KCNQ/M currents in sensory neurons: Significance for pain therapy

Journal of Neuroscience

Volumn 23, Issue 18, 2003, Pages 7227-7236

  Passmore, Gayle M ^a   Selyanko, Alexander A ^a   Mistry, Mohini ^a   Al Qatari, Mona ^a   Marsh, Stephen J ^a   Matthews, Elizabeth A ^a   Dickenson, Anthony H ^a   Brown, Terry A ^b   Burbidge, Stephen A ^b   Main, Martin ^b   Brown, David A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Dorsal root ganglion; KCNQ; M current; Neuropathic pain; Nociceptors; Retigabine

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; ANTHRACENE DERIVATIVE; LINOPIRDINE; RETIGABINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; IMMUNOFLUORESCENCE; MALE; NERVE CELL EXCITABILITY; NERVE LIGATION; NERVE STIMULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SPINAL CORD; SPINAL GANGLION;

EID: 0043127363     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-18-07227.2003     Document Type: Article

References (50)

1. Adams PR, Brown DA, Constanti A (1982) M-currents and other potassium currents in bullfrog sympathetic neurones. J Physiol (Lond) 330:537-572.
2. Aiken SP, Lampe BJ, Murphy PA, Brown BS (1995) Reduction of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (Du 996), a neurotransmitter release enhancer. Br J Pharmacol 115:1163-1168.
3. Blackburn-Munro G, Jensen BS (2003) The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur J Pharmacol 460:109-116.
4. Boettger MK, Till S, Chen MX, Anand U, Otto WR, Plumpton C, Trezise DJ, Tate SJ, Bountra C, Coward K, Birch R, Anand P (2002) Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors. Brain 125:252-263.
5. Brown DA (1988) M-currents. In: Ion channels, Vol 1 (Narahashi T, ed), pp 55-94. New York: Plenum.
6. + current in a vertebrate neurone. Nature 283:673-676.
7. Clayton NM, Oakley I, Thompson S, Wheeldon A, Sargent B, Bountra C (1997) Validation of the dual channel weight averager as an instrument for the measurement of inflammatory pain. Br J Pharmacol 120:219P.
8. Clayton N, Marshall FH, Bountra C, O'Shaughnessy CT (2002) CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 96:253-260.
9. Dickenson AH (1995) Spinal cord pharmacology of pain. Br J Anaesth 75:193-200.
10. Dickenson AH, Sullivan AF (1986) Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain 24:211-222.
11. Hadley JK, Noda M, Selyanko AA, Wood IC, Abogadie FC, Brown DA (2000) Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol 129:413-415.
12. Hadley JK, Passmore GM, Tatulian L, Al-Qatari M, Ye F, Wickenden AD, Brown DA (2003) Stoichiometry of expressed KCNQ2/KCNQ3 channels and subunit composition of native ganglionic M-currents deduced from block by tetraethylammonium (TEA). J Neurosci 23:5012-5019.
13. Hunt SP, Mantyh PW (2001) The molecular dynamics of pain control. Nat Rev Neurosci 2:83-91.
14. Ishikawa K, Tanaka M, Black JA, Waxman SG (1999) Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy. Muscle Nerve 22:502-507.
15. Jensen TS, Gottrup H, Kasch H, Nikolajsen L, Terkelsen AJ, Witting N (2001) Has basic research contributed to chronic pain treatment? Acta Anaesthesiol Scand 45:1128-1135.
16. Jentsch TJ (2000) Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 1:21-30.
17. Kaczorowski GJ, Garcia ML (1999) Pharmacology of voltage-gated and calcium-activated potassium channels. Curr Opin Chem Biol 3:448-458.
18. Karchewski L, Burbidge SA, Woolf CJ (2001) Localization of KCNQ potassium channels in primary sensory neurons. Soc Neurosci Abstr 27:2167.
19. Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-363.
20. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (1999) KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96:437-446.
21. K(M)) and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons. Eur J Neurosci 9:605-616.
22. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (2000) Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. J Biol Chem 275:22395-22400.
23. Main MJ, Cryan JE, Dupere JRB, Cox B, Clare JJ, Burbidge SA (2000) Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol 58:253-262.
24. Marrion NV (1997) Control of M-current. Annu Rev Physiol 59:483-504.
25. Matthews EA, Dickenson AH (2001) Effects of spinally delivered N-and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy. Pain 92:235-246.
26. McCleskey EW, Gold MS (1999) Ion channels of nociception. Annu Rev Physiol 61:835-856.
27. Owen DG, Marsh SJ, Brown DA (1990) M-current noise and putative M-channels in cultured rat sympathetic ganglion cells. J Physiol (Lond) 431:269-290.
28. Pan Z, Selyanko AA, Hadley JK, Brown DA, Dixon JE, McKinnon D (2001) Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. J Physiol (Lond) 531:347-358.
29. Rae J, Cooper K, Gates P, Watsky M (1991) Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods 37:15-26.
30. Rundfeldt C, Netzer R (2000) The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci Lett 282:73-76.
31. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (2000) KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem 275:24089-24095.
32. + channels involved in epilepsy. J Biol Chem 275:13343-13348.
33. + channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell. J Neurosci 19:7742-7756.
34. 1 muscarinic acetylcholine receptors. J Physiol (Lond) 522 3:349-355.
35. Selyanko AA, Passmore GM, Brown TA, Burbidge SA, Main M, Brown DA (2001) Identification and nociceptive significance of M current in small dorsal root ganglion neurons. Soc Neurosci Abstr 27:711.
36. Shah MM, Mistry M, Marsh SJ, Brown DA, Delmas P (2002) Molecular correlates of the M-current in cultured rat hippocampal neurons. J Physiol (Lond) 544.1:29-37.
37. + channels that underlie the neuronal M current. J Neurosci 20:1710-1721.
38. Stansfeld CE, Marsh SJ, Halliwell JV, Brown DA (1986) 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current. Neurosci Lett 64:299-304.
39. Suzuki R, Dickenson AH (2000) Neuropathic pain: nerves bursting with excitement. NeuroReport 11:R17-R21.
40. Suzuki R, Matthews EA, Dickenson AH (2002) Neurobiology of neuropathic pain: mode of action of anticonvulsants. Eur J Pain 6:51-60.
41. Tatulian L, Delmas P, Abogadie FC, Brown DA (2001) Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci 21:5535-5545.
42. Tinel N, Lauritzen I, Chouabe C, Lazdunski M, Borsotto M (1998) The KNCQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS Lett 438:171-176.
43. Tokimasa T, Akasu T (1990) ATP regulates muscarine-sensitive potassium current in dissociated bull-frog primary afferent neurones. J Physiol (Lond) 426:241-264.
44. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-1893.
45. Watanabe H, Nagata E, Kosakai A, Nakamura M, Yokoyama M, Tanaka K, Sasai H (2000) Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J Neurochem 75:28-33.
46. Waxman SG, Dib-Haji S, Cummins TR, Black JA (1999) Sodium channels and pain. Proc Natl Acad Sci USA 96:7635-7639.
47. Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK (2000) Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol 58:591-600.
48. Wickenden AD, Ye F, Liu Y, McNaughton-Smith G, Roeloffs R, Rigdon GC (2002) KCNQ channel expression in rat DRG following nerve ligation. Soc Neurosci Abstr 454.7.
49. Yang WP, Levesque PC, Little WA, Conder ML, Ramakrishnan P, Neubauer MG, Blanar MA (1998) Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy. J Biol Chem 273:19419-19423.
50. ZimmermanM (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.