.9
Jenkinson, D.H.10
-
19
-
-
0037443501
-
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice
-
Stocker JW, De Franceschi L, McNaughton-Smith GA, Corrocher R, Beuzard Y, Brugnara C: ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood (2003) 101(6):2412-2418. The development and characterization of ICA-17043 is described; this compound potently inhibits red blood cell dehydration in a mouse model of sickle cell anemia.
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2412-2418
-
-
Stocker, J.W.1
De Franceschi, L.2
McNaughton-Smith, G.A.3
Corrocher, R.4
Beuzard, Y.5
Brugnara, C.6
-
20
-
-
26144453870
-
+ channel as a new therapeutic strategy for restenosis
-
in press
-
+ channel as a new therapeutic strategy for restenosis. Circulation (2003): in press.
-
(2003)
Circulation
-
-
Köhler, R.1
Wulff, H.2
Eichler, I.3
Kneifel, M.4
Neumann, D.5
Knorr, A.6
Grgic, I.7
Kampfe, D.8
Wibawa, J.9
Real, R.10
Bomer, K.11
-
21
-
-
0018657062
-
Actions of a carbocyanine dye on calcium-dependent potassium transport in human red cell ghosts
-
Simons TJ: Actions of a carbocyanine dye on calcium-dependent potassium transport in human red cell ghosts. J Physiol (1979) 288:481-507.
-
(1979)
J Physiol
, vol.288
, pp. 481-507
-
-
Simons, T.J.1
-
22
-
-
0035943601
-
Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1
-
Wulff H, Gutman GA, Cahalan MD, Chandy KG: Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem (2001) 276(34):32040-32045.
-
(2001)
J Biol Chem
, vol.276
, Issue.34
, pp. 32040-32045
-
-
Wulff, H.1
Gutman, G.A.2
Cahalan, M.D.3
Chandy, K.G.4
-
24
-
-
0037646521
-
A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes
-
Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan, MD, Pennington M, Chandy KG: A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem (2003) 278(11):9928-9937.
-
(2003)
J Biol Chem
, vol.278
, Issue.11
, pp. 9928-9937
-
-
Beeton, C.1
Wulff, H.2
Singh, S.3
Botsko, S.4
Crossley, G.5
Gutman, G.A.6
Cahalan, M.D.7
Pennington, M.8
Chandy, K.G.9
-
25
-
-
0034944952
-
Molecular properties and physiological roles of ion channels in the immune system
-
Cahalan MD, Wulff H, Chandy KG: Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol (2001) 21(4):235-252.
-
(2001)
J Clin Immunol
, vol.21
, Issue.4
, pp. 235-252
-
-
Cahalan, M.D.1
Wulff, H.2
Chandy, K.G.3
-
26
-
-
0031157738
-
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo
-
Koo GC, Blake JT, Talento A, Nguyen M, Lin S, Sirotina A, Shah K, Mulvany K, Hora D Jr, Cunningham P, Wunderler DL et al: Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol (1997) 158(11):5120-5128. This study constitutes the first demonstration that Kv1.3 blockade suppresses immune responses in vivo. Margatoxin prevents DTH response in mini-pigs without any acute toxic side effects.
-
(1997)
J Immunol
, vol.158
, Issue.11
, pp. 5120-5128
-
-
Koo, G.C.1
Blake, J.T.2
Talento, A.3
Nguyen, M.4
Lin, S.5
Sirotina, A.6
Shah, K.7
Mulvany, K.8
Hora D., Jr.9
Cunningham, P.10
Wunderler, D.L.11
-
27
-
-
17444453850
-
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels
-
Koo GC, Blake JT, Shah K, Staruch MJ, Dumont F, Wunderier D, Sanchez M, McManus OB, Sirotina-Meisher A, Fischer P, Boltz RC et al. Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell Immunol (1999) 197(2):99-107.
