Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix

Nucleic Acids Research

Volumn 30, Issue 21, 2002, Pages 4618-4625

  Phan, Anh Tuân ^a,c   Mergny, Jean Louis ^b  

^a LABORATOIRE DE PHYSIQUE DE LA MATIÈRE CONDENSÉE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; DNA; GUANINE; OLIGONUCLEOTIDE; SODIUM CHLORIDE; TELOMERE DNA; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONCENTRATION (PARAMETERS); CONFORMATION; CONTROLLED STUDY; DNA HELIX; DNA STRAND; DNA STRUCTURE; HUMAN; KINETICS; NUCLEOTIDE REPEAT; PH; PRIORITY JOURNAL; TELOMERE; TEMPERATURE; THERMODYNAMICS;

EID: 0036849582     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf597     Document Type: Article

References (41)

1. Greider, C.W. (1998) Telomerase activity, cell proliferation and cancer. Proc. Natl Acad. Sci. USA, 95, 90-92.
2. Greider, C.W. and Blackburn, E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43, 405-413.
3. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L.C., Coviello, G.M., Wright, W.E., Weinrich, S.L. and Shay, J.W. (1994) Specific association of human telomerase activity with immortal cells and cancer. Science, 266, 2011-2015.
4. Mergny, J.L., Riou, J.F., Mailliet, P., Teulade-Fichou, M.P. and Gilson, E. (2002) Natural and pharmacological regulation of telomerase. Nucleic Acids Res., 30, 839-865.
5. n, present at the telomeres of human chromosomes. Proc. Natl Acad. Sci. USA, 85, 6622-6626.
6. Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature, 345, 458-460.
7. Allsopp, R.C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E.V., Futcher, A.B., Greider, C.W. and Harley, C.B. (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl Acad. Sci. USA, 89, 10114-10118.
8. Makarov, V.L., Hirose, Y. and Langmore, J.P. (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell, 88, 657-666.
9. Sen, D. and Gilbert, W. (1988) Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its applications for meiosis. Nature, 334, 364-366.
10. Sundquist, W.I. and Klug, A. (1989) Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature, 342, 825-829.
11. Gehring, K., Leroy, J.L. and Guéron, M. (1993) A tetrameric structure with protonated cytosine.cytosine base pairs. Nature, 363, 561-565.
12. 3] G-tetraplex. Structure, 1, 263-282.
13. Phan, A.T., Guéron, M. and Leroy, J.L. (2000) The solution structure and internal motions of a fragment of the cytidine-rich strand of the human telomere. J. Mol. Biol., 299, 123-144.
14. Parkinson, G.N., Lee, M.P.H. and Neidle, S. (2002) Crystal structure of parallel quadruplexes from human telomeric DNA. Nature, 417, 876-880.
15. Hardin, C.C., Henderson, E., Watson, T. and Prosser, J.K. (1991) Monovalent cation induced structural transitions in telomeric DNAs: G-DNA folding intermediates. Biochemistry, 30, 4460-4472.
16. 3GCG). Biochemistry, 31, 833-841.
17. Williamson, J.R. (1994) G-quartet structures in telomeric DNA. Annu. Rev. Biophys. Biomol. Struct., 23, 703-730.
18. Kerwin, S.M. (2000) G-quadruplex DNA as a target for drug design. Curr. Pharm. Design, 6, 441-471.
19. Leroy, J.L., Guěron, M., Mergny, J.L. and Hélène, C. (1994) Intramolecular folding of a fragment of the cytosine-rich strand of telomeric DNA into an i-motif. Nucleic Acids Res., 22, 1600-1606.
20. Mergny, J.L., Lacroix, L., Han, X., Leroy, J.L. and Hělène, C. (1995) Intramolecular folding of pyrimidine oligodeoxynucleotides into an i-DNA motif. J. Am. Chem. Soc., 117, 8887-8898.
