Antipsychotie-like effect of retigabine [N-(2-amino-4-(fluorobenzylamino)- phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 951-962

  Sotty, Florence ^a   Damgaard, Trine ^a   Montezinho, Liliana P ^a   Mørk, Arne ^a   Olsen, Christina K ^a   Bundgaard, Christoffer ^a   Husum, Henriette ^a,b  

^a H LUNDBECK A S   (Denmark)

^b H Lundbeek A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; DEXAMPHETAMINE; NEUROLEPTIC AGENT; PHENCYCLIDINE; POTASSIUM CHANNEL KCNQ; RETIGABINE; 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE; ANTHRACENE DERIVATIVE; CARBAMIC ACID DERIVATIVE; DOPAMINE; PHENYLENEDIAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; DOPAMINE UPTAKE; DOPAMINERGIC TRANSMISSION; DOSE RESPONSE; LOCOMOTION; MALE; MESENCEPHALON; MESOLIMBIC DOPAMINERGIC SYSTEM; NERVE CELL EXCITABILITY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PSYCHOSIS; RAT; SCHIZOPHRENIA; VENTRAL TEGMENTUM; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; LIMBIC SYSTEM; METABOLISM; METHODOLOGY; MICRODIALYSIS; PHYSIOLOGY; SYNAPTIC TRANSMISSION; WISTAR RAT;

ANIMALS; ANTHRACENES; ANTIPSYCHOTIC AGENTS; CARBAMATES; DOPAMINE; KCNQ POTASSIUM CHANNELS; LIMBIC SYSTEM; MALE; MICRODIALYSIS; NUCLEUS ACCUMBENS; PHENYLENEDIAMINES; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 62449333567     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.146944     Document Type: Article

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