Benzopyran sulfonamides as KV1.5 potassium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3271-3275

  Lloyd, John ^a   Atwal, Karnail S ^a   Finlay, Heather J ^a   Nyman, Michael ^a   Huynh, Tram ^a   Bhandaru, Rao ^a   Kover, Alexander ^a   Schmidt, Joan ^a   Vaccaro, Wayne ^a   Conder, Mary Lee ^a   Jenkins West, Tonya ^a   Levesque, Paul ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antiarrhythmic; Atrial arrhythmia; Atrial fibrillation; IKur; Ion channel blocker; KV1.5; Potassium ion channel; Ultra rapid potassium current

Indexed keywords

BENZOPYRAN DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.5; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ATRIUM FIBRILLATION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; POTASSIUM CURRENT; STRUCTURE ACTIVITY RELATION; CHEMICAL MODEL; CHEMISTRY; DRUG EFFECT; HEART ATRIUM FUNCTION; METABOLISM; PHYSIOLOGY; SYNTHESIS;

ATRIAL FIBRILLATION; ATRIAL FUNCTION; BENZOPYRANS; KV1.5 POTASSIUM CHANNEL; MODELS, CHEMICAL; POTASSIUM CHANNEL BLOCKERS; SULFONAMIDES;

EID: 34249329586     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.020     Document Type: Article

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