Telomere, telomerase and cancer;Telomero, telomerasa y cancer

Acta Cientifica Venezolana

Volumn 55, Issue 3, 2004, Pages 288-303

  Arvelo, Francisco ^a   Morales, Alvaro ^b  

^a FACULTAD DE CIENCIAS   (Venezuela)

^b Instituto Internacional de Estudios Avanzados IDEA   (Venezuela)

Author keywords

Cancer; Chemotherapy; Senescence; Telomerase; Telomere

Indexed keywords

EID: 72449196327     PISSN: 00015504     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (147)

1. Abdul-Ghani, R., Ohana, P., Matouk, I., Ayesh, B., Laster, M., Bibi, O., Giladi, H., Molnar Kimber, K., Sughayer, M. A., De Groot, N. and Hochberg, A. Use of transcriptional regulatory sequences of telomerase (HTER and hTERT) for selective killing of cancer cells. Mol. Ther. 2: 539-544, 2000.
2. Aigner, S., Lingner, J., Goodrich, K. J., Grosshans, C. A., Shevchenko, A., Mann, M. and Cech, T. R. Euplotes telomerase contains an La motif proteins produced by apparent translational frameshifting. EMBO J. 19: 6230-6239, 2000. (Pubitemid 30943347)
3. Akalin, A., Elmore, L. W., Forsythe, H. L., Amaker, B. A., McCollum, E. D., Nelson, P. S., Ware, J. I. and Holt, S. E. A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Res. 61: 4791-4796, 2001. (Pubitemid 32691893)
4. Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D. and Barret, J. C. Involvement of the cyclin-depedent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93: 13742-13747, 1996. (Pubitemid 26424190)
5. Balagurumoorthy, P., Brahmachari, S. K., Mohanty, D., Bansal, M. and Sasisekharan, V. Hairpin and parallel structures for telomeric sequences. Nucleic Acids Res. 20: 4061-4067, 1992.
6. Balagurumoorthy, P. and Brahmachari, S. K. Structure and stability of human telomeric sequence. J. Biol. Chem. 269: 21858-21869, 1994. (Pubitemid 24274830)
7. Beausejour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P. and Campisi, J. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22: 4212-4222, 2003. (Pubitemid 37021749)
8. Bessler, M., Wilson, D. B. and Mason, P. J. Dyskeratosis congenita and telomerase. Curr. Opin. Pediatr. 16: 23-28, 2004.
9. Bilaud, T., Brun, C., Ancelin, K., Koering, C. E., Laroche, T. and Gilson, E. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 17: 236-239, 1997.
10. Blackburn, E. H. and Gall, J. G. A Tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J. Mol. Biol 120: 33-53, 1978. (Pubitemid 8312910)
11. Blackburn, E. H. Structure and function of telomeres. Nature 350: 569-573, 1991.
12. Bourns, B. D., Alexander, M. K., Smith, A. M. and Zakian, V.A. Sir proteins, Rif proteins and Cdc13p bind Saccharomyces telomeres in vivo. Mol. Cell Biol. 18: 5600-5608, 1998.
13. Bryce, L. A., Morrison, N., Hoare, S. F., Muir, S. and Keith, W. N. Mapping of the gene for human telomerase reverse transcriptase hTERT to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia 2: 197-201, 2000. (Pubitemid 30346075)
14. Burger, A. M., Double, J. A. and Newell, D. R. Inhibition of telomerase activity by cisplatin in human testicular cancer cells. Eur. J. Cancer 33: 638-644, 1997. (Pubitemid 27223751)
15. Chan, S. W. and Blackburn, E. H. Telomerase and ATM/TE11p protect telomeres from non homologous end joining. Mol. Cell 11: 1379-1387, 2003.
16. Chang, E. and Harley, C. B. Telomere lenght and replicative aging in human vascular tissues. Proc. Natl. Acad. Sci. USA 92: 11190-11194, 1995.
17. Chang, W., Dynek, J. N. and Smith, S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes Dev. 17: 1328-1333, 2003. (Pubitemid 36666001)
18. Charames, G. S. and Bapat, B. Genomic instability and cancer. Curr. Mol. Med. 3: 589-596,2003.
19. Cheng, J. L., Smith, C. L. and Cantor, C. R. Isolation and characterization of human telomere. Nucleic Acid Res. 17: 61109-61127, 1989.