21. Phan, A.T. and Leroy, J.L. (2000) Intramolecular i-motif structures of telomeric DNA. J. Biomol. Struct. Dyn., S2, 245-252.
22. Schaffitzel, C., Berger, I., Postberg, J., Hanes, J., Lipps, H.J. and Plückthun, A. (2001) In vitro generated antibodies specific for telomeric guanine quadruplex DNA react with Stylonychia lemnae macronuclei. Proc. Natl Acad. Sci. USA, 98, 8572-8577.
23. Miura, T. and Thomas, G.J. (1994) Structural polymorphism of telomere DNA: interquadruplex and duplex-quadruplex conversions probed by Raman spectroscopy. Biochemistry, 33, 7848-7856.
24. Deng, H. and Braunlin, W.H. (1995) Duplex to quadruplex equilibrium of the self-complementary oligonucleotide d(GGGGCCCC). Biopolymers, 35, 677-681.
25. Salazar, M., Thompson, B.D., Kerwin, S.M. and Hurley, L.H. (1996) Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase. Biochemistry, 35, 16110-16115.
26. Rangan, A., Fedoroff, O.Y. and Hurley, L.H. (2001) Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. J. Biol. Chem., 276, 4640-4646.
27. Datta, B. and Armitage, B.A. (2001) Hybridization of PNA to structured DNA targets: quadruplex invasion and the overhang effect. J. Am. Chem. Soc., 123, 9612-9619.
28. Li, W., Wu, P., Ohmichi, T. and Sugimoto, N. (2002) Characterization and thermodynamic properties of quadruplex/duplex competition. FEBS Lett., 526, 77-81.
29. Phan, A.T., Guéron, M. and Leroy, J.L. (2001) Investigations of unusual DNA motifs. Methods Enzymol., 338, 341-371.
30. Mergny, J.L., Phan, A.T. and Lacroix, L. (1998) Following G-quartet formation by UV-spectroscopy. FEBS Lett., 435, 74-78.
31. Leroy, J.L., Gehring, K., Kettani, A. and Guéron, M. (1993) Acid multimers of oligodeoxycytidine strands: stoichiometry, base pair characterization and proton exchange properties. Biochemistry, 32, 6019-6031.
32. Cantor, C.R., Warshaw, M.M. and Shapiro, H. (1970) Oligonucleotide interactions. 3. Circular dichroism studies of the conformation of deoxyoligonucleotides. Biopolymers, 9, 1059-1077.
33. Mills, M., Arimondo, P., Lacroix, L., Garestier, T., Hělène, C., Klump, H.H. and Mergny, J.L. (1999) Energetics of strand displacement reactions in triple helices: a spectroscopic study. J. Mol. Biol., 291, 1035-1054.
34. Plateau, P. and Guéron, M. (1982) Exchangeable proton NMR without base-line distortion, using strong pulse sequences. J. Am. Chem. Soc., 104, 7310-7311.
35. Phan, A.T. (1999) Structures and motions of nucleic acids in solution: telomeres and centromeres; water and ions associated to nucleic acids; NMR methods. PhD Thesis, Ecole Polytechnique, Palaiseau, France.
36. Alberti, P., Ren, J., Teulade-Fichou, M.P., Guittat, L., Riou, J.F., Chaires, J.B., Hélène, C., Vigneron, J.P., Lehn, J.M. and Mergny, J.L. (2001) Interaction of an acridine dimer with DNA quadruplex structures. J. Biomol. Struct. Dyn., 19, 505-513.
37. Ren, J., Qu, X., Trent, J.O. and Chaires, J.B. (2002) Tiny telomere DNA. Nucleic Acids Res., 30, 2307-2315.
38. Griffith, J.D., Comeau, L., Rosenfield, S., Stansel, R.M., Bianchi, A., Moss, H. and de Lange, T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
39. Stansel, R.M., de Lange, T. and Griffith, J.D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J., 20, 5532-5540.
40. Siddiqui-Jain, A., Grand, C.L., Bearss, D.J. and Hurley, L.H. (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl Acad. Sci. USA, 99, 11593-11598.
41. Neidle, S. and Parkinson, G. (2002) Telomere maintenance as a target for anticancer drug discovery. Nature Rev. Drug Discov., 1, 383-393.