The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

Journal of Clinical Investigation

Volumn 111, Issue 11, 2003, Pages 1703-1713

  Wulff, Heike ^a   Calabresi, Peter A ^b   Allie, Rameeza ^b   Yun, Sung ^b   Pennington, Michael ^c   Beeton, Christine ^a   Chandy, K George ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Bachem Holding AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; GLUTAMATE DECARBOXYLASE; INSULIN; INSULIN PEPTIDE; MITOGENIC AGENT; MYELIN; OVALBUMIN; PEPTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.3; PROTEIN; SHK PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; CALCIUM; CD3 ANTIGEN; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNA3 PROTEIN, HUMAN; KCNN4 PROTEIN, HUMAN;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CALCIUM ACTIVATED POTASSIUM CHANNEL IKCA1; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EFFECTOR CELL; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; MALE; MEMORY CELL; MULTIPLE SCLEROSIS; PATCH CLAMP; PATHOGENESIS; PHENOTYPE; POTASSIUM CHANNEL KV1.3 HIGH IKCA1 LOW; PRIORITY JOURNAL; SEA ANEMONE; STICHODACTYLA HELIANTHUS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL SEPARATION; CHEMISTRY; COELENTERATE; DOSE RESPONSE; ELECTROPHYSIOLOGY; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; T LYMPHOCYTE;

ADULT; ANIMALS; ANTIGENS, CD3; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL SEPARATION; CNIDARIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC MEMORY; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KV1.3 POTASSIUM CHANNEL; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MULTIPLE SCLEROSIS; PEPTIDES; PHENOTYPE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; T-LYMPHOCYTES;

EID: 0038481183     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16921     Document Type: Article

References (48)