20. Chen, J. L., Blasco, M. A. and Greider, C. W. Secondary structure of vertebrate telomerase RNA. Cell 100: 503-514, 2000.
21. Chou, W. C., Hawkins, A. L., Barret, J. F., Griffin, C. A. and Dang, C. V. Arsenic inhibition of telomerase transcription leads to genetic instability. J. Clin. Invest. 108: 1541-1547, 2001.
22. Collins, K. and Mitchell, J. Telomerase in the human Organism. Oncogene 21: 564-579, 2002.
23. Cook, B. D., Dynek, J. N., Chang, W., Shostak, G. and Smith, S. Role for the related poly (ADP-ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell Biol. 22: 332-342, 2002. (Pubitemid 33144279)
24. Counter, C. M., Avilion, A. A., Le Feuvre, C. E., Stewart, N.G., Greider, C. W. and Harley, C. B. Telomere shorting associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11: 1921-1929, 1992.
25. Damm, K., Hemmann, U., Garin-Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., Guilliard, B., Lauritsch, I., Muller, E., Pascolo, E., Sauter, G., Pantic, M., Martens, U. M., Wenz, C., Lingner, J., Kraut, N., Rettig, W. J. and Sahnapp, A. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J. 20: 6958-6968, 2001. (Pubitemid 34062288)
26. De Kok, J. B., Ruers, T. J., Van Muijen, G. N., Van Bokhoven, A., Willems, H. L. and Swinkels, D. W. Realtime quantification of human telomerase reverse transcriptase mRNA in tumors and healthy tissues. Clin. Chem. 46: 313-318, 2000. (Pubitemid 30152255)
27. Decary, S., Mouly, V., Hamida, C. B., Sautete, A., Barbet, J. P. and Butler-Brown, G. S. Replicative potential and telomere length in human skeletal muscle: implication for satellite cell mediated gene therapy. Human Gene Ther. 8: 1429-1438, 1997. (Pubitemid 27393998)
28. Deng, Z., Atanasiu, C., Burg, J. S., Broccoli, D. and Lieberman, P. M. Telomere repeat binding factors TRF1, TRF2, and hRAP1 modulate replication of Epstein-Barr virus Orip J. Virol. 77: 11992-12001, 2003. (Pubitemid 37339853)
29. Dessain, S. K., Yu, H. Y., Reddel, R. R., Beijersbergen, R. L. and Weinberg, R. A. Methylation of the human telomerase gene CpG island. Cancer Res. 60: 537-541, 2000. (Pubitemid 30094546)
30. Di Leonardo, A., Linke, S. P., Clarkin, K. and Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8: 2540-2551, 1994. (Pubitemid 24347245)
31. Dimri, G. P., Lee, X. and Basile, G. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc.Natl. Acad. Sci. USA 92: 9363-9367, 1995.
32. Dragon, F., Pogacic, V. and Filipowicz, W. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell Biol. 20: 3037-3048, 2000. (Pubitemid 30215016)
33. El-Deiry, W. S. P21/p53, cellular growth control and genomic integrity. Curr. Top. Microbiol. Immunol. 227: 121-137, 1998.
34. Elkak, A. B., Newbold, R. F., Thomas, V. and Mokbel, K. Is telomerase reactivation associated with the down-regulation of TGF-ß receptor-II expression in human breast cancer?. Cancer Cell Int. 3: 9-14, 2003. (Pubitemid 38751076)
35. Eversole, A. and Maizels, N. In vitro properties of the conserved mammalian protein hnRNP suggest a role in telomere maintenance. Mol. Cell Biol. 20: 5425-5432, 2000. (Pubitemid 30482880)
36. Ferreira, M. G., Miller, K. M. and Cooper, J. P. Indecent exposure: when telomeres become uncapped. Mol. Cell 13: 7-18, 2004.
37. Fletcher, T. M., Cathers, B. E., Ravikumar, K. S., Mamiya, B. M. and Kerwin, S. M. Inhibition of human telomerase by 7-deaza-2′-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza- 2′-deoxiguanosine 5′-triphosphate. Bioorg. Chem. 29: 36-55, 2001.
