Modulation of telomerase activity by zinc in human prostatic and renal cancer cells

Biochemical Pharmacology

Volumn 59, Issue 4, 2000, Pages 401-405

  Nemoto, Kaoru ^a   Kondo, Yukihiro ^a   Himeno, Seiichiro ^b   Suzuki, Yasutomo ^a   Hara, Shuntaro ^b   Akimoto, Masao ^a   Imura, Nobumasa ^b  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b School of Pharmaceutical Sciences   (Japan)

Author keywords

Prostatic cancer cell; Renal cell carcinoma; Telomerase activation; Zinc

Indexed keywords

CADMIUM; CHELATING AGENT; COPPER; CYCLOHEXIMIDE; METALLOTHIONEIN; TELOMERASE; ZINC;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR CELL LINE;

CADMIUM; COPPER; ENZYME ACTIVATION; HUMANS; KIDNEY NEOPLASMS; MALE; PROSTATIC NEOPLASMS; TELOMERASE; TUMOR CELLS, CULTURED; ZINC;

EID: 0033976074     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00334-2     Document Type: Article

References (16)

1. Rhyu M.S. Telomeres, telomerase, and immortality. J Natl Cancer Inst. 87:1995;884-894.
2. Sedivy J.M. Can ends justify the means? Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. Proc Natl Acad Sci USA. 95:1998;9078-9081.
3. Greider C.W., Blackburn E.H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:1989;331-337.
4. Nugent C.I., Lundblad V. The telomerase reverse transcriptase Components and regulation . Genes Dev. 12:1998;1073-1085.
5. Greider C.W. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA. 95:1998;90-92.
6. Autexier C., Greider C.W. Telomerase and cancer Revisiting the telomere hypothesis . Trends Biochem Sci. 21:1996;387-391.
7. Lingner J., Hughes T.R., Shevchenko A., Mann M., Lundblad V., Cech T.R. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 276:1997;561-567.
8. Prasad A.S. Zinc, An overview. Nutrition. 11:(Suppl 1):1995;93-99.
9. Vallee B.L., Falchuk K.H. The biochemical basis of zinc physiology. Physiol Rev. 73:1993;79-118.
10. Shankar A.H., Prasad A.S. Zinc and immune function The biological basis of altered resistance to infection . Am J Clin Nutr. 68:(Suppl 2):1998;447S-463S.
11. Kondo Y., Kuo S.M., Lazo J.S. Interleukin-1β-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum. J Pharmacol Exp Ther. 270:1994;1313-1318.
12. Sommerfeld H.J., Meeker A.K., Piatyszek M.A., Bova G.S., Shay J.W., Coffey D.S. Telomerase activity A prevalent marker of malignant human prostate tissue . Cancer Res. 56:1996;218-222.
13. Basu A., Lazo J.S. A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs. Toxicol Lett. 50:1990;123-135.
14. Terashima M., Ogawa Y., Toda K., Nishioka A., Inomata T., Kubonishi I., Taguchi H., Yoshida S., Shizuta Y. Effects of irradiation on telomerase activity in human lymphoma and myeloma cell lines. Int J Mol Med. 2:1998;567-571.
15. Schmidt C., Beyersmann D. Transient peaks in zinc and metallothionein levels during differentiation of 3T3L1 cells. Arch Biochem Biophys. 364:1999;91-98.
16. Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., Dalla-Favera R. Direct activation of TERT transcription by c-MYC. Nat Genet. 21:1999;220-224.