1. Allegretta, M., Nicklas, J.A., Sritam, S., and Albertini, R.J. 1990. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science. 247:718-721.
2. Lovett-Racke, A.E., et al. 1998. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients: a marker of activated/memory T cells. J. Clin. Invest. 101:725-730.
3. Scholz, C., Anderson, D.E., Freeman, G.J., and Hafler, D.A. 1998. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol 160:1532-1538.
4. -costimulation-independent T cells in multiple sclerosis. J. Clin. Invest 108:1188-1194. doi:10.1172/JCI200112516.
5. Viglietta, V., Kent, S.C., Orban, T., and Hafler, D.A. 2002. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J. Clin. Invest. 109:895-903. doi:10.1172/JCI200214114.
6. Friedrich, M., et al. 2000. Flow cytometric characterization of lesional T cells in psoriasis: intracellular cytokine and surface antigen expression indicates an activated, memory effector/type 1 immunophenotype. Arch. Dermatol. Res. 292:519-521.
7. Hohlfeld, R., and Wekerle, H. 2001. Immunological update on multiple sclerosis. Curr. Opin. Neurol. 14:299-304.
8. Steinman, L. 2001. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2:762-764.
9. O'Connor, K., Bar-Or, A., and Hafler, D.A. 2001. The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis. J. Clin. Immunol. 21:81-92.
10. Holoshitz, J., Naparstek, Y., Ben-Nun, A., Marquardt, P., and Cohen, I.R. 1984. T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis. Eur. J. Immunol. 14:729-734.
11. 't Hart, B.A., et al. 2000. A new primate model for multiple sclerosis in the common marmoset. Immunol. Today. 21:290-297.
12. + channels in human T lymphocytes: a role in mitogenesis? Nature. 307:465-468.
13. Chandy, K.G., DeCoursey, T.E., Cahalan, M.D., McLaughlin, C., and Gupta, S. 1984. Voltage-gated potassium channels are required for human T lymphocyte activation. J. Exp. Med. 160:369-385.
14. Lewis, RS., and Cahalan, M.D. 1995. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13:623-653.
15. Ghanshani, S., et al. 2000. Up-regulation of the IKCa1 potassium channel during T-cell activation: molecular mechanism and functional consequences. J. Biol. Chem. 275:37137-37149.
16. Cahalan, M.D., Wuff, H., and Chandy, K.G. 2001. Molecular properties and physiological roles of ion channels in the immune system. J. Clin. Immunol. 21:235-252.
17. Chandy, K.G., et al. 2001. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 39:1269-1276.
18. Beeton, C., et al. 2001. Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc. Natl. Acad Sci. U. S. A. 98:13942-13947.
19. Beeton, C., et al. 2003. A novel fluorescent toxin to detect and investigate Kv1.3-channel up-regulation in chronically activated T lymphocytes. J. Biol. Chem. 278:9928-9937.
20. Matteson, D.R., and Deutsch, C. 1984. K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature. 307:468-471.
21. Cahalan, M.D., Chandy, K.G., DeCoursey, T.E., and Gupta, S. 1985. A voltage-gated potassium channel in human T lymphocytes. J. Physiol. 358:197-237.
22. Deutsch, C., Krause, D., and Lee, S.C. 1986. Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester. J. Physiol. 372:405-423.
23. + channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation. J. Immunol. 166:936-944.
24. Sallusto, F., Lenig, D., Fotster R., Lipp, M., and Lanzavecchia, A. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:708-712.
25. + T cells. J. Exp. Med. 194:1711-1719.
26. Hemmer, B., et al. 1996. Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide 83-99. J. Neurosci. Res. 45:852-862.
27. Calabresi, P.A., Martin, R., and Jacobson, S. 1999. Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis. J. Neurovirol. 5:102-108.
28. Martin, R., Voskuhl, R., Flerlage, M., McFarlin, D.E., and McFarland, H.F. 1993. Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Ann. Neurol. 34:524-535.
29. Grissmer, S., et al. 1990. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc. Natl. Acad. Sci. U. S. A. 87:9411-9415.
30. 22, a potent Kv1.3-specific immunosuppressive polypeptide. J. Biol. Chem. 273:32697-32707.
31. + channel, IKCa1: a potential immunosuppressant. Proc. Natl. Acad. Sci. U. S. A. 97:8151-8156.
32. Atkinson, M.A., and Maclaren, N.K. 1994. The pathogenesis of insulin-dependent diabetes mellitus. N. Engl. J. Med. 331:1428-1436.
33. Alleva, D.G., et al. 2001. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J. Clin. Invest. 107:173-180.
34. Koo, G.C., et al. 1997. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J. Immunol. 158:5120-5128.
35. + currents of encephalitogenic memory T cells decrease with encephalitogenicity while interleukin-2 (IL-2) receptor expression remains stable during IL-2 dependent expansion. Receptors Channels. 6:73-87.
36. 2+ signaling. Cell Calcium. 17:287-300.
37. Clipstone, N.A., and Crabtree, G.R. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 357:695-697.
38. 2+ signals and immunosuppression. Nature. 383:837-840.
39. Grissmer, S., Nguyen, A.N., and Cahalan, M.D. 1993. Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J. Gen. Physiol. 102:601-630.
40. Hess, S.D., Oortgiesen, M., and Cahalan, M.D. 1993. Calcium oscillations in human T and natural killer cells depend upon membrane potential and calcium influx. J. Immunol. 150:2620-2633.
41. Fanger, C.M., et al. 2001. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. J. Biol. Chem. 276:12249-12256.
42. Dolmetsch, R.E., Xu, K., and Lewis, R.S. 1998. Calcium oscillations increase the efficiency and specificity of gene expression. Nature. 392:933-936.
43. Lewis, R.S. 2001. Calcium signaling mechanisms in T lymphocytes. Ann. Rev. Immunol. 19:497-521.
44. + and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. J. Exp. Med. 191:1167-1176.
45. Artym, V.V., and Petty, H.R. 2002. Molecular proximity of the Kv1.3 voltage-gated potassium channel and beta1-integrins on the plasma membrane of melanoma cells: effects of cell adherence and channel blockers. J. Gen. Physiol. 120:29-37.
46. Vanderlugt, C.L., and Miller, S.D. 2002. Epitope spreading in immunemediated diseases: implications for immunotherapy. Nat. Rev. 2:85-95.
47. Koo, G.C., et al. 1999. Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell. Immunol. 197:99-107.
48. Schmalhofer, W.A., et al. 2002. Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties. Biochemistry 18:7781-7794.