38. Folini, M., Colella, G., Villa, R., Lualdi, S., Daidone, M. G. and Zaffaroni, N. Inhibition of telomerase activity by a hammerhead ribozyme targeting the RNA component of telomerase in human melanoma cells. J. Invest. Dermatol. 114: 259-267, 2000. (Pubitemid 30417759)
39. Ford, L. P., Suh, J. M., Wright, W. E. and Shay, J. W. Heterogenous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Mol. Cell Biol. 20: 9084-9091, 2000. (Pubitemid 32245937)
40. Ford, L. P., Wright, W. E. and Shay, J. W. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation. Oncogene 21:580-583, 2002.
41. Girard, J. P., Lehtonen, H., Caizergues-Ferrer, M., Amalric, F., Tollervy, D. and Lapeyre, B. GAR1 is a essential small nucleolar RNP protein required for pre - rRNA processing in yeast. EMBO J. 11: 673-682, 1992.
42. Gomez,D., Aouali, N., Renaud, A., Dovarre, C., Shin-Ya, K., Tazi,J., Martinez, S., Trentesaux, C., Morjani, H and Riou, J. F. Resistance to senescence induction and telomerase shorting by a G-quadruplex ligand inhibitor of telomerase. Cancer Res. 63: 49-53, 2003. (Pubitemid 37255154)
43. Greider, C. W. Telomeres Do D-Loop. Cell 97: 419-422, 1999.
44. Griffith, J. D., Comeau, L., Rosefield, S., Stansel R. M., Bianchi, A., Moss, H. and De Lange, T. Mammalian telomeres end in a large duplex loop. Cell 97: 503-514, 1999. (Pubitemid 29231173)
45. Gryaznov, S., Asai, A., Oshima, Y., Yamamoto, Y., Pongracz, K., Pruzan, R., Wunder, E., Piatyszek, M., Li, S., Chin, A., Harley, C., Akinaga, S. and Yamashita, Y. Oligonucleotide N3′→P5′ thio-phosphoramidate telomerase template antagonists as potential anticancer agents. Nucl. Nucl. 22: 577-581, 2003. (Pubitemid 37139211)
46. Gu, J., Kagawa, S., Takakura, M., Kyo, S., Inoue, M., Roth, J. A. and Fang, B. L. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancer. Cancer Res. 60: 5359-5364, 2000. (Pubitemid 30761241)
47. Guiducci, C., Cerone, M. A. and Bacchetti, S. Expression of mutant telomerase in immortal telomerasenegative human cells results in cell cycle deregulation nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene 20: 714-725, 2001. (Pubitemid 32179340)
48. Guilleret, I. and Benhattar, J. Demethylation of the human telomerase catality subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres. Exp. Cell Res. 289: 326-334, 2003. (Pubitemid 37117418)
49. Hanaoka, S., Nagadoi, A., Yoshimura,S., Aimoto, S., Li, B., de Lange, T. and Nishimura, Y. NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positve surface charge typical of Myb DNA-binding domains. J. Mol. Biol. 312:167-175, 2001. (Pubitemid 32835684)
50. Harley, C. Telomerase is not an Oncogene. Oncogene 21: 494-505, 2002.
51. Harrington, L., McPhail, T., Mar, V., Zhou, W., Oulton, R., Bass, M. B., Arruda, I. and Robinson, M. O. A mammalian telomerase-associated protein. Science 275: 973-977, 1997.
52. Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K. and Alishire, R. C. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868, 1990. (Pubitemid 20272111)
53. Hayakawa, N., Nozawa, A., Ogawa, A., Kato, N., Yoshida, K., Akamatsu, K., Tsuchiya, M., Nagasaka, A. and Yoshida, S. Isothiazonole derivatives selectively inhibit telomerase from human and rat cancer cells in vitro. Biochemistry 38: 11501-11507, 1999. (Pubitemid 129516728)
54. Henras, A., Henry, Y., Bousquet-Antonelli, C., Noaillac-Depeyre, J., Gelunge, J. and Caizergues- Ferrer, M. Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J. 17: 7078-7090, 1998. (Pubitemid 28550301)
55. Herbert, B. S., Pongracz, K., Shay, J. W., Gryaznov, S. M. and Shea-Herbet, B. Oligonucleotide N3′→P5′ phosphoromidates as efficient telomerase inhibitors. Oncogene 21: 638-642, 2002. (Pubitemid 34146265)
56. Hoare, S. F., Bryce, L. A., Wisman, G. B., Burns, S., Going, J. J., Van der Zee, A.G and Keith, W. N. Lack of telomerase RNA gene hTERT expression in alternative lengthening of telomeres cells is associated with methylation of the hTERT promoter. Cancer Res. 61: 27-32, 2001. (Pubitemid 32095693)
57. Holt, S. E., Aisner, D. L., Baur, J., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J. B., Morin, G. B., Toft, D. O., Shay, J. W., Wright, W. E. and White, M. A. Functional requirement of p23 and Hsp90 in telomerase complex. Genes Dev. 13: 817-826, 1999. (Pubitemid 29169841)
58. Hou, M., Xu, D., Bjorkholm, M. and Gruber, A. Real- Time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity. Clin. Chem. 47: 519-524, 2001. (Pubitemid 32222468)
59. Iwano, T., Tachibana, M., Reth, M. and Shinkai, Y. Importance of TRF1 for functional telomere structure. J. Biol. Chem. 279: 1442-1448, 2004. (Pubitemid 38082672)
60. Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. and De Lange, T. p53 and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325, 1999. (Pubitemid 129507217)
61. Karlseder, J., Smogorzewska, A. and De Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295: 2446-2449, 2002. (Pubitemid 34270257)
62. Karlseder, J. Telomere repeat binding factors: keeping the ends in check. Cancer lett. 194: 189-197, 2003. (Pubitemid 36577330)
63. Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T. and De Lange, T. Targeted deletion reveals an essential function for the telomeres length regulator Trf1. Mol. Cell Biol. 23: 6533-6544, 2003. (Pubitemid 37075764)
64. Khanna, K. K., Keating, K. E. and Kozlov, S. ATM associates with and phosphorylates p53 mapping the region of interaction. Nat. Genet. 20: 398-400, 1998. (Pubitemid 28541643)
65. Kilian, A., Bowtell, D. D., Abud, H. E., Hime, G. R., Venter, D. J., Keese, P. K., Dunacn, E. L., Reddel, R. R. and Jefferson, R. A. Isolation of a candidate human telomerase catalytic subunuit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet. 6: 2011-2019, 1997. (Pubitemid 27477942)
66. Kim, M. M., Piatyszek, M. A., Prowes, K. R., Harley, C. B., West, M. D., Ho, P. C., Coviello, G. M., Wright, W. E., Weinrich, S. L. and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
67. Kim, M. M., Rivera, M. A., Botchkina, I. L., Shslaby, R., Thor, A. D. and Blackburn, E. H. A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc. Natl. Acad. Sci. USA 98: 7982-7987, 2001.
68. Kim, M., Xu, L. and Blackburn, E. H. Catalytically active human telomerase mutants with allele-specific biological propierties. Exp. Cell Res. 288: 277-278, 2003. (Pubitemid 36959945)
69. Komata, T., Kondo, Y., Kanzawa, T., Koga, S., Sumiyoshi, H., Srinivasul, S. M., Barna, B. P., Germano, I. M., Takakura, M., Inoue, M., Alnemri, E. S., Shay, J. W., Kyo, S. and Kondo, S. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit ( human telomerase reverse transcriptase) gene promoter. Cancer Res. 61: 5796-5802, 2001. (Pubitemid 32769097)
70. Kondo, T., Oue, N., Yoshida, K., Mitani, T., Naka, K., Nakayama, H. and Yasui, W. Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. Cancer Res. 64: 523-529, 2004. (Pubitemid 38120891)
71. Ku, W. C., Cheng, A. J. and Wang, T. C. Inhibition of telomerase acttivity by PKC inhibitors in human nasopharygeal cancer cells in culture. Biochem. Biophys. Res. Commun. 241: 730-736, 1997. (Pubitemid 28036726)
72. Kuimov, A. N. Polypeptide components of telomere nucleoprotein complex. Biochemistry 69: 117-129, 2004
73. Kyo, S., Takakura, M., Kohama, T. and Inoue, M. Telomerase activity in human endometrium. Cancer Res. 57: 610-614, 1997.