-
(1999)
Cell Immunol
, vol.197
, Issue.2
, pp. 99-107
-
-
Koo, G.C.1
Blake, J.T.2
Shah, K.3
Staruch, M.J.4
Dumont, F.5
Wunderier, D.6
Sanchez, M.7
McManus, O.B.8
Sirotina-Meisher, A.9
Fischer, P.10
Boltz, R.C.11
-
28
-
-
0036212794
-
GAD65-reactive T cells are activated in patients with autoimmune type la diabetes
-
Viglietta V, Kent SC, Orban T, Hafler DA: GAD65-reactive T cells are activated in patients with autoimmune type la diabetes. J Clin Invest (2002) 109(7):895-903.
-
(2002)
J Clin Invest
, vol.109
, Issue.7
, pp. 895-903
-
-
Viglietta, V.1
Kent, S.C.2
Orban, T.3
Hafler, D.A.4
-
29
-
-
0035923519
-
+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
-
+ channel phenotype that is not observed in acutely activated rat T-cells. The Kv1.3 blocker ShK is demonstrated to prevent and treat adoptive transfer EAE in Lewis rats induced by memory cells.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.24
, pp. 13942-13947
-
-
Beeton, C.1
Wulff, H.2
Barbaria, J.3
Clot-Faybesse, O.4
Pennington, M.5
Bernard, D.6
Cahalan, M.D.7
Chandy, K.G.8
Beraud, E.9
-
30
-
-
0023945469
-
Subset-specific expression of potassium channels in developing murine T lymphocytes
-
Lewis RS, Cahalan MD: Subset-specific expression of potassium channels in developing murine T lymphocytes. Science (1988) 239(4841 Pt 1):771-775.
-
(1988)
Science
, vol.239
, Issue.4841 PART 1
, pp. 771-775
-
-
Lewis, R.S.1
Cahalan, M.D.2
-
31
-
-
0037037585
-
+ lymphocyte differentiation
-
+ lymphocyte differentiation. J Exp Med (2002) 196(7):897-909.
-
(2002)
J Exp Med
, vol.196
, Issue.7
, pp. 897-909
-
-
Liu, Q.-H.1
Fleischmann, B.K.2
Hondowitcz, B.3
Maier, C.C.4
Turka, L.A.5
Yui, K.6
Kotlikoff, M.I.7
Wells, A.D.8
Freedman, B.D.9
-
32
-
-
0034773579
-
CD4+CD28-costimulation-independent T cells in multiple sclerosis
-
Markovic-Plese S, Cortese I, Wandinger KP, McFarland HF, Martin R: CD4+CD28-costimulation-independent T cells in multiple sclerosis. J Clin Invest (2001) 108(8):1185-1194.
-
(2001)
J Clin Invest
, vol.108
, Issue.8
, pp. 1185-1194
-
-
Markovic-Plese, S.1
Cortese, I.2
Wandinger, K.P.3
McFarland, H.F.4
Martin, R.5
-
33
-
-
0142073053
-
-
Potassium channel inhibitors. US-06083986 (2000)
-
ICAGEN lNC/ELI LILLY & COMPANY (Castle NA, Hollinshead SP, Hughes PF, Mendoza JS, Wilson JW, Amato GS, Beaudoin S, Gross M, McNaughton-Smith G): Potassium channel inhibitors. US-06083986 (2000).
-
-
-
-
34
-
-
0142104670
-
-
Heterocyclic dihydropyrimidines as potassium channel inhibitors. WO-00140231 (2001)
-
BRISTOL-MYERS SQUIBB CO (Atwal KS, Vaccaro W, Lloyd J, Finlay H, Lin Y, Bhandaru RS): Heterocyclic dihydropyrimidines as potassium channel inhibitors. WO-00140231 (2001).
-
-
-
-
35
-
-
0142041168
-
-
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction. WO-09925347 (1998)
-
Olesen SP, Jensen BS, Strobaek D, Christophersen P, Jorgensen TD: Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction. WO-09925347 (1998).
-
-
-
Olesen, S.P.1
Jensen, B.S.2
Strobaek, D.3
Christophersen, P.4
Jorgensen, T.D.5
|