74. Lange, T. Control of human telomere lenght by TRF1 and TRF2. Mol. Cell Biol. 20: 1659-1668, 2000. (Pubitemid 30100185)
75. Lavin, M. F. and Shiloh, Y. The genetic defect in ataxiatelangiectasia. Ann. Rev. Immuno. 15: 177-202, 1997.
76. Le Peuch, C. and Dorée, M. Le temps du cycle cellulaire. Med. Sci. 16: 461-468, 2000
77. Le, S., Sternglanz, R. and Greider, C. W. Identification of two RNA-binding proteins associated with human telomerase RNA. Mol. Cell Biol. 11: 999-1010, 2000 (Pubitemid 30159317)
78. Li, H., Zhao, L. I., Funder, J. W. and Liu, J. P. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J. Biol. Chem. 272: 16729-16732, 1997. (Pubitemid 27289765)
79. Li, H., Zhao, L. L., Yang, Z. Y., Funder, J. W. and Liu, J. P. Telomerase is controlled by protein kinase C alpha in human breast cancer cell. J. Biol. Chem. 273: 33436-33442, 1998. (Pubitemid 129754423)
80. Lin, Z. S., Lim, S., Viani, M. A., Sapp, M. and Lim, M. S. Down-regulation of telomerase activity in malignant lymphomas by radiation and chemotherapeutic agents. Am. J. Pathol. 159: 711-719, 2001. (Pubitemid 32751101)
81. Lin, J. and Blacburn, E. H. Nucleolar protein PinX1 regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes Dev.18: 387-396,2004. (Pubitemid 38316346)
82. Ly, H., Blackburn, E. H. and Parslow, T. G. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol. Cell Biol. 23: 6849-6856, 2003. (Pubitemid 37214655)
83. Martin, G. M., Sprague, C. A. and Epstein, C. J. Replicative lifespan of cultivated human cells effects of donor's age, tissue and genotype. Lab. Invest. 23: 86-92, 1970.
84. Masutomi, K., Kaneko, S., Hayashi, N., Yamashita, T., Shirota, Y., Kobayashi, K. and Murakami, S. Telomerse activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component. J. Biol.Chem. 275: 22568-22573, 2000. (Pubitemid 30621849)
85. McElligott, R. and Wellinger, R. J. The terminal DNA structure of mammalian chromosomes. EMBO J. 16: 3705-3714, 1997. (Pubitemid 27250063)
86. Meeker, A. K. and De Manzo, A. M. Recent advances in telomere biology: implications for human cancer. Curr. Opin. Oncol. 16: 32-38, 2004. (Pubitemid 38703469)
87. Minev, B., Hipp, J., Firat, H., Smith, J. D., Langlade- Demoyen, P. and Zanetti, M. Cytotoxic T cell cell inmunity telomerase reverse transcriptase in humans. Proc. Natl. Acad. Sci. USA 97: 4796-4801, 2000. (Pubitemid 30238637)
88. Misiti, S., Nanni, S., Fontemaggi, G., Cong, Y. S., Wen, J. P., Hirte, H. W., Piaggio, G., Sacchi, A., Pontocorvi, A., Bachetti, S. and Farsetti, A. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol. Cell Biol. 20: 3764-3771, 2000. (Pubitemid 30314476)
89. Mitchell, J. R., Cheng, J. and Collins, K. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell Biol. 19: 567-576, 1999. (Pubitemid 29018458)
90. Mitchell, J. R. and Collins, K. Human telomerase activation requires two indepedent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6: 361-371, 2000.
91. Miyoshi, D., Nakao, A. and Sugimoto, N. Structural Transition from antiparallel to parallel G-quadruplex of (G4T4G4) induced by Ca2+. Nucleic Acids Res. 31: 1156-1163, 2003. (Pubitemid 37139452)
92. Morin, G. B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529, 1989.
93. Multani, A. S., Furlong, C. and Pathak, S. Reduction of telomeric signals in murine melanoma and human breast cancer cell lines treated with 3′-azido-2′-3′- dideoxythymidine. Int. J. Oncol. 13: 923-925, 1998. (Pubitemid 28506058)
94. Naasani, I., Seimiya, H. and Tsuruo, T. Telomerase inhibition telomere shorting and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Commum. 249: 391-396, 1998. (Pubitemid 28431764)
95. Naasani, I., Seimiya, H., Yamori, T. and Tsuruo, T. FJ5002: a potent telomerase inhibitor identified by exploting the disease oriented screening program with COMPARE analysis. Cancer Res. 59: 4004-4011, 1999. (Pubitemid 29393569)
96. Nair, S. K., Heiser, A., Boczkowski, J. S., Vieweg, J. and Gilboa, E. Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. Nature Med. 6: 1011-1017, 2000.
97. Nemoto, K., Kondo, Y., Himeno, S., Suzuki, Y., Hara, S., Akimoto, M. and Imura, N. Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. Biochem. Pharmacol. 59:401-405, 2000. (Pubitemid 30015969)
98. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W. and Corey, D. R. Inhibition of human telomerase activity by peptide nucleic acids. Natura Biotechnol. 14: 615-619, 1996. (Pubitemid 26135126)
99. Ohki, R. and Ishikawa, F. Telomere bound TRF1 and TRF2 stall the replication fork at telomeric repeats. Nucleic Acids Res. 32: 1627-1637, 2004. (Pubitemid 38832708)
100. Olovnikov, A. M. A theory of marginotomy the incomplete copyng of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41: 181-190, 1973.
101. Patel, P. K., Koti, A. S. and Hosur, R. V. NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad. Nucleic Acid Res. 27: 3836-3843, 1999.
102. Petraccone, L., Erra, E., Esposito, V., Randazzo, A., Mayol, L., Nasti, L., Barone, G. and Giancola, C. Stability and structure of telomeric DNA sequences forming quadruplex containing four G-tetrads with different topological arrangements. Biochemistry 43: 4877-4884, 2004. (Pubitemid 38509109)
103. Phan, A. T. and Mergny, J. L. Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res. 30: 4618-4625, 2002.
104. Pitts, A. E. and Corey, D. R. Inhibition of human telomerase by 2′-O-methyl-RNA. Proc. Natl. Acad. Sci. USA 95: 11549-11554, 1998.
105. Ren, J. S. and Chaires, J. B. Sequence and structural selectivity of nucleic acid binding ligands. Biochemistry 38: 16067-16075, 1999.
106. Sawant, S. G., Gregoire, V., Dhar, S., Umbrich, C. B., Cvilic, S., Sukumar, S. and Pandita, T. K. Telomerase activity as a mesure for monotoring radiocurability of tumor cells. FASEB J. 13: 1047-1054, 1999. (Pubitemid 29249730)
107. Schindler, A., Fiedler, U., Meye, A., Schmidt, U., Fussel, S., Pilarsky, C., Herrmann, J. and Wirth, M. P. Human telomerase reverse transcriptase antisense treatment dowregulates the viability of prostate cancer cells in vitro. Int. J. Oncol. 19: 25-30, 2001.
108. Schnapp, G., Rodi, H. P., Rettig, W. J., Shnapp, A. and Damm, K. One-step affinity purification protocol for human telomerase. Nucleic Acids Res. 26: 3311-3313, 1998. (Pubitemid 28288936)
109. Seto, A. G., Zaug, A. J., Sobel, S. G., Wolin, S. L. and Cech, T. R. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 401: 177-180, 1999.
110. Shall, S. and Murcia, G. Poly (ADP-ribose) Polymerase- 1: what have learned from the deficient mouse model?. Mutation Res. 460: 1-15, 2000. (Pubitemid 30365046)
111. Sharma, G. G., Gupta, A., Wang, H., Scherthan, H., Dhar, S., Gandhi, V., Iliakis, G., Shay, J. W., Young, C. S. and Pandita, T. K. hTERT associates with human telomeres and enhance genomic stability and DNA repair. Oncogene 22: 131-146, 2003. (Pubitemid 36152891)
112. Shimya, K., Wierzba, K., Matsuo, K., Ohtani, T., Yamada, Y., Furihata, K., Hayakawa, Y. and Seto, H. Telomestatin a novel telomerase inhibitor from Streotomyces anulatus. J. Am. Chem. Soc. 123: 1262-1263, 2001. (Pubitemid 32148203)
113. Simbulan-Rosenthal, C. M., Rosenthal, D. S., Luo, R. and Smulson, M. E. Poly (ADP-ribosyl) of p53 during apoptosis in human osteosarcoma cells. Cancer Res. 59: 2190-2194, 1999. (Pubitemid 29217684)
114. Smith, C. D., Smith, D. L., DeRisi J. L. and Blackburn, E. H. Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 556-570, 2003. (Pubitemid 36237016)
115. Smith, S., Giriat, I., Schimitt, A. and De Lange, T. Tankyrase a poly ( ADP-ribose polymerase) at human telomeres. Science 282: 1484-1487, 1998. (Pubitemid 28538609)
116. Smogorzewska, A., Steensel, B., Bianchi, A., Oelmann, S., Shaefer, M., Schnapp, G. and De Lange, T. Control of human telomere length by TRF1 and TRF2. Mol. Cell Biol. 20: 1659-1668, 2000. (Pubitemid 30100185)
117. Stampfer, M. R., Garbe, J., Niijar, T., Wingington, D., Swisshelm, K. and Yaswen, P. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary apithelial cell lines. Oncogene 22: 5238-5251, 2003. (Pubitemid 37056086)
118. Stein, G. H., Beeson, M. and Gordon, L. Failure to phosphorylate the retinoblastoma gene product in senescencet human fibroblasts. Science 249: 666-669, 1990. (Pubitemid 20259085)
119. Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M. and Inoue, M. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59: 551-557, 1999. (Pubitemid 29076049)
120. Takay, H., Smorgorzewska, A. and De Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13: 1549-1556, 2003. (Pubitemid 37078413)
121. Teng, S. C., Chen, Y. Y., Su, Y. N., Chou, P. C., Chiang, Y. C., Tseng, S. F. and Wu, K. J. Direct activation .of HSP90A transcription by c-Myc contributes to c-Myc induced transformation. J. Biol. Chem. 27: 14649-14655, 2004.
122. Tesmer, V. M., Ford, L. P., Holt, S. E., Frank, B. C., Yi, X., Aisner, D. L., Ouellette, M., Shay, J. W. and Wright, W. E. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell Biol. 19: 6207-6216, 1999. (Pubitemid 29399325)
123. Testorelli, C. Telomerase and Cancer. J. Exp. Clin. Cancer Res. 22: 165-169, 2003.
124. Togashi,K., Kakeya, H., Morishita, M., Song, Y. X. and Osada, H. Inhibition of human telomerase activity by alterperylenol. Oncol. Res. 10:449-453, 1998 (Pubitemid 128740438)
125. Ueda, M., Ouhtit, A., Bito, T., Nakazawa, K., Lubbe, J., Ichihashi, M., Yamasaki, H. and Nakazawa, H. Evidence for UV-associated activation of telomerase in human skin. Cancer Res. 57: 370-374, 1997. (Pubitemid 27081647)
126. Ueno, T., Takahashi, H., Oda, M., Mizunuma, M., Yokoyama, A., Goto, Y., Mizushina, Y., Sagaguchi, K. and Hayashi, H. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry 39: 5995-6002, 2000. (Pubitemid 30327073)
127. Ulaner, G. A., Hu, J. F., Vu, T. H., Oruganti, H., Giudice, L. C. and Hoffman, A. R. Regulation of telomerase alternate splicing of human telomerase reverse transcriptase (HTERT) in normal and neoplastic ovary, endometrium and myometrium. Int. J. Cancer 85: 330-335, 2000. (Pubitemid 30030404)
128. Van Steensel, B. and De Lange, T. Control of telomere lenght by tha human telomeric protein TRF1. Nature 385: 740-743, 1997. (Pubitemid 27098097)
129. Vaziri, H., West, M. D. and Allsopp R. C. ATMdependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. EMBO J. 16: 6018-6033, 1997. (Pubitemid 27427297)
130. Vaziri, H., West, M. D., Allsopp, R. C., Davinson, T. S., Wu, Y. S., Arrowsmith, C. H., Poirier, G. G. and Benchimol, S. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to tha post-translational activation of p53 protein involving poly (ADP-ribose) polymerase. EMBO J. 16: 6018-6033, 1997. (Pubitemid 27427297)
131. Villa, R., Della-Porta, C., Folini, M., Daidone, M. G. and Zaffaroni, N. Possible regulation of telomerase activity by transcription and alternative splicing of telomerase transcriptase in human melanoma. J. Invest. Dermatol. 116: 867-873, 2001. (Pubitemid 32554370)
132. Vogelstein, B. and Kinzler, K. W. The multistep nature of cancer. Trends Genet. 9: 138-141, 1993.
133. Von Zglinicki, T. Telomeres and replicative senescence: Is it only length that counts?. Cancer Lett. 168:111-116, 2001. (Pubitemid 32524271)
134. Von Zglinicki, T., Burkle, A. and Kirwood, T. B. Stress, DNA damage and ageing-an integrative approach. Exp. Gerontol. 36: 1049-1062, 2001. (Pubitemid 32515220)
135. Vulliamy, T. J., Knight, S. W., Mason, P. J and Dokal, I. Very short telomeres in the peripheral blood of patients with X-linked and autosomal dyskeratosis congenita. Blood Cells Dis. 27: 353-357, 2001. (Pubitemid 32547829)
136. Wang, J., Xie, L. Y., Allan, S., Beach, D and Hannon, G. J. Myc activates telomerase. Genes Dev. 12: 1769-1774, 1998.
137. Wick, M., Zubov, D. and Hagen, G. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (HTERT). Gene 232: 97-106, 1999. (Pubitemid 29305322)
138. Wisman, G. B., Hollem, H., Helder, M. N., Knol, A. J., Van der Meer, G. T., Kraus, M., De Jong, S., De Vries, E. G. and Van der Zee, A. G. Telomerase in relation to expression of p53,c-Myc and estreogen receptor in ovarian tumours. Int. J.Oncol. 23: 1451-1459, 2003.
139. Wright, W. E. and Shay, J. W. The two stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 27: 383-389, 1992.
140. Wright W. E. and Shay, J. W. Time telomeres and tumours: is cellular senescence more than an anticancer mechanism? Trends Cell Biol. 5: 293-297, 1995.
141. Wu, X., Amos, C. I., Zhu, Y., Zhao, H., Grossman, B. H., Shay, J. W., Luo, S., Hong, W. K. and Spitz, M. R. Telomero, telomerasa y cáncer 303 Telomere dysfunction: a potential cancer predisposition factor. J. Natl. Cancer Inst. 95: 1211-1218, 2003. (Pubitemid 47368377)
142. Yamakuchi, M., Nakata, M., Kawahara, K., Kitajima, I. and Maruyama, I. New quinolones ofloxacin and levofloxacin inhibit telomerase activity in transitional cell carcinoma cell lines. Cancer Lett. 119: 213-219, 1997. (Pubitemid 27478106)
143. Yamakuchi, T., Yamada, R., Tomikawa, A., Shudo, K., Saito, M., Ishikawa, F. and Saneyoshi, M. Recognition 2′-deoxi-L-ribonucleoside 5' triphosphates by human telomerase. Biochem. Biophys. Res. Commun. 279: 475-481, 2000. (Pubitemid 32016740)
144. Ye, J. Z. and De Lange, T. TIN2 is a Tankyrase PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36: 618-623, 2004. (Pubitemid 38715990)
145. Yin, L., Hubbard, A. K. and Giardina, C. NF-kappa B regulates transcription of the mouse telomerase catalytic subunit. J. Biol. Chem. 275: 36671-36675, 2000. (Pubitemid 32002070)
146. Yokoyama, Y., Takahashi, Y., Shinohara, A., Lian, Z. L., Wan, X. Y., Niwa, K. and Tamaya, T. Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res. 58: 5406-5410, 1998. (Pubitemid 28551123)
147. Yoon, H. J., Choi, I. Y., Kang, M. R., Kim, S. S., Muller, M. T., Spitzner, J. R. and Chung, I. K. DNA Topoisomerase II cleavage of telomeres in vitro and in vivo. Biochim. Biophys. Acta 1395: 110-120, 1998. (Pubitemid 28